Skip to main content

The complex interplay between clinical and person-centered diabetes outcomes in the two genders

Abstract

Background

New approaches to cope with clinical and psychosocial aspects of type 2 diabetes (T2DM) are needed; gender influences the complex interplay between clinical and non-clinical factors. We used data from the BENCH-D study to assess gender-differences in terms of clinical and person-centered measures in T2DM.

Methods

Clinical quality of care indicators relative to control of HbA1c, lipid profile, blood pressure, and BMI were derived from electronic medical records. Ten self-administered validated questionnaires (SF-12 Health Survey; WHO-5 well-being index; Problem Areas in Diabetes (PAID) 5, Health Care Climate Questionnaire, Patients Assessment of Chronic Illness Care, Diabetes Empowerment Scale, Diabetes Self-care Activities, Global Satisfaction for Diabetes Treatment, Barriers to Taking Medications, Perceived Social Support) were adopted as person-centered outcomes indicators.

Results

Overall, 26 diabetes clinics enrolled 2,335 people (men: 59.7%; women: 40.3%). Lower percentages of women reached HbA1c levels < =7.0% (23.2% vs. 27.8%; p = 0.03), LDL-cholesterol < 100 mg/dl (48.3 vs. 57.8%; p = 0.0005), and BMI <27 Kg/m2 (27.2 vs. 31.6%; p = 0.04) than men. Women had statistically significant poorer scores for physical functioning, psychological well-being, self-care activities dedicated to physical activities, empowerment, diabetes-related distress, satisfaction with treatment, barriers to medication taking, satisfaction with access to chronic care and healthcare communication, and perceived social support than men; 24.8% of women and 8.8% of men had WHO-5 < =28 (likely depression) (p < 0.0001); 67.7% of women and 55.1% of men had PAID-5 > 40 (high levels of diabetes-related distress) (p < 0.0001). At multivariate analysis, factors associated with an increased likelihood of having elevated HbA1c levels (≥8.0%) were different in men and women, e.g. having PAID-5 levels >40 was associated with a higher likelihood of HbA1c ≥8.0% in women (OR = 1.15; 95%CI 1.05–1.25) but not in men (OR = 1.00; 95%CI 0.93–1.08).

Conclusions

In T2DM, women show poorer clinical and person-centered outcomes indicators than men. Diabetes-related distress plays a role as a correlate of metabolic control in women but not in men. The study provides new information about the interplay between clinical and person-centered indicators in men and women which may guide further improvements in diabetes education and support programs.

Background

The considerable pressure on health care systems to provide high-quality care while controlling costs has led several public and private health care organizations to promote initiatives to measure and improve the quality of care for people with diabetes [1, 2].

In Italy, the Associazione Medici Diabetologi (AMD) scientific society has implemented since 2006 a continuous improvement effort involving a large network of diabetes clinics throughout the country (AMD-Annals) [3]. The periodic dissemination of Annals has been effective in improving several process and intermediate outcome indicators clinical indicators over a few years [4]. The model has also been proven to be cost-effective [5].

Data from AMD-Annals have been recently used to evaluate gender differences in pharmacological and non-pharmacological treatment of diabetes [6]. The analysis was important to demonstrate that gender disparities are less pronounced in Italy than in other countries, but that the likelihood to reach specific clinical outcomes is systematically unfavorable for women as compared to men; in particular, women were 14% more likely than men to have HbA1c levels >9.0% in spite of insulin treatment, 42% more likely to have LDL-cholesterol ≥130 mg/dl in spite of lipid-lowering treatment, and 50% more likely to have BMI ≥30 Kg/m2. These findings suggested that a complex interplay among biological, clinical and behavioral differences can underlie these differences and call for diversifying the care and specializing the support provided to men and women.

In parallel, the increasing recognition of patient-centered care as the best model to ensure a care respectful of, and responsive to patient preferences, needs, and values [7] call for the need to include psychosocial aspects in the quality model of diabetes care, as clearly emphasized by the international Diabetes Attitudes, Wishes, and Needs (DAWN-2) Program [8]. The DAWN-2 study well documented that people with diabetes have major psychosocial issues; in particular, 44.6% (country range 17.2–67.6%) of people with diabetes have diabetes-related distress (i.e. Problem Areas in Diabetes Scale 5 (PAID-5) score ≥ 40) [9], while 13.8% have likely depression [WHO-5 Well-Being Index (WHO-5) score ≤ 28] [10] (country range 6.5–24.1%). Furthermore, diabetes had a negative impact on physical health and social relationship; approximately 40% of participants reported that their medication interfered with their ability to live a normal life.

Due to this body of evidence, individualized interventions based on patient needs, concerns, and capabilities have been promoted while taking gender into account.

In the context of the AMD-Annals and the DAWN2 initiatives, the BENCH-D study (Benchmarking Network for Clinical and Humanistic Outcomes in Diabetes) was launched aiming to test a model of regional benchmarking to monitor and improve not only clinical indicators, but also person-centered outcomes [11]. Besides the AMD clinical indicators for the evaluation of quality of care, the BENCH-D study used validated questionnaires, largely derived from the DAWN2 study, for measuring person-centered dimensions.

The first important step of the BENCH- study was to describe the person-centered indicators in type 2 population and to explore the relationship among different quality of care and quality of life dimensions. As described in two previous papers [12, 13], BENCH-D documented that: high levels of diabetes distress are common among people with type 2 diabetes (T2DM), affecting almost two-thirds of patients; high diabetes distress is associated with worse clinical and psychosocial outcomes; higher empowerment is on the other hand associated with better glycemic control, psychosocial functioning and perceived access to person-centered chronic illness care.

In the present secondary analysis of the BENCH-D data, database has been used to assess gender-differences in T2DM in terms of diabetes-related distress, physical and psychological well-being, empowerment, perceived social support and other measures of satisfaction with treatment and care. We wanted to test the hypothesis that systematic differences exist in the two genders in the interplay between clinical and person-centered indicators, especially on the likelihood on poor metabolic control (i.e. HbA1c > =8.0%). A deeper comprehension of these differences may inform individualized, gender-specific educational approaches.

Methods

A detailed description of the BENCH-D study protocol and of the questionnaires utilized as person-centered indicators was published elsewhere [11]. Briefly, a random sample of patients with T2DM stratified by diabetes treatment (oral agents, insulin + oral agents, insulin) was selected by 26 diabetes outpatient clinics in Italy.

Following the AMD-Annals methodology [36], clinical data were extracted from electronic databases of diabetes clinics, including information on body mass index (BMI), diabetes duration, HbA1c, blood pressure and lipid profile values, glucose-lowering, antihypertensive and lipid-lowering treatments, diabetic complications (i.e. retinopathy, diabetic nephropathy, foot complications, and previous cardiovascular and cerebrovascular events). AMD-Annals intermediate outcome measures were evaluated on the BENCH-D sample; these indicators include the proportion of patients with satisfactory values as well as the percentage of those with unacceptably high values. Outcomes were considered satisfactory if HbA1c levels were ≤7.0% (≤53 mmol/mol), blood pressure values were ≤130/80 mmHg, LDL cholesterol (LDL-c) levels were <100 mg/dl, and BMI was <27 Kg/m2. Unsatisfactory outcomes include HbA1c levels >8.0%, blood pressure values ≥140/90 mmHg, LDL levels ≥130 mg/dl, and BMI ≥30 Kg/m2 [6].

Information on socio-demographic characteristics, quality of life, satisfaction, and self-care behaviors and attitudes was collected using an ad hoc self-administered questionnaire including ten validated instruments which are described in Table 1 [9, 10, 1432]. The scores of these instruments represented the person-centered outcomes. In line with the methodology applied in the DAWN2 study [8], the instruments were chosen to evaluate the impact of diabetes and its management on physical and psychological well-being and satisfaction. In addition, perceived barriers, diabetes distress, and social support were included as mediators of the relationship between self-care activities, quality of life, and diabetes outcomes. All the instruments were validated and showed satisfactory psychometric properties [9].

Table 1 Questionnaires used and validated in the BENCH-D study

All the scores (i.e. person-centered indicators) ranged between 0 and 100, with higher values indicating higher levels of the dimension investigated. The only exception is the SDSCA6 scale [27] that provides a single score for each item, ranging from 0 to 7 to indicate the average number of days in the previous week respondent had performed each self-care activity. Two dichotomous person-centered indicators were also utilized: percentage of people with WHO-5 < =28 indicating likely depression [10, 15], and percentage of people with PAID-5 > 40 indicating high diabetes-related distress [9, 1620].

All the clinical and person-centered data collected in the study have been anonymized and centrally analyzed. Local ethics committees of all participating centers approved the protocol.

Statistical analysis

No formal sample size estimation was performed. Each center was required to enroll up to 100 patients.

Differences in socio-demographic characteristics, clinical outcomes and in mean quality of life/satisfaction scores according to gender were evaluated and compared using the chi-square tests for categorical variables and the Mann-Whitney test for continuous variables. Data were expressed as mean and standard deviation or frequency. A p-value <0.05 was considered statistically significant.

Mean scores of questionnaires were also adjusted for age, diabetes duration, BMI, presence of diabetes complications, glucose-lowering treatment class, school education, and living status. Data were expressed as mean and standard error.

Fully adjusted multivariate logistic models, separated for men and women, were applied to identify socio-demographic, clinical and person-centered factors associated with the achievement of HbA1c levels ≥8.0% in the two genders. Results are expressed as Odds Ratios (ORs) with their 95% confidence intervals (95%CI). All statistical analyses were performed using SAS 9.4 (The SAS Institute, Cary, NC, USA),

Results

Between January 2010 and July 2011, 26 diabetes clinics enrolled 2,390 people with T2DM; information on gender was available for 2,335 (97.7%); men were 1,393 (59.7%) and women were 942 (40.3%). Population characteristics by gender are reported in Table 2: compared to men, women were slightly older, had a lower level of school education, and were more likely to live alone. Women were less frequently smokers than men. From a clinical point of view, despite a longer diabetes duration and a higher likelihood to be treated with insulin, women showed a lower prevalence of known diabetes complications than men. Higher levels of HbA1c, total and LDL-cholesterol and BMI were found in women and AMD-Annals intermediate outcome indicators were systematically less satisfactory in women than in men, with lower percentages of women reaching favorable therapeutic goals for HbA1c, lipid profile and BMI than men, and parallel higher percentages of women with unacceptably high levels of the same parameters (Fig. 1).

Table 2 Socio-demographic and clinical characteristics according to gender
Fig. 1
figure1

Between-gender differences in the intermediate outcomes indicators of AMD-Annals

Between-gender differences in person-centered indicators are shown in Table 3. Women had statistically significant poorer scores for physical functioning, psychological well-being, self-care activities dedicated to physical activities, empowerment, diabetes-related distress, satisfaction with treatment, barriers to medication taking, satisfaction with access to chronic care and healthcare communication, and perceived social support than men. On the other hand, women showed higher adherence than men to self-care activities dedicated to self-monitoring of blood glucose and foot monitoring. The comparison of scores between genders after adjusting for clinical and socio-demographic characteristics showed that the difference in empowerment scores was no longer significant, while all the other differences remain consistent with the crude scores (Table 3). One in four women and one in ten men showed likely depression (WHO-5 < =28), while two in three women and one in two men showed high diabetes-related distress (PAID-5) (Fig. 2).

Table 3 Person-centered indicators in men and women with type 2 diabetes. Crude data are expressed as mean and standard deviation (std); adjusted data are expressed as mean and standard error (se)
Fig. 2
figure2

Between-gender differences in the prevalence of likely depression (WHO-5 < =28) and high diabetes-related distress (PAID-5 > 40)

In a multivariate analysis, factors associated with an increased likelihood of having elevated HbA1c levels (≥8.0%) were different in men and women (Table 4). In particular:

Table 4 Factors associated with increased likelihood of poor metabolic control (HbA1c > =8.0%)
  • Both in men and in women, insulin treatment alone or in association with OHAs increased the likelihood of having HbA1c ≥ 8.0% from 13 to 33% vs. OHAs only;

  • In men but not in women, the likelihood of having HbA1c ≥ 8.0% decreased as age increased (−3% for each additional 5 years) and was associated with the level of school education;

  • In women but not in men, high levels of diabetes related distress were associated with a higher likelihood of poor metabolic control.

Discussion

Data from the BENCH-D study provide new insights into the quality of care and quality of life as perceived by men and women with T2DM. Health related quality of life represents not only a key outcome of any person-centered chronic care model, but also an important mediator for adherence to treatment and the achievement of therapeutic goals.

Our data show, in line with the results of AMD-Annals [6], that women with T2DM have poorer intermediate outcome indicators than men, i.e. higher levels of HbA1c and poorer control of key cardiovascular risk factors such as BMI and LDL-cholesterol. Data also show that, compared to men, women have lower levels of general well-being, diabetes-related quality of life, satisfaction with treatment and care, self-care attitudes dedicated to physical activity, and empowerment. On the other hand, women report a higher level of adherence to SMBG and foot monitoring. It has been documented that SMBG not supported by adequate education to develop skills to modify therapy and behaviors based on the SMBG readings can worsen quality of life [33].

Our data also show that gender differences in the level of empowerment are largely dependent on the differences in the socio-demographic and clinical characteristics, while all the other person-centered indicators remain less satisfactory in women than in men also after adjustment for patient case-mix. This suggests that the lower socioeconomic status of women with T2DM in our sample was associated with autonomy and informed decision-making, as well as problem solving and goal setting (i.e. the areas covered by the DES scale) [34], but not with the general and diabetes-specific dimensions of quality of life and patient satisfaction investigated through all the other questionnaires.

Finally, at multivariate analysis adjusted for all the patient characteristics, in men the likelihood of poor glycemic control (HbA1c ≥8.0%) was associated with socio-demographic and clinical characteristics, i.e. age, school level, and insulin treatment (to be intended as a proxy of diabetes severity), while in women insulin treatment and diabetes-related distress, but not socio-demographic characteristics played a role.

Patients with higher diabetes-related distress put a greater weight on their disease, which absorbs daily mental and physical energy. Higher diabetes related emotional distress levels are associated with lower patient adherence and empowerment levels [35, 36]. Our data show that diabetes distress plays a role as a correlate of good metabolic control in women but not in men.

The study suggests that new gender-specific approaches to cope with clinical and psychosocial aspects of diabetes may be needed. The interplay among clinical and non-clinical factors is complex and gender influences the relationship between the different components.

The existence of gender-specific needs has been suggested by a relevant body of literature and healthcare systems are increasingly challenged to consider the different health issues of women and men in terms of prevention, clinical signs, therapeutic approach, prognosis, psychological and social impact [37].

From a mere clinical point of view, a gender-based approach in the management of T2DM must consider the different CVD profile of men and women. In fact, although the overall CVD risk is higher in T2DM men, the relative risk of coronary heart disease (CHD) is higher in T2DM women when compared to people without diabetes, with the loss of the typical oestrogen protection in the premenopausal state [38]. Diabetes is a powerful cardiovascular risk factor for both genders, but the relative risk of coronary heart disease deriving from having T2DM is higher in women than in men [39, 40]. Multiple factors are responsible for these differences, including gender-differences in metabolic control, cardiovascular risk, and treatments [41, 42], especially disparities in the routine management of LDL-C levels [43].

From a psychosocial point of view, many differences exist between men and women in beliefs, attitudes, fears and concerns about diabetes and its management [44]. In particular, women report significantly more depressive symptoms than men [45], female sex is a predictor of poor psychological outcomes [46], and depressive symptom severity is associated with poorer diet and medication regimen adherence [30]. Also, women more often experience diabetes related distress than men [47]. Recently, Fisher [35] clarified that diabetes distress is not a proxy for clinical depression but reflects an emotional response to a demanding health-related condition; conversely, major depressive disorder is a psychiatric disorder which is not content-related in so far that it does not describe pathology based on relevant causes, perturbations or contextual stressors. The investigation of diabetes related and unrelated stressors should represent an integral component of ongoing comprehensive care for all patients with diabetes [35].

Additional elements deriving from previous qualitative and quantitative studies are that: Women with diabetes showed less patient satisfaction and a lower health-related quality of life than men with diabetes [48]; men are more concerned about how diabetes affects their provider role [49], whereas women worry more about how self-care will hinder their familial responsibilities [50]; women tend to sacrifice their dietary regimen for their family’s food preferences [51]; men focused on practical aspects of SMBG whereas women focused on affective components of SMBG [44]; men find support from family and friends more helpful than do women [44]. Disease management programs for people with diabetes have been shown to save money and improve outcomes and it is recognized that they cannot ignore information about gender-specific differences [52].

In line with the cross-national design of the Diabetes Attitudes, Wishes and Needs second study (DAWN2™), BENCH-D study promotes benchmarking using psychometrically validated indicators to identify areas for improvement and best practices to drive changes that improve outcomes for people with diabetes [8]. Gender-differences in person-centered indicators identified in this analysis highlight the importance of considering gender as an important part of further research into person-centered diabetes care.

The study has strengths and limitations. As main strength, BENCH-D is the first study allowing a comprehensive evaluation of the association between clinical and person-centered care dimensions in the two genders, increasing the knowledge about the complex interplay among patient characteristics and perceptions. Main limitations of this analysis is its cross-sectional nature, that does not allow to establish a cause-effect relationship between clinical and person-centered indicators. However, the longitudinal phase of the BENCH-D study, focusing on informing quality of care improvements through person-centered outcomes, will allow for an assessment of the person-centered medicators of impacts of educational approaches in diabetes care on clinical and quality of life outcomes.

Finally, the study sample is representative of patients attending diabetes clinics, and results cannot be generalized to individuals who only attend their general practitioner.

Conclusions

In the BENCH-D study we collected reliable information about a range of person-centered outcomes such as depression, diabetes-related distress, self-care activities, empowerment, satisfaction with treatment, barriers to medication taking, satisfaction with access to chronic care and healthcare communication, and perceived social support in routine clinical practice and were able to identify important gender differences in the impact of diabetes. Specifically, we found that in T2DM women show poorer clinical and person-centered outcomes indicators than men. Diabetes-related distress plays a role as a correlate of metabolic control in women but not in men. The study provides new information about the interplay between clinical and person-centered indicators in men and women which may guide further improvements in diabetes education and support programs.

References

  1. 1.

    TRIAD Study Group. The translating research into action for diabetes (TRIAD) study: a multicenter study of diabetes in managed care. Diabetes Care. 2002;25:386–9.

    Article  Google Scholar 

  2. 2.

    Saaddine JB, Cadwell B, Gregg EW, et al. Improvements in diabetes processes of care and intermediate outcomes: United States, 1988–2002. Ann Intern Med. 2006;144:465–74.

    Article  PubMed  Google Scholar 

  3. 3.

    Rossi MC, Nicolucci A, Arcangeli A, Associazione Medici Diabetologi Annals Study Group, et al. Baseline quality-of-care data from a quality-improvement program implemented by a network of diabetes outpatient clinics. Diabetes Care. 2008;31:2166–8.

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Rossi MC, Candido R, Ceriello A, et al. Trends over 8 years in quality of diabetes care: results of the AMD-annals continuous quality improvement initiative. Acta Diabetol. 2015;52:557–71.

    Article  PubMed  Google Scholar 

  5. 5.

    Giorda CB, Nicolucci A, Pellegrini F, et al. Improving quality of care in people with type 2 diabetes through the associazione medici diabetologi-annals initiative: a long-term cost-effectiveness analysis. Diabet Med. 2014;31:615–23.

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Rossi MC, Cristofaro MR, Gentile S, AMD-Annals Study Group, et al. Sex disparities in the quality of diabetes care: biological and cultural factors may play a different role for different outcomes: a cross-sectional observational study from the AMD-annals initiative. Diabetes Care. 2013;36:3162–68.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Glasgow RE, Peeples M, Skovlund SE. Where is the patient in diabetes performance measures? The case for including patient-centered and self-management measures. Diabetes Care. 2008;31:1046–50.

    Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Nicolucci A, Kovacs Burns K, DAWN2 Study Group, et al. Diabetes attitudes, wishes and needs second study (DAWN2™): cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabet Med. 2013;30:767–77.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Nicolucci A, Kovacs Burns K, Holt RI, Lucisano G, Skovlund SE, Kokoszka A,Massi Benedetti M, Peyrot M. Correlates of psychological outcomes in people with diabetes: results from the second Diabetes Attitudes, Wishes and Needs (DAWN2(™)) study. Diabet Med 2016;33:1194-203.

  10. 10.

    Hajos TR, Pouwer F, Skovlund SE, Den Oudsten BL, Geelhoed-Duijvestijn PH, Tack C, Snoek FJ. Psychometric and screening properties of the WHO-5 well-being index in adult outpatients with type 1 or type 2 diabetes mellitus. Diabet Med. 2013;30:e63–69.

    CAS  Article  PubMed  Google Scholar 

  11. 11.

    Nicolucci A, Rossi MC, Pellegrini F, et al. Benchmarking network for clinical and humanistic outcomes in diabetes (BENCH-D) study: protocol, tools, and population. Springerplus. 2014;3:83.

    Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Pintaudi B, Lucisano G, Gentile S, BENCH-D Study Group, et al. Correlates of diabetes-related distress in type 2 diabetes: findings from the benchmarking network for clinical and humanistic outcomes in diabetes (BENCH-D) study. J Psychosom Res. 2015;79:348–54.

    Article  PubMed  Google Scholar 

  13. 13.

    Rossi MC, Lucisano G, Funnell M, BENCH-D Study Group, et al. Interplay among patient empowerment and clinical and person-centered outcomes in type 2 diabetes. The BENCH-D study. Patient Educ Couns. 2015;98:1142–9.

    Article  PubMed  Google Scholar 

  14. 14.

    Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M. Cross-validation of item selection and scoring for the SF-12 health survey in nine countries: results from the IQOLA project. International quality of life assessment. J Clin Epidemiol. 1998;51:1171–8.

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Bech P, Gudex C, Johansen KS. The WHO (ten) well-being index: validation in diabetes. Psychother Psychosom. 1996;65:183–90.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Snoek FJ, Pouwer F, Welch GW, Polonsky WH. Diabetes-related emotional distress in Dutch and U.S. diabetic patients: cross-cultural validity of the problem areas in diabetes scale. Diabetes Care. 2000;23:1305–9.

    CAS  Article  PubMed  Google Scholar 

  17. 17.

    Pouwer F, Skinner TC, Pibernik-Okanovic M, et al. Serious diabetes-specific emotional problems and depression in a Croatian-Dutch-English Survey from the European depression in diabetes [EDID] research consortium. Diabetes Res Clin Pract. 2005;70:166–73.

    Article  PubMed  Google Scholar 

  18. 18.

    McGuire BE, Morrison TG, Hermanns N, Skovlund S, Eldrup E, Gagliardino J, Kokoszka A, Matthews D, Pibernik-Okanović M, Rodríguez-Saldaña J, de Wit M, Snoek FJ. Short-form measures of diabetes-related emotional distress: the problem areas in diabetes scale (PAID)-5 and PAID-1. Diabetologia. 2010;53:66.

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Polonsky WH, Anderson BJ, Lohrer PA, Welch G, Jacobson AM, Aponte JE, Schwartz CE. Assessment of diabetes-related distress. Diabetes Care. 1995;18:754.

    CAS  Article  PubMed  Google Scholar 

  20. 20.

    Welch G, Weinger K, Anderson B, Polonsky WH. Responsiveness of the problem areas in diabetes (PAID) questionnaire. Diabet Med. 2003;20:69.

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Williams GC, McGregor HA, Zeldman A, Freedman ZR, Deci EL. Testing a self-determination theory process model for promoting glycemic control through diabetes self-management. Health Psychol. 2004;23:58.

    Article  PubMed  Google Scholar 

  22. 22.

    Schafer LC, McCaul KD, Glasgow RE. Supportive and nonsupportive family behaviors: relationships to adherence and metabolic control in persons with type I diabetes. Diabetes Care. 1986;9:179.

    CAS  Article  PubMed  Google Scholar 

  23. 23.

    Glasgow RE, Wagner EH, Schaefer J, Mahoney LD, Reid RJ, Greene SM. Development and validation of the patient assessment of chronic illness care (PACIC). Med Care. 2005;43:436.

    Article  PubMed  Google Scholar 

  24. 24.

    Gugiu PC, Coryn C, Clark R, Kuehn A. Development and evaluation of the short version of the patient assessment of chronic illness care instrumen. Chron Illness. 2009;5:268.

    Article  Google Scholar 

  25. 25.

    Anderson RM, Funnell MM, Fitzgerald JT, Marrero DG. The diabetes empowerment scale: a measure of psychosocial self-efficacy. Diabetes Care. 2000;23:739.

    CAS  Article  PubMed  Google Scholar 

  26. 26.

    Anderson RM, Fitzgerald JT, Gruppen LD, Funnell MM, Oh MS. The diabetes empowerment scale-short form (DES-SF). Diabetes Care. 2003;26:1641.

    Article  PubMed  Google Scholar 

  27. 27.

    Toobert DJ, Hampson SE, Glasgow RE. The summary of diabetes self-care activities measure: results from 7 studies and a revised scale. Diabetes Care. 2000;23:943.

    CAS  Article  PubMed  Google Scholar 

  28. 28.

    Brod M, Skovlund SE, Wittrup-Jensen KU. Measuring the impact of diabetes through patient report of treatment satisfaction, productivity and symptom experience. Qual Life Res. 2006;15:481.

    Article  PubMed  Google Scholar 

  29. 29.

    Conference Report. 2nd International DAWN Summit: a call-to-action to improve psychosocial care for people with diabetes. Pract Diab Int. 2004;21:201

  30. 30.

    Peyrot M, Rubin RR, Lauritzen T, Skovlund SE, Snoek FJ, Matthews DR, Landgraf R, Kleinebreil L, International DAWN Advisory Panel. Resistance to insulin therapy among patients and providers. Results of the cross-national diabetes attitudes, wishes, and needs (DAWN) study. Diabet Med. 2005;22:1379.

    CAS  Article  PubMed  Google Scholar 

  31. 31.

    Peyrot M, Burns KK, Davies M, Forbes A, Hermanns N, Holt R, Kalra S, Nicolucci A, Pouwer F, Wens J, Willaing I, Skovlund SE. Diabetes attitudes wishes and needs 2 (DAWN2): a multinational, multi-stakeholder study of psychosocial issues in diabetes and person-centred diabetes care. Diabetes Res Clin Pract. 2013;99:174.

    Article  PubMed  Google Scholar 

  32. 32.

    Wroe J. The 3rd International DAWN Summit: from research and practice to large-scale implementation. Pract Diab Int. 2006;23:313.

    Article  Google Scholar 

  33. 33.

    Franciosi M, Lucisano G, Pellegrini F, ROSES Study Group, et al. ROSES: role of self-monitoring of blood glucose and intensive education in patients with type 2 diabetes not receiving insulin. A pilot randomized clinical trial. Diabet Med. 2011;28:789–96.

    CAS  Article  PubMed  Google Scholar 

  34. 34.

    Anderson RM, Funnell MM, Aikens JE, et al. Evaluating the efficacy of an empowerment-based self-management consultant intervention: results of a two-year randomized controlled trial. Ther Patient Educ. 2009;1:3–11.

    Article  PubMed  PubMed Central  Google Scholar 

  35. 35.

    Fisher L, Gonzalez JS, Polonsky WH. The confusing tale of depression and distress in patients with diabetes: a call for greater clarity and precision. Diabet Med. 2014;31:764–72.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  36. 36.

    Anderson RM, Funnell MM. Compliance and adherence are dysfunctional concepts in diabetes care. Diabetes Educ. 2000;26:597–604.

    CAS  Article  PubMed  Google Scholar 

  37. 37.

    Baggio G, Corsini A, Floreani A, Giannini S, Zagonel V. Gender medicine: a task for the third millennium. Clin Chem Lab Med. 2013;51:713–27.

    CAS  Article  PubMed  Google Scholar 

  38. 38.

    Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. Br Med J. 2006;332:73–6.

    Article  Google Scholar 

  39. 39.

    Kalyani RR, Lazo M, Ouyang P, et al. Sex differences in diabetes and risk of incident coronary artery disease in healthy young and middle-aged adults. Diabetes Care. 2014;37:830–8.

    Article  PubMed  PubMed Central  Google Scholar 

  40. 40.

    Ballotari P, Ranieri SC, Luberto F, et al. Sex differences in cardiovascular mortality in diabetics and nondiabetic subjects: a population-based study (Italy). Int J Endocrinol. 2015;2015:914057.

    Article  PubMed  PubMed Central  Google Scholar 

  41. 41.

    Kautzky-Willer A, Kamyar MR, Gerhat D, et al. Sex-specific differences in metabolic control, cardiovascular risk, and interventions in patients with type 2 diabetes mellitus. Gend Med. 2010;7:571–83.

    Article  PubMed  Google Scholar 

  42. 42.

    Penno G, Solini A, Bonora E, et al. Gender differences in cardiovasculardisease risk factors, treatments and complications in patients with type 2 diabetes: the RIACE Italian multicenter study. J Intern Med. 2013;2:176–91.

    Article  Google Scholar 

  43. 43.

    Russo G, Pintaudi B, Giorda C, et al. Age- and gender-related differences in LDL-cholesterol management in outpatients with type 2 diabetes mellitus. Int J Endocrinol. 2015;2015:957105.

    PubMed  PubMed Central  Google Scholar 

  44. 44.

    Mathew R, Gucciardi E, De Melo M, Barata P. Self-management experiences among men and women with type 2 diabetes mellitus: a qualitative analysis. BMC Fam Pract. 2012;19:12.

    Google Scholar 

  45. 45.

    Gucciardi E, Wang SC, DeMelo M, Amaral L, Stewart DE. Characteristics of men and women with diabetes: observations during Patients’ initial visit to a diabetes education centre. Can Fam Physician. 2008;54:219–27.

    PubMed  PubMed Central  Google Scholar 

  46. 46.

    Snoek FJ, Kersch NY, Eldrup E, et al. Monitoring of individual needs in diabetes (MIND)-2: follow-up data from the cross-national diabetes attitudes, wishes, and needs (DAWN) MIND study. Diabetes Care. 2012;35:2128–32.

    Article  PubMed  PubMed Central  Google Scholar 

  47. 47.

    Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;60:3278–85.

    Article  Google Scholar 

  48. 48.

    Graue M, Haugstvedt A, Wentzel-Larsen T, Iversen MM, Karlsen B, Rokne B. Diabetes-related emotional distress in adults: reliability and validity of the Norwegian versions of the problem areas in diabetes scale (PAID) and the diabetes distress scale (DDS). Int J Nurs Stud. 2012;49:174–82.

    Article  PubMed  Google Scholar 

  49. 49.

    Jonsson PM, Sterky G, Gåfvels C, Ostman J. Gender equity in health care: the case of Swedish diabetes care. Health Care Women Int. 2000;21:413–31.

    CAS  Article  PubMed  Google Scholar 

  50. 50.

    Hjelm KG, Bard K, Nyberg P, Apelqvist J. Beliefs about health and diabetes in men of difference ethnic origin. J Adv Nurs. 2005;50:47–59.

    Article  PubMed  Google Scholar 

  51. 51.

    Sarkadi A, Rosenqvist U. Social network and role demands in women’s type 2 diabetes: a model. Health Care Women Int. 2002;23:600–11.

    Article  PubMed  Google Scholar 

  52. 52.

    Legato MJ, Gelzer A, Goland R, Writing Group for The Partnership for Gender-Specific Medicine, et al. Gender-specific care of the patient with diabetes: review and recommendations. Gend Med. 2006;3:131–58.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We acknowledge all participating centers and Novo Nordisk SpA, Italy for the unconditional support to the study.

Funding

The study was supported by an unconditional grant from Novo Nordisk S.p.A., Rome, Italy.

Availability of data and material

The data that support the findings of this study are available from Associazione Medici Diabetologi (AMD) scientific society but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of AMD.

Authors’ contributions

MCR, AN, and SES wrote the manuscript, MCR and GL analyzed data, all the authors contributed to discussion and revision of the manuscript. All authors approved the manuscript.

Competing interests

AN is a member of the advisory board of Novo Nordisk, Novartis, Merk Sharp & Dohme. He has received speaker fees from Novo Nordisk, Novartis, Merk Sharp & Dohme; AB is an employee of Novo Nordisk, Rome, Italy; SES is an employee of Novo Nordisk A/S, Copenhagen, Denmark. MCR, GL, BP, SG, MS, GV declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The study protocol was approved by Ethics committees of all the participating centers; all enrolled patients signed an informed consent.

the BENCH-D Study Group

Scientific committee : A Nicolucci, G Vespasiani, MC Rossi, S Gentile, A Bulotta, SE Skovlund.

Participating centers (by region) : LAZIO: E Forte, F Tuccinardi, A Griffo, Fondi (LT); S Leotta, L Fontana, M Altomare, L Pellegrini, Roma; F Malci, C Moscatelli, Subiaco (RM); P Tatti, M Neri, Marino (RM); G Santantonio, Civitavecchia (RM); F Chiaramonte, Roma; MARCHE: RA Rabini, S Rosati, F D’Angelo, Ancona; G Maolo, B Polenta, S Lardelli, AM Tesi, Macerata; L Cotti, G Garrapa, R Viola, M Manuela, F Lizzadro, Fano (PU); MG Cartechini, N Busciantella Ricci, G Agostinelli, Camerino (MC); G Vespasiani, I Meloncelli, M Galetta, V Marconi, L Carini, I Crema, L Clementi, San Benedetto del Tronto (AP); S Manfrini, L Olivi, Senigallia (AN); P Foglini, R Maricotti, P Pantanetti, Fermo; A Spalluto, Pesaro; M Andreani, G Martinelli, Urbino (PU); PIEMONTE: A Chiambretti, R Fornengo, L Di Vito, M Albertone, V Magliano, D Cortale, Chivasso (TO); AR Bogazzi, M Rivelli, SB Del Rosso, F Picataggi, P Bonfani, E Baccaro,Venaria Reale (TO); M Comoglio, R Manti, O Boscolo, C Laiolo, Moncalieri (TO); A Clerico, L Richiardi, K Sinato, Torino; GP Carlesi, S Garrone, Novi Ligure (AL); G Magro, C Paverin, D Gaviglio, Cuneo; G Saglietti, Omegna (VB); L Monge, Torino; G Grassi, Torino; SICILIA: A Di Benedetto, M Russo, B Pintaudi, G Di Vieste, Messina; A Garofalo, F Vitale, L Bernardo, Vittoria (RG); G Saitta, Messina; A Lo Presti, Marsala (TP); MA Fulantelli, Palermo; G Mattina, M Cortese, A Parrinello, Palermo; V Provenzano, L Ferrara, R Ferranti, Partinico (PA); D Gioia, M Conti, Palermo.

Coordinating center : A Nicolucci, MC Rossi, G Lucisano, R Memmo - CORESEARCH - Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy

Data managers and AMD regional coordinators : L Fontana, F Chiaramonte (Lazio); R Viola, L Cotti (Marche); R Chiodo, L Monge (Piemonte); B Pintaudi, C De Francesco (Sicilia).

Author information

Affiliations

Authors

Consortia

Corresponding author

Correspondence to Maria Chiara Rossi.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rossi, M.C., Lucisano, G., Pintaudi, B. et al. The complex interplay between clinical and person-centered diabetes outcomes in the two genders. Health Qual Life Outcomes 15, 41 (2017). https://doi.org/10.1186/s12955-017-0613-0

Download citation

Keywords

  • Type 2 diabetes
  • Gender-disparities
  • Diabetes-related distress
  • Psychological wellbeing