- Research
- Open Access

# From KIDSCREEN-10 to CHU9D: creating a unique mapping algorithm for application in economic evaluation

- Gang Chen
^{1, 3}Email author, - Katherine Stevens
^{2}, - Donna Rowen
^{2}and - Julie Ratcliffe
^{2}

**12**:134

https://doi.org/10.1186/s12955-014-0134-z

© Chen et al.; licensee BioMed Central Ltd. 2014

**Received:**25 March 2014**Accepted:**14 August 2014**Published:**29 August 2014

## Abstract

### Background

The KIDSCREEN-10 index and the Child Health Utility 9D (CHU9D) are two recently developed generic instruments for the measurement of health-related quality of life in children and adolescents. Whilst the CHU9D is a preference based instrument developed specifically for application in cost-utility analyses, the KIDSCREEN-10 is not currently suitable for application in this context. This paper provides an algorithm for mapping the KIDSCREEN-10 index onto the CHU9D utility scores.

### Methods

A sample of 590 Australian adolescents (aged 11–17) completed both the KIDSCREEN-10 and the CHU9D. Several econometric models were estimated, including ordinary least squares estimator, censored least absolute deviations estimator, robust MM-estimator and generalised linear model, using a range of explanatory variables with KIDSCREEN-10 items scores as key predictors. The predictive performance of each model was judged using mean absolute error (MAE) and root mean squared error (RMSE).

### Results

The MM-estimator with stepwise-selected KIDSCREEN-10 items scores as explanatory variables had the best predictive accuracy using MAE, whilst the equivalent ordinary least squares model had the best predictive accuracy using RMSE.

### Conclusions

The preferred mapping algorithm (i.e. the MM-estimate with stepwise selected KIDSCREEN-10 item scores as the predictors) can be used to predict CHU9D utility from KIDSCREEN-10 index with a high degree of accuracy. The algorithm may be usefully applied within cost-utility analyses to generate cost per quality adjusted life year estimates where KIDSCREEN-10 data only are available.

## Keywords

- Health-related quality of life
- CHU9D
- KIDSCREEN
- Mapping
- Utility
- Adolescent

## Background

Health-related quality of life (HRQoL) is a multidimensional construct that measures the impact of health or disease on physical and psychosocial functioning [1],[2]. The measurement and valuation of HRQoL is a major issue for health services research and has become an essential component for assessing the cost-effectiveness of treatments and interventions in public health and clinical medicine research internationally [3]. HRQoL instruments can be categorised into two groups: health profile measures providing simple summative index summary scores for individual dimensions (items) and/or overall health, and preference based instruments/multi-attribute utility instruments containing preference weights for individual dimensions relative to each other and a preference weighted summary score for each health state defined by the instrument. Multi-attribute utility instruments can be used to generate quality adjusted life years (QALYs) for use in cost-utility analyses. QALYs are the preferred outcome measure for many regulatory bodies including the National Institute for Health and Clinical Excellence in the UK and the Pharmaceutical Benefits Advisory Committee in Australia [3],[4].

The majority of HRQoL instruments developed specifically for children and adolescent populations are not suitable for application within the framework of cost-utility analysis because they are non-preference based. One of the most prevalent non-preference based instruments, widely used in both public health and clinical medicine disciplines across countries, is the KIDSCREEN [5]-[8]. The KIDSCREEN has a simple summative scoring system in which equal weights are attached to different dimensions of HRQoL. However, a valid instrument that can be used to generate QALYs in cost-utility analyses needs to have the ability to ‘measure’ health status and also the ability to ‘value’ health status by incorporating preferences relating to the relative desirability of the dimensions and severity levels of each of the dimensions included in the instrument.

Mapping or cross walking techniques may be applied to link profile instruments and preference based instruments together thereby enabling non-preference based HRQoL instrument results to be utilised within the framework of cost-utility analyses [4],[9]. A comprehensive review by Brazier and colleagues [9] identified 30 mapping studies in the literature. All of these studies had been conducted using instruments designed for measuring HRQoL in adults, and had been applied exclusively in adult populations. To date, only one previous study has conducted a mapping exercise exclusively in a paediatric population. Furber and colleagues mapped the Strengths and Difficulties Questionnaire responses into Child Health Utility 9D (CHU9D) utilities [10].

The main objective of this study was to develop an algorithm for generating CHU9D utility scores from KIDSCREEN-10 index summary scores, facilitating cost-utility analyses within studies where health outcomes are assessed only by the KIDSCREEN-10 index.

## Methods

### Study design

An online survey was developed for administration to a community based sample of adolescents living in Australia, aged 11–17 years. Following parent and adolescent consent, adolescents were invited to complete a survey which included the CHU9D and KIDSCREEN-10 instruments, socio-demographic variables (gender, age and socio-economic status as measured by the Family Affluence Scale) [11], a five-scale self-reported general health question (measured as excellent, very good, good, fair and poor), and whether they had a long standing disability, illness or medical condition. This study was approved by the Social and Behavioural Research Ethics Committee, Flinders University (project number 4701).

### Instruments

The KIDSCREEN-10 is a generic non-preference based measure of well-being and HRQoL developed internationally for children and adolescents aged 8 to 18 years old [5]. It is a short version of the KIDSCREEN-52 and KIDSCREEN-27 instruments and has demonstrated criterion validity, convergent validity and known groups validity [12],[13]. The KIDSCREEN-10 contains 10 items: fit and well (KS_I1), energy (KS_I2), sad (KS_I3), lonely (KS_I4), had enough time for yourself (KS_I5), been able to do the things that you want to do in your free time (KS_I6), parent(s) treated you fairly (KS_I7), had fun with friends (KS_I8), got on well at school (KS_I9) and been able to pay attention (KS_I10), each with a 5 point response scale [13]. The calculation of KIDSCREEN-10 index involve three steps: firstly, a raw overall score is summed by adding each item score with equal weight; secondly, the sum scores are converted to a score by assigning Rasch person parameters to each possible sum score; and lastly, the person parameters are transformed into values with a mean of approximately 50 and standard deviation approximately 10 [12]. A higher score is indicative of a better HRQoL. Both self-reported and parent proxy versions are available for KIDSCREEN instruments. The self-reported version was adopted in this study.

The CHU9D is a newly developed generic preference based measure of HRQoL that was designed specifically for application with young people [14]. Whilst it was originally developed for use with younger children aged 7 to 11 years, recent studies have also demonstrated the practicality and validity of using CHU9D in older adolescent populations aged 11–17 years [15]-[17]. The CHU9D consists of 9 dimensions: worried, sad, pain, tired, annoyed, schoolwork/homework, sleep, daily routine, ability to join in activities, with 5 different levels representing increasing levels of severity within each dimension. The original health state valuation algorithm for CHU9D was generated from the application of the standard gamble method within the UK adult general population [18]. In this study, since Australian adolescent data is used, we applied a recently developed Australian adolescent specific scoring algorithm for the CHU9D instrument based upon the best-worst scaling method and anchored on the 1–0 full-health to dead scale using the UK standard gamble results [19]. The CHU9D utilities range between 0.33 and 1. The strength of overlap between the KIDSCREEN-10 and the CHU9D has been reported in detail elsewhere [17]. Briefly Stevens and Ratcliffe found a moderate degree of significant correlation between CHU9D utility scores and the KIDSCREEN-10 index (r = 0.61), with some differences in the coverage of the items for the respective descriptive systems. The KIDSCREEN-10 is broader in scope than the CHU9D which focuses on a narrower definition of HRQoL.

### Statistical analysis

To develop the mapping algorithm from the KIDSCREEN-10 index to CHU9D utility scores, a dataset containing responses to both instruments from the same individual is used to estimate the mapping algorithm that can then be applied to other studies. In this study two groups of models were considered. In the first group the CHU9D utility score was regressed upon the KIDSCREEN-10 index, and also a higher order of the KIDSCREEN-10 index if the relationship between the two instruments was found to be non-linear. In the second group the CHU9D utility score was regressed upon the individual KIDSCREEN-10 item raw response scores. In the event that not all KIDSCREEN-10 items coefficients were statistically significant, the stepwise regression with forward selection technique (with significance levels for entrance of 0.05) was used to choose the “best” combination of predictors from the 10 items [20]. In the mapping literature, Model 2 is the most widely used additive model [9]. In addition to individual item and overall summary scores several previous mapping studies have also included socio-demographic characteristics, in particular age and gender, to improve predictive performance [9]. The significance (or otherwise) of including age and gender was also considered here. To summarise, the following two models were considered.

where CHU9D is the CHU9D utility score, KS is the KIDSCREEN-10 index, KS^{2} is the KIDSCREEN-10 index squared, KS_Ij_sw are the selected KIDSCREEN-10 items based upon statistical significances using the stepwise regression technique, k is the number of selected KIDSCREEN-10 items. The significance level is set to be 5% in this study.

The ordinary least squares estimator is sensitive to potential outliers as it is based on the minimisation of the variance of the residuals. The censored least absolute deviations estimator mentioned above is a special case of robust regressions that does not suffer from this sensitivity and is therefore considered to be more suitable in this context. In this study we propose to include another effective robust estimator, the MM-estimator [26], that has been shown to have both a high breakdown point (i.e. the percentage of incorrect observations an estimator can handle before giving an incorrect result) and a high efficiency [27],[28], but has not yet been utilised in mapping exercises. Heteroskedasticity robust standard errors are reported for inference.

Previous studies have indicated that the censored least absolute deviations estimator outperforms the Tobit estimator in relation to goodness-of-fit criteria (e.g. mean prediction error) (see for example Sullivan and Ghushchyan [29]). However since no other definitive evidence is available regarding the superiority of a particular estimator, we chose to utilise four estimators (ordinary least squares, censored least absolute deviations, MM and generalised linear model) in this study. Among different combinations of *family* and *link* function for the generalised linear model, the binomial family with logit link was chosen as the most appropriate since it showed the best performance of predicting the mean utility close to the observed. Regression analyses were estimated in Stata version 12.1 (StataCorp LP, College Station, Texas, USA).

Goodness-of-fit was examined using mean absolute error (MAE) and root mean square error (RMSE) – whereby the lower the value, the better the performance. MAE was selected as the key criteria to measure average model performance as it has been found to be a more natural measure of average error than RMSE; it is unambiguous [30].

Since no external validation dataset is currently available, model performance was assessed using the internal dataset in two approaches. The combination of model and method with the best goodness-of-fit results in two groups of validation analyses would be the optimal one chosen for the full sample. In the first set of validation analyses (Validation I), the full sample was divided equally into five groups using computer-generated random numbers. Each time, 80% of the sample (i.e. four random groups) was assigned to the “estimation sample” that was used to generate the mapping algorithm, while the remaining 20% of the sample (assigned to the “validation sample”) were used to predict CHU9D utilities based on the above algorithm. This procedure was repeated 5 times, so that each of the five random groups was used in the estimation and validation exercises. Model performance was assessed based on the pooled estimated prediction errors. This validation method is usually referred to as a cross-validation approach in the literature [31],[32]. In the second set of validation analyses (Validation II), the mapping algorithms generated through the full sample were tested on three random samples [33]. The three random samples with sample size of 100, 300, and 500 were generated by random selection within the full sample.

## Results

**Sample characteristics**

CHU9D utility score, mean (SD) | 0.808 (0.155) |

KIDSCREEN-10 index, Mean (SD) | 43.737 (7.932) |

Age (year), Mean (SD) | 14.5 (2.0) |

Gender, N (%) | |

Boys | 322 (54.6) |

Girls | 268 (45.4) |

Family affluence scale, N (%) | |

High (scores 6–9) | 55 (52.7) |

Medium (scores 4–5) | 223 (37.9) |

Low (scores 0–3) | 310 (9.4) |

Missing | 2 (0.3) |

Self-reported health, N (%) | |

Excellent | 145 (24.6) |

Very good | 268 (45.4) |

Good | 129 (21.9) |

Fair | 39 (6.6) |

Poor | 9 (1.5) |

Disability, N (%) | |

Yes | 67 (11.4) |

No | 523 (88.6) |

Figure 1 shows the kernel density of the CHU9D utility scores and the KIDSCREEN-10 index. The CHU9D utility score is non-normally (left-skewed) distributed while the KIDSCREEN-10 index tends towards a normally distribution (although the null hypothesis for normality was rejected based on Shapiro-Wilk normality test).

Pairwise Pearson’s correlations between each item of the KIDSCREEN-10 index and CHU9D utility score suggest that the strongest correlated item is KS_I1 (“fit and well”, r = 0.488), followed by another 5 items with a correlation higher than 0.4, i.e. KS_I10 (r = 0.447), KS_I3 (r = 0.437), KS_I2 (r = 0.427), KS_I4 (r = 0.416) and KS_I9 (r = 0.406). The remaining 4 items have a correlation with a CHU9D utility score that is lower than 0.4, including KS_I5 (r = 0.365), KS_I8 (r = 0.317), KS_I7 (r = 0.271) and the lowest correlated item was KS_I6 (“been able to do the things that you want to do in your free time”, r = 0.175).

### Prediction of CHU9D utility scores

**Goodness-of-fit results from full sample**

Model specification | (1) | (2) | (3) | (4) | (5) | (6) | (7) |
---|---|---|---|---|---|---|---|

Mean CHU9D | Min CHU9D | Max CHU9D | MAE | RMSE | MAE | RMSE | |

Observed | 0.8082 | 0.3479 | 1.0000 | ― | ― | ― | ― |

Method 1: Ordinary least squares estimator | |||||||

Model 1 | 0.8082 | 0.4535 | 0.9817 | 0.0978 | 0.1238 | ― | ― |

Model 2 | 0.8082 | 0.4909 | 1.0342 | 0.0950 | 0.1193 | 0.0946 | 0.1190 |

Method 2: Censored least absolute deviations estimator | |||||||

Model 1 | 0.8185 | 0.4473 | 0.9944 | 0.0971 | 0.1243 | ― | ― |

Model 2 | 0.8179 | 0.4281 | 1.0802 | 0.0971 | 0.1247 | 0.0944 | 0.1219 |

Method 3: MM-estimator | |||||||

Model 1 | 0.8136 | 0.4156 | 1.0019 | 0.0972 | 0.1243 | 0.0971 | 0.1243 |

Model 2 | 0.8146 | 0.4807 | 1.0555 | 0.0946 | 0.1199 | 0.0937 | 0.1193 |

Method 4: Generalised linear model | |||||||

Model 1 | 0.8082 | 0.4693 | 0.9950 | 0.0975 | 0.1240 | ― | ― |

Model 2 | 0.8082 | 0.3760 | 0.9483 | 0.0971 | 0.1217 | ― | ― |

### Validation

**Goodness-of-fit results from validation analysis**

Validation I | Validation II | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|

Pooled sample (N = 590) | Random sample I (N = 100) | Random sample II (N = 300) | Random sample III (N = 500) | |||||||||

Mean utility | MAE | RMSE | Mean utility | MAE | RMSE | Mean utility | MAE | RMSE | Mean utility | MAE | RMSE | |

(1) | (2) | (3) | (4) | (5) | (6) | (7) | (8) | (9) | (10) | (11) | (12) | |

Observed | 0.8082 | ― | ― | 0.8265 | ― | ― | 0.8094 | ― | ― | 0.8102 | ― | ― |

Method 1: Ordinary least squares estimator | ||||||||||||

Model 1 | 0.8085 | 0.0982 | 0.1245 | 0.8166 | 0.0874 | 0.1091 | 0.8107 | 0.0938 | 0.1205 | 0.8111 | 0.0985 | 0.1248 |

Model 2 | 0.8088 | 0.0963 | 0.1209 | 0.8127 | 0.0845 | 0.1054 | 0.8112 | 0.0943 | 0.1187 | 0.8104 | 0.0947 | 0.1194 |

Method 2: Censored least absolute deviations estimator | ||||||||||||

Model 1 | 0.8202 | 0.0993 | 0.1268 | 0.8274 | 0.0867 | 0.1084 | 0.8211 | 0.0931 | 0.1209 | 0.8214 | 0.0977 | 0.1253 |

Model 2 | 0.8207 | 0.1006 | 0.1273 | 0.8378 | 0.0866 | 0.1097 | 0.8358 | 0.0946 | 0.1227 | 0.8344 | 0.0954 | 0.1232 |

Method 3: MM-estimator | ||||||||||||

Model 1 | 0.8133 | 0.0983 | 0.1253 | 0.8232 | 0.0865 | 0.1082 | 0.8164 | 0.0931 | 0.1208 | 0.8167 | 0.0977 | 0.1253 |

Model 2 | 0.8147 | 0.0962 | 0.1216 | 0.8201 | 0.0842 | 0.1053 | 0.8181 | 0.0937 | 0.1193 | 0.8168 | 0.0944 | 0.1200 |

Method 4: Generalised linear model | ||||||||||||

Model 1 | 0.8082 | 0.0977 | 0.1243 | 0.8149 | 0.0881 | 0.1097 | 0.8104 | 0.0940 | 0.1215 | 0.8108 | 0.0984 | 0.1252 |

Model 2 | 0.8085 | 0.0979 | 0.1226 | 0.8104 | 0.0920 | 0.1144 | 0.8085 | 0.0964 | 0.1206 | 0.8092 | 0.0967 | 0.1211 |

### Mapping equations

**Mapping equations from KIDSCREEN-10 index to Child Health Utility 9D utility scores**

Ordinary least squares estimator | Censored least absolute deviations estimator | MM-estimator | Generalised linear model | |||||
---|---|---|---|---|---|---|---|---|

Coeff. | SE | Coeff. | SE | Coeff. | SE | Coeff. | SE | |

| ||||||||

KS | 0.043515 | 0.005291* | 0.046580 | 0.006828* | 0.049504 | 0.006682* | 0.092650 | 0.008747* |

KS | −0.000334 | 0.000053* | −0.000359 | 0.000072* | −0.000384 | 0.000070* | ||

Constant | −0.435412 | 0.129225* | −0.510120 | 0.160989* | −0.593052 | 0.157245* | −2.472760 | 0.359525* |

| ||||||||

KS_I1 | 0.035797 | 0.008005* | 0.059820 | 0.009940* | 0.037867 | 0.010995* | 0.296834 | 0.042888* |

KS_I2 | 0.017943 | 0.007725* | 0.023085 | 0.009292* | ||||

KS_I3 | 0.037163 | 0.008005* | 0.039315 | 0.011111* | 0.037192 | 0.009329* | 0.331778 | 0.040524* |

KS_I4 | 0.022713 | 0.006543* | 0.027291 | 0.010421* | 0.021284 | 0.007952* | ||

KS_I9 | 0.016046 | 0.007037* | 0.024877 | 0.008434* | ||||

KS_I10 | 0.027138 | 0.008991* | 0.060152 | 0.010321* | 0.022256 | 0.010361* | 0.300356 | 0.041449* |

Constant | 0.250215 | 0.029866* | 0.156848 | 0.053203* | 0.222655 | 0.034914* | −1.735730 | 0.167557* |

In Model 2, the stepwise selected significant KIDSCREEN-10 items are the key predictors. As can be seen, not all of the 10 items were significant, but for all statistically significant items the positive coefficients were consistent with the expectation that a high item score (better health) is associated with a higher utility. The potential multicollinearity issue was detected using variance inflation factor and the mean/highest variance inflation factor in this case is 1.88/2.01, suggestion that none of the items suffered from multicollinearity and can be included simultaneously in the regressions. The items that were found to be robustly non-significant across four estimators were KS_I5 (“had enough time for yourself”), KS_I6 (“been able to do the things that you want to do in your free time”), KS_I7 (“parent(s) treated you fairly”) and KS_I8 (“had fun with friends”). This is consistent with the findings from the pairwise correlation analysis, specifically that all four items exhibited a relative lower correlation relationship with CHU9D (r < 0.4). A bootstrap stepwise ordinary least squares regression technique (with 100 replications) was also conducted. Ranked by the number of times each variable is selected, KS_I3 topped the list (100 out of 100 times been selected), followed by KS_I1 (99 out of 100), KS_I10 (93 out of 100), KS_I4 (91 out of 100), KS_I9 (59 out of 100), KS_I2 (55 out of 100), KS_I7 (36 out of 100), KS_I8 (29 out of 100), KS_I5 (21 out of 100), and KS_I6 (8 out of 100). Consistent with these findings, KS_I7, KS_I8, KS_I5, and KS_I6 demonstrate the least importance in mapping onto the CHU9D utility. See Table 4 for the detailed regression outputs of four estimators. Based on the MAE result discussed above, the optimal equation used to predict the CHU9D utility based on KIDSCREEN-10 items would be:

CHU9D utility score = 0.222655 + 0.037867*KS_I1 + 0.023085*KS_I2 + 0.037192*KS_I3 + 0.021284*KS_I4 + 0.024877*KS_I9 + 0.022256*KS_I10.

**Mapping equations from KIDSCREEN-10 index to UK Child Health Utility 9D utility scores**

Ordinary least squares estimator | Censored least absolute deviations estimator | MM-estimator | Generalised linear model | |||||
---|---|---|---|---|---|---|---|---|

Coeff. | SE | Coeff. | SE | Coeff. | SE | Coeff. | SE | |

| ||||||||

KS | 0.032434 | 0.004171* | 0.029623 | 0.004257* | 0.032500 | 0.004142* | 0.082786 | 0.007694* |

KS | −0.000249 | 0.000041* | −0.000218 | 0.000045* | −0.000246 | 0.000041* | ||

Constant | −0.075688 | 0.102939 | −0.006549 | 0.097355 | −0.077689 | 0.102295 | −1.749110 | 0.316079* |

| ||||||||

KS_I1 | 0.026771 | 0.006051* | 0.025167 | 0.008471* | 0.022931 | 0.007461* | 0.257334 | 0.038624* |

KS_I2 | 0.010975 | 0.005552* | 0.022333 | 0.006579* | 0.018505 | 0.006152* | ||

KS_I3 | 0.029050 | 0.006725* | 0.028383 | 0.007295* | 0.022030 | 0.006130* | 0.298660 | 0.038848* |

KS_I4 | 0.015820 | 0.005122* | 0.015550 | 0.006502* | 0.014684 | 0.005477* | ||

KS_I9 | 0.013502 | 0.005639* | 0.025567 | 0.004682* | 0.023993 | 0.004852* | ||

KS_I10 | 0.020093 | 0.007056* | 0.012365 | 0.006212* | 0.271802 | 0.037553* | ||

Constant | 0.437368 | 0.024759* | 0.440167 | 0.032133* | 0.451961 | 0.024881* | −1.080010 | 0.162497* |

## Discussion

The measurement and valuation of the HRQoL of children and adolescents is increasingly being recognised as an important component of economic evaluations of health care treatment and preventive programs targeted for young people. The KIDSCREEN-10 instrument has been validated across several European countries for the measurement of health status and since its development in 2004 the instrument has been also widely used across countries. However, a current limitation of the KIDSCREEN-10 is the absence of preference weights meaning that the measure cannot be used directly to estimate QALYs for use in cost-utility analyses. This study has developed a mapping algorithm that can be used to predict CHU9D utility scores based on the KIDSCREEN-10 index. The utilisation of the algorithm will enable cost-utility analyses to be conducted within studies where health outcomes were assessed using only the KIDSCREEN-10 index.

There are two main strengths of this study. Firstly, the target and base measures are both generic HRQoL instruments and as such they have a conceptual overlap between each other. This is an important determinant to the success of mapping analysis [9],[22],[34]. Secondly, multiple estimators that are appropriate for the data have been adopted to explore the optimal mapping algorithms [22]. Specifically, we have used the MM-estimator, an effective robust estimator to map the KIDSCREEN-10 to CHU9D. The MM-estimator has not to our knowledge been previously used in mapping and in this dataset outperforms the censored least absolute deviations and generalised linear model techniques that have been used previously in the mapping literature, and performs similarly to ordinary least squares in this dataset. As the MM-estimator offers some theoretical advantages over ordinary least squares estimator and performs similarly for this reason it is our preferred model here. The model performance as indicated by MAE (0.0946) of the preferred MM-estimate model based on the Model 2 specification is within the range reported by previously published studies (0.0011 to 0.19) [9].

Despite our preference for the MM-estimator, it should be noted that these two estimators do perform similarly. In terms of their predictive ability as the RMSE value (0.1193) of the optimal ordinary least squares estimate is also within the published ranges (0.084 to 0.2) [9]. The largely comparable predictive performance of ordinary least squares and MM-estimator models, despite the MM-estimator overcoming the theoretical limitations of ordinary least squares estimator for the analysis of CHU9D, is of interest. However in the literature this has also been found in some studies mapping onto the EQ-5D using ordinary least squares estimator and other models overcoming the theoretical limitations of ordinary least squares estimator [22].

Although aggregated sample/group level and dis-aggregated individual level predictions of CHU9D utility scores can be incorporated within economic evaluation, it is recommended that only the aggregated sample/group level prediction be adopted based on the current algorithm. At the individual level the predicted utility scores are less reliable as the prediction error could be large as indicated in the Figures 2 and 3. The over-prediction at the lower end of utility values is an issue that not uncommon in the mapping analysis where regression technique is used [35]. Furthermore, as can be seen from Columns (2) and (3) of Table 2, there is no guarantee that the predicted utility will lie within the observed ranges if the transformation algorithm is based upon ordinary least squares estimator, censored least absolute deviations or MM- estimators. Some studies have suggested that in practice if the predicted utility fell outside the defined range, then it should be truncated to the appropriate boundary value (e.g. Sullivan and Ghushchyan [29], Wu *et al*. [31], Payakachat *et al*. [36]). Following this suggestion, the predicted utility score should be specified to 1 if the prediction is larger than 1. How this modification will change the goodness-of-fit results in our sample is shown in Columns (6) and (7) of Table 2. As can be seen, this adjustment always improves the goodness-of-fit results.

This study has some limitations. Response rates and data quality are two potential issues with online modes of survey administration. On-line modes of administration are increasingly familiar, particularly for young people and have the potential to engage large numbers of community based adolescents who would otherwise be more difficult to reach. It is possible to include checks for data quality in on-line surveys and we have taken care to scrutinise the data generated for illogical responses and to check that respondents appeared to understand the task adequately. It is also important to note that other modes of survey administration including self-completion questionnaires and interviews may also be plagued by low response rates and issues of data quality.

In relation to the modelling approach adopted it is important to highlight that model performance was validated using the internal dataset only. A cross-validation would be ideal once a suitable external dataset becomes available. In addition, the study sample was relatively healthy and as such it is also possible that the best performing model specification and type would have differed if the mapping algorithms had been estimated using a dataset with a larger number of respondents in poorer health. Therefore, an external validation using a patient sample is recommended prior to using these mapping algorithms in a dataset with children in poor health. An alternative mapping method, the linking approach that has not yet been empirically tested could be explored in future studies [37].

## Conclusion

When a preference based instrument has not been included in a study to enable QALYs to be estimated for use in cost-utility analyses, the adoption of a mapping approach from a non-preference based instrument to obtain health state utilities served as a second best alternative facilitating cost-utility analyses. This paper has produced a mapping algorithm to generate a CHU9D utility score from KIDSCREEN-10 items. The preferred model is the MM-estimate with stepwise selected KIDSCREEN-10 item scores as the predictors (i.e. Model 2 in Table 4) according to the MAE. The ordinary least squares estimate with stepwise selected KIDSCREEN-10 item scores as the predictors also show good performance based on RMSE.

## Declarations

### Acknowledgements

This paper has benefited from presentation at the 9th World Congress of the International Health Economics Association (iHEA). We are grateful to Dr. Billingsley Kaambwa from Flinders University and three anonymous referees for their detailed and helpful comments. Responsibility for any remaining errors or omissions lies solely with the authors.

**Financial support**

Financial support from a Flinders University seeding grant and an Australian NHMRC Project Grant 1021899 entitled ‘Adolescent values for the economic evaluation of adolescent health care treatment and preventive programs’ is gratefully acknowledged.

## Authors’ Affiliations

## References

- Fontaine K, Barofsky I: Obesity and health-related quality of life.
*Obes Rev*2001, 2(3):173–182. 10.1046/j.1467-789x.2001.00032.xView ArticlePubMedGoogle Scholar - Tsiros M, Olds T, Buckley J, Grimshaw P, Brennan L, Walkley J, Hills AP, Howe PR, Coates AM: Health-related quality of life in obese children and adolescents.
*Int J Obes*2009, 33(4):387–400. 10.1038/ijo.2009.42View ArticleGoogle Scholar - Brazier JE, Ratcliffe J, Tsuchiya A, Salomon J:
*Measuring and Valuing Health Benefits for Economic Evaluation*. Oxford University Press, New York; 2007.Google Scholar - National Institute for Health and Care Excellence: Guide to the methods of technology appraisal 2013.., [http://www.nice.org.uk/article/PMG9/chapter/Foreword]
- Erhart M, Ottova V, Gaspar T, Jericek H, Schnohr C, Alikasifoglu M, Morgan A, Ravens-Sieberer U: Measuring mental health and well-being of school-children in 15 European countries using the KIDSCREEN-10 Index.
*Int J Public Health*2009, 54(Suppl 2):160–166. 10.1007/s00038-009-5407-7View ArticlePubMedGoogle Scholar - Crespo C, Carona C, Silva N, Canavarro M, Dattilio F: Understanding the quality of life for parents and their children who have asthma: family resources and challenges.
*Contemp Fam Ther*2011, 33(2):179–196. 10.1007/s10591-011-9155-5View ArticleGoogle Scholar - Levin KA: Glasgow smiles better: an examination of adolescent mental well-being and the ‘Glasgow effect’.
*Public Health*2012, 126(2):96–103. 10.1016/j.puhe.2011.10.010View ArticlePubMedGoogle Scholar - Block K, Gibbs L, Staiger PK, Gold L, Johnson B, Macfarlane S, Long C, Townsend M: Growing community: the impact of the Stephanie Alexander Kitchen Garden Program on the social and learning environment in primary schools.
*Health Educ Behav*2012, 39(4):419–432. 10.1177/1090198111422937View ArticlePubMedGoogle Scholar - Brazier JE, Yang Y, Tsuchiya A, Rowen DL: A review of studies mapping (or cross walking) non-preference based measures of health to generic preference-based measures.
*Eur J Health Econ*2010, 11(2):215–225. 10.1007/s10198-009-0168-zView ArticlePubMedGoogle Scholar - Furber G, Segal L, Leach M, Cocks J: Mapping scores from the Strengths and Difficulties Questionnaire (SDQ) to preference-based utility values.
*Qual Life Res*2014, 23(2):403–411. 10.1007/s11136-013-0494-6View ArticlePubMedGoogle Scholar - Boyce W, Torsheim T, Currie C, Zambon A: The Family Affluence Scale as a measure of national wealth: validation of an adolescent self-report measure.
*Soc Indic Res*2006, 78(3):473–487. 10.1007/s11205-005-1607-6View ArticleGoogle Scholar - Ravens-Sieberer U:
*The KIDSCREEN Questionnaires—Quality of Life Questionnaires for Children and Adolescents—Handbook*. Pabst Science Publisher, Lengerich; 2006.Google Scholar - Ravens-Sieberer U, Erhart M, Rajmil L, Herdman M, Auquier P, Bruil J, Power M, Duer W, Abel T, Czemy L, Mazur J, Czimbalmos A, Tountas Y, Hagquist C, Kilroe J: Reliability, construct and criterion validity of the KIDSCREEN-10 score: a short measure for children and adolescents’ well-being and health-related quality of life.
*Qual Life Res*2010, 19(10):1487–1500. 10.1007/s11136-010-9706-5PubMed CentralView ArticlePubMedGoogle Scholar - Stevens K: Developing a descriptive system for a new preference-based measure of health-related quality of life for children.
*Qual Life Res*2009, 18(8):1105–1113. 10.1007/s11136-009-9524-9View ArticlePubMedGoogle Scholar - Ratcliffe J, Couzner L, Flynn T, Sawyer M, Stevens K, Brazier J, Burgess L: Valuing Child Health Utility 9D health states with a young adolescent sample: a feasibility study to compare best-worst scaling discrete-choice experiment, standard gamble and time trade-off methods.
*Appl Health Econ Health Policy*2011, 9(1):15–27. 10.2165/11536960-000000000-00000View ArticlePubMedGoogle Scholar - Ratcliffe J, Stevens K, Flynn T, Brazier J, Sawyer M: An assessment of the construct validity of the CHU9D in the Australian adolescent general population.
*Qual Life Res*2012, 21(4):717–725. 10.1007/s11136-011-9971-yView ArticlePubMedGoogle Scholar - Stevens K, Ratcliffe J: Measuring and valuing health benefits for economic evaluation in adolescence: an assessment of the practicality and validity of the Child Health Utility 9D in the Australian adolescent population.
*Value Health*2012, 15(8):1092–1099. 10.1016/j.jval.2012.07.011View ArticlePubMedGoogle Scholar - Stevens K: Valuation of the child health utility 9D index.
*Pharmacoeconomics*2012, 30(8):729–747. 10.2165/11599120-000000000-00000View ArticlePubMedGoogle Scholar - Ratcliffe J, Flynn T, Terlich F, Stevens K, Brazier J, Sawyer M: Developing adolescent-specific health state values for economic evaluation: an application of profile case best-worst scaling to the Child Health Utility 9D.
*Pharmacoeconomics*2012, 30(8):713–727. 10.2165/11597900-000000000-00000View ArticlePubMedGoogle Scholar - Rabe-Hesketh S, Everitt B:
*A Handbook of Statistical Analyses Using Stata (Fourth Edition)*. Chapman & Hall/CRC, Boca Raton, FL; 2007.Google Scholar - Mortimer D, Segal L: Comparing the incomparable? A systematic review of competing techniques for converting descriptive measures of health status into QALY-weights.
*Med Decis Mak*2008, 28(1):66–89. 10.1177/0272989X07309642View ArticleGoogle Scholar - Longworth L, Rowen D: The use of mapping to obtain EQ-5D utility values for use in NICE health technology assessments.
*Value Health*2013, 16(1):202–210. 10.1016/j.jval.2012.10.010View ArticlePubMedGoogle Scholar - Jolliffe D, Krushelnytskyy B, Semykina A: Censored least absolute deviations estimator: CLAD.
*Stata Tech Bull*2006, 58: 13–16.Google Scholar - Cameron AC, Trivedi PK:
*Microeconometrics: Methods and Applications*. Cambridge University Press, New York; 2005.View ArticleGoogle Scholar - Fox J:
*Applied Regression Analysis and Generalized Linear Models (Second Edition)*. SAGE Publications, Thousand Oaks, CA; 2008.Google Scholar - Yohai VJ: High breakdown-point and high efficiency robust estimates for regression.
*Ann Stat*1987, 15(2):642–656. 10.1214/aos/1176350366View ArticleGoogle Scholar - Verardi V, Croux C: Robust regression in Stata.
*Stata J*2009, 9(3):439–453.Google Scholar - Jann B: ROBREG: Stata module providing robust regression estimators.., [http://ideas.repec.org/c/boc/bocode/s457114.html]
- Sullivan P, Ghushchyan V: Mapping the EQ-5D index from the SF-12: US general population preferences in a nationally representative sample.
*Med Decis Mak*2006, 26(4):401–409. 10.1177/0272989X06290496View ArticleGoogle Scholar - Willmott CJ, Matsuura K: Advantages of the mean absolute error (MAE) over the root mean square error (RMSE) in assessing average model performance.
*Clim Res*2005, 30(1):79–82. 10.3354/cr030079View ArticleGoogle Scholar - Wu EQ, Mulani P, Farrell MH, Sleep D: Mapping FACT-P and EORTC QLQ-C30 to patient health status measured by EQ-5D in metastatic hormone-refractory prostate cancer patients.
*Value Health*2007, 10(5):408–414. 10.1111/j.1524-4733.2007.00195.xView ArticlePubMedGoogle Scholar - Wong CKH, Lam CLK, Rowen D, McGhee SM, Ma K-P, Law W-L, Poon JT, Chan P, Kwong DL, Tsang J: Mapping the functional assessment of cancer therapy-general or -colorectal to SF-6D in Chinese patients with colorectal neoplasm.
*Value Health*2012, 15(3):495–503. 10.1016/j.jval.2011.12.009View ArticlePubMedGoogle Scholar - Kontodimopoulos N, Aletras V, Paliouras D, Niakas D: Mapping the cancer-specific EORTC QLQ-C30 to the preference-based EQ-5 D, SF-6 D, and 15 D instruments.
*Value Health*2009, 8: 1151–1157. 10.1111/j.1524-4733.2009.00569.xView ArticleGoogle Scholar - Chuang L-H, Whitehead SJ: Mapping for economic evaluation.
*Br Med Bull*2012, 101(1):1–15. 10.1093/bmb/ldr049View ArticlePubMedGoogle Scholar - Rowen D, Brazier J, Roberts J: Mapping SF-36 onto the EQ-5D index: how reliable is the relationship?
*Health Qual Life Outcomes*2009, 7(1):27. 10.1186/1477-7525-7-27PubMed CentralView ArticlePubMedGoogle Scholar - Payakachat N, Summers K, Pleil A, Murawski M, Thomas J III, Jennings K, Anderson JG: Predicting EQ-5D utility scores from the 25-item National Eye Institute Vision Function Questionnaire (NEI-VFQ 25) in patients with age-related macular degeneration.
*Qual Life Res*2009, 18(7):801–813. 10.1007/s11136-009-9499-6View ArticlePubMedGoogle Scholar - Fayers PM, Hays RD: Should linking replace regression when mapping from profile-based measures to preference-based measures?
*Value Health*2014, 17(2):261–265. 10.1016/j.jval.2013.12.002PubMed CentralView ArticlePubMedGoogle Scholar

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