Table 4 Predictors of Physical health MSQoL-54 scales by IFN-β treatment (Multivariate hierarchical analysis)
From: Influence of Interferon beta treatment on quality of life in multiple sclerosis patients
Energy | Health perceptions | Physical function | Role limitation physical | Bodily pain | Social function | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Effect | β | p | β | p | β | p | β | p | β | p | β | p |
Intercept* | 45.11 | <.0001 | 44.67 | <.0001 | 69.40 | <.0001 | 71.72 | <.0001 | 74.23 | <.0001 | 72.54 | <.0001 |
Age at inclusion | -0.12 | 0.36 | 0.06 | 0.68 | -0.4 | 0.01 | -0.60 | 0.03 | -0.36 | 0.04 | 0.06 | 0.66 |
Gender (Male vs. Female) | -0.51 | 0.84 | 2.00 | 0.52 | 1.07 | 0.75 | -17.3 | 0.003 | 3.74 | 0.31 | -0.32 | 0.90 |
Disease duration | -0.02 | 0.92 | -0.36 | 0.08 | 0.10 | 0.64 | 0.19 | 0.60 | -0.38 | 0.12 | -0.30 | 0.10 |
Disease course (SP vs. RR) | 9.54 | 0.03 | 7.35 | 0.16 | -8.44 | 0.12 | 8.77 | 0.34 | 17.33 | 0.004 | 8.65 | 0.06 |
Relapse rate 2-yrs before study entry | 0.37 | 0.90 | -2.01 | 0.58 | 0.70 | 0.86 | 1.39 | 0.83 | -0.20 | 0.96 | 3.76 | 0.24 |
EDSS | -2.33 | 0.06 | -3.54 | 0.02 | -8.44 | <.0001 | -4.69 | 0.09 | -2.82 | 0.11 | -2.65 | 0.05 |
BDI | -1.16 | <.0001 | -0.26 | 0.20 | 0.25 | 0.26 | -0.92 | 0.01 | 0.22 | 0.36 | -0.66 | 0.0004 |
FSS | -4.80 | <.0001 | -6.8 | <.0001 | -8.69 | <.0001 | -10.0 | <.0001 | -9.74 | <.0001 | -6.72 | <.0001 |
MMSE-c | -0.19 | 0.71 | -0.43 | 0.46 | 0.05 | 0.94 | -1.90 | 0.10 | 0.02 | 0.98 | -0.30 | 0.57 |
IFN-β treatment (Yes vs No) | 1.43 | 0.65 | 3.56 | 0.32 | 1.20 | 0.77 | 5.03 | 0.50 | 4.54 | 0.32 | 0.23 | 0.94 |
Relapse rate change after 2-yrs | 4.96 | 0.17 | 2.40 | 0.61 | 3.76 | 0.20 | -2.71 | 0.69 | 2.96 | 0.54 | 6.77 | 0.08 |
EDSS change after 2-yrs | -0.11 | 0.95 | -1.49 | 0.54 | -4.54 | 0.003 | 0.59 | 0.86 | 0.70 | 0.77 | -2.72 | 0.16 |
BDI change after 2-yrs | -0.67 | 0.0005 | -0.48 | 0.05 | -0.14 | 0.37 | -1.59 | <.0001 | -0.82 | 0.002 | -0.67 | 0.001 |
FSS change after 2-yrs | -5.20 | <.0001 | -4.89 | 0.001 | -4.65 | <.0001 | -4.75 | 0.03 | -5.98 | 0.0001 | -4.39 | 0.0003 |
MMSE-c change after 2-yrs | -1.09 | 0.15 | 0.20 | 0.84 | -0.10 | 0.87 | -3.04 | 0.04 | -0.64 | 0.53 | 0.18 | 0.81 |
Time** | 8.67 | 0.004 | 3.36 | 0.37 | -4.84 | 0.05 | -1.00 | 0.86 | -1.81 | 0.65 | 0.64 | 0.84 |
Time × IFN-β treatment (Yes vs No) | -0.76 | 0.86 | -1.72 | 0.74 | -6.15 | 0.07 | -2.54 | 0.77 | 3.82 | 0.50 | -1.73 | 0.69 |