Effect Sizes for Gender Differences in HRQOL. The domains of HRQOL are shown on the X-axis and the effect size on the Y-axis where effect size = [meanM-meanF]/SDM. Effect sizes between 0.2 and 0.5 are felt to be minimally clinically important and those between 0.5 and 0.8 are felt to be moderately clinically important. Positive effect sizes indicate better HRQOL for males than females. Role physical (RP) domain is negative because males reported worse HRQOL than females. Domains: Global Health (GH); Physical Functioning (PF); Bodily Pain (BP); Behavior (BE); Mental Health (MH); Self-esteem (SE); General Health Perception (GP); Family Cohesion (FC); Family Activities (FA); Role/social Physical; Role/social Emotional (RE); Role/social Behavioral (RB).