- Open Access
Health related quality of life in sickle cell patients: The PiSCES project
© McClish et al; licensee BioMed Central Ltd. 2005
- Received: 14 April 2005
- Accepted: 29 August 2005
- Published: 29 August 2005
Sickle cell disease (SCD) is a chronic disease associated with high degrees of morbidity and increased mortality. Health-related quality of life (HRQOL) among adults with sickle cell disease has not been widely reported.
We administered the Medical Outcomes Study 36-item Short-Form to 308 patients in the Pain in Sickle Cell Epidemiology Study (PiSCES) to assess HRQOL. Scales included physical function, physical and emotional role function, bodily pain, vitality, social function, mental health, and general health. We compared scores with national norms using t-tests, and with three chronic disease cohorts: asthma, cystic fibrosis and hemodialysis patients using analysis of variance and Dunnett's test for comparison with a control. We also assessed whether SCD specific variables (genotype, pain, crisis and utilization) were independently predictive of SF-36 subscales, controlling for socio-demographic variables using regression.
Patients with SCD scored significantly worse than national norms on all subscales except mental health. Patients with SCD had lower HRQOL than cystic fibrosis patients except for mental health. Scores were similar for physical function, role function and mental health as compared to asthma patients, but worse for bodily pain, vitality, social function and general health subscales. Compared to dialysis patients, sickle cell disease patients scored similarly on physical role and emotional role function, social functioning and mental health, worse on bodily pain, general health and vitality and better on physical functioning. Surprisingly, genotype did not influence HRQOL except for vitality. However, scores significantly decreased as pain levels increased.
SCD patients experience health related quality of life worse than the general population, and in general, their scores were most similar to patients undergoing hemodialysis. Practitioners should regard their HRQOL as severely compromised. Interventions in SCD should consider improvements in health related quality of life as important outcomes.
- Cystic Fibrosis
- Sickle Cell Disease
- Bodily Pain
- Sickle Cell Disease Patient
- Scale Recalibration
Functional status and health-related quality of life (HRQOL) may be impaired in sickle cell disease (SCD) due to morbid events, such as stroke, or other organ system failures. The Cooperative Study of Sickle Cell Disease (CSSD) found that morbid events such as strokes that impaired function often preceded death in childhood [1–3] Until recent decades, SCD was associated with chronic childhood pain, organ failure and death in very early adulthood. Treatment advances have now transformed SCD into a chronic disease suffered by children and adults. Frequently, patients surviving until adulthood experience significant organ system damage that may include stroke, pulmonary failure and pulmonary hypertension, renal failure, congestive heart failure, leg ulcers, and osteonecrosis of the femoral or humeral heads .
Children and adolescents with SCD report poor HRQOL in qualitative studies using focus groups , and fare worse in their HRQOL compared to controls on health surveys  or on assessments of general physical, motor and independent daily functioning [6, 7]. Despite the considerable evidence in children for reduced HRQOL in SCD, few studies have evaluated the impact of this disease on health related quality of life in adults [8–11].
The impact of this disease on HRQOL for adults may be even greater than for children. Quality of life is deteriorated by episodic, debilitating pain associated with substantial analgesic use, frequent hospitalization for pain episodes, and ultimately organ failure. Although SCD related pain can often be managed by analgesics and opioids, adults with SCD may be under-treated because clinicians suspect drug dependence in this population. This provider bias may lead to reluctance by patients to seek medical attention [12, 13]. Further, HRQOL may be over-estimated by providers that do not regularly care for patients with SCD due to lack of understanding of the severity of the painful crises and the potential impact on function. Therefore, assessing the quality of life among a US adult SCD population and providing comparisons with HRQOL reported among comparable adults with other chronic diseases may be an important method for providing health care practitioners who care for these patients a more objective perspective on the impact and severity of this disease. In addition, quality of life in SCD is important to describe because it amplifies the ability to identify patients for whom potentially dangerous but potent interventions such as hydroxyurea or bone marrow transplantation is justified at an early stage.
The Pain in Sickle Cell Epidemology Study (PiSCES) is a longitudinal cohort study of over 300 adult patients with SCD designed to understand the relationship between pain and response to pain. The emphasis is on potentially mutable etiologic, and non-biologic variables. The PiSCES methods have been described in detail elsewhere . Briefly, we enrolled 308 adult patients with SCD from July 2002 through August 2004. Baseline information, laboratory data and daily pain diary data were collected. Baseline data was collected at the time of enrollment using a self-administered questionnaire which included questions on demographics, health related quality of life, and other information including medical history and medication use. In addition to the survey information, blood was obtained for genotyping and urine specimens were collected to assess renal function.
As part of the PiSCES study, patients filled out daily diaries for up to 6 months . The diary was modeled after the one used in the Multicenter Study of Hydroxyurea . Among other things, the diary asked patients to report about the previous 24 hours: the worst sickle cell pain intensity, on a scale from 0 (none) to 9 (unbearable), whether or not they were in a sickle cell crisis, and whether they had gone for an unscheduled physician visit, ED visit or were hospitalized due to sickle cell pain.
Patients were solicited for enrollment from across Virginia, but focused on the Richmond and Tidewater areas of Virginia. Patients aged 16 years and older were eligible for enrollment Patients identified as potentially eligible for the study were invited and scheduled for an enrollment visit, at which time informed consent was obtained. The study, along with recruitment methods, was approved by the VCU IRB.
Interested patients were then screened using the Mini Mental Status Examination  to assure competency (excluded if score less than 27) and the ability to provide informed consent. Patents were compensated ten dollars for the initial visit, when blood and urine specimens are obtained, and the baseline survey was completed.
To assess the relative HRQOL in SCD patients, comparison groups from published reports representing three different cohorts of patients with chronic diseases including asthma , cystic fibrosis  and hemodialysis  patients were included. These comparison groups were selected to be similar in age and gender to the PiSCES cohort. The asthma sample consisted of 301 patients whose mean age was 38 and 56% of whom were female. The hemodialysis sample consisted of 1000 prevalent cases with a mean age of 58 and of whom 50% were female. Data regarding cystic fibrosis came from 223 adolescents and adult subjects participating in a validation of the quality of life instrument with a mean age of 25, and 54% female.
The Medical Outcome Study 36 item Short Form (SF-36)  is a generic measure of health related to functional status and well being. The survey is not disease- or age-specific and has been validated across a wide variety of age, race and disease groups, including many chronic diseases [20–22]. The SF-36 has high test-retest reliability, has been shown to predict a number of poor outcomes , has been compared with biological markers for their sensitivity to change in severity of chronic illness , and has been used as outcomes in clinical trials of chronic illness .
The SF-36 is multidimensional with subscales representing eight of the most important dimensions of HRQOL: physical function, physical role functions, emotional role functioning, bodily pain, vitality, general health, mental health and social function. Subscales are measured on a scale from 0 – 100 (with 0 being the worst and 100 the best score). Values are available for specific age and gender population subgroups for the US and other populations. In addition to the chronic disease samples used for comparison, the normal values for age matched males and females from the general US population are provided and compared with our study population.
Sickle cell genotype (Sβ+ Thalasemia, Sßo Thalasemia, SC and SS) is a known predictor of mortality and disease severity. The CSSCD evaluated the natural history of 3578 patients ranging in age from newborns to age 66. Hospital utilization due to pain varied according to genotype (SS = 0.8 episodes/pt/yr., Sßo Thalasemia = 1.0 episodes/pt/yr., SC and Sß+ Thalasemia = 0.4 episodes/pt/yr) . Genotype was also a predictor of the age at death . Further, among patients over the age of 20, the hospital utilization rate due to pain was correlated with mortality over the years . For this study, genotype was obtained either directly from the blood specimen obtained from the patient at enrollment or from the patient's medical record. Since there were few patients with Sβ+ Thalasemia and Sßo Thalasemia, for purposes of analyses, two groups were defined. The more severe genotype grouping included SS and Sßo Thalasemia, the less severe group included SC and Sβ+ Thalasemia,
We used three calculated variables from the diary for this study. Mean daily pain was calculated as the sum of the pain intensity for all diary days, divided by the total number of days the diary was completed. The percentage of days for which a crisis was marked on the diary was calculated as 100*the number of days with crisis marked, divided by the total number of days the diary was completed. Percentage of days on which there was utilization was constructed similarly, with utilization consisting of either an unscheduled clinic visit, an ED visit or an overnight hospitalization. Since these latter two variable was very skewed, with many having no crisis or utilization, for analysis the diary variables were divided into 3 categories of roughly equal size (coded 1, 2, 3): Percent of days with self-reported crises: 0, 0.1–10, 10+; Percent of days with utilization: 0, 0.1–3, 3+.
Means and standard deviations are presented. Comparison values were created from MOS national norms data by using a weighted average of age-gender specific values, with the weights equal to the proportion of the PiSCES sample in that age group. Subscales for the PiSCES cohort were compared to national norms with a t-test. Analysis of variance was used as an overall test for equality of each subscale across chronic disease cohorts. When the overall F test was significant, Dunnett's test was used to compare each of the chronic diseases to the mean for the PiSCES cohort. To determine whether SCD-specific variables were independently predictive of HRQOL, we used multiple linear regression, controlling for socio-demographic variables (age, gender, education). SCD-specific variables included genotype, mean pain, and percent days of diary days reporting crisis and utilization. These analyses were limited to patients who had returned at least 30 diaries. This reduced the sample from 308 to 226. Three additional subjects were excluded from regression analyses because they lacked information on genotype. Analysis used SAS 8.2 for UNIX.
Demographic description of PiSCES cohort
High School grad
SF-36 – PiSCES cohort vs National Norms (Mean ± standard deviation)
66.4 ± 24.1
92.3 ± 15.5
59.9 ± 25.1
87.4 ± 19.7
40.1 ± 38.7
90.5 ± 24.0
38.6 ± 39.9
83.8 ± 31.5
50.8 ± 28.6
79.6 ± 21.1
45.2 ± 26.0
77.3 ± 22.1
42.7 ± 22.3
77.1 ± 17.3
37.0 ± 21.7
73.9 ± 19.0
50.4 ± 22.5
64.9 ± 19.2
37.6 ± 21.0
59.2 ± 20.6
62.3 ± 27.6
86.6 ± 19.9
62.4 ± 24.8
82.8 ± 22.1
62.7 ± 43.1
85.0 ± 29.4
54.7 ± 42.8
80.7 ± 33.1
75.3 ± 20.7
76.4 ± 16.8
69.2 ± 20.0
72.8 ± 18.3
SF-36: Comparison of PiSCES sample with other chronic disease cohorts (mean ± standard deviation)
ANOVA F value†
N = 308
N = 1000
N = 223
N = 241
62.4 ± 24.9
44.3 ± 27.8*
76.3 ± 24.0*
63.2 ± 21.4
39.2 ± 39.4
39.7 ± 40.4
72.9 ± 38.4*
38.7 ± 39.9
47.4 ± 27.2
60.4 ± 29.1*
82.2 ± 21.3*
67.2 ± 23.2*
39.2 ± 22.1
50.0 ± 22.4*
43.4 ± 23.7*
57.9 ± 19.0*
42.7 ± 22.5
46.5 ± 22.3*
58.4 ± 23.1*
48.2 ± 20.8*
63.5 ± 25.2
66.0 ± 29.9
80.4 ± 23.8*
72.1 ± 22.2*
57.8 ± 43.1
58.2 ± 42.7
77.0 ± 36.9*
63.3 ± 41.5
71.6 ± 20.4
69.7 ± 21.6
73.7 ± 18.1
70.7 ± 18.4
Results of regression of SCD-specific variables on SF-36 subscales, controlling for socio-demographic variables1 (regression coefficients ± standard error)
Proportion Days with Crisis3
Proportion Days with Utilization4
-5.01 ± 3.30
-4.55 ± 0.72**
-0.42 ± 2.12
3.51 ± 1.97
-1.62 ± 5.73
-6.12 ± 1.27**
-0.91 ± 3.70
2.75 ± 3.39
0.14 ± 3.57
-4.41 ± 0.79**
-5.93 ± 2.31*
-0.59 ± 2.13
3.52 ± 3.19
-3.34 ± 0.71**
-1.31 ± 2.09
-1.44 ± 1.92
6.43 ± 3.27*
-3.54 ± 0.72**
0.55 ± 2.10
3.06 ± 1.94
3.16 ± 3.77
-4.27 ± 0.82**
-3.28 ± 2.44
1.93 ± 2.25
7.06 ± 6.27
-5.81 ± 1.39**
2.30 ± 4.09
2.12 ± 3.71
4.23 ± 3.14
-1.44 ± 0.69*
-1.53 ± 2.02
0.35 ± 1.87
In general, SCD patients experience a poor health related quality of life. Except for mental health, the SF-36 subscale values were considerably lower than norms of the general US population. They reported a HRQOL that was equal to or poorer than patients with other significant chronic conditions in many domains. Similar to patients with SCD, until somewhat recently, patients with cystic fibrosis rarely lived until adulthood, marking this as a disease with significant sequelae and high mortality. It is interesting, then, to see that quality of life of adult survivors of this chronic disease, even though impaired, was comparable to national norms, and was generally far superior than that reported by adults with SCD. Of the three chronic conditions selected for comparison, the PiSCES cohort had HRQOL patterns most similar to that of patients undergoing chronic hemodialysis.
That SCD patients did not report poorer mental health and well being than the general US population is consistent with findings for many medical conditions. In 1978 Brickman, et al  presented a famous result showing that lottery winners are not much happier than paraplegics. Since that time many studies have confirmed similar results, that while people who are sick may report their health as being worse than the general population, they appear to have similar well-being. Not only was it true of the asthma, dialysis and cystic fibrosis cohorts presented here, but similar results have been shown for people with other chronic diseases both in the US and other countries [21, 22, 27].
It has been suggested that the fact that many people with chronic diseases report good psychological well being could be a result of increased social support, lack of other stressors, or a "response shift" associated with the managing their chronic disease . The "response shift" could be a result of a scale recalibration, a change in the patient's values, or a reconceptualization of their mental health and well-being [28, 29] in order to accommodate their illness. Riis et al  dispute the idea of scale recalibration, proposing instead that people have adapted to their illness or situation.
Heady and Wearing  propose that there is a baseline level of mood or well-being that people have to which they return after events cause them to move from that baseline. This is supported by a twin study indicating that most variation in well-being is due to variations in genetics, not life circumstances . That would suggest that, while perhaps people with SCD may temporarily report poorer well-being associated with high levels of pain or other disease sequalae, most often they would report a baseline well-being similar to that of others.
Despite the similar level of well-being in SCD patients compared with both norms and patients with other chronic diseases, patients with SCD experience significant decrements in other important aspects of HRQOL. This is supported in a study of adult SCD patients in the UK, where Anie et al, found their population also had much lower HRQOL scores than general UK population norms. Further, the patients in this study had reported HRQOL similar to patients with arthritis due to hereditary haemochromatisis, another chronic disease . Patients in the PiSCES cohort reported somewhat lower general health and higher mental health scores than Anie et al found. This may result in part from differences in the two cohorts, including their relative access to health care in the two settings.
Surprisingly, HRQOL was not associated with genotype except for the vitality subscale. However there was a strong association with reduced HRQOL and pain levels, and, for a few subscales, there was a trend with increasing levels of utilization. The relationship between genotype severity and HRQOL may have been mediated by these variables, particularly pain. Anie et al  also found a relationship between pain and some subscales of the SF-36 (physical and social functions, mental and general health) but found no significant association with utilization measures. Whether the more severe manifestations of the disease cause the poorer quality of life, or patients who report poorer quality of life suffer more and use more health care cannot be determined from this study.
It is unclear why the direction of the statistically significant association between vitality for SS/Sßo Thalasemia vs SC/Sß+ Thalasemia is opposite of what would be expected, with the more severe genotype being associated with better vitality. Even the nonsignificant relationships between genotype and the other HRQOL subscales in these regressions were in the same direction, except for physical functioning. Similarly, increased utilization tended to be associated, albeit nonstatistically with better HRQOL scores for most subscales These counter-intuitive findings should be explored by other SCD researchers.
There are several limitations of this study. First, this study enrolled patients from only one state, so may not be representative of the entire US SCD population. When comparing to populations with chronic disease, the gender and age distributions were not ideally matched. In particular, the PiSCES cohort, at a mean age of 33, is significantly younger than the dialysis comparison group However, since SF-36 subscale scores tend to decrease with age, the fact that these younger patients with SCD had worse HRQOL scores on some subscales than an older hemodialysis cohort is even more alarming
Practitioners caring for adult SCD patients should regard their quality of life as severely compromised, with scores that are most similar to hemodialysis patients in our comparison of other chronic diseases. Although reducing mortality is of paramount importance among SCD patients, future interventions should consider improving health related quality of life as a clinical endpoint.
This work was supported by a grant from NHLBI: 1R01HL64122-01A1
- Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, Kinney TR: Pain in sickle cell disease: Rates and risk factors. N Engl J Med 1991, 325: 11–16.PubMedView ArticleGoogle Scholar
- Platt OS, Brambilla DJ, Milner PF, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP: Mortality in sickle cell disease: Life expectancy and risk factors for early death. N Engl J Med 1994, 330: 1639–1644. 10.1056/NEJM199406093302303PubMedView ArticleGoogle Scholar
- Bonds DR: Three decades of innovation in the management of sickle cell disease: the road to understanding the sickle cell disease clinical phenotype. Blood Rev 2005, 19: 99–110. 10.1016/j.blre.2004.04.002PubMedView ArticleGoogle Scholar
- Thomas VJ, Taylor LM: The psychosocial experience of people with sickle cell disease and its impact on quality of life: Qualitative findings from focus groups. Br J Health Psychol 2002, 7: 345–363. 10.1348/135910702760213724PubMedView ArticleGoogle Scholar
- Fuggle P, Shand PA, Gill LJ, Davies SC: Pain, quality of life, and coping in sickle cell disease. Arch Dis Child 1996, 75: 199–203.PubMed CentralPubMedView ArticleGoogle Scholar
- Kater AP, Heijboer H, Peters M, Vogels T, Prins MH, Heymans HS: Quality of life in children with sickle cell disease in Amsterdam area. Ned Tijdschr Geneeskd 1999, 143: 2049–2053.PubMedGoogle Scholar
- Stegenga KA, Ward-Smith P, Hinds PS, Routhieaux JA, Woods GM: Quality of life among children with sickle cell disease receiving chronic transfusion therapy. J Pediatr Oncol Nurs 2004, 21: 207–213. 10.1177/1043454204265841PubMedView ArticleGoogle Scholar
- Strickland OL, Jackson G, Gilead M, McGuire DB, Quarles S: Use of focus groups for pain and quality of life assessment in adults with sickle cell disease. J Natl Black Nurses Assoc 2001, 12: 36–43.PubMedGoogle Scholar
- Anie KA, Steptoe A, Bevan D: Sickle cell disease: Pain, coping and quality of life in a study of adults in the UK. Br J Health Psychol 2002, 7: 331–344. 10.1348/135910702760213715PubMedView ArticleGoogle Scholar
- Thomas VJ, Taylor LM: The psychosocial experience of people with sickle cell disease and its impact on quality of life: Qualitative findings from focus groups. Br J Health Psychol 2002, 7: 345–363. 10.1348/135910702760213724PubMedView ArticleGoogle Scholar
- Ramsey LT, Woods KF, Callahan LA, Mensay GA, Barbeau P, Gutin B: Quality of life improvement for patients with sickle cell disease. Am J Hematol 2001, 66: 155–156. Publisher Full Text 10.1002/1096-8652(200102)66:2<155::AID-AJH1038>3.0.CO;2-DPubMedView ArticleGoogle Scholar
- Maxwell K, Streetly A, Bevan D: Experience of hospital care and treatment seeking for pain from sickle cell disease: qualitative study. BMJ 1999, 318: 1585–1590.PubMed CentralPubMedView ArticleGoogle Scholar
- Elander J, Lusher J, Bevan D, Telfer P: Pain management and symptoms of substance dependence among patients with sickle cell disease. Soc Sci Med 2003, 57: 1683–1696. 10.1016/S0277-9536(02)00553-1PubMedView ArticleGoogle Scholar
- Smith WR, Bovbjerg VE, Penberthy LT, McClish DK, Levenson JL, Roberts JD, Roseff SD, Aisidu IP: Understanding pain and improving management of sickle cell disease: the PiSCES Study. J Natl Med Assoc 2005, 97: 183–192.PubMed CentralPubMedGoogle Scholar
- Carache S, Terrin ML, Moore RD, Dover GJ, McMahon RP, Barton FB, Waclawiw M, Eckert SV, the Investigators of the Multicenter Study of Hydroyurea: Design of the multicenter study of hydroxyrea in sickle cell anemia. Controlled Clinical Trials 1995, 16: 432–446. 10.1016/S0197-2456(95)00098-4View ArticleGoogle Scholar
- Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical guide for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975,12(3):189–98. 10.1016/0022-3956(75)90026-6PubMedView ArticleGoogle Scholar
- Lee TA, Hollingworth W, Sullivan : Comparison of directly elicited preferences to preferences derived from the SF-36 in adults with asthma. Med Decis Making 2003, 23: 323–334. 10.1177/0272989X03256009PubMedView ArticleGoogle Scholar
- Gee L, Abbott J, Conway SP, Etherington C, Webb AK: Validation of the SF-36 for the assessment of quality of life in adolescents and adults with cystic fibrosis. J Cyst Fibros 2002, 1: 137–145. 10.1016/S1569-1993(02)00079-6PubMedView ArticleGoogle Scholar
- DeOreo PB: Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization and dialysis attendance compliance. Am J Kidney Dis 1997, 30: 204–212.PubMedView ArticleGoogle Scholar
- Ware JE, Snow KK, Kosinski M, Gandek B: SF-36 Health Survey. Manual & Interpretation Guide. Boston MA. Health Institute; 1993.Google Scholar
- Alonso J, Ferrer M, Gandek B, Ware JE Jr, Aaronson NK, Mosconi P, Rasmussen NK, Bullinger M, Fukuhara S, Kaasa S, Leplege A, the IQOLA Project Group: Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project. Qual Life Res 2004, 13: 283–298. 10.1023/B:QURE.0000018472.46236.05PubMedView ArticleGoogle Scholar
- Rijken M, van Kerkhof M, Dekker J, Schellevis FG: Comorbidity of chronic diseases: effects of disease pairs on physical and mental functioning. Qual Life Res 2005, 14: 45–55. 10.1007/s11136-004-0616-2PubMedView ArticleGoogle Scholar
- Wachtel T, Piette J, Mor V, Stein M, Fleishman J, Carpenter C: Quality of life in persons with human immunodeficiency virus infection: measurement by the Medical Outcomes Study instrument. Ann Intern Med 1992, 116: 129–137.PubMedView ArticleGoogle Scholar
- Ware JE Jr, Kemp JP, Buchner DA, Singer AE, Nolop KB, Goss TF: The responsiveness of disease-specific and generic health measures to changes in the severity of asthma among adults. Qual Life Res 1998, 7: 235–244.PubMedView ArticleGoogle Scholar
- Kosinski M, Keller SD, Hatoum HT, Kong SX, Ware JE Jr: The SF-36 Health Survey as a generic outcome measure in clinical trials of patients with osteoarthritis and rheumatoid arthritis: tests of data quality, scaling assumptions and score reliability. Med Care 1999, 37: MS10–22. 10.1097/00005650-199905001-00002PubMedGoogle Scholar
- Brickman P, Coates D, Janoff-Bulman R: Lottery winners and accident victims: Is happiness relative? J Pers Soc Psychol 1978, 36: 917–927. 10.1037//0022-3518.104.22.1687PubMedView ArticleGoogle Scholar
- Schlenk EA, Erlen JA, Dunbar-Jacob J, McDowell J, Engberg S, Serinka SM, Rohay JM, Bernier MH: Health related quality of life in chronic disorders: a comparison across studies using the SF-36. Qual Life Res 1998, 7: 57–65. 10.1023/A:1008836922089PubMedView ArticleGoogle Scholar
- Sprangers MAG, Schwarts CE: Integrating response shift into health-related quality of life research: a theoretical model. Soc Sci Med 1999, 48: 1507–1515. 10.1016/S0277-9536(99)00045-3PubMedView ArticleGoogle Scholar
- Rapkin BD, Schwartz CR: Towards a theoretical model of quality-of-life appraisal: Implications of findings from studies of response shift. HQLO 2004, 2: 14. 10.1186/1477-7525-2-14PubMed CentralPubMedGoogle Scholar
- Riis J, Loewenstien G, Baron J, Fepson C, Fagerlin A, Ubel PA: Ignorance of hedonic adaptation for hemodialyis: A study using ecological momentary assessment. J Exp Psychol: Gen 2005, 134: 3–9. 10.1037/0096-3422.214.171.124View ArticleGoogle Scholar
- Heady B, Wearing A: Understanding happiness: A theory of subjective well being. Melboune, Vicotira Australia: Longman Cheshire; 1992.Google Scholar
- Lykken D, Tellegen A: Happiness is a stochastic phenomenon. Psychological Science 1996, 7: 186–189.View ArticleGoogle Scholar
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