- Open Access
The factors that influence the oral health-related quality of life in 12-year-old children: baseline study of a longitudinal research
Health and Quality of Life Outcomes volume 15, Article number: 155 (2017)
Oral health-related quality of life (OHRQoL) could be affected not only by oral health but also by demographic and ecosocial factors. This research aimed to analyze the sociodemographic and clinical factors that may influence the OHRQoL of 12-year-old children.
A representative sample was selected from Hong Kong. Periodontal status and caries were examined according to WHO criteria. Four orthodontic indices were used to assess malocclusion. Child Perception Questionnaires (CPQ11–14-ISF:8 and CPQ11–14-RSF:8) including four domains, namely oral symptoms (OS), functional limitations (FL), emotional well-being (EWB), and social well-being (SWB), were used to measure OHRQoL. Adjusted OR was calculated by ordinal logistic regression.
Totally 589 eligible subjects (305 females, 284 males) were recruited. Males tended to rank higher in OS domain but lower in EWB domain (adjusted OR = 1.89 and 0.67). Mother’s education was linked more closely with children’s CPQ scores. Higher education levels were associated with better quality of life (adjusted OR = 0.45 and 0.37). Household income showed no effect on CPQ scores. Unhealthy periodontal conditions had a negative effect on EWB and total CPQ (adjusted OR = 1.61 and 1.63). High caries experience only had a negative effect on SWB (adjusted OR = 1.60). Malocclusion affected FL, EWB, SWB and total CPQ: all malocclusion severities affected SWB; only severe malocclusions affected FL, EWB and total CPQ.
Males were more tolerant of oral symptoms than females were. Higher levels of mother’s education led to better OHRQoL of their children. Unhealthy periodontal conditions affected emotional well-being, while high caries experience affected social well-being. All malocclusion severities had an effect on social well-being; severe malocclusion further caused functional limitations, worse emotional well-being, and hence worse OHRQoL.
Clinical techniques in dentistry have been developed rapidly. The aim of these techniques is to give subjects a better life experience. Thus the psychosocial aspects of dentistry have also been researched extensively. Contemporarily researchers are focusing on dental fear, treatment expectations and oral health-related quality of life (OHRQoL). A hypothesis is that subjects’ OHRQoL is affected not only by oral health status but also by other demographic and ecosocial factors. Subjects of different ages, with different education levels and financial situations may put different emphases on their dental care. Those with limited concern of oral health protection may suffer more from dental diseases, hence worse OHRQoL.
Although many studies were conducted on the influence factors of OHRQoL, a consensus has not been reached. This is mainly because different studies included different sampling methods, age groups and influence factors. In addition, most studies adopted cross-sectional design; many articles have recommended that population-based longitudinal study is helpful in this area [1,2,3,4,5,6,7]. This article is a baseline study of a longitudinal research aiming to analyze the impact factors of OHRQoL. The cohort of this study was comprised of 12-year-old students in Hong Kong. The subjects will be further studied in their 15- and 18- years old.
Different measurement tools can assess OHRQoL. For children aged 11 to 14 years old, the questionnaire of Child Perception Questionnaire (CPQ11–14) has been widely validated and used [8,9,10,11,12]. The questionnaire consists of four domains namely oral symptoms domain (OS, 6 items), functional limitations domain (FL, 9 items), emotional well-being domain (EWB, 9 items) and social well-being domain (SWB, 13 items). Each item has a 5-point response format ranging from 0 to 4. The item scores of each domain are added together to get a domain score, and four domains scores are added together to get the total CPQ11–14 score. Higher scores represent poorer quality of life.
To facilitate its use in clinical settings and population-based surveys, CPQ11–14 was shortened to 16 and 8 items by item impact and stepwise regression methods . Previous studies concluded that the short forms of CPQ11–14 (ISF:8 and RSF:8) contained sufficient information in measuring OHRQoL of children in Hong Kong; they were shown to be valid and reliable [14, 15]. The short forms of CPQ11–14 (ISF:8 and RSF:8) were used in this research.
Community Periodontal Index (CPI) and the Decayed, Missing and Filled Teeth (DMFT) were used to measure periodontal and caries conditions according to the criteria of WHO . Also, Significant Caries Index (SiC index) was used to classify caries. Individuals are sorted according to their DMFT values; the one third of the population with the highest caries score is selected and the mean DMFT for this subgroup is calculated; this value constitutes the SiC Index .
Index of Orthodontic Treatment Need (IOTN), Dental Aesthetic Index (DAI), Index of complexity, outcome and need (ICON), and peer assessment rating (PAR) were used to assess orthodontic treatment need and complexity [18,19,20,21,22,23].
IOTN was introduced form the UK in 1989, which includes two components of Dental health component (DHC) and Aesthetic component (AC). DHC is originated from the Index of the Swedish Medical Health Board . It has 5 grades (no need to very great need) and the worst occlusal trait is recorded to allocate the grade. AC is comprised of 10 front view photographs selected by non-dental judges from 1000 photographs of 12-year-old subjects, which representing the 10 scales of dental attractiveness. The IOTN (DHC) or IOTN (AC) grading can be further categorized into three orthodontic treatment groups (DHC 1–2 or AC 1–4, no need; DHC 3 or AC 5–7, borderline need; DHC 4–5 or AC 8–10, definite need) [25, 26].
The index of DAI was created in 1986 from the United States. The index was based on approximately 2000 adolescents and adults’ perceptions on the aesthetics of 200 photographs of occlusal configurations. These 200 occlusal configurations were randomly selected from 1337 study models of 15–18 years age . It used regression analysis to choose 10 occlusal traits and put weights on them. The malocclusion measurements are multiplied by their weights, the addition of their products and the addition of a constant number, 13, is the final DAI score. It can be categorized into 4 scales of orthodontic severity and treatment need (<=25, normal or minor malocclusion-no treatment need or slight need; 26–30, definite malocclusion-treatment selective; 31–35: severe malocclusion-treatment highly desirable; > = 36: very severe (handicapping) malocclusion-treatment mandatory) . DAI has been adopted by WHO to examine malocclusion in oral health surveys .
ICON was introduced from the UK in 2000 to evaluate treatment need, treatment outcome and complexity . It was based on 97 international orthodontists’ opinion on 240 dental casts for treatment need, and 98 pairs of pre- and post-treatment casts for treatment outcomes. The aesthetic score is assessed using IOTN (AC). Five malocclusion traits are assigned with different weights by stepwise multiple logistic regression. These occlusal trait scores are then multiplied by their respective weightings and summed to calculate the ICON score. The ICON score can be scaled into 2 categories for treatment need (<=43 No; >43 Yes), and 5 categories for orthodontic complexity (<29 easy; 29–50, mild; 51–63 moderate; 64–77 difficult; >77 very difficult). It puts heavy emphasis on aesthetics.
PAR was introduced from the UK based on 10 experts’ estimate of over 200 dental casts. The dental casts represented development as well as pre- and post-treatment stages. The concept is to assign a score to 11 components of occlusal traits that make up a malocclusion. The individual scores are summed together to obtain an overall total, representing the degree a case deviates from normal occlusion. Generally a measure of 10 or less indicates an acceptable alignment and occlusion, and 5 or less suggests an almost ideal occlusion .
Study population and data collection
Cluster randomized trial was used in this research. The sampling frame was all local secondary schools in Hong Kong (by law all children are required to attend secondary school). A random sample of 45 schools (approximately 10% of all local secondary schools) from 18 districts in Hong Kong, SAR, was selected. Students born between April 1st and May 31st, 1997 were invited to participate in oral health survey in 2010 conducted by Faculty of Dentistry, the University of Hong Kong. The sample of this study was selected from the birth cohort of “children of 1997” . Sample size was calculated based on a previous study [28,29,30], with the prevalence of orthodontic treatment need (ICON) being 80.3%, and the mean total CPQ score (SD) being no need: 14.8 (15.0), and need 20.1 (14.0). With α = 0.05, 1-β = 0.8, design effect for cluster sampling, and a lost rate of 30% at each follow-up considered, the sample sizes at ages 12, 15, and 18 should be 237, 166, and 116, respectively.
An invitation letter was first sent to the parents/primary caregivers. If a written consent from parents/primary caregivers and a verbal consent from students were obtained, students’ oral health status would be examined using an intra-oral disposable mouth mirror with a built-in LED light source. The same trained and calibrated examiner performed the oral examination according to the criteria of WHO . Front-view dental photos were taken by extracting lips using oral retractors to assess IOTN (AC). Dental impressions were collected and the plaster models were sent to OrthoLab (Poland) to make digital models. Software O3DM (version3.8.5 (c) by OrthoLab, Poland) was used to analyze digital models by the same examiner. Reassessments were performed among 10% randomly selected samples after 2 weeks of first assessment to test intra-examiner’s reliability.
Systematic health information, dental treatment history, ecosocial factors including father’s education, mother’s education, and household income were collected from a self-completed questionnaire. OHRQoL was assessed by inviting participants to answer questions of CPQ11–14-ISF:8 and CPQ11–14-RSF:8.
Subjects were excluded from the final analysis if they were systemically unhealthy, had orthodontic treatment history, or had oral diseases other than caries, periodontitis and malocclusion. Missing data in questionnaires was filled with the mode of the corresponding category.
Ethics, consent and permissions
The ethical approval of this study was granted by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster (UW 09–453).
Intra-examiner reliability was tested by kappa values for CPI, weighted kappa for IOTN (DHC) and IOTN (AC), and Intra-class correlation coefficient (ICC) for DAI score, ICON score and DMFT.
Mann-Whitney U test was used to analyze whether there was a difference of oral health status between females and males; independent samples t test was used to detect the difference of mean DMFT.
The effects of sociodemographic and clinical factors on OHRQoL were analyzed with parameters set as follows:
Dependent variables: for bivariate analysis, dependent variables were set as the scores of OS, FL, EWB, SWB and total CPQ; for ordinal regression, dependent variables were set by grouping these scores into four ranks with quartile values as cut-off points.
Independent variables: gender, father’s education, mother’s education, household incoming, periodontal status, caries experience, and orthodontic treatment need.
Bivariate analysis: for parametric tests, comparison between two samples used the independent samples t test, others used the one-way ANOVA; for nonparametric tests, comparison between two samples used the Mann-Whitney U test, others used the Kruskal-Wallis H test.
Multivariate analysis: ordinal logistic regression was used to calculate adjusted odds ratios (OR). To avoid interaction effect, orthodontic treatment needs measured by different orthodontic indices were entered into regression separately.
Totally 668 students participated in this research in 2010, of whom 589 were eligible for the final analysis (305 females, 284 males). Kappa value for CPI was 0.740; weighted kappa for IOTN (DHC) and IOTN (AC) were 0.918 and 0.790; ICC for DAI score, ICON score and DMFT were 0.821, 0.820 and 0.990.
Missing data only existed in some questions of family information and CPQ11–14. Totally 25 subjects had missing data of one or two questions, which were filled with the mode of the corresponding questions.
In this 12-year-old cohort, no differences of oral health status were found between females and males (Table 1). The mean DMFT (SD) was 0.57 (1.02) and the SiC index value (SD) was 1.68 (1.12). Unhealthy periodontal conditions were much more prevalent than caries (86.4% and 31.6%, respectively). The orthodontic treatment need was 45.5% by IOTN (DHC), 20.4% by IOTN (AC), 47.0% by DAI, 35.0% by ICON, and 36.2% by PAR.
For bivariate analysis (Table 2), parameter analyses identified almost the same significant factors with non-parameter analyses. Males had a higher OS score (ISF:8) but a lower EWB score (RSF:8) than females.
Mother’s education was linked more closely with children’s CPQ scores than father’s education was. Mother’s education had effects on all CPQ domains (ISF:8 or RSF:8). The higher the education level, the lower the scores. Father’s education only showed a significant effect on OS score. Household income showed no effect on CPQ scores.
Subjects with unhealthy periodontal conditions and high caries experiences had higher scores in all domains (ISF:8 and RSF:8). However, significant results only existed in the domains of EWB, SWB and total CPQ: periodontal status affected EWB and total CPQ (ISF:8), while caries affected SWB and total CPQ (RSF:8).
Three tendencies are shown by the descriptive statistics of malocclusion and CPQ scores. First, malocclusion measured by ICON treatment need showed that in all domains subjects with malocclusion had higher scores than those without malocclusion (ISF:8 and RSF:8). Second, malocclusion measured by PAR and IOTN (DHC) showed that a severer malocclusion was associated with a higher score in almost all domains, except that in OS domain, the RSF questionnaire had this tendency while the ISF did not. Third, in the domains of FL and SWB (ISF:8), all orthodontic indices showed that the severer the malocclusion, the higher the scores.
Different orthodontic indices generated different statistical results, of which ICON detected the most significant results. The significant results mainly existed in the domains of FL, SWB and total CPQ (Table 2).
In ordinal regression, the dependent variables were set as CPQ ranks (Table 3); higher ranks represented poorer quality of life. For gender, ordinal regression generated the same result with the bivariate analysis: compared with females, males tended to rank higher in OS domain but lower in EWB domain (adjusted OR = 1.89 and 0.67, respectively).
Mother’s education had a positive effect on children’s CPQ rank; while father’s education had almost a reverse effect (Table 3). Take total CPQ for example: compared with the lowest education level, the adjusted ORs for mother’s middle and highest levels of education were respectively 0.45 and 0.37 (P = 0.001 and 0.007) (RSF:8); whereas the adjusted OR for father’s middle level of education was 1.78 (P = 0.017) (ISF:8). Multivariate analysis detected more significant results than bivariate analysis did, for it detected an effect of father’s education not only on OS, but also on EWB and total CPQ after adjusting other factors.
Household income did not show significant results in all domains, except that in FL domain, compared with the lowest income, the “HK$30,001-HK$40,000” group was associated with 1.89 times the odds of having a higher FL rank (p = 0.031) (ISF:8); while no effect was detected by bivariate analysis.
Unhealthy periodontal conditions had a negative effect on EWB and CPQ ranks (adjusted OR = 1.61 and 1.63, respectively) (ISF:8), which was the same with the result of bivariate analysis; high caries experience only had a significant effect on SWB rank (adjusted OR = 1.60) (RSF:8), but not on total CPQ.
Malocclusion mainly affected FL, EWB, SWB and total CPQ, of which SWB was the most affected domain. This was the same with the result of the bivariate analysis. Different orthodontic indices generated different results, of which DAI detected the most significant results.
Generally speaking, a severer malocclusion was associated with a higher likelihood of having a higher rank. However, statistical results showed that only in SWB, all malocclusion severities measured by IOTN (AC) had a significant effect; in other CPQ domains, only the severe and/or the very severe malocclusion showed significant effects. Take the total CPQ for example: when compared with the no/minor malocclusion measured by DAI, only the severe and the very severe malocclusion were associated with high likelihoods of having a higher CPQ rank after adjusting the effects of other factors (adjusted OR = 1.59 and 1.90, respectively) (ISF:8 or RSF:8).
This research was a cross-sectional analysis on the influence factors of OHRQoL. Males tended to have worse OS but better EWB. Mother’s education had more effect on children’s CPQ scores than father’s education did; higher levels of mother’s education were associated with lower CPQ scores of their children, whereas the effect of father’s education was opposite. Household income showed little effect on OHRQoL. Unhealthy periodontal conditions had a worse effect on EWB and CPQ, while high caries experience had a worse effect on SWB. Malocclusion could affect FL, EWB, SWB and total CPQ, of which SWB was the most affected domain. All malocclusion severities had a worse effect on SWB, but only severe malocclusions had an effect on other domains.
Males experienced worse OS but higher EWB. It may reveal that males were more tolerant of oral symptoms than females were. It was mother’s education, but not father’s education or household income, that had a positive effect on children’s OHRQoL. Parents shoulder different responsibilities in a family unit; under most circumstances, mother is the main caregiver of children. Caregivers with high education levels may have more sense of children’s oral hygiene and health, thus their children tend to have better OHRQoL.
Unhealthy Periodontal conditions were more prevalent than caries in this 12-year-old cohort. There may be two possible reasons: first, caries has effective preventions like water fluoridation; second, in puberty period children are more susceptible to gingivitis .
Periodontal conditions could affect EWB and the total CPQ. Children with unhealthy periodontal conditions may feel upset, irritable or frustrated because of their teeth. High caries experience only had an effect on SWB, but not on OS or FL as in common knowledge. Hong Kong is an economically developed area, where government puts great efforts on preventive and educational measures of children’s oral health. Therefore, children’s teeth of this 12-year-cohort were normally in good condition; even if there was caries, the erosions were almost either shallow ones or had been well treated, which tended not to cause pulpal sensibility and pain.
SWB was the most detected domain affected by malocclusion. Children with malocclusion were more likely to be teased or called names; they might avoid smiling or speaking loud in class, and they argued more frequently with other children or with their family because of their teeth.
In this study, the effects of the severe and very severe malocclusions on the domains of FL, EWB and total CPQ were detected. Studies have shown that severe malocclusion could add difficulties of plaque cleaning, which cause periodontitis; plus, temporomandibular disorders are more likely to occur in subjects with severer malocclusion than in those with less severe or no malocclusion [32, 33]. Therefore, children with severe malocclusion may have higher possibilities of having function limitations and emotional burdens.
Orthodontic indices put emphasis on different malocclusion traits and generated different results. Take IOTN (AC) for example: this index only reflects the frontal traits of dental arches, in other words, the frontal aesthetics of subjects. No inter- or intra- arch malocclusion is considered . Dental aesthetics usually affect people’s social attractiveness; thus IOTN (AC) easily detected the significant result in SWB. Therefore, this index may be perfect to judge the extent of the effect of malocclusion on subjects’ social lives. The higher the IOTN (AC) rates, the worse the subjects’ social well-beings.
ICON adopts IOTN (AC) for its aesthetic judgment and puts a great weight on it. At the same time, some other malocclusion traits, such as crowding and inter-arch relationship, are also assessed . DAI also puts great weights on frontal aesthetics, and the inter-arch malocclusion is also considered; literatures showed that this index is particularly sensitive to occlusal conditions causing psychological or social dysfunctions . Hence, ICON and DAI could easily detect the effect of malocclusion on the domain of SWB, and on other domains.
PAR measures all occlusal anomalies based on experts’ judgment of their deviation from normal occlusion . In this research, CPQ scores showed a gradient ascent across PAR rates. IOTN (DHC) is based on the criteria drawn up by the orthodontic section of the Swedish Dental Society and the Swedish Medical Board (1966), which is also the authoritative judgments of occlusal anomalies . It showed the same gradient ascent with PAR. Both indices could easily examine the effect of malocclusion on FL; IOTN (DHC) further detected the effect on SWB.
The sociodemographic and clinical factors that may influence OHRQoL were analyzed in this article based on a population-based sample. Given its cross-sectional analysis, the results should be treated with caution. The sample of this research was selected in Hong Kong. When generalizing the conclusion to other regions, the differences of geographical, cultural, and economical factors also need to be considered. Subjects in this research would be followed up in their 15- and 18- years old. The results of longitudinal observations should provide more definitive evidences.
The influence factors of OHRQoL in a representative sample of 12-year-old children were studied. Males were more tolerant of oral symptoms than females were. Mother’s education level was more positively associated with children’s OHRQoL than father’s education was. Household income had little effect on OHRQoL. Unhealthy periodontal conditions could result in a worse emotional well-being; while high caries experience could result in a worse social well-being. All malocclusion severities affected social well-being, while severe malocclusions further led to functional limitations, worse emotional experiences, and hence worse OHRQoL.
Community Periodontal Index
child perceptions questionnaire
dental aesthetic index
dental health component
Decayed, Missing and Filled Teeth
functional limitations domain
index of complexity, outcome and need
index of orthodontic treatment need
oral health-related quality of life
oral symptoms domain
peer assessment rating
- SiC index:
Significant Caries Index
World Health Organization
Steele JG, Sanders AE, Slade GD, Allen PF, Lahti S, Nuttall N, Spencer AJ. How do age and tooth loss affect oral health impacts and quality of life? A study comparing two national samples. Community Dent Oral Epidemiol. 2004;32:107–14.
McGrath C, Bedi R. The association between dental anxiety and oral health-related quality of life in Britain. Community Dent Oral Epidemiol. 2004;32:67–72.
Needleman I, McGrath C, Floyd P, Biddle A. Impact of oral health on the life quality of periodontal patients. J Clin Periodontol. 2004;31:454–7.
John MT, Koepsell TD, Hujoel P, Miglioretti DL, LeResche L, Micheelis W. Demographic factors, denture status and oral health-related quality of life. Community Dent Oral Epidemiol. 2004;32:125–32.
Piovesan C, Antunes JLF, Guedes RS, Ardenghi TM. Impact of socioeconomic and clinical factors on child oral health-related quality of life (COHRQoL). Qual Life Res. 2010;19:1359–66.
Ilma de Souza Cortes M, Marcenes W, Sheiham A. Impact of traumatic injuries to the permanent teeth on the oral health-related quality of life in 12–14-year-old children. Community Dent Oral Epidemiol. 2002;30:193–8.
Thomson WM, Lawrence HP, Broadbent JM, Poulton R. The impact of xerostomia on oral-health-related quality of life among younger adults. Health Qual Life Outcomes. 2006;4:86.
Jokovic A, Locker D, Stephens M, Kenny D, Tompson B, Guyatt G. Validity and reliability of a questionnaire for measuring child oral-health-related quality of life. J Dent Res. 2002;81:459–63.
McGRATH C, Pang HN, Lo E, King NM, HÄGG U, Samman N. Translation and evaluation of a Chinese version of the child oral health-related quality of life measure. Int J Paediatr Dent. 2008;18:267–74.
Brown A, AL-KHAYAL Z: Validity and reliability of the Arabic translation of the child oral-health-related quality of life questionnaire (CPQ11− 14) in Saudi Arabia. Int J Paediatr Dent 2006, 16:405-411.
Bekes K, John MT, Zyriax R, Schaller H-G, Hirsch C. The German version of the child perceptions questionnaire (CPQ-G11-14): translation process, reliability, and validity in the general population. Clin Oral Investig. 2012;16:165–71.
Wogelius P, Gjørup H, Haubek D, Lopez R, Poulsen S. Development of Danish version of child oral-health-related quality of life questionnaires (CPQ8–10 and CPQ11–14). BMC Oral health. 2009;9:11.
Jokovic A, Locker D, Guyatt G. Short forms of the child perceptions questionnaire for 11–14-year-old children (CPQ11–14): development and initial evaluation. Health Qual Life Outcomes. 2006;4:4.
Lau AW, Wong M, Lam K, McGrath C. Confirmatory factor analysis on the health domains of the child perceptions questionnaire. Community Dent Oral Epidemiol. 2009;37:163–70.
Lau AW. Structural equation modeling of the child perceptions questionnaire measuring oral health-related quality of life of children in HongKong. MPhil. thesis of the University of Hong Kong. The University of Hong Kong; 2008.
WHO. Oral health surveys: basic methods. ed 4 ed. Geneva: World Health Organization; 1997.
Bratthall D. Introducing the significant caries index together with a proposal for a new global oral health goal for 12-year-olds. Int Dent J. 2000;50:378–84.
Brook PH, Shaw WC. The development of an index of orthodontic treatment priority. Eur J Orthod. 1989;11:309–20.
Shaw W, Richmond S, O'Brien K. The use of occlusal indices: a European perspective. Am J Orthod Dentofac Orthop. 1995;107:1–10.
Daniels C, Richmond S. The development of the index of complexity, outcome and need (ICON). Journal of orthodontics. 2000;27:149–62.
Richmond S, Shaw W, O'brien K, Buchanan I, Jones R, Stephens C, Roberts C, Andrews M. The development of the PAR index (peer assessment rating): reliability and validity. Eur J Orthod. 1992;14:125–39.
Jenny J, Cons NC. Establishing malocclusion severity levels on the dental aesthetic index (DAI) scale. Aust Dent J. 1996;41:43–6.
Cons NC, Jenny J, Kohout FJ: Dental Aesthetic Index. Health quest; 1986.
Linder-Aronson S. Orthodontics in the Swedish public dental health service. Trans Eur Orthod Soc. 1974;233
Lunn H, Richmond S, Mitropoulos C. The use of the index of orthodontic treatment need (IOTN) as a public health tool: a pilot study. Community Dent Health. 1993;10:111–21.
Richmond SOB, K; Buchanan, I; Burden, D. An introduction to occlusal indices. Mandent Press, Victoria University of Manchester, Manchester, UK.; (1992).
Schooling CM, Hui LL, Ho LM, Lam T-H, Leung GM. Cohort profile:‘children of 1997’: a Hong Kong Chinese birth cohort. Int J Epidemiol. 2011;41:611–20.
Zhang M. Changes in children’s oral health related quality of life following orthodontic treatment. Ph. D. thesis of The University of Hong Kong. The University of Hong Kong; 2007.
Eldridge SM, Ashby D, Kerry S. Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis method. Int J Epidemiol. 2006;35:1292–300.
Killip S, Mahfoud Z, Pearce K. What is an intracluster correlation coefficient? Crucial concepts for primary care researchers. Ann Fam Med. 2004;2:204–8.
Sutcliffe P. A longitudinal study of gingivitis and puberty. J Periodontal Res. 1972;7:52–8.
Geiger AM. Malocclusion as an etiologic factor in periodontal disease: a retrospective essay. Am J Orthod Dentofac Orthop. 2001;120:112–5.
Clark G. Etiologic theory and the prevention of temporomandibular disorders. Adv Dent Res. 1991;5:60–6.
Linder-Aronson S. Orthodontics in the Swedish public dental health service. Eur J Orthod. 2007;29:i124–7.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
The ethical approval of this study was granted by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster (UW 09–453).
Consent for publication
The authors declare that they have no competing interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Sun, L., Wong, H.M. & McGrath, C.P.J. The factors that influence the oral health-related quality of life in 12-year-old children: baseline study of a longitudinal research. Health Qual Life Outcomes 15, 155 (2017). https://doi.org/10.1186/s12955-017-0729-2
- Oral health-related quality of life
- Periodontal status
- Sociodemographic factors
- Baseline study