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Validation of the Clinical COPD Questionnaire (CCQ) in primary care
Health and Quality of Life Outcomes volume 7, Article number: 26 (2009)
Patient centred outcomes, such as health status, are important in Chronic Obstructive Pulmonary Disease (COPD). Extensive questionnaires on health status have good measurement properties, but are not suitable for use in primary care. The newly developed, short Clinical COPD Questionnaire, CCQ, was therefore validated against the St George's Respiratory Questionnaire (SGRQ).
111 patients diagnosed by general practitioners as having COPD completed the questionnaires twice, 2–3 months apart, without systematic changes in treatment. Within this sample of patients with "clinical COPD" a subgroup of patients with spirometry verified COPD was identified. All analyses was performed on both groups.
The mean FEV1 (% predicted) was 58.1% for all patients with clinical COPD and 52.4% in the group with verified COPD (n = 83). Overall correlations between SGRQ and CCQ were strong for all patients with clinical COPD (0.84) and the verified COPD subgroup (0.82). The concordance intra-class correlation between SGRQ and CCQ was 0.91 (p < 0.05). Correlations between CCQ and SGRQ were moderate to good, regardless of COPD severity.
The CCQ is a valid and reliable instrument for assessments of health status on the group level in patients treated for COPD in primary care but its reliability may not be sufficient for the monitoring of individual patients.
Chronic Obstructive Pulmonary Disease (COPD) is a systemic disease with considerable impact on several dimensions of daily life. The primary aim of treatment is to prevent deterioration of health status/quality of life and to minimize exacerbations which drive quality of life deterioration. Thus, there is a need to evaluate responses to therapy based on these patient related outcomes.
Extensive questionnaires for research purposes provide valuable information, but are time-consuming to fill in and require trained personnel to assist the patient and to calculate the sometimes complicated scoring. These extensive questionnaires have often been validated for group comparisons in patients in chest clinics. Shorter, easy-to-use questionnaires are needed in primary care, as patient visits generally are brief, and nurses and doctors often lack research experience.
The validity of a questionnaire is linked to the context where it is administered. Since patients with mild to moderate COPD  are treated at primary health care centres (PHCCs), health status questionnaires for COPD-patients have to be validated in that environment . We therefore performed this study, which is the first validation of the newly developed, brief clinical COPD questionnaire (CCQ)  in primary care. St George's Respiratory Questionnaire (SGRQ)  was chosen as our gold standard, since it is well validated and frequently used in COPD trials, it is available in a Swedish version, and was used in the original validation of CCQ .
The study was a prospective multi-centre study in 24 PHCCs located in the Stockholm area. The participating centres had patients with different socioeconomic backgrounds, and doctors and nurses with limited or no experience of research routines. The study was approved by the Ethics Committee of the Karolinska Institutet, Stockholm, Sweden.
131 patients diagnosed by general practitioners (GPs) as having COPD were included in the study. Exclusion criteria were age <18 years, malignant disease, severe psychiatric disease, dementia or poor understanding of written Swedish. All participants gave written informed consent. 20 patients were excluded: eight were lost to follow up, seven had incomplete SGRQs, three had spirometric recordings revealing restrictivity, one was an asthmatic included by mistake, and one had a normal spirometry. The excluded patients did not significantly differ from the study population regarding age, sex or smoking habits. The final analysis thus included 111 patients (Table 1).
The COPD-population found in primary care makes up a more heterogeneous population than COPD populations usually included in treatment studies. Correct spirometric evaluations are often lacking in primary care . Nevertheless, spirometry had been performed on all but four patients in our study. Among the 111 patients in our study, 85 were diagnosed as having COPD only, whereas 26 patients were considered to have both COPD and asthma by their treating physician. However, the diagnosis of COPD with or without asthma by the GP did not always meet the spirometric criteria for COPD diagnosis according to Global Initiative for Chronic Obstructive Lung Disease (GOLD). Nevertheless, we chose to use the GPs diagnosis as inclusion criterion, since this is how patients are diagnosed and treated in primary care. Statistical analyses were performed for the entire study sample with clinical COPD (n = 111) and for the subgroup of patients with spirometry verified COPD (n = 83) which were the major part of the study population. The results from the analyses on the subgroup with verified COPD are reported only if they differed significantly from the results of the primary analyses.
The patients were characterised with regard to age, gender, and pharmacotherapy during the week preceding each visit. Spirometry (FEV1, % of predicted) was performed with ongoing medication according to local routines, but subjected to central evaluation.
We compared the 10-item CCQ [3, 5, 7] with the well validated, extensive SGRQ [4, 8, 9] on two occasions 10 ± 2 weeks apart without systematic changes in treatment between visits. The time interval was chosen to allow for spontaneous change to occur. If considered needed by the GP, treatment was changed according to local routines after the first visit (Table 1).
The patients completed three questionnaires in their Swedish, self-administered versions in the following order: Short Form-36 Health Survey (SF-36) (Standardised Swedish Version 1.0) [10, 11], SGRQ [4, 8, 9], and finally the authorized Swedish translation of the CCQ provided by the developer [3, 5, 7]. The questionnaires were filled in before meeting the health professional, i.e. the GP or a nurse. During the meeting The GP or a nurse (according to local routines) estimated if and how the patients' clinical status had changed between the visits.
The SF-36 provides a descriptive measure of generic health related quality of life and is valid for use in COPD [12, 13]. The SF-36 was included in the study as a means of characterising the study population. As instructed by the developers, SF-36 was always administered first [10, 11]. The SF-36 contains 8 scales that measure physical functioning (10 items), role physical (4 items), bodily pain (2 items), general health (5 items), vitality (4 items), social function (2 items), role emotional (3 items), and mental health (5 items). All scale scores are transformed to range from 0 (worst health) to 100 (best health). The minimal important difference, MID, for the SF-36 version 1.0 has been reported to range between 3–5 points . SF-36 scores are related to the utilization of healthcare resources by COPD patients , and their mortality .
The SGRQ is a standardized self-administered airways disease-specific questionnaire divided into three subscales: symptoms (eight items), activity (16 items), and impacts (26 items), and 1 overall score. Each score ranges from 0 to 100% (0 = no impairment). The measurement properties of the SGRQ have been found to be satisfactory also in a Swedish population . The recall period in the Swedish version of the SGRQ that was used, is defined as "lately". The minimal important difference, MID, is a score change of ≥ 4 points between occasions .
The CCQ consists of 10 items with an overall score and 3 domains: Symptoms (4 items), Functional state (4 items) and Mental state (2 items). All scores range from 0 to 6; (0 = no impairment). The first validation revealed some weaknesses, such as skewed distributions in functional and mental state domains . The recall period in the Swedish version of the CCQ is defined as the last seven days. The MID for CCQ is 0.41 .
Clinicians' Global Rating
At visit 2, the GP or COPD-nurse classified changes in the patient's global COPD status as: much worse, worse, stable, better or much better. These ratings were made according to normal clinical routines. There were no instructions given to the GP or nurse as to what to base this rating on. It was left to their discretion to do this according to their professional expertise. The only restrictions made to the ratings were that the patients' individual scores on the QoL questionnaires were blinded for the patient and the GP or nurse at this time.
Non-parametric methods were mainly used, as we did not assume normality of distribution for any variable. For comparison with previous validation studies, however, data in the tables are given as mean ± Standard Deviation (SD) unless otherwise indicated. The software used was SPSS version 12.0.1. (SPSS Inc., Chicago, USA).
Analysis of floor and ceiling effects in all domains in both the CCQ and the SGRQ were made. This was done by calculating the proportion of subjects that had highest possible score and the proportion of subjects that had lowest possible score in each domain.
The closeness of association of CCQ and SGRQ questionnaire data was assessed by Spearman correlation coefficients. We used the following cut-offs: 0 < | r | < 0.3 weak correlation, 0.3 < | r | < 0.7 moderate correlation, | r | > 0.7 strong correlation. The concordance between the instruments was examined with an intra class correlation coefficient.
Measurement properties, intra-class correlation (ICC) and test-retest reliability of the instruments were evaluated using data from a subgroup of stable patients according to SGRQ ratings, which has been defined ± <4 points (the MID) at visit 2.
Test-retest reliability was estimated as the ICC, i.e. the ratio of the between subjects variance and total variance.
Internal consistency, longitudinal and cross-sectional validity were evaluated using data from all patients. Internal consistency was estimated by the Cronbach α (alpha) coefficient . Commonly accepted minimal standards for reliability coefficients are 0.70 for group comparisons and 0.90 for comparisons within individuals . Reliability requirements are higher with individualized use because confidence intervals of the scores are based on the Standard Error of the Mean (SEM), and reliability coefficients <0.9 provide too wide intervals for individual monitoring .
To examine cross-sectional validity, we postulated that if the SGRQ and CCQ measure the same construct, they should correlate reasonably well. The a priori expectations were that the total score of SGRQ as well as the symptoms and activity domain scores would correlate strongly with the CCQ total score and with the corresponding domains of CCQ (symptoms and functional state) respectively. For the impacts domain of SGRQ and mental health domain of CCQ, the expectation was that there would be a moderate correlation, since these domains only partially measure the same construct. Only data from the second visit was used.
Longitudinal validity is the ability of the change scores obtained with the investigated instrument to correlate highly, 0 < | r | < 0.3 weak correlation, 0.3 < | r | < 0.7 moderate correlation, | r | > 0.7 strong correlation, with change scores of the criterion/benchmark test SGRQ.
75% of the 111 patients fulfilled the spirometric COPD criterion of GOLD (FEV1/FVC <70%). 34 patients had very severe or severe COPD, 42 moderate and 7 mild COPD according to the GOLD classification (Table 1). The mean FEV1 (% predicted) in the entire population with clinical COPD was 58.1% (range 14.8–111.5) and in the verified COPD subgroup 52.5%, range (14.8–102.6) (Table 1). FEV1 did not correlate with SGRQ or CCQ scores (data not shown). Table 1 shows baseline characteristics of the patients and medication at both visits. The additional analyses on the subpopulation of patients with verified COPD (FEV1/FVC <70%) at baseline did not in any case significantly differ from the results reported.
The entire sample of patients with clinical COPD as well as the subgroup with verified COPD scored lower than the national norm for all SF-36 domains. The SF-36 scores of the subgroup with verified COPD were almost identical with the scores of the entire patient sample with clinical COPD (Figure 1), and this did not change between visits (not shown).
Comparison of instruments
The total scores of the instruments have completely different scales (Table 2). Nevertheless, the distributions of total scores were similar, and the concordance ICC for the entire population was 0.91 (p < 0.05). The concordance ICC for the Symptom domain was also very good, 0.81 (p < 0.05). Similar results were obtained for the verified COPD subgroup.
Floor & Ceiling effects
The total and symptom domain scores of the CCQ were approximately normally distributed. Floor and ceiling effects were negligible (1.8% in the symptoms domain, less in other domains). Distributions in the functional and mental state domains were skewed. In the entire population 4 subjects (3.6%) had optimal functional state scores (0) at visit 1. This increased to 8 subjects (7.2%) at visit 2. Only 1 subject reached the highest possible value at her/his second visit. In the mental state domain, 16 subjects (14.4%) scored optimally (0) at visit 1 and 18 subjects (16.2%) at visit 2; 4 subjects reached the highest possible value at both visits.
The SGRQ did not suffer from floor or ceiling effects. The proportion of subjects that scored at the high or low end were negligible (0 – 3.6%) in all domains and the total score. The pattern was the same for the verified COPD subgroup.
Correlations between SGRQ and CCQ overall scores were strong for the entire population with clinical COPD (0.84; Fig. 2a) and the verified COPD subgroup (0.82, not shown). The Symptoms domains of SGRQ and CCQ correlated moderately (0.70 for clinical COPD). In our study, the internal consistency (Cronbach's alpha) was good, except in the Symptoms domains of both instruments. The Spearman correlation coefficients were good both in patients with FEV1 <50% and >50% of predicted (data not shown).
The reliabilities of the SGRQ and the CCQ were assessed using data from 48 stable patients according to SGRQ scores (23 patients deteriorated and 40 improved and were thus excluded from this analysis). The ICC's were good for both instruments at the overall and domain levels (Table 3). The ICC's for the CCQ were, however, consistently lower than those for SGRQ. The test-retest correlations showed a similar pattern as the ICC's. Similar results were obtained in the verified COPD subgroup (Table 3).
Construct validity: longitudinal
Correlations between the CCQ and the SGRQ were moderate to weak for total scores and within domains. The total scores correlated best. Domain correlations were good, especially between functional state in CCQ and Activities in SGRQ (Table 4).
Construct validity: cross sectional
Cross-sectional correlations between the SGRQ and the CCQ were fairly good for the entire study sample with clinical COPD (Table 5) and the verified COPD subgroup. The total scores of the two questionnaires correlated best. Some correlations between domains in the SGRQ and CCQ were not significant, but these domains measure very different aspects of health status.
Correlations between CCQ and SF-36 indices were poor, with the exception of functional state and the physical index (not shown). A similar pattern was seen in the verified COPD subgroup (not shown).
The clinicians' global ratings of improvement/stability/deterioration did not correlate with changes estimated using SGRQ or CCQ (Figure 2c).
Overall, the correlations between CCQ and SGRQ were moderate to good, with a similar pattern to that originally found . The notion that the Functional State domain of CCQ corresponds to the Activity domain of SGRQ was supported. There was also a good correlation between the Impacts and Mental State domains.
Our analysis suggests that CCQ is valid for studies of both mild and moderate to severe COPD in primary care, since equally good correlations were obtained in patients with FEV1 less than or more than 50% of predicted, respectively. The measurement properties of the CCQ were not destroyed by concomitant asthma. The relevance of the present data is supported by the subgroup analysis of patients that at baseline fulfilled spirometric criteria for COPD according to GOLD . Compared to a recent validation of the standardized chronic respiratory questionnaire (CRQ) , our results suggest that CCQ has better longitudinal validity but not as good cross sectional validity as the CRQ. However, no direct comparison of the two questionnaires exists. We confirmed 75% of the COPD diagnoses by central examination of spirometries. In a recent Welsh primary care study , only 49% of the COPD diagnoses could be confirmed by spirometry. We used the GPs diagnosis of COPD as inclusion criterion in order to validate the CCQ for a COPD population in primary care, where adequate spirometric tests are not common. Of interest, patients who did not fulfill the GOLD requirements for a COPD diagnosis did not worsen the measurement properties of the CCQ (not shown). This is hardly surprising though, since these subjects are probably at least "at risk" subjects, otherwise the GP diagnose of COPD makes no sense.
We found a remarkable lack of agreement between changes in SGRQ health status scores and the clinicians' global ratings, which is in line with previous research . This raises questions as to what the clinicians' rating is based on, and if standardized questionnaires might add value to the primary care consultation.
The SGRQ has properties allowing use at the individual level, but it is extensive and not adapted for everyday use in primary care. The scoring system is complicated, and 7 of our patients were unable to complete the SGRQ acceptably. The reliability coefficient for CCQ was <0.9, suggesting that it may not be sensitive enough for the monitoring of individual patients in ordinary health care .
To evaluate the stability of the CCQ, it was tested in the target context under realistic primary care conditions, based on a test-retest design. Studies of test-retest reliability for health-related quality of life instruments have used varying intervals between test administrations. We have found no evidence on which to base the time interval between questionnaire administrations. Short periods will be subject to recall bias and longer periods will eventually lead to changes if the time span is long enough. In order to reflect real life conditions, we chose a relatively long time interval, 10–12 weeks. Then, patients who were expected to remain stable between measurements were selected for the analysis. This was done by using the SGRQ as a GOLD standard. The choice of using the SGRQ as a GOLD standard, might be viewed problematic, but at the time it was (and still is) the best respiratory-specific gold standard available in Swedish. Several reports have shown it to be more responsive to change than generic or preference-based instruments, and it is thus relatively suitable for determinations of temporal stability. This approach may not have been optimal, but we feel that it does not threaten the validity of our result or conclusions.
Another limitation of the study might be the patient selection and whether the severity-distribution of the patients was representative for primary care. Out of the total sample of 111 subjects with clinical COPD, 83 subjects' diagnoses were verified as COPD according to GOLD guidelines. Only four of the 28 subjects who were not classified as having COPD according to GOLD criteria lacked spirometry data.
At baseline, about half of the patients in this study had FEV1 (post bronch. dil.) above 50% of predicted and about half of them below 50% of predicted (table 1). Nine percent had very severe COPD and 38% severe COPD according to the GOLD classification. In a Swedish survey in 2005 with 1096 randomly selected patients with COPD attending primary health care centres in Sweden, 5% had very severe COPD, 26% severe, 44% moderate and 25% mild COPD according to pulmonary function tests (unpublished data). Considering these figures, we assume that the patient group in our study is probably representative for the COPD population in primary care in Sweden.
In conclusion, our results indicate that the CCQ has good measurement properties for studies of health status at the group level, whereas its reliability may not be sufficient for the monitoring of individual patients. The CCQ is easy to score, and allows data to be quickly collected and processed, and is thus suitable for use in every day practice for clinical trials or quality of care monitoring.
Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease [http://www.goldcopd.org]
Assessing health status and quality-of-life instruments: attributes and review criteria Qual Life Res 2002, 11: 193–205. 10.1023/A:1015291021312
Mear I, Molen T, Moerk A-C, Lindemann M: Linguistic validation of the clinical COPD questionnaire (CCQ) for use in international studies. Eur Respir J 2005.
Engstrom CP, Persson LO, Larsson S, Sullivan M: Reliability and validity of a Swedish version of the St George's Respiratory Questionnaire. Eur Respir J 1998, 11: 61–66. 10.1183/09031936.98.11010061
Molen T, Willemse BW, Schokker S, Ten Hacken NH, Postma DS, Juniper EF: Development, validity and responsiveness of the Clinical COPD Questionnaire. Health Qual Life Outcomes 2003, 1: 13. 10.1186/1477-7525-1-13
Bolton CE, Ionescu AA, Edwards PH, Faulkner TA, Edwards SM, Shale DJ: Attaining a correct diagnosis of COPD in general practice. Respir Med 2005, 99: 493–500. 10.1016/j.rmed.2004.09.015
Kooi HH, Tuinenga MG, Schokker S, Molen T: How to measure Clinical Control in Patients with COPD. The Development of the Clinical COPD Questionnaire (CCQ). QoL Newsletter 2003, 31: 9–11.
Jones PW, Quirk FH, Baveystock CM, Littlejohns P: A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992, 145: 1321–1327.
Jones PW, Quirk FH, Baveystock CM: The St George's Respiratory Questionnaire. Respir Med 1991,85(Suppl B):25–31. 10.1016/S0954-6111(06)80166-6
Stewart A, Hays R, Ware J: The MOS short-form general health survey. Reliability and validity in a patient population. Med Care 1988, 26: 724–732. 10.1097/00005650-198807000-00007
Bousquet J, Knani J, Dhivert H, Richard A, Chicoye A, Ware JE Jr, Michel FB: Quality of life in asthma. I. Internal consistency and validity of the SF-36 questionnaire. Am J Respir Crit Care Med 1994, 149: 371–375.
Alonso J, Prieto L, Ferrer M, Vilagut G, Broquetas JM, Roca J, Batlle JS, Anto JM: Testing the measurement properties of the Spanish version of the SF-36 Health Survey among male patients with chronic obstructive pulmonary disease. Quality of Life in COPD Study Group. J Clin Epidemiol 1998, 51: 1087–1094. 10.1016/S0895-4356(98)00100-0
Mahler DA, Mackowiak JI: Evaluation of the short-form 36-item questionnaire to measure health-related quality of life in patients with COPD. Chest 1995, 107: 1585–1589. 10.1378/chest.107.6.1585
Ware JE Jr, et al.: SF-36 Health Survey Manual and Interpretation Guide. 1995.
Samsa G, Edelman D, Rothman ML, Williams GR, Lipscomb J, Matchar D: Determining clinically important differences in health status measures: a general approach with illustration to the Health Utilities Index Mark II. Pharmacoeconomics 1999, 15: 141–155. 10.2165/00019053-199915020-00003
Desikan R, Mason HL, Rupp MT, Skehan M: Health-related quality of life and healthcare resource utilization by COPD patients: a comparison of three instruments. Qual Life Res 2002, 11: 739–751. 10.1023/A:1020836719321
Domingo-Salvany A, Lamarca R, Ferrer M, Garcia-Aymerich J, Alonso J, Felez M, Khalaf A, Marrades RM, Monso E, Serra-Batlles J, Anto JM: Health-related quality of life and mortality in male patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002, 166: 680–685. 10.1164/rccm.2112043
Schunemann HJ, Griffith L, Jaeschke R, Goldstein R, Stubbing D, Guyatt GH: Evaluation of the minimal important difference for the feeling thermometer and the St. George's Respiratory Questionnaire in patients with chronic airflow obstruction. J Clin Epidemiol 2003, 56: 1170–1176. 10.1016/S0895-4356(03)00115-X
Kocks JW, Tuinenga MG, Uil SM, Berg JW, Stahl E, Molen T: Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire. Respir Res 2006, 7: 62. 10.1186/1465-9921-7-62
Nunnally JC, Bernstein IH: Psychometric theory. 3rd edition. New York: McGraw-Hill; 1994.
Schunemann HJ, Goldstein R, Mador MJ, McKim D, Stahl E, Puhan M, Griffith LE, Grant B, Austin P, Collins R, Guyatt GH: A randomised trial to evaluate the self-administered standardised chronic respiratory questionnaire. Eur Respir J 2005, 25: 31–40. 10.1183/09031936.04.00029704
Janse AJ, Gemke RJ, Uiterwaal CS, Tweel I, Kimpen JL, Sinnema G: Quality of life: patients and doctors don't always agree: a meta-analysis. J Clin Epidemiol 2004, 57: 653–661. 10.1016/j.jclinepi.2003.11.013
We are grateful to the participating PHCCs for including and evaluating the patients, and to research nurse Lena Wahlberg for monitoring and assembling data. The study was supported by the drug and therapeutics committees in Stockholm and Sörmland, the Stockholm County Council, the Vårdal Foundation, and Karolinska Institutet. No financial or other potential conflicts of interest related to the subject of the manuscript exist for any of the authors.
The authors declare that they have no competing interests.
BS has made substantial contributions to conception, design, acquisition of data, analysis and interpretation of data; he has also been involved in drafting the manuscript and revising it critically. MN has been involved in the acquisition, analysis and interpretation of data, as well as in drafting the manuscript and revising it. POE contributed to the conception, design, acquisition and interpretation of data. PH and EWJ both made important contributions to the conception, design, analysis and interpretation of data, and revised the manuscript critically.
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Ställberg, B., Nokela, M., Ehrs, PO. et al. Validation of the Clinical COPD Questionnaire (CCQ) in primary care. Health Qual Life Outcomes 7, 26 (2009). https://doi.org/10.1186/1477-7525-7-26
- Chronic Obstructive Pulmonary Disease
- Severe Chronic Obstructive Pulmonary Disease
- Minimal Important Difference
- Mild Chronic Obstructive Pulmonary Disease
- Chronic Obstructive Pulmonary Disease Diagnosis
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