Fortin M, Bravo G, Hudon C, Vanasse A, Lapointe L. Prevalence of multimorbidity among adults seen in family practice. Ann Fam Med. 2005;3(3):223–8.
Article
PubMed Central
PubMed
Google Scholar
Van den Aker M, Buntinx F, Metsemakers JF, Roos S, Knottnerus JA. Multimorbidity in general practice: prevalence, incidence and determinants of co-occurring and recurrent disease. J Clin Epidemiol. 1998;51(5):365–75.
Google Scholar
Uijen AAA, Van de Lisdonk EH. Multimorbidity in Primary care: prevalence and trend over the past 20 years. Eur J Gen Pract. 2008;14(suppl):28–32.
Article
PubMed
Google Scholar
WHO. Global status report on noncommunicable diseases 2010: description of the global burden of NCDs, their risk factors and determinants. Geneva: World Health Organization; 2011. http://www.who.int/nmh/publications/ncd_report2010/en.
Google Scholar
Inouye SK, Wagner R, Acampora D, Horowitz RI, Cooney LM, Hurst LD, et al. A predictive index for functional decline in hospitaliszed elderly patients. J Gen Intern Med. 1993;8:645–52.
Article
CAS
PubMed
Google Scholar
Hebert R. Functional decline in old age. Can Med Assoc J. 1997;157:1037–45.
CAS
Google Scholar
Campbell SE, Seymour DG, Primrose WR, for the ACMEplus Project. A systematic literature review of factors affecting outcome in older medical patients admitted to hospital. Age Aging. 2004;33:110–5.
Article
Google Scholar
Koyano W, Shibata H, Haga H, Suyama Y. Prevalence and outcome of low ADL and incontinence among the elderly: five years follow-up in a Japanese urban community. Arch Gerontol Geriatr. 1986;5(3):197–206.
Article
CAS
PubMed
Google Scholar
Ní Mhaoláin AM, Gallagher D, O’Connell H, Chin AV, Bruce I, Hamilton F, et al. Subjective well-being amongst community-dwelling elders: what determines satisfaction with life? Findings from the Dublin Healthy Aging Study. Int Psychogeriatr. 2012;24(2):316–23.
Article
PubMed
Google Scholar
Taylor AW, Price K, Gill TK, Adams R, Pilkington R, Carrangis N, et al. Multimorbidity - not just an older person's issue. BMC Public Health. 2010;10:718. doi:10.1186/1471-2458-10-718.
Article
PubMed Central
PubMed
Google Scholar
Wolff J, Starfield B, Anderson G. Prevalence, expenditure and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;62:2269–76.
Article
Google Scholar
Hoffman C, Rice D, Sung HY. Persons with chronic conditions. Their prevalence and costs. JAMA. 1996;276:1473–79.
Article
CAS
PubMed
Google Scholar
Barnett K, Mercer S, Norbury M, Watt G, Wkye S, Guthrie B. Epidemiology of Multimorbidity and implications for health care, research, and medical education: a cross sectional study. Lancet. 2012;380(9836):37–43.
Article
PubMed
Google Scholar
Van Den Bussche H, Shon G, Kolonko T, Wegscheider K, Glaeske G, Koller D. Patterns of ambulatory medical care utilisation in elderly patients with special reference to chronic diseases and multimorbidity- results from a claims data based observational study in Germany. BMC Geriatr. 2011;11:54.
Article
PubMed Central
PubMed
Google Scholar
Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois MF, et al. Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res. 2006;15:83–91.
Article
PubMed
Google Scholar
Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430–9.
Article
PubMed
Google Scholar
Ambrose-Liu TYL, Ashe MC, Marra C and The Physical Activity and Chronic Conditions Research Team. Among older adults with multiple chronic conditions, physical activity is independently and inversely associated with health care utilization. British Journal of Sports Medicine. 2008; doi:10.1136/bjsm.2008.046458.
Kadam UT, Croft PR, North Staffordshire GP Consortium Group. Clinical multimorbidity and physical function in older adults: a record and health status linkage study in general practice. Fam Pract. 2007;24(5):412–9.
Article
CAS
PubMed
Google Scholar
Smith SM, Soubhi H, Fortin M, Hudon C, O'Dowd T. Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Database Syst Rev. 2012;4:CD006560.
PubMed
Google Scholar
Fortin M, Lapointe L, Hudon C, Vanasse A, Ntetu AL, Maltais D. Multimorbidity and quality of life in primary care: a systematic review. Health Qual Life Outcomes. 2004;2:51.
Article
PubMed Central
PubMed
Google Scholar
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1.
Article
PubMed Central
PubMed
Google Scholar
National Academy Press. Primary care: America's health in a new era. Washington, DC: National Academy Press; 1996.
Google Scholar
Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Baker JG, Johnston MV. Prevalence and identification of problems in daily functioning in a primary medicine clinic. Disabil Rehabil. 2000;22(16):716–24.
Article
CAS
PubMed
Google Scholar
Baker TA, Whitfield KE. Physical functioning in older blacks: an exploratory study identifying psychosocial and clinical predictors. J Natl Med Assoc. 2006;98(7):1114–20.
PubMed Central
PubMed
Google Scholar
Bayliss M, Rendas-Baum R, White MK, Maruish M, Bjorner J, Tunis SL. Health-related quality of life (HRQL) for individuals with self-reported chronic physical and/or mental health conditions: panel survey of an adult sample in the United States. Health Qual Life Outcomes. 2012;10:154.
Article
PubMed Central
PubMed
Google Scholar
Bayliss Ellis JL, Shoup JA, Zeng C, McQuillan DB, Steiner JF. Association of patient-centered outcomes with patient-reported and ICD-9-based morbidity measures. Ann Fam Med. 2012;10(2):126–33.
Article
PubMed
Google Scholar
Brettschneider C, Leicht H, Bickel H, Dahlhaus A, Fuchs A, Gensichen J, et al. Relative impact of multimorbid chronic conditions on health-related quality of life--results from the MultiCare Cohort Study. PLoS One. 2013;8(6), e66742.
Article
PubMed Central
PubMed
Google Scholar
Agborsangaya CB, Lau D, Lahtinen M, Cooke T, Johnson JA. Health-related quality of life and healthcare utilization in multimorbidity: results of a cross-sectional survey. Qual Life Res. 2013;22(4):791–9.
Article
PubMed
Google Scholar
Cesari M, Onder G, Russo A, Zamboni V, Barillaro C, Ferrucci L, et al. Comorbidity and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study). Gerontology. 2006;52(1):24–32.
Article
PubMed
Google Scholar
Chen HY, Baumgardner DJ, Rice JP. Health-related quality of life among adults with multiple chronic conditions in the United States, Behavioral Risk Factor Surveillance System, 2007. Prev Chronic Dis. 2011;8(1):A09.
PubMed Central
PubMed
Google Scholar
Cheng L, Cumber S, Dumas C, Winter R, Nguyen KM, Nieman LZ. Health related quality of life in pregeriatric patients with chronic diseases at urban, public supported clinics. Health Qual Life Outcomes. 2003;1:63.
Article
PubMed Central
PubMed
Google Scholar
Formiga F, Pujol R, Perez-Castejon JM, Ferrer A, Henriquez E. Low comorbidity and male sex in nonagenarian community-dwelling people are associated with better functional and cognitive abilities: the NonaSantfeliu study. J Am Geriatr Soc. 2005;53(10):1836–7.
Article
PubMed
Google Scholar
Fortin M, Dubois MF, Hudon C, Soubhi H, Almirall J. Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes. 2007;5:52.
Article
PubMed Central
PubMed
Google Scholar
Goins RT, Pilkerton CS. Comorbidity among older American Indians: the native elder care study. J Cross Cult Gerontol. 2010;25(4):343–54.
Article
PubMed Central
PubMed
Google Scholar
Griffith L, Raina P, Wu H, Zhu B, Stathokostas L. Population attributable risk for functional disability associated with chronic conditions in Canadian older adults. Age Ageing. 2010;39(6):738–45.
Article
PubMed
Google Scholar
Heyworth IT, Hazell ML, Linehan MF, Frank TL. How do common chronic conditions affect health-related quality of life? Br J Gen Pract. 2009;59(568):e353–8.
Article
PubMed Central
PubMed
Google Scholar
Hunger M, Thoron B, Chunk M, During A, Men P, Peters A, et al. Multimorbidity and health-related quality of life in the older population: results from the German KORA-age study. Health Qual Life Outcomes. 2011;9:53.
Article
PubMed Central
PubMed
Google Scholar
Jayasinghe UW, Proudfoot J, Barton CA, Amoroso C, Holton C, Davies GP, et al. Quality of life of Australian chronically-ill adults: patient and practice characteristics matter. Health Qual Life Outcomes. 2009;7:50.
Article
PubMed Central
PubMed
Google Scholar
Joshi K, Kumar R, Avasthi A. Morbidity profile and its relationship with disability and psychological distress among elderly people in Northern India. Int J Epidemiol. 2003;32(6):978–87.
Article
PubMed
Google Scholar
Kadam UT, Croft PR. Clinical multimorbidity and physical function in older adults: a record and health status linkage study in general practice. Fam Pract. 2007;24(5):412–9.
Article
CAS
PubMed
Google Scholar
Kadam UT, Schellevis FG, Lewis M, van der Windt DA, de Vet HC, Bouter LM, et al. Does age modify the relationship between morbidity severity and physical health in English and Dutch family practice populations? Qual Life Res. 2009;18(2):209–20.
Article
PubMed
Google Scholar
Keles H, Ekici A, Ekici M, Bulcun E, Altinkaya V. Effect of chronic diseases and associated psychological distress on health-related quality of life. Intern Med J. 2007;37(1):6–11.
Article
CAS
PubMed
Google Scholar
Kim KI, Lee JH, Kim CH. Impaired health-related quality of life in elderly women is associated with multimorbidity: results from the Korean National Health and Nutrition Examination Survey. Gend Med. 2012;9(5):309–18.
Article
PubMed
Google Scholar
Lawson KD, Mercer SW, Wyke S, Grieve E, Guthrie B, Watt GC, et al. Double trouble: the impact of multimorbidity and deprivation on preference-weighted health related quality of life a cross sectional analysis of the Scottish Health Survey. Int J Equity Health. 2013;12:67.
Article
PubMed Central
PubMed
Google Scholar
Michelson H, Bolund C, Brandberg Y. Multiple chronic health problems are negatively associated with health related quality of life (HRQoL) irrespective of age. Qual Life Res. 2000;9(10):1093–104.
Article
CAS
PubMed
Google Scholar
Mujica-Mota RE, Roberts M, Abel G, Elliott M, Lyratzopoulos G, Roland M, et al. Common patterns of morbidity and multi-morbidity and their impact on health-related quality of life: evidence from a national survey. Qual Life Res. 2015;24(4):909–18.
Article
PubMed Central
CAS
PubMed
Google Scholar
Noel PH, Parchman ML, Williams Jr JW, Cornell JE, Shuko L, Zeber JE, et al. The challenges of multimorbidity from the patient perspective. J Gen Intern Med. 2007;22 Suppl 3:419–24.
Article
PubMed Central
PubMed
Google Scholar
Parker L, Moran GM, Roberts LM, Calvert M, McCahon D. The burden of common chronic disease on health-related quality of life in an elderly community-dwelling population in the UK. Fam Pract. 2014;31(5):557–63.
Article
PubMed
Google Scholar
Rijken M, van Kerkhof M, Dekker J, Schellevis FG. Comorbidity of chronic diseases: effects of disease pairs on physical and mental functioning. Qual Life Res. 2005;14(1):45–55.
Article
PubMed
Google Scholar
Wensing M, Vingerhoets E, Grol R. Functional status, health problems, age and comorbidity in primary care patients. Qual Life Res. 2001;10(2):141–8.
Article
CAS
PubMed
Google Scholar
Abizanda P, Romero L, Sanchez-Jurado PM, Martinez-Reig M, Alfonso-Silguero SA, Rodriguez-Manas L. Age, frailty, disability, institutionalization, multimorbidity or comorbidity. Which are the main targets in older adults? J Nutr Health Aging. 2014;18(6):622–7.
Article
CAS
PubMed
Google Scholar
Aarts S, den Akker M, Bosma H, Tan F, Verhey F, Metsemakers J, et al. The effect of multimorbidity on health related functioning: temporary or persistent? Results from a longitudinal cohort study. J Psychosom Res. 2012;73(3):211–7.
Article
PubMed
Google Scholar
Bayliss EA, Bayliss MS, Ware Jr JE, Steiner JF. Predicting declines in physical function in persons with multiple chronic medical conditions: what we can learn from the medical problem list. Health Qual Life Outcomes. 2004;2:47.
Article
PubMed Central
PubMed
Google Scholar
Byles JE, D'Este C, Parkinson L, O'Connell R, Treloar C. Single index of multimorbidity did not predict multiple outcomes. J Clin Epidemiol. 2005;58(10):997–1005.
Article
PubMed
Google Scholar
Drewes YM, den Elzen WP, Mooijaart SP, de Craen AJ, Assendelft WJ, Gussekloo J. The effect of cognitive impairment on the predictive value of multimorbidity for the increase in disability in the oldest old: the Leiden 85-plus Study. Age Ageing. 2011;40(3):352–7.
Article
PubMed Central
PubMed
Google Scholar
Kiely DK, Morris JN, Morris SA, Cupples LA, Ooi WL, Sherwood S. The effect of specific medical conditions on functional decline. J Am Geriatr Soc. 1997;45(12):1459–63.
Article
CAS
PubMed
Google Scholar
Nikolova R, Demers L, Beland F, Giroux F. Transitions in the functional status of disabled community-living older adults over a 3-year follow-up period. Arch Gerontol Geriatr. 2011;52(1):12–7.
Article
PubMed
Google Scholar
Prior JA, Jordan KP, Kadam UT. Influence of chronic diseases on long-term change in physical health: a consultation-survey linkage cohort study in general practice. Qual Life Res. 2012;21(4):581–91.
Article
CAS
PubMed
Google Scholar
Rigler SK, Studenski S, Wallace D, Reker DM, Duncan PW. Co-morbidity adjustment for functional outcomes in community-dwelling older adults. Clin Rehabil. 2002;16(4):420–8.
Article
PubMed
Google Scholar
Whelan BJ, Savva GM. Design and methodology of the Irish Longitudinal Study on Ageing. J Am Geriatr Soc. 2013;61 Suppl 2:S265–8.
Article
PubMed
Google Scholar
Kahlon S, Pederson J, Majumdar SR, Belga S, Lau D, Fradette M, et al. Association between frailty and 30-day outcomes after discharge from hospital. CMAJ. 2015;187(11):799–804.
Article
PubMed Central
PubMed
Google Scholar
Noel PH, Frueh BC, Larme AC, Pugh JA. Collaborative care needs and preferences of primary care patients with multimorbidity. Health Expect. 2005;8(1):54–63.
Article
PubMed
Google Scholar
Mair FS, May CR. Thinking about the burden of treatment. BMJ (Clinical research ed). 2014;349:g6680.
Google Scholar
Garvey J, Connolly D, Boland F, Smith SM. OPTIMAL, an occupational therapy led self-management support programme for people with multimorbidity in primary care: a randomized controlled trial. BMC Fam Pract. 2015;16:59.
Article
PubMed Central
PubMed
Google Scholar
Gitlin LN, Winter L, Dennis MP, Corcoran M, Schinfeld S, Hauck WW. A randomized trial of a multicomponent home intervention to reduce functional difficulties in older adults. J Am Geriatr Soc. 2006;54(5):809–16.
Article
PubMed
Google Scholar
Wallace E, Salisbury C, Guthrie B, Lewis C, Fahey T, Smith SM. Managing patients with multimorbidity in primary care. BMJ (Clinical research ed). 2015;350:h176.
Google Scholar
Smith SM, Bayliss EA, Mercer SW, Gunn J, Vestergaard M, Wyke S, et al. How to design and evaluate interventions to improve outcomes for patients with multimorbidity. Journal of Comorbidity. 2013;3:10–7.
Article
Google Scholar