- Open Access
Validation of the Danish version of the disease specific instrument EORTC QLQ-CR38 to assess Health-related quality of life in patients with colorectal cancer
Health and Quality of Life Outcomesvolume 10, Article number: 150 (2012)
The European Organisation for Research and Treatment of Cancer (EORTC) quality of life colorectal questionnaire module (QLQ-CR38) was developed in 1999, and an update, the QLQ CR29 was published recently. To date the Danish version of the questionnaire has not been validated. The aim of this study was to examine the psychometric properties of the Danish version of EORTC QLQ-CR38.
EORTC QLQ-CR38 was administered to 190 patients with colorectal cancer in two Danish hospitals, one month after their operation. A psychometric evaluation of the questionnaire’s structure, reliability, convergent, divergent and known-groups validity was performed.
Data from 164 (86.3%) patients were available for analysis. The Danish version of EORTC QLQ-CR38 showed satisfactory psychometric properties for the scales: body image, sexual functioning, male sexual problems and defecations problems. Suboptimal psychometric performances were found for the scales: micturition problems, symptoms of the gastrointestinal tract and weight loss. Evaluation of the psychometric properties of the scale chemotherapy side effects was limited by the low number of patients receiving chemotherapy. It was not possible to assess the psychometric properties of the scale female sexual problems and the single item sexual enjoyment due to a high number of missing values. The homogeneity of the study population made the evaluation of known-group validity difficult.
The results of this study suggest that the validity of the Danish version of EORTC QLQ-CR38 is acceptable. Furthermore, the results support the appropriateness of the updated version, the EORTC QLQ-CR29.
Health-related quality of life (HRQoL) has become an important outcome endpoint in cancer research and can be measured by generic and/or disease – specific instruments. A specific instrument for colorectal cancer patients, the European Organisation for Research and Treatment of Cancer (EORTC), quality of life colorectal questionnaire module (QLQ-CR38), was developed in 1999 by EORTC. EORTC QLQ-CR38 was designed as a supplement to the core questionnaire (EORTC QLQ-C30), which assesses HRQoL of patients with cancer, but is not specific for any kind of cancer. EORTC QLQ-CR38 looks into important issues relevant for colorectal cancer, such as bowel, bladder, and sexual dysfunction as well as problems in relation to stoma function. It has been translated into several languages, including Danish. The Danish version was devised based on forward-backward translation and pilot-testing among patients, as described in the guidelines of EORTC. An update and international validation of EORTC QLQ-CR38 were undertaken between 2007–2009, resulting in a shorter version of the questionnaire, EORTC QLQ-CR29[3, 4]. Although the Danish version of EORTC QLQ-CR38 has been used in Danish research, the questionnaire has never been formally validated, which is also the case with other Scandinavian versions.
The aim of this study was to examine the psychometric properties of the Danish version of EORTC QLQ-CR38, in post-surgical colorectal cancer settings.
EORTC QLQ-CR38 and EORTC QLQ-C30 were administrated to patients with colorectal cancer treated at Hillerød Hospital and Aarhus University Hospital approximately one month after their operation. This was carried out as part of their participation in two randomized, international, multi-centre studies: Colorectal cancer laparoscopic or open resection (COLOR II) (only Hillerød Hospital) and COLOFOL. COLOR II was designed to investigate short- and long-term outcomes of open versus laparoscopic surgery for rectal cancer. In COLOFOL the effects of two different frequencies of surveillance programs following radical resection for colorectal cancer on mortality, recurrence-free survival, cost-effectiveness and quality of life were examined. In both studies, the patients completed the questionnaires during a follow-up visit in the outpatient clinic. A research nurse was present to introduce the patients to the questionnaire. The patients were instructed to fill out the questionnaire by themselves. Inclusion criteria were as defined in the two studies[5, 6].
Clinical and sociodemographic data were extracted from the Danish Colorectal Cancer Group (DCCG) database. Data for this database are collected by all surgical departments in Denmark and are obtained through questionnaires filled in by the patients and surgeons. Complications were defined as postoperative complications occurring within 30 days after surgery, and were divided into surgical and medical complications. Information concerning the presence of stoma was acquired from the question “yes or no to stoma” from EORTC QLQ-CR38. Data were collected between April 2007 and June 2010. Written consent was obtained when patients first entered COLOR II and COLOFOL.
EORTC QLQ-CR38 was developed to be used in conjunction with EORTC QLQ-C30. It incorporates two functional scales: body image and sexual functioning: and two single items assessing future perspective and sexual enjoyment. The seven symptom scales comprise micturition problems, symptoms in the area of the gastrointestinal tract, chemotherapy side effects, problems with defecation, stoma-related problems, male and female sexual problems, and one single item on weight loss. Completed questionnaires were scored according to the instructions from the EORTC group. Items are scored on a four-point scale from 1(”not at all) to 4 (“very much”). Raw scores are aggregated and converted to a linear scale ranging from 0 to 100, with higher scores representing a higher level of functioning or a higher level of symptoms. Of the 38 items, 19 are applicable for all patients. The remaining 19 items are applicable to sub-groups of patients: males, females, patients who are sexually active, and patients with or without stoma. All questions refer to the previous week, with exception of sexual issues which have a 4-week time frame.
Means and medians were both calculated for a more comprehensive description of the data than when only one of these summary statistics is used. Missing answers were dealt with according to the Scoring Manual: if at least half of the items in the scale had been completed, it was assumed that the missing item(s) would have had values equal to the average of the items present. Ceiling and floor effect was explored through proportion of respondents with maximum and minimum scores, respectively.
Internal consistency was evaluated by Cronbach’s alpha coefficient. A coefficient value of at least 0.7 were considered acceptable.
Methods of known-groups comparison were used to assess the ability of the questionnaire to discriminate between subgroups of patients with different demographic and clinical status. Comparison between subgroups was only made where differences were expected. Subgroup comparisons included age (>64 years or ≤ 64 years), gender, type of cancer (colon or rectal cancer), type of surgery (open or laparoscopic), presence of stoma (with or without stoma), The American Society of Anaesthesiologists (ASA) score was assigned by the surgeon and performance status was evaluated by the patient before surgery. Performance status and ASA score were dichotomised. Performance status was divided into “excellent or good” versus “more or less, less good or bad”. ASA scores were divided into normal healthy patients (ASA score I) versus patients with mild to severe systematic disease (ASA score II-III).
Clinical significance is an important issue in the interpretation of differences in HRQoL. For EORTC QLQ-C30[12, 13] Cocks suggested that a range of 3–6 points reflects small differences and 9–19 points indicates medium differences. Such ranges have not been determined for EORTC QLQ-CR38. Based on measurements with a variety of instruments, Fayers suggested that a change of 5–10 points as being perceptible by the patient and deemed by the patients as significant. Accordingly, differences ≥ 5 points were accepted as a clinical significant difference between subgroups in this study. Group differences were assessed using the Mann-Witney U-tests.
Convergent and discriminant validity
Analysis of convergent and discriminant validity were used to examine whether items fit with their proposed scale. Item convergent validity was defined as an item-scale correlation of 0.40 or greater (corrected for overlap). Item discriminant validity was defined as an item having a higher correlation with its own scale (corrected for overlap) than with another scales. Spearman’s Rho was used.
One hundred and sixty seven (87.9%) of the patients included in COLOR II and COLOFOL answered the EORTC QLQ -CR38 one month after the operation. All questionnaires were filled out by the patient themselves. Clinical and sociodemographic data were missing for three patients. In all, data from 164 patients (86.3%) were available for further analysis.
Clinical and sociodemographic data are shown in Table 1. The median age was 64 years. Seventy-nine (59.2%) had colon cancer and 67 (40.8%) had rectal cancer. Stoma was present in 7.3% patients treated for colon and 68.7% patients treated for rectal cancer.
It was not possible to obtain data about whether patients had started postoperative chemotherapy when they answered the questionnaire.
The distribution of the answers for each item and scale are shown in Table 2 (first column). The majority of missing data were from items concerning sexuality issues, with 7.9% -11% of the answers to sexual functioning missing. The answers to the sexual enjoyment item as well as the two items concerning male and female sexual problems were conditional on having been sexually active (item 49). Surprisingly, only 39 (37.5%) men answered the item concerning sexual enjoyment, while 82 (78.8%) men answered the questions concerning male sexual problems. There was a much lower response rate to the equivalent questions among women. Only 14 (23.3%) women answered the question about sexual enjoyment, and of those, 11 (18.3%) answered the questions concerning female sexual problems. The questions about female sexual problems could not be further analysed due to the high number of missing values.
Mean, median, floor and ceiling values of the function and symptom scales are presented in Table 2. The symptom scores were heavily skewed towards the lower end. The maximum score (100) was observed for micturition problems, male sexual problems, and weight loss, but not for other symptom scales. Functional scores were high for body image, while lower values were observed in future perspective, sexual function, and sexual enjoyment. A floor and/or ceiling effect was observed for all subscales and single items.
Cronbach’s alpha coefficient for each scale is shown in Table 2. A value exceeding the 0.70 criterion was achieved in the body image, sexual function, male sexual problems, defecation problems, and stoma-related problems scales. The criterion was not met in scales regarding micturition problems (0.65), symptoms of the gastrointestinal tract (0.55), female sexual problems (0.35), or chemotherapy side effects (0.37).
Convergent and discriminant validity
The results of the convergent and disciminant validity analyses are provided in Table 3. The criterion of 0.40 for convergent validity was fulfilled for all items in three scales: body image, sexual functioning, and male sexual problems. In the remaining scales of micturition problems, symptoms of the gastrointestinal tract, defecation problems, and stoma-related problems, some of the items did not display satisfactory convergent validity. None of the items in the chemotherapy side effects scale met the 0.40 criterion. In terms of discriminant validity, the “irritated skin” item in the stoma-related problems scale had a very low correlation with its own scale but a higher correlation with the body image scale.
Thirteen (50.0%) out of 26 comparisons distinguished between clinical and demographic variables subgroups of patients, with differences of five points or more. Mean scores of the sub-groups are shown in Table 4. For three of the scales, namely body image, male sexual problems and defecation problems, the majority of comparisons distinguished between the defined subgroups as anticipated. However, unexpectedly, a higher degree of defecation problems was found in patients aged ≤ 64 than in the older group. Anticipated differences in sexual functioning were only found in three out of five sub-group comparisons. A lower score was expected for patients with a stoma and patient treated with open surgery, but this was not found. The symptoms of the gastrointestinal tract scale could only distinguish between subgroups in one of two comparisons. As expected, patients treated with open surgery had a higher score compared with patients treated with laparoscopic surgery. A lower score for patients with rectal cancer was expected but not found. For micturition problems and future perspective scales, only one out of three anticipated differences were found. Difference in future perspective was only found amongst patients with different physical performance levels, where patients with better performance status also had better future perspective. The micturition problem scale could only distinguish between genders. Anticipated differences in relation to weight loss were not found in any comparisons.
This study examines the psychometric properties of EORTC QLQ-CR38 in a sample of 164 Danish patients with colorectal cancer, who were assessed one month after primary open or laparoscopic surgery. In this study data were obtained from two clinical studies one month after operation. The sample included patients with or without stoma and patients treated with different types of surgical procedures. The proportion of patients treated with laparoscopic surgery was high in this study compared with any other validation study of EORTC QLQ-CR38[15–17]. A postoperative setting was chosen, in order to examine the performance of the questionnaire in reflecting function and symptoms after surgical treatment. Known-groups comparisons were conducted based on carefully prespecified hypotheses.
The body image, sexual functioning, defecation problems and male sexual problems scales could discriminate between the majority of the defined subgroups. These scales also had a high convergent validity except for the scale concerning defecation problems, which was similar to the original validation. In the original study, convergent, and discriminant analysis confirmed the structure of the functional scales, but did not strongly support the structure of the symptoms scales. With regards to internal consistency, three of the symptoms scales, namely micturition problems, symptoms of the gastrointestinal tract, and chemotherapy side effects had low Cronbach`s alpha coefficients (0.37-0.65), but this is comparable to the original validation and some other subsequent studies[16, 17]. In previous studies, the psychometric problems shown in the symptoms scales have been attributed to the fact that symptoms and side-effects do not necessarily occur together, which makes it difficult to cluster items in a meaningful way, and thus raising doubt about the usefulness of these scales.
A limitation of this study could be the homogeneity of the population in relation to disease stage, disease severity and performance status. This may underlie a narrower response range and lead to low data variability, which could have compromised the known-group comparison results. It is well-known that the strength of correlations, including Cronbach’s alpha, increases with data variability. The low variability in this data set, reflected in the skewness towards high functional scores and low symptoms scores, may partially account for the less than ideal validity results. A low correlation between items and scales was particularly evident in some symptom scales: symptoms of the gastrointestinal tract, the pain while urinating item in the micturition problems scale and all items concerning chemotherapy side effects. The low correlation for chemotherapy side effects was probably attributable to the low proportion of patients undergoing chemotherapy.
The weight loss item could not distinguish between any of the subgroups. A floor effect was observed for this item, indicating low variability. This could be due to the time reference in the item. The patient is asked to answer the question in relation to the past week, whereas weight loss may have occurred prior to that. This item also demonstrated a low validity in another validation study and has been eliminated from the updated version.
It was not possible to carry out known-groups comparison for stoma related problems. The stoma related problems scale is only applicable to patients with stoma, and the number of such patients was too small for further division into subgroups.
The amount of missing data associated with the sexual problems and enjoyment scales rendered known-groups comparison analysis impossible. These questions are conditional on the patient being sexually active. The original EORTC QLQ-CR38 validation study also found a high rate of missing values in these questions, where both male (3%) and female (12%) found them too intrusive and chose not to answer. Since there is no specific question asking whether the patient is sexually active, reasons for non-response could not be differentiated (sexually inactive versus unwillingness to answer). In addition, at just one month after surgery, the proportion of sexually active patients may have been lower than usual. Reluctance of women to respond to questions about their sex life has been well described, which may partially account for the especially high missing values seen in the female sexual problems scale[15, 16, 18, 19].
The capability of the Danish version of EORTC QLQ-CR38 to capture changes over time was not examined in this study, but responsiveness is an important feature of a questionnaire. Responsiveness has been examined in some of the studies validating EORTC QLQ-CR38[1, 15]. The body image, defecation problems, micturition problems, and symptoms of the gastrointestinal tract scales have been reported responsive to treatment-induced change over time. Lack of responsiveness has been reported for the chemotherapy side-effects scale[1, 15, 20]. One study found the EORTC QLQ-C30 to be more responsive in patients receiving chemotherapy than the EORTC QLQ-CR38. In addition to the validation studies, some studies have used EORTC QLQ-CR38 for prospective follow-up. The same scales as in the validation studies as well as the scales addressing male sexual problems, future perspective, weight loss, and chemotherapy side-effects were found to be able to detect relevant differences over time in different treatment groups of patients with colorectal cancer[21–29]. Thus, considerable evidence for the responsiveness to change has been found.
There were several reasons for the revision of EORTC QLQ-CR38 into the shorter version EORTC QLQ-CR29. These included changes in the treatment of colorectal cancer, problems with missing data, and that the EORTC QLQ-CR38 contains scales that are unique to subgroups of patients[3, 4]. The items and scales from EORTC QLQ-CR38 which remained unchanged in the EORTC QLQ-CR29 are highlighted in Table 2. The EORTC QLQ-CR29 contains 17 unchanged items from EORTC QLQ-CR38, five reworded items, and seven new items[3, 4]. The EORTC QLQ-CR29 can be summarized into four scales: body image, urinary frequency, blood or mucus and stool frequency. The body image scale was the only scale that remained unchanged from the EORTC QLQ-CR38, a decision that is supported by its satisfactory psychometric performance found in this study. The micturition problems scale was changed to urinary frequency, and the pain with urination item was removed from the scale due to poor convergent validity, a finding which was replicated in this study. The symptoms in gastro-intestinal tract scale was split into single items (some items were removed and some were reworded). The results of this study support the alteration of both micturition problems scale and the gastro-intestinal tract scale, due to their low convergent validity and known-group validity. The scales concerning stoma and defecation problems were split into single items and were standardised, so that patient response could be compared where possible. The question concerning weight loss has been re-worded from:” Have you lost weight?” to “Have you worried about your weight?” Again, this is supported by this study, as the change may make it easier for the patient to answer. The psychometric properties of the scales concerning sexual functioning and male sexual problems were good, but the amounts of missing values were high. In the EORTC QLQ-CR29, several changes have been made with the aim of reducing missing data in the sexual domain. First, items in this domain have been cut down to two items for men and two items for women: one of which addresses interest in sex and the other addresses sexual problems. Second, the answers are not conditional on being sexually active. Third, these items are moved to the end of questionnaire. These changes may reduce missing values, but at the same time would also decrease the information related to sexual functioning after treatment for colorectal cancer, which is an important aspect of outcome.
In conclusion, the Danish version of EORTC QLQ-CR38 showed satisfactory psychometric properties for the scales concerning body image, sexual functioning, male sexual problems and defecations problems. Reduced psychometric properties were found especially for the following symptom scales: micturition problems, symptoms of the gastrointestinal tract, and weight loss, which could partially be explained by the homogeneity of the study population. Although the stoma related problems scale showed good internal consistency and convergent validity, no clear conclusion could be drawn regarding its psychometric performance, as known-groups comparison could not be conducted. Evaluation of the psychometric properties of the scale chemotherapy side effects was limited by the low number for patients receiving chemotherapy. It was not possible to assess the psychometric properties of the female sex problems and sexual enjoyment scales due to a high number of missing values.
According to the results of this study, the update of EORTC QLQ-CR38 to the EORTC QLQ-CR29 seems appropriate[3, 4]. The results also suggest that EORTC QLQ-CR29 is likely to be a more valid instrument. Nevertheless, a proper validation of this questionnaire in a Danish setting is required.
Health-related quality of life
European organisation for research and treatment
- EORTC QLQ-C30:
Quality of life core questionnaire
- EORTC QLQ-CR38:
Quality of life colorectal questionnaire
- EORTC QLQ-CR29:
Quality of life colorectal questionnaire
- COLOR II:
Colorectal cancer laparoscopic or open resection
Danish colorectal cancer group
- ASA score:
The American society of anaesthesiologists score.
Sprangers MA, te Velde A, Aaronson NK: The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38). European organization for research and treatment of cancer study group on quality of life. Eur J Cancer 1999, 35(2):238–247. 10.1016/S0959-8049(98)00357-8
Dewolf L, Koller M, Velikova G, Johnson C, Scott N, Bottomley A: Translation Procedure. 3rd edition. Brussels: European Organisation for Research and Treatment of Cancer; 2009.
Gujral S, Conroy T, Fleissner C, Sezer O, King PM, Avery KN, et al.: Assessing quality of life in patients with colorectal cancer: an update of the EORTC quality of life questionnaire. Eur J Cancer 2007, 43(10):1564–1573. 10.1016/j.ejca.2007.04.005
Whistance RN, Conroy T, Chie W, Costantini A, Sezer O, Koller M, et al.: Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. Eur J Cancer 2009, 45(17):3017–3026. 10.1016/j.ejca.2009.08.014
Buunen M, Bonjer HJ, Hop WC, Haglind E, Kurlberg G, Rosenberg J, et al.: COLOR II. A randomized clinical trial comparing laparoscopic and open surgery for rectal cancer. Dan Med Bull 2009, 56(2):89–91.
Wille-Jorgensen P, Laurberg S, Pahlman L, Carriquiry L, Lundqvist N, Smedh K, et al.: An interim analysis of recruitment to the COLOFOL trial. Colorectal Dis 2009, 11(7):756–758. 10.1111/j.1463-1318.2008.01668.x
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al.: The European-Organization-For-Research-And-Treatment-Of-Cancer Qlq-C30 - A Quality-Of-Life Instrument for Use in International Clinical-Trials in Oncology. J Natl Cancer Inst 1993, 85(5):365–376. 10.1093/jnci/85.5.365
Fayers PM, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A: The EORTC QLQ-C30 Scoring Manual. 3rd edition. Brussels: European Organisation for Research and Treatment of Cancer; 2001.
Klee M, Groenvold M, Machin D: Using data from studies of health-related quality of life to describe clinical issues examples from a longitudinal study of patients with advanced stages of cervical cancer. Qual Life Res 1999, 8(8):733–742. 10.1023/A:1008903818379
Fayers P, Machin D: Multi-item scales. Quality of Life: the assessment, analysis and interpretation of patient-reported outcomes. 2nd edition. England: John Wiley and Sons Ltd, Chichester; 2008:109–129.
Fayers P, Machin D: Scores and measurements: validity, reliability, sensitivity. Quality of Life: the assessment, analysis, and interpretation of patient-reported outcome. 2nd edition. England: John Wiley and Sons Ltd, Chichester; 2008:77–108.
Osoba D, Rodrigues G, Myles J, Zee B, Pater J: Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 1998, 16(1):139–144.
Cocks K, King MT, Velikova G, Martyn St-James M, Fayers PM, Brown JM: Evidence-based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30. J Clin Oncol 2011, 29(1):89–96. 10.1200/JCO.2010.28.0107
Fayers P, Machin D: Clinical interpretation. Quality of Life: the assessment, analysis and interpretation of patient-reported outcome. 2nd edition. England: John Wiley and Sons Ltd, Chichester; 2008:427–455.
Tsunoda A, Yasuda N, Nakao K, Yokoyama N, Marumori T, Hashimoto H, et al.: Validation of the Japanese version of EORTC QLQ-CR38. Qual Life Res 2008, 17(2):317–322. 10.1007/s11136-007-9298-x
Rotonda C, Conroy T, Mercier M, Bonnetain F, Uwer L, Miny J, et al.: Validation of the French version of the colorectal-specific quality-of-life questionnaires EORTC QLQ-CR38 and FACT-C. Qual Life Res 2008, 17(3):437–445. 10.1007/s11136-008-9322-9
Law CC, Tak Lam WW, Fu YT, Wong KH, Sprangers MA, Fielding R: Validation of the Chinese version of the EORTC colorectal cancer-specific quality-of-life questionnaire module (QLQ-CR38). J Pain Symptom Manage 2008, 35(2):203–213. 10.1016/j.jpainsymman.2007.03.013
Rauch P, Miny J, Conroy T, Neyton L, Guillemin F: Quality of life among disease-free survivors of rectal cancer. J Clin Oncol 2004, 22(2):354–360.
Ho VP, Lee Y, Stein SL, Temple LK: Sexual function after treatment for rectal cancer: a review. Dis Colon Rectum 2011, 54(1):113–125. 10.1007/DCR.0b013e3181fb7b82
Uwer L, Rotonda C, Guillemin F, Miny J, Kaminsky MC, Mercier M, et al.: Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer. Health Qual Life Outcomes 2011, 9: 70. 10.1186/1477-7525-9-70
Neuman HB, Patil S, Fuzesi S, Wong WD, Weiser MR, Guillem JG, et al.: Impact of a temporary stoma on the quality of life of rectal cancer patients undergoing treatment. Ann Surg Oncol 2011, 18(5):1397–1403. 10.1245/s10434-010-1446-9
Pucciarelli S, Del BP, Efficace F, Serpentini S, Capirci C, De PA, et al.: Patient-reported outcomes after neoadjuvant chemoradiotherapy for rectal cancer: a multicenter prospective observational study. Ann Surg 2011, 253(1):71–77. 10.1097/SLA.0b013e3181fcb856
Stephens RJ, Thompson LC, Quirke P, Steele R, Grieve R, Couture J, et al.: Impact of short-course preoperative radiotherapy for rectal cancer on patients’ quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial. J Clin Oncol 2010, 28(27):4233–4239. 10.1200/JCO.2009.26.5264
Urso E, Serpentini S, Pucciarelli S, De Salvo GL, Friso ML, Fabris G, et al.: Complications, functional outcome and quality of life after intensive preoperative chemoradiotherapy for rectal cancer. Eur J Surg Oncol 2006, 32(10):1201–1208. 10.1016/j.ejso.2006.07.003
Allal AS, Gervaz P, Gertsch P, Bernier J, Roth AD, Morel P, et al.: Assessment of quality of life in patients with rectal cancer treated by preoperative radiotherapy: a longitudinal prospective study. Int J Radiat Oncol Biol Phys 2005, 61(4):1129–1135. 10.1016/j.ijrobp.2004.07.726
Guren MG, Dueland S, Skovlund E, Fossa SD, Poulsen JP, Tveit KM: Quality of life during radiotherapy for rectal cancer. Eur J Cancer 2003, 39(5):587–594. 10.1016/S0959-8049(02)00741-4
Camilleri-Brennan J, Steele RJ: Prospective analysis of quality of life and survival following mesorectal excision for rectal cancer. Br J Surg 2001, 88(12):1617–1622. 10.1046/j.0007-1323.2001.01933.x
Camilleri-Brennan J, Steele RJ: Prospective analysis of quality of life after reversal of a defunctioning loop ileostomy. Colorectal Dis 2002, 4(3):167–171. 10.1046/j.1463-1318.2002.00352.x
Arraras Urdaniz JL, Arias DL V, Vera GR, Manterola BA, Martinez AM, Villafranca LE, et al.: Quality of Life assessment through the EORTC questionnaires of locally advanced rectal cancer patients treated with preoperative chemo-radiotherapy. Clin Transl Oncol 2006, 8(6):423–429. 10.1007/s12094-006-0196-4
The authors thank the Colofol study group for the access to data concerning Health-related Quality of life and Jesper Vilandt for the access to DCCG data at Hillerød Hospital.
The authors declare that they have no competing interests.
All four authors were involved in drafting the article or critically revising it for important intellectual content, and all authors approved the final version to be submitted for publication. PJ, MG and HVT designed the study. Data collection was made by PJ, SL and HVT. Analysis and interpretation of the results PJ, MG and HVT. The statistical analysis was managed by HVT.