Validation of the self-management ability scale (SMAS) and development and validation of a shorter scale (SMAS-S) among older patients shortly after hospitalisation
© Cramm et al; licensee BioMed Central Ltd. 2012
Received: 29 September 2011
Accepted: 24 January 2012
Published: 24 January 2012
The 30-item Self-Management Ability Scale (SMAS) measures self-management abilities (SMA). Objectives of this study were to (1) validate the SMAS among older people shortly after hospitalisation and (2) shorten the SMAS while maintaining adequate validity and reliability.
Our study was conducted among older individuals (≥ 65) who had recently been discharged from a hospital. Three months after hospital admission, 296/456 patients (65% response) were interviewed in their homes. We tested the instrument by means of structural equation modelling, and examined its validity and reliability. In addition, we tested internal consistency of the SMAS and SMAS-S among a study sample of patients at risk for cardiovascular diseases.
After eliminating 12 items, the confirmatory factor analyses revealed good indices of fit with the resulting 18-item SMAS (SMAS-S). To estimate construct validity of the instrument, we looked at correlations between SMAS subscale scores and overall well-being scores as measured by Social Product Function (SPF-IL) and Cantril's ladder. All SMAS subscales of the original and short version significantly correlated with SPF-IL scores (all at p ≤ 0.001) and Cantril's ladder (for the cognitive well-being subscale p ≤ 0.01; all other subscales at p ≤ 0.001). The findings indicated validity. Analyses of the SMAS and SMAS-S in the sample of patients at risk for cardiovascular diseases showed that both instruments are reliable.
The psychometric properties of both the SMAS and SMAS-S are good. The SMAS-S is a promising alternate instrument to evaluate self-management abilities.
Besides a growing population of older people, a greater proportion live alone and sociological changes have forced them to rely more often on their own resources . They are also hospitalised with increasing frequency as the risk for (multiple) chronic diseases increases with age . They often experience losses in various domains of functioning, which leads to frailty, especially after hospitalisation . Accurately assessing how they manage their well-being is thus critical.
Successful aging requires the proactive management of resources in an environment of increasing losses and declining gains , and depends on individuals' abilities to self-manage their lives and aging processes. Although such self-regulation is often related primarily to aspects of physical health, such as physical activity and diet [4–6], the social and psychological aspects of life - social contacts, adaptation, well-being - are equally important to older peoples' ability to 'age well' . Despite acknowledgement of the importance of individuals' contributions to aging successfully and the existence of psychosocial theories of successful aging [2, 8–12], relatively few suggestions have been made to help older people self-regulate and maintain their well-being .
The self-management of well-being (SMW) theory , based on the theory of social production functions (SPF) [14, 15], offers guidelines for achieving better self-regulation with regard to well-being. SMW theory posits that successful aging is a life-long process of realizing and sustaining well-being, even in the face of declining resources. Rather than being the process of neutralising losses and discrepancies, successful aging focuses on individuals' reserve capacities to realize and sustain physical and social well-being using external and internal resources . External resources contribute directly to aspects of well-being, such as food, shelter, fitness (physical well-being) and friends (social well-being). They tend to decline with age. Self-management abilities (internal resources) are needed to manage external resources in such a way that physical and social well-being are maintained or restored when lost . SMW theory incorporates six core abilities to form the composite construct of self-management: (1) take initiatives (be instrumental or self-motivating in realizing aspects of well-being); (2) invest in resources for long-term benefits; (3) maintain variety in resources (achieve and maintain various resources for each dimension of well-being); (4) ensure resource multifunctionality (gain and maintain resources or activities that serve multiple dimensions of well-being simultaneously and in a mutually reinforcing way); (5) self-efficaciously manage resources (gain and maintain a belief in personal competence to achieve well-being); and (6) maintain a positive frame of mind. Each of these abilities must be related explicitly to the dimensions of well-being specified in the SPF theory: physical well-being (comfort and stimulation) and social well-being (affection, behavioural confirmation, and status) [13–15, 17, 18].
The 30-item Self-Management Ability Scale (SMAS) was developed to measure SMA . Losses in functioning - something that is especially associated with hospitalisation - lead to a decreased reserve capacity for coping with losses. Self-management abilities become particularly important. Our first objective was to validate the SMAS among older people shortly after hospitalisation. The six subscales of the SMAS reflect the six SMA core abilities. Schuurmans and colleagues  concluded that future research could focus on shorter forms of the scale because (i) high correlations were found between some subscales and (ii) some items seemed to be less indicative of SMA (lower loadings). Our second objective was thus to reduce the number of items in the SMAS while maintaining validity and reliability.
Our study was conducted in 2010 among older people who had recently been admitted to a hospital in the context of the 'Prevention and Reactivation Care Programme', which was designed to prevent loss of function in older patients due to hospitalisation and targeted older hospital patients (≥ 65 years of age) who were vulnerable to loss of function after hospital admission. Three months after hospital admission is known to be a good moment to assess effects of a programme [20, 21]. Therefore, patients were interviewed three months after hospital admission. Our research is based on the pilot study of 456 patients (≥ 65 years old) prior to implementation of the 'Prevention and Reactivation Care Programme'. The results of the pilot study have been used to identify possible practical implementation problems in preparation for the main evaluation study and serve as a base for power calculations for the main study. We interviewed 296 patients in their homes (response rate 65%). This work was supported by Netherlands organisation for health research and development (ZonMw) grant number: 60-61900-98-130.
The study protocol was approved by the medical ethics committee of the Erasmus Medical Centre, Rotterdam, the Netherlands, under protocol number MEC2011-041.
The 30-item SMAS consists of six five-item subscales. The scale's overall internal consistency is 0.90 . Within the subscales of taking initiative, investing, self-efficacy, variety, and multifunctionality, abilities are related to the physical and social dimensions of well-being in the SPF theory [13, 14]. The ability to have a positive frame of mind is considered a more general cognitive frame; its subscale is thus not directly related to specific dimensions of well-being. Average overall SMAS scores range from 5 to 30, with higher scores indicating higher SMA.
Overall subjective well-being was measured with the SPF-IL(s) (15-item Social Production Function Instrument for the Level of well-being) . The scale integrates both affective and cognitive components of well-being, and measures levels of physical and social well-being. Cronbach's alpha of the SPF-IL in our study was 0.72, indicating a reliable instrument.
Cantrill's Ladder was used to assess satisfaction with life and reflects a general, cognitive evaluation of a person's overall well-being .
The analyses included the following seven steps.
1. The sample characteristics were analysed using descriptive statistics.
2. We data-screened the items by examining the number of missing items and each item's mean and standard deviation.
3. To verify the factor structure of the questionnaire and to test whether the relationship between observed variables and their underlying latent constructs existed, confirmatory factor analysis was executed using the LISREL program version 8.80 . By using structural equation modelling the overlap between items and dimensions can be traced via modification indices that were used to further refine the measurement model and eliminate potential overlap between items. No correlation errors either within or across sets of items were allowed in the model.
4. Item reduction analysis was performed to develop a short version of the questionnaire. Item removal following several criteria: (i) items were excluded following modification indices provided by LISREL and the strength of the factor loadings; (ii) item elimination stopped when the reliability of each subscale dropped below 0.65; (iii) subscales were left with as few items as possible (but a minimum of three) without loss of content and psychometric quality; and (iv) at least one physical well-being item (comfort or stimulation) and one social well-being item (affection, behavioural confirmation or status) was kept in each subscale while maintaining validity and reliability. Listwise deletion of cases with missing data on the 30 items resulted in N = 204. Imputation was done by replacing missing values with the mean of the data, restoring the original sample of N = 296.
We used four indices of model fit to test the measurement models, with cut-off criteria proposed by Hu and Bentler . First, the overall test of goodness-of-fit assesses the discrepancy between the implied model and the sample covariance matrix by means of a normal-theory weighted least squares test. A plausible model has low, preferably non-significant χ2 values. Chi-square is, however, overly sensitive when the sample size is large (over 200) , leading to difficulty in obtaining a desired non-significant level . Second, the Root Means Square Error of Approximation (RMSEA) reflects the estimation error divided by the degrees of freedom as a penalty function. Values on RMSEA below 0.06 indicate small differences between the estimated and observed model. Values of up to 0.08 suggest a reasonable fit of the model in the population. Third, we used the Standardized Root Means square Residual (SRMR), which is a scale invariant index for global fit that ranges between 0 and 1. Values on SRMR lower than 0.08 indicate a good fit. Fourth, we calculated the Incremental Fit Index (IFI), which compares the independent model (i.e., observed variables are unrelated) to the estimated model. Values on IFI are preferably larger than 0.95.
5. After item reduction analyses the first full version and final short version of the instrument were tested on the non-imputed dataset (N = 204). Listwise deletion of missing data on the basis of the 18 items in the short version resulted in N = 221. We re-ran the final short version on this sample.
6. Internal consistency of the subscales was assessed by calculating Cronbach's alphas, inter-item correlations within each subscale, and correlations between subscales.
7. Validity is the degree to which a scale measures what it is intended to measure; here we focused on the construct validity of the questionnaire. Construct validity is supported if instruments purported to assess the same concept correlate substantially with one another. Since the SPF-IL and SMAS are both based on the SPF theory we evaluated construct validity by comparing the SMAS scale scores with well-being measured by the SPF-IL scale. In addition, we will compare the SMAS scale scores with well-being measured by Cantril's ladder.
We additionally tested the SMAS (original and short version) in another longitudinal study sample, namely patients at risk for cardiovascular diseases (low and high-risk). These patients were selected by GPs of primary healthcare practices. At both T0 and T1 Questionnaires were mailed to patients' homes. T1 was about 12 months after T0. A few weeks later, a reminder notice and another copy of the questionnaire were sent to non-respondents. Response rates were 72% (307 out of 426; T0) and 47% (200 out of 425; T1). A detailed description of the study can be found in our study protocol .
The study was approved by the ethics committee of the Erasmus University Medical Centre of Rotterdam and informed consent was obtained from all participants.
At T0 we measured three subscales of the SMAS and SMAS-S (taking initiative, investment behavior and self-efficacy). At T1 we measured the full SMAS-S.
Internal consistency of the three subscales (SMAS and SMAS-S) at T0 was assessed by calculating Cronbach's alphas. At T1 we calculated Cronbach's alphas of all six SMAS-S subscales. In addition, we assessed correlations between three subscales of the SMAS and SMAS-S at T0 and between three subscales of the SMAS-S at T0 and T1.
Respondents' median age was 75.8 (sd 6.8; range = 65-94); slightly more were female (54.2%). Just over half were married/living together (56.6%); the others were single, widowed or divorced (43.4%). Most lived independently with others (55.9%); about a third lived independently alone (37.3%); the remaining lived in elderly or nursing homes (6.8%).
Item characteristics and factor loadings of the first full model
How often do you take the initiative to keep yourself busy?
How often are you engaged in making your home or room as comfortable as possible?
How often do you take the initiative to get in touch with people who are dear to you?
Do you sometimes try to be good at something?
How often do you make an effort to have friendly contacts with other people?
Do you ensure that you have enough interests on a regular basis (such as a hobby) to keep you active?
Do you make sure that you get enough physical exercise in order to stay fit longer?
Do you occasionally do something so that your contact with your acquaintances remains good?
Do you devote some time and attention to those who are dear to you in order to maintain good contact?
Do you keep busy with the things you are good at so that you stay good at them?
How many hobbies or activities do you have on a regular basis?
Do you have different ways to relax when necessary?
Do you have different occasions on which you have friendly contacts with others?
With how many people do you have a confidential relationship?
Are there certain things that you are good at?
The activities I enjoy, I do together with others.
I sometimes help the people I care about.
Others benefit from the things I do for my pleasure.
I generally spend my holidays with others.
I practice my hobbies together with others.
Are you able to find agreeable activities?
Are you capable of taking good care of yourself?
Are you able to have friendly contacts with others?
Are you able to let others know that you care about them?
Are you good at something?
Positive Frame of Mind
How often are you able to see the positive side of the situation when something disagreeable happens?
When things go against you, how often do you think that it could always be worse?
When you are not doing well, how often do you think that there are others who are worse off?
When you have a bad day, how often do you think that things will be better tomorrow?
When things are not going so well, how often do you succeed in thinking positively?
Confirmatory Factor Analysis
Model fit indices
full model with 6 abilities systematically linked to dimensions of well-being as latent variables
On imputed data (n = 296)
Listwise deletion 30 items (n = 204)
Full and short models with 6 abilities not systematically linked to dimensions of well-being as latent variables
On imputed data (n = 296)
Final short version 18 items
Listwise deletion 30 items (n = 204)
Final short version 18 items
Listwise deletion 18 items (n = 221)
Final short version 18 items
If we a priori do not link each measure of SMA to the five dimensions of well-being the indices of model fit also showed that the model fit was sufficient (table 2). The RMSEA was just above cut-off value, indicating reasonable fit. IFI value was 0.955, near the cut-off value of .95, and SRMR was well below the cut-off value of 0.08. All indices indicated that the model not systematically linked to the five dimensions of well-being was acceptable, but left room for improvement.
Item reduction analysis
Following the factor loadings, modification indices, and an internal consistency check of each subscale, the stepwise procedure resulted in the elimination of 12 items. With respect to the 'investment behavior' subscale, modification indices and factor loadings showed that item 7 (getting enough exercise) could be eliminated. The results on the other items of the subscale showed some contradictory results. Eliminating item 6 (having a hobby) resulted in a better fit of the model; however, the physical component was no longer represented in the remaining items (8, 9 and 10) and led to a Cronbach's alpha below 0.70. Therefore, based on a lower factor loading of item 8 and construct validity, item 6 remained in the selection and item 8 (actively maintain contact with acquaintances) was eliminated.
The final short version consisted of 18 items with three items for each subscale (table 1). Item reduction was possible without loss of model fit; in fact, its overall fit was better than the full version. Due to a decrease in the number of estimated parameters, the Normal Theory Weighted Least Square χ2 significantly decreased to 530.427. RMSEA still indicated reasonable fit. The value of IFI improved to 0.967, indicating that the specified relations between variables were well supported by the data. The SRMR index decreased to 0.0669, still considerably below the cut-off point of 0.08, indicating good global fit. The final short model on imputed data resulted in comparable factor loadings. A re-run of the full model and item reduction analysis on the non-imputed dataset (N = 217) resulted in somewhat less favourable but still acceptable fit indices and comparable factor loadings.
Internal consistency and inter-correlations
Scale characteristics and inter-correlations of the shortened subscales (n = 296)
original full scale
inter-item correlations range
1. Taking Initiatives
1, 3, 5
2. Investment Behavior
6, 9, 10
11, 13, 15
16, 17, 18
21, 23, 24
6. Positive Frame of Mind
27, 29, 30
To estimate construct validity of the instrument, we looked at correlations between SMAS subscale scores and overall well-being scores. All SMAS subscales of the original and short versions significantly correlated with SPF-IL scores (all at p ≤ 0.001) and Cantril's ladder (for cognitive well-being p ≤ 0.01; all other subscales p ≤ 0.001), indicating convergent validity. The relative strength of association with SPF-IL scores are the same for the original SMAS (range = 0.311-0.593) and the short version (0.311-0.580), which also applies to the association between Cantril's ladder and SMAS (0.155-0.430) and SMAS-S (0.150-0.420).
We additionally tested the SMAS and SMAS-S in another study sample, namely patients at risk for cardiovascular diseases (low and high-risk). At T0 respondents' median age was 59.8 (sd 9.6; range = 31-88); slightly more were female (56.4%). The majority were married/living together (76.6%). At T1 respondents' median age was 60.2 (sd 9.1; range = 34-86); 58.2% female and 79.1% were married/living together.
At T0 we tested the three subscales 'taking initiative', 'investment behavior' and 'self-efficacy' of both the SMAS and SMAS-S for internal consistency. Cronbach's alpha of the SMAS and SMAS-S were both reliable: 'taking initiative' (0.79 SMAS vs 0.78 SMAS-S), 'investment behavior' (0.83 SMAS vs 0.78 SMAS-S), and 'self-efficacy' (0.84 SMAS vs 0.80 SMAS-S). At T1 we tested all six subscales of the SMAS-S. These results showed that the SMAS-S is a reliable instrument (range from 0.73 for 'positive frame of mind' to 0.85 for 'self-efficacy'). The correlations between the three original SMAS subscales and short subscales (SMAS-S) at T0 were also good (0.93-0.95) indicating acceptable coverage of the original sub-dimensions. The three SMAS-S subscales measured at T0 and T1 were also significantly related (0.57-0.70) indicating reliability.
Due to high risk of functional losses among older people after hospitalisation, SMA becomes particularly important. Our objectives were to (1) validate the SMAS among older people who had recently been admitted to a hospital and (2) reduce the number of items in the SMAS while maintaining validity and reliability. After performing an item reduction analysis, the resulting 18-item short version (SMAS-S) was shown to be reliable and valid. The results of the confirmatory factor analyses revealed good indices of fit with the SMAS and SMAS-S. The SMAS-S is thus a good alternative to the lengthier SMAS. We also found high correlations between some subscales in the SMAS and several items may have been less indicative of SMA (lower loadings). Our study showed that the subscales of the SMAS-S represented separate concepts. Therefore, SMA may even be better measured using the SMAS-S. Each measure of 30-item SMAS (except positive frame of mind) is however, specifically related to the five dimensions of well-being specified in the SPF theory and thus provides insight into all five well-being dimensions; the SMAS-S items are related to the two higher-level dimensions (physical and social well-being).
We found support for convergent validity of the original SMAS and SMAS-S through high correlations between the SMA dimensions and subjective well-being as measured by SPF-IL and Cantril's ladder.
We could not evaluate several psychometric properties in this study: the relationship of the SMAS-S with other self-management instruments, assessment of the SMAS-S responsiveness, its predictive value (e.g., clinical outcomes), and different modes of administration. They thus remain undefined. The instrument's sensitivity to change requires further investigation. We recommend testing the English version of the SMAS-S in other countries to ensure international validity. Last, our sample size was relatively small and our sample population was older people who had recently been discharged from the hospital. Future research is necessary to test the SMAS-S on other as well as larger populations. While the SMAS is validated and designed to assess self-management abilities among older people, this study additionally tested the SMAS-S among patients at risk for cardiovascular diseases (aged 30+). Our study findings show promising results to assess self-management abilities with the SMAS-S among other populations.
We conclude that the psychometric properties of both the SMAS and SMAS-S are good and the subscales of SMAS-S clearly represent separate concepts. The SMAS-S is a promising alternate instrument to evaluate self-management abilities. Having a shorter instrument makes it more feasible to assess SMA in a broader number of people, especially among frail older populations.
Study 1 is funded with a grant from the Netherlands organisation for health research and development (ZonMw) grant number: 606190098130. Study 2 was also supported by the ZonMw grant number 300030201. The views are those of the authors.
- Lewis J: Should We Worry About Family Change? Toronto: University of Toronto Press; 2003.Google Scholar
- Baltes PB, Baltes MM: Psychological perspectives on successful aging: the model of selective optimization with compensation. Edited by: Baltes PB, Baltes MM. Successful Aging: Perspectives from the Behavioral Sciences. Cambridge: Cambridge University Press; 1990:1–34.View ArticleGoogle Scholar
- Wolff JL, Starfield B, Anderson G: Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med 2002, 126(20):2269–2276.View ArticleGoogle Scholar
- Clark NM, Rakowski W, Wheeler JR, et al.: Impact of self-management education on the functional health status of older adults with heart disease. Gerontologist 1992, 32: 438–443. 10.1093/geront/32.4.438View ArticlePubMedGoogle Scholar
- Hopman-Rock M, Westhoff MH: The effects of a health educational and exercise program for older adults with osteoarthritis for the hip or knee. J Rheumatol 2000, 27: 1947–1954.PubMedGoogle Scholar
- Holman HR, Lorig KR: Overcoming barriers to successful aging. Self-management of osteoarthritis. West J Med 1997, 167: 265–268.PubMed CentralPubMedGoogle Scholar
- von Faber M, Bootsma-van-der-Wiel A, van Exel E, et al.: Successful aging in the oldest old: who can be characterized as successfully aged? Arch Intern Med 2001, 161: 2694–2700. 10.1001/archinte.161.22.2694View ArticlePubMedGoogle Scholar
- Brandtstädter J, Rothermund K: The life-course dynamics of goal pursuit and goal adjustment: a two-process framework. Dev Rev 2002, 22: 117–150. 10.1006/drev.2001.0539View ArticleGoogle Scholar
- Carstensen LL, Isaacowitz DM, Charles ST: Taking time seriously: a theory of socioemotional selectivity. Am Psychol 1999, 54: 165–181.View ArticlePubMedGoogle Scholar
- Freund AM, Baltes PB: Selection, optimization, and compensation as strategies of life management: correlations with subjective indicators of successful aging. Psychol Aging 1998, 13: 531–543.View ArticlePubMedGoogle Scholar
- Schulz R, Heckhausen J: A life span model of successful aging. Am Psychol 1996, 51: 702–714.View ArticlePubMedGoogle Scholar
- Nieboer AP, Koolman AHE, Stolk EA: Preferences for long-term care services: Willingness to pay estimates derived from a discrete choice experiment. Soc Sci Med 2010, 70(9):1317–1325. 10.1016/j.socscimed.2009.12.027View ArticlePubMedGoogle Scholar
- Steverink N, Lindenberg S, Slaets JPJ: How to understand and improve older people's self-management of wellbeing. Eur J Ageing 2005, 2: 235–244. 10.1007/s10433-005-0012-yView ArticleGoogle Scholar
- Lindenberg S: Continuities in the theory of social production functions. In Verklarende Sociologie [Explanatory Sociology]. Edited by: Ganzeboom H, Lindenberg S. Amsterdam: Thesis Publishers; 1996:169–184.Google Scholar
- Steverink N, Lindenberg S, Ormel J: Towards understanding successful ageing: patterned change in resources and goals. Ageing Soc 1998, 18: 441–467.Google Scholar
- Steverink N, Lindenberg S: Do good self-managers have less physical and social resource deficits and more well-being in later life? Eur J Ageing 2008, 5: 181–190. 10.1007/s10433-008-0089-1View ArticleGoogle Scholar
- Nieboer A, Lindenberg S, Boomsma A, et al.: Dimensions of well-being and their measurement: the SPF-IL scale. Soc Indic Res 2005, 73: 313–353. 10.1007/s11205-004-0988-2View ArticleGoogle Scholar
- Nieboer A, Lindenberg S: Substitution, buffers and subjective well-being: a hierarchical approach. In The Universality of Subjective Well-Being Indicators. Edited by: Gullone E, Cummins RA. Dordrecht: Kluwer Academic Publishers; 2002:175–189.View ArticleGoogle Scholar
- Schuurmans H, Steverink N, Frieswijk N, et al.: How to measure self-management abilities in older people by self-report? The development of the SMAS-30. Qual Life Res 2005, 14: 2215–2228. 10.1007/s11136-005-8166-9View ArticlePubMedGoogle Scholar
- Beswick AD, Rees K, Dieppe P, Ayis S, Gooberman-Hill R, Horwood J, Ebrahim S: Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis. Lancet 2008, 371: 725–35. 10.1016/S0140-6736(08)60342-6PubMed CentralView ArticlePubMedGoogle Scholar
- Cunliffe AL, Gladman JR, Husbands SL, Miller P, Dewey ME, Harwood RH: Sooner and healthier: a randomised controlled trial and interview study of an early discharge rehabilitation service for older people. Age Ageing 2004, 33(3):246–52. 10.1093/ageing/afh076View ArticlePubMedGoogle Scholar
- Cantril H: The pattern of human concern. New Brunswick: Rutgers University Press; 1965.Google Scholar
- Jöreskog K, Sörbom D: User's Reference Guide. Chicago. Scientific Software International; 1996.Google Scholar
- Hu L, Bentler PM: Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Structural Equation Modeling 1999, 6: 1–55. 10.1080/10705519909540118View ArticleGoogle Scholar
- Hayduk LA: Structural Equation Modeling with LISREL: Essentials and Advances. Baltimore: Johns Hopkins University Press; 1987.Google Scholar
- Bagozzi RP, Yi Y, Phillips LW: Assessing Construct Validity in Organizational Research. Admin Sci Q 1991, 36: 421–458. 10.2307/2393203View ArticleGoogle Scholar
- Lemmens KM, Rutten-Van Molken MP, Cramm JM, Huijsman R, Bal RA, Nieboer AP: Evaluation of a large scale implementation of disease management programmes in various Dutch regions: a study protocol. BMC Health Serv Res 2011, 11(1):6. 10.1186/1472-6963-11-6PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.