- Open Access
Assessment of the structure of the Hospital Anxiety and Depression Scale in musculoskeletal patients
© Pallant and Bailey; licensee BioMed Central Ltd. 2005
- Received: 08 November 2005
- Accepted: 19 December 2005
- Published: 19 December 2005
Research suggests there is a high prevalence of anxiety and depression amongst patients with chronic musculoskeletal pain, which can influence the effectiveness of rehabilitation programs. It is therefore important for clinicians involved in musculoskeletal rehabilitation programs to consider screening patients for elevated levels of anxiety and depression and to provide appropriate counselling or treatment where necessary. The HADS has been used as a screening tool for assessment of anxiety and depression in a wide variety of clinical groups. Recent research however has questioned its suitability for use with some patient groups due to problems with dimensionality and the behaviour of individual items. The aim of this study is to assess the underlying structure and psychometric properties of the HADS among patients attending musculoskeletal rehabilitation.
Data was obtained from 296 patients attending an outpatient musculoskeletal pain clinic. The total sample was used to identify the proportion of patients with elevated levels of anxiety and depression. Half the sample (n = 142) was used for exploratory factor analysis (EFA), with the holdout sample (n = 154) used for confirmatory factor analysis (CFA) to explore the underlying structure of the scale.
A substantial proportion of patients were classified as probable cases on the HADS Anxiety subscale (38.2%) and HADS Depression subscale (30.1%), with the sample recording higher mean HADS subscales scores than many other patient groups (breast cancer, end-stage renal disease, heart disease) reported in the literature. EFA supported a two factor structure (representing anxiety and depression) as proposed by the scale's authors, however item 7 (an anxiety item) failed to load appropriately. Removing Item 7 resulted in a clear two factor solution in both EFA and CFA.
The high levels of anxiety and depression detected in this sample suggests that screening for psychological comorbidity is important in musculoskeletal rehabilitation settings. It is necessary for clinicians who are considering using the HADS as a screening tool to first assess its suitability with their particular patient group. Although EFA and CFA supported the presence of two subscales representing anxiety and depression, the results with this musculoskeletal sample suggest that item 7 should be removed from the anxiety subscale.
- Confirmatory Factor Analysis
- Exploratory Factor Analysis
- Anxiety Subscale
- Depression Subscale
- Holdout Sample
Anxiety and depression are major factors impacting patient's quality of life, and the associated symptoms (inability to concentrate, loss of motivation, disturbed sleep, fatigue, pessimistic mood) may influence their ability to benefit from treatment and rehabilitation programs. High levels of anxiety have been associated with poor concentration and difficulty in comprehending information provided by clinicians . Depressed mood may also adversely affect patients' willingness to comply with prescribed medications and to undertake the necessary lifestyle changes (eg. exercise, diet).
Studies have found quite high levels of psychological distress among patients with musculoskeletal diseases in particular [2, 3]. It is therefore important for clinicians involved in musculoskeletal rehabilitation programs to consider screening patients for elevated levels of anxiety and depression and to provide appropriate counselling or treatment where necessary. Reduction in levels of anxiety and depression should also be considered an important program outcome.
One of the issues facing clinicians wishing to screen for high levels of anxiety and depression among their patients is the choice of a screening tool. In a hospital setting, the tool needs to be quickly administered, easy to use and have good psychometric properties. Many of the available measures (eg. Beck Depression Inventory ) are quite long and detailed, and are restricted for use by psychologists, psychiatrists, or other suitably trained personnel. This makes them unsuitable for routine administration as part of the normal pre-program assessment procedures.
In the selection of assessment tools for screening and evaluation there are a number of issues to be considered. Guyatt, Feeny, and Patrick  in their guidelines on the selection of health related quality of life measures highlight a number of factors that are relevant here (for a more comprehensive review see Streiner and Norman, ). Measures need to be reliable (internally consistent, and stable over time), valid (measuring the intended characteristic), and responsive (able to detect change). Reliability, accuracy and reproducibility are important qualities for a discriminative instrument (for use as a screening tool in distinguishing those with high versus low levels of a characteristic). For an evaluative instrument, responsiveness (as indicated by sensitivity to detect changes in patients who have improved or deteriorated) is also essential.
One of the tools that could be considered for use as a discriminative measure in the rehabilitation context is the Hospital Anxiety and Depression Scale (HADS) . It was originally developed as a short questionnaire designed to identify clinical 'caseness' for anxiety and depression in general medical outpatient populations. The items included in the HADS were chosen to reduce contamination with somatic symptoms, which are common in patient populations. The HADS consists of an anxiety and depression subscale, each containing seven items, making it quick and easy to use in clinical settings.
Since its publication in the early 1980's the HADS has been used in a growing number of studies across a variety of patient groups and clinical contexts (see review by Bjelland, et al., ). As a brief screening tool the HADS scale is increasing in popularity, particularly in clinical settings, because of its ease of administration and independence from physical symptomatology. After reviewing over 70 journal articles Bjelland and coauthors  concluded that the HADS 'performs well in screening for the separate dimensions of anxiety and depression and caseness of anxiety disorders and depression in patients from non-psychiatric hospital clinics' (p. 75).
The HADS was originally designed to assess two separate dimensions of anxiety and depression. The case for the bidimensionality of the HADS was supported in a review paper published by Bjelland et al. . Of the 18 studies reviewed that reported findings of factor analyses, eleven of the papers supported a two-factor solution. A strong argument for the use of the two factors is also made at the clinical level  where it is clinically relevant to separately determine levels of anxiety and depression.
In twenty-one studies investigating the HADS, the Pearson correlation coefficients between the two subscales of anxiety and depression were reported to have a mean of .56 . These high correlation rates have encouraged some authors to question the dimensionality of the scale. Razavi, Delvaux, Farvacques and Robaye  recommended totalling the two subscales to create a total score of generalised psychological distress. Martin, Tweed and Metcalfe  in a study of patients with end-stage renal disease, suggested that it may be 'appropriate to consider adopting a global total score of psychological distress' (p. 61) as an alternative to the original two subscale structure.
A growing number of authors have argued that there are three or more factors contained within the scale [12–14]. In a recent review of the HADS, Martin  states that 'there is accumulating evidence that the fundamental factor structure of the HADS comprises not two, but three factors and indeed, that the three-factor structure offers a superior fit to clinical data than the two factor (anxiety and depression model)' (p.70). Drawing on Clark and Watson's  tripartite theory of anxiety and depression, Dunbar and colleagues  found empirical support using confirmatory factor analysis (CFA) for a three factor model of the HADS, distinguishing autonomic anxiety (items 3,9,13), negative affectivity (items 1,5,7,11) and anhedonic depression (items 7,2,4,6,8,10,12,14). Item 7 (an anxiety item) was found to load on two factors (negative affectivity and depression). Martin  suggests that the autonomic arousal component of the HADS anxiety subscale may be a potential confounding factor when used with patients experiencing physical symptoms, affecting its reliability as a screening tool.
Another issue that has been raised in regard to the HADS is the appropriateness of individual items with specific patient groups . The review by Bjelland et al.  revealed that the anxiety item 7 "I can sit at ease, and feel relaxed" showed consistently low correlations with the anxiety subscale, and higher correlations with the depression subscale across a range of patient groups.
Although used extensively with some patient groups (eg. cancer patients) there appears to be relatively little good quality research into the psychometric properties of the HADS for use in a rehabilitation context. One exception is a study conducted by Harter et al.  in a number of in-patient rehabilitation clinics in Germany, which assessed the HADS (as compared with the General Health Questionnaire: GHQ) as a screening tool with musculoskeletal patients. The accuracy of the diagnostic ability of the HADS (sensitivity and specificity) compared to standardised interviews was found to be superior to that of the commonly used GHQ. Harter et al. , recommend the HADS 'as an efficient instrument to identify patients with musculoskeletal disease and potential psychiatric comorbidity' (p. 743). Based on the findings of their study they propose that the assessment and identification of patients with high levels of anxiety and depression should be given high priority, particularly given their influence on aspects such as quality of life, pain experiences and treatment conformity.
Although the Harter et al.  study appears to support the use of the HADS in rehabilitation settings, the authors chose to use the HADS as a total score, rather than as two subscales, as recommended by the scale developers. No justification was given for this decision, and no analyses were conducted to evaluate the appropriateness of this approach. Ideally factor analysis could have been undertaken to assess the structure of the HADS in the rehabilitation context, and to evaluate its psychometric properties.
The aim of this study therefore was to assess the suitability of the HADS as a screening tool for routine use in rehabilitation settings for patients with musculoskeletal disorders. This paper assesses the levels of anxiety and depression in a sample of musculoskeletal patients, and explores the dimensionality of the scale using both exploratory and confirmatory factor analysis.
The sample consisted of 296 outpatients attending a 6-week musculoskeletal rehabilitation program at Cedar Court HealthSouth Hospital, a private rehabilitation hospital in Melbourne, Australia. There were 152 (51.4%) females, 140 (47.9%) males), 4 cases (1.4 %) sex unspecified. Patients ranged in age from 16 yrs to 80 yrs (mean = 44.3, SD = 12.47). Fifty-five percent of patients reported pain in the lower back, 20% in an upper or lower limb, 15% in the cervical region and 10% in other locations.
The HADS is routinely administered to all patients on admission to the Cedar Court HealthSouth Hospital rehabilitation program as part of standard clinical procedures. Scores on the HADS from all patients attending the program between 2001 and 2003 were extracted from the medical records for this study, with permission from the Hospital Research Committee.
From the original sample of 296 cases, the dataset was randomly divided into two separate and independent sub-samples. The first sample contained 142 cases and was subjected to exploratory factor analysis. The second sample of 154 was used as an independent, holdout sample for confirmatory factor analysis. Although this procedure resulted in two smaller samples it was considered important to use both an exploratory and confirmatory approach with this sample of musculoskeletal patients. It was not appropriate to only use CFA, as the structure of the HADS in musculoskeletal patients had not been previously established using exploratory approaches. Although the sample sizes were smaller than desirable for these analyses, they are similar to other recent studies assessing the HADS on specific clinical samples. Jomeen & Martin  conducted both EFA and CFA on a sample of 101 antenatal women; Bedford, Pauw and Grant  used a sample of 132 adult psychiatric outpatients; and the sample used by Martin, Tweed & Metcalfe  consisted on 160 end stage renal patients. According to Tabachnick and Fidell  sample sizes of 150 should be sufficient when solutions show several high loading marker variables (>.80).
Hospital Anxiety and Depression Scale (HADS ) is a 14-item scale designed to detect anxiety and depression, independent of somatic symptoms. It consists of two 7-item subscales measuring depression and anxiety. A 4-point response scale (from 0 representing absence of symptoms, to 3 representing maximum symptomatology) is used, with possible scores for each subscale ranging from 0 to 21. Higher scores indicate higher levels of disorder. A number of clinical classification schemes have been used to categorise scores on the HADS. In the original article the following cut offs were suggested: 0–7 = 'non-cases'; 8–10 = 'possible case'; 11–21 = 'probable case'.
The reliability of the two subscales was assessed using Cronbach alpha coefficients. The underlying structure of the HADS was explored using both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). EFA was performed on the first sample using SPSS version 11.5, after first confirming that the data was suitable for factor analysis. Principal components analysis (PCA) was used to extract the factors followed by oblique rotation of factors using Oblimin rotation (delta = 0). The number of factors to be retained was guided by three decision rules: Kaiser's criterion (eigenvalues above 1), inspection of the screeplot, and by the use of Horn's parallel analysis  (Horn, 1965). Parallel analysis is one of the most accurate approaches to estimating the number of components [23, 24]. The size of eigenvalues obtained from PCA are compared with those obtained from a randomly generated data set of the same size. Only factors with eigenvalues exceeding the values obtained from the corresponding random data set are retained for further investigation. Parallel analysis was conducted using the software developed by Watkins .
Confirmatory factor analysis (CFA) using maximum likelihood estimation was conducted on the second holdout sample using AMOS Version 4  to evaluate model fit. Although good model fit can be indicated by a non-significant chi-square, in practice other factors can influence this figure, and therefore a range of fit statistics were assessed. For the incremental fit statistics (Goodness of Fit Index :GFI; the Tucker-Lewis Index :TLI; and the Comparative Fit index: CFI) values less than .90 indicate lack of fit, values between .90 and .95 indicate reasonable fit and values between .95 and 1.00 indicate good fit . Byrne  describes the Root Mean-Square Error of Approximation (RMSEA) as the most informative statistic in determining model fit as it takes into account the number of variables that are estimated in the model. RMSEA values are required to be .05 or lower to indicate good fit. Values between .05 and .08 indicate reasonable fit.
Scores on the HADS Anxiety scale ranged from 0 to 21, with a mean of 9.26 (SD = 4.43) and a median of 9.0. HADS Depression scale scores also covered the full range from 0 to 21, with a mean of 8.14 (SD = 4.43) and a median of 8.0. Scores on both subscales showed an approximately normal distribution.
Comparison of HADS anxiety and depression subscale mean scores with other samples
Current sample of Musculoskeletal patients
Non clinical UK normative sample 
Coronary heart disease patients 
End-stage renal patients 
Breast cancer patients 
Chronic Obstructive Pulmonary Disease rehabilitation patients 
Psychiatric patients 
Patients' scores were classified into the clinical categories defined by the scale's authors. For the anxiety subscale 38.2% of patients were classified as a probable case (score 11 to 21), with a further 23% classified as a possible case (score 8 to 10). On the depression subscale 30.1% were classified as probable cases (score 11 to 21) and 21.3% as possible cases (score 8 to 10).
The Cronbach alpha value for the anxiety subscale was .83, while the Cronbach alpha value for the depression subscale was .84. Both values exceeded the recommended value of .7 , indicating adequate internal consistency.
Exploratory factor analysis
Pattern and structure matrix for PCA with oblimin rotation of two factor solution
Analysis of the structure matrix indicated good discrimination between the factors. For the depression component, the lowest factor loading for depression items was .62 for Item 10, which was still higher than the highest loading (Item 1, loading at .58) on the depression factor of an anxiety item (except for item 7). The anxiety component also showed good discrimination: the lowest loading anxiety item (Item 11, loading at .58) was still higher than the highest loading depression item onto the anxiety component (Item 6, loading at .56).
Overall these results support the bi-dimensionality of the HADS, however the content of the factors obtained do not fully support the original scale structure proposed by the authors. The major inconsistency in relation to this sample is the tendency of one of the anxiety items (item 7: "I can sit at ease and feel relaxed') to show more substantial loadings on the Depression factor. It was therefore decided to explore the structure of the HADS with this item removed.
Pattern and Structure Matrix for Principal Components Analysis of HADS-13
The HADS-13 (with item 7 removed) showed simple structure consistent with Zigmond and Snaith's  original conception of the factor structure for the HADS. Unlike the 14-item scale, all the items loaded onto the correct subscales.
Confirmatory factor analysis
Whilst the structure matrix in the exploratory factor analysis indicated that the components were clearly distinguishable constructs, the structure matrix for this CFA model indicated that the items were not distinct from each other. On the anxiety subscale, the lowest loading for anxiety items was .53, whilst the highest loading of depression items onto the anxiety subscale was .63. This was reflected in the depression subscale, where the lowest loading of depression items was .45, whilst the highest loading of anxiety items onto the depression subscale was .67. This indicates a large amount of overlap between the factors, which is also supported by the strong correlation (.80) between the two factors.
Given evidence of the strong overlap of the two factors it was decided to formally test a one-factor model of generalised psychological distress, as proposed by previous researchers [10, 11]. Two models were tested: the full 14 item original version of the HADS and the 13 item version with item 7 removed.
Comparative fit indices for five CFA HADS models
HADS 13 items 2 factors
HADS 14 items 2 factors
HADS 14 items 1 factor
HADS 13 items 1 factor
HADS 14 item 3 factor (Dunbar et al. final model )
Although not supported by the results of the EFA analyses, a three factor modified model proposed by Dunbar  (based on Clark and Watson's tripartite theory) was also tested with this sample (see Dunbar p. 88 for specific details of the model). The model fit statistics shown in Table 4 were adequate, but not as good as those obtained from the 13-item 2 factor solution.
Overall the best fitting model for this data was a two correlated factor model representing anxiety and depression, but with item 7 removed from the scale.
The results of this study revealed high levels of anxiety and depression among patients undergoing rehabilitation for musculoskeletal disorders. The mean score obtained on each of the HADS subscales was higher than other reported samples of patients with breast cancer , renal disease , chronic obstructive pulmonary disease  and coronary heart disease , but lower than for psychiatric patients . In the current sample more than 60% of patients were defined as 'cases' or 'possible cases' of anxiety, and more than 50% of patients were defined as 'cases' or 'possible cases' of depression.
Previous reviews of prevalence rates  suggest that patients with chronic pain (including fibromyalgia, and back pain) had higher prevalence of anxiety and depression than patients with oncology, cardiac and neurological disorders. Similar high rates for anxiety were reported in a study of breast cancer patients , with a total of 68.2% of patients being classified as 'possible' (46.4%) or 'probable' (21.8%) cases. For this sample, however, only 12.7% of the cancer patients were classified as 'possible' or 'probable' cases on the depression subscale. In a recent study of cardiac patients  40% of patients were classified as a 'possible' or 'probable' case on the depression scale. Compared to other samples, this current sample of musculoskeletal patients had substantial levels of both anxiety and depression.
These results suggest that issues concerning psychological comorbidity with chronic pain need to be addressed, particularly in patients with musculoskeletal disease. Both anxiety and depression can have a negative impact on patients' quality of life, on their perception and response to pain, their treatment adherence and on their ability to benefit from treatment programs . Screening procedures to detect patients with elevated anxiety and depression are important in rehabilitation settings to allow the identification of patients requiring additional psychological assessment, prior to commencement of programs. The results of this study suggest that, with one minor adjustment (removal of item 7), the HADS may be suitable for use as a screening instrument for use in rehabilitation settings with musculoskeletal patients.
As detailed in the introduction, a number of concerns have been raised in recent years concerning the dimensionality of the HADS and the behaviour of individual items. The results of the current study generally provide support for the bi-dimensionality of the HADS, however the content of the factors obtained do not fully concur with the original scale conceptualisation. The major inconsistency in relation to this sample is the tendency for item 7 ("I can sit at ease and feel relaxed') to show more substantial loadings on the Depression factor, rather than its Anxiety factor. Problems with this item have been reported by a number of other researchers working with different clinical patient groups [20, 31, 34–36]. Dunbar et al. , in their study of the HADS, adjusted the CFA model to allow item 7 to also load on the depression factor. It was suggested that this crossloading may be due to the fact that the item taps the loss of a pleasurable state (that is, 'being at ease'), consistent with the other depression items tapping anhedonia (loss of pleasure).
In further considering the content of this item it is not surprising that this item may behave 'inappropriately', given the nature of the musculoskeletal disorders experienced by patients in this sample. For many patients with back injuries and chronic pain, sitting is not always comfortable and many would not 'feel at ease'. This is not necessarily due to a psychological disturbance (anxiety), but instead is likely to be due to physical factors.
Given the clearly inappropriate loadings noted in EFA it was decided to remove item 7 from the scale in the subsequent CFA analyses. We did not feel there were sufficient theoretical, conceptual or clinical grounds to support the inclusion of item 7 with the depression items. It was considered inappropriate to rely solely on statistical evidence in this study to reassign the item, particularly given its inconsistent behaviour reported in the literature. By not including item 7 with the depression items, the Depression subscale remains consistent with that recommended by the original authors, and in the format used by the majority of previous researchers and clinicians.
The 13-item two-factor CFA (excluding item 7) indicated that the revised model was a good fit to the data, with 7 items representing depression and 6 items representing anxiety. A one-factor general psychological distress model was also examined to test proposals put forward by some authors concerning the use of the HADS as a unidimensional scale [10, 11]. The one factor model however, did not display good fit to the data.
The two-factor solution obtained in this study contributes to the growing body of papers investigating the factor structure of the HADS, as reviewed by Bjelland et al. . The consistent correlation between the two subscales in this study (r = .48) indicates that the overlap between the two factors could be inherent in the nature of these dimensions. Roberts et al.  describe this as a "somewhat 'muddy' area in the middle where symptoms common to both syndromes overlap" (p 380).
In this study Clark and Watson's  tripartite model was not supported by EFA but was tested for comparative purposes using CFA. The three factor model specified by Dunbar et al.  was tested, and although it showed adequate model fit, the fit statistics were not as good as those recorded for the 13-item two factor model with item 7 removed. It is questionable whether the HADS would be an appropriate place to fully test a tripartite model, due to the small item pool, the emphasis of anhedonia items in the depression subscale, and the lack of somatic items. The clinical utility of a three subscale structure of the HADS is also questionable, an issue raised by Rodgers and colleagues . The separation of negative affectivity, autonomic anxiety and anhedonic depression, of interest theoretically, is of little use to clinicians wishing to use the HADS to quickly and simply screen their patients for elevated levels of anxiety and depression.
The results of this current study suggest that modifications to the original structure of the HADS  are necessary when using the scale in a sample of musculoskeletal patients. Item 7 should not be included in the calculation of the HADS Anxiety subscale scores. The Depression subscale however remains consistent with the original scale design and can be used with the cut points recommended by the scale authors . Further research will be necessary to establish new cut-points for the revised 6-item anxiety subscale by validating it against a structured clinical interview.
The high levels of anxiety and depression detected in the patients in this study suggest that screening for psychological comorbidity is important in musculoskeletal rehabilitation settings. It is necessary, however, for clinicians, who are considering using the HADS as a screening tool, to first assess its suitability with their particular patient group. Although EFA and CFA supported the presence of two subscales representing anxiety and depression, the results with this musculoskeletal sample suggest that item 7 should be removed from the anxiety subscale.
We wish to acknowledge the staff of Cedar Court HealthSouth Rehabilitation Hospital for permission to use this data.
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