- Open Access
Health-related quality of life among older adults with arthritis
© Dominick et al; licensee BioMed Central Ltd. 2004
- Received: 06 November 2003
- Accepted: 13 January 2004
- Published: 13 January 2004
Health-related quality of life (HRQOL) is a key outcome in arthritis, but few population-based studies have examined the relationship of specific arthritic conditions, such as osteoarthritis (OA) and rheumatoid arthritis (RA) with HRQOL.
Older adults in Pennsylvania completed a mail version of the Centers for Disease Control and Prevention (CDC) HRQOL modules. Medicare data were used to identify subjects with OA, RA, and no arthritis diagnosis. We compared HRQOL responses among these groups, and we also examined relationships of demographic characteristics to HRQOL among subjects with arthritis.
In analyses controlling for demographic characteristics and comorbidity, subjects with OA and RA had poorer scores than those without arthritis on all HRQOL items, including general health, physical health, mental health, activity limitation, pain, sleep, and feeling healthy and full of energy. HRQOL scores were also lower for those with RA compared to OA. Among individuals with arthritis, all subject characteristics (including age, race, sex, nursing home residence, marital status, income, and comorbid illnesses) were significantly related to at least one HRQOL item. Older age, nursing home residence, and greater comorbidity were the most consistently associated with poorer HRQOL.
Results of this study show that both OA and RA have a significant impact on multiple dimensions of HRQOL among older adults. Results also suggest the CDC HRQOL items are suitable for use among older adults and in mail surveys. Due to the rising number of older adults in many countries, the public health burden of arthritis is expected to increase dramatically. Efforts are needed to enhance access to medical care and disseminate self-management interventions for arthritis.
- Rheumatoid Arthritis
- Behavioral Risk Factor Surveillance System
- Rheumatoid Arthritis Group
- Poor HRQOL
- Poor General Health
Arthritis is one of the most common chronic diseases and a leading cause of disability in the United States (U.S.), and other developed countries [1–8]. In the U.S., 55% of individuals age 65 and older report having arthritis or chronic joint symptoms . Due to the increasing number of older adults in many countries, the prevalence of arthritis is expected to rise dramatically [1, 8, 10–13]. In the U.S., it is estimated that the prevalence of arthritis will rise from 43 million in 1997 to 60 million in 2020 [12, 13]. In Canada, it is projected that the prevalence of arthritis will increase from 2.9 million to 6.5 million between 1991 and 2031 . These estimates portend a mounting public health burden.
Because of this growing epidemic, it is important to understand and monitor the impact of arthritis on health outcomes. One health outcome of primary interest within the context of arthritis is health-related quality of life (HRQOL). Arthritis can affect a variety of physical and psychological health domains, and HRQOL measures provide a broad picture of this impact. Therefore HRQOL is now a standard, widely accepted measure in both clinical trials and observational studies. A number of large population- and community-based studies have examined the effects of arthritis on disability and physical function [14–19], but few have assessed overall HRQOL [20–22]. One challenge to population-based assessment of HRQOL is that the length of most traditional measures makes widespread distribution (via telephone or mail) cumbersome. However, the Centers for Disease Control and Prevention (CDC) has developed a brief set of HRQOL items that are now used routinely in the U.S. Behavioral Risk Factor Surveillance System (BRFSS) and other national surveys . Analyses of BRFSS data have shown that individuals with self-reported arthritis or chronic joint symptoms have poorer HRQOL than those without arthritis [20, 24]. These HRQOL items have also been shown to perform well in a clinical population of individuals with rheumatic diseases.
In this study, we used the CDC measure to examine the relationship of HRQOL with osteoarthritis (OA) and rheumatoid arthritis (RA) among a statewide sample of older adults. We also examined the relationship of demographic characteristics with HRQOL among older adults with OA and RA. This study adds to previous findings in several important ways. First, this study compared HRQOL scores among a large sample of individuals with physician diagnoses of specific diseases (OA and RA) to individuals without these diagnoses. Previous studies of HRQOL and arthritis have either relied on self reported diagnosis [20–22, 24] or have not included a group of individuals without rheumatic disease . Second, this study specifically involved older adults. Since older adults are the demographic group most commonly affected by arthritis, it is important to understand how OA and RA influence HRQOL in this population. Third, this study tested the feasibility of large-scale mail administration of the CDC HRQOL items, which are most commonly administered via phone. Fourth, this study involved linkage of HRQOL survey data with diagnosis codes from administrative medical databases. This methodology can be used by health care systems and government organizations to examine HRQOL in large samples of individuals with other chronic diseases.
All subjects were enrolled in Pennsylvania's Pharmaceutical Assistance Contract for the Elderly (PACE). PACE is a state program that helps to pay for prescription medications for Pennsylvanians age 65 and older whose annual income does not exceed $17,200 if married or $14,000 if single. During 1997, HRQOL surveys were included with PACE applications mailed to cardholders who were scheduled to renew their coverage. Among the 161,851 individuals who reapplied for coverage, 84,065 returned completed surveys. Due to complications in survey processing during April, surveys were not sent out with all PACE renewal applications during this month. Therefore, individuals scheduled to reapply for PACE benefits during April were excluded when calculating a survey response rate. Out of the 144,819 individuals who reapplied for PACE benefits in months other than April, 83,471 returned surveys, resulting in a 57.6 % response rate. Respondents and non-respondents were similar with respect to demographic characteristics including age, gender, race, residential status, marital status, and annual income.
Arthritis diagnoses for the current study were based on Medicare Part B (Physician/Supplier) claims occurring within one year prior to subjects' survey completion. Only subjects with complete Medicare Part B data for the year prior to survey completion were eligible for this study. Approximately 49% of survey respondents were excluded because they were either not Medicare eligible for the full year prior to survey completion or were members of a health maintenance organization (HMO) that processed their Medicare claims. This resulted in a final study sample of 41,467. HMO enrollment was a considerable source of ineligibility. For example, approximately 24% of survey respondents were enrolled in an HMO for at least one month of 1997. Subjects with complete Medicare data were similar to subjects excluded due to incomplete Medicare data with regard to age, race, income, and residential subjects. However, subjects with complete Medicare data were more likely to be male (23.6% vs. 20.5%, p < 0.001) and were less likely to be married and living with their spouse (16.9% vs. 4.4%, p < 0.001).
OA and RA were identified on the basis of International Classification of Diseases, Version 9 (ICD-9) codes (715 and 714, respectively) from both principal and secondary diagnosis fields within Medicare Physician/Supplier data files. Individuals were placed into three categories: no arthritis diagnosis, OA diagnosis, and RA diagnosis. Approximately 1% of individuals in sample had ICD-9 codes for both OA and RA during the year prior to survey completion. HRQOL scores of individuals with both OA and RA were similar to those for individuals with an RA diagnosis code only. Because of the small sample size of this group, they were combined with individuals with an RA diagnosis code only.
Demographic Factors and Comorbidity
Demographic characteristics included in these analyses were age, gender, annual income (treated as a continuous variable), marital status (married and living with spouse vs. other), residential status (nursing home vs. community dwelling), and race. The sample was predominantly (94%) white, with small proportions of other racial/ethnic groups (5% African American, and <1% of each of the following groups: Asian, Hispanic, Indian, and other – not otherwise described). Therefore we examined race as a dichotomous variable – white and non-white. All demographic factors were obtained from the PACE Enrollment History File. Comorbidity was assessed via the Charlson Comorbidity Score, which uses ICD-9 codes to identify specific diseases [26, 27]. The Charlson Score gives greater weight to mores severe illnesses. For this study, subjects' outpatient visits (Medicare Part B) occurring within one year prior to participants' survey completion date were used to derive the Charlson Score. The Charlson Score was treated as a continuous variable in all analyses.
HRQOL was assessed via a mail version of the CDC's Core and Optional HRQOL Modules. In this study, we examined nine items from the CDC HRQOL measure (Appendix A; See Additional File 1). These HRQOL items have been shown to be internally consistent and to identify unmet health-related needs, health disparities, and health behaviors [23, 28–30]. Four of these items (numbers 1–4 in Appendix A) are part of the Core HRQOL module, which is administered to all BRFSS participants. The five remaining questions are part of a 10-item Optional Module that measures more detailed aspects of HRQOL. We selected these additional five items because of their relevance to arthritis. For the general health item (number 1 in Appendix A), we grouped responses into two categories: excellent, very good, or good health compared to fair or poor health. Two additional items, presence of a health-related activity limitation (number 8 in Appendix A) and needing help with personal care (number 9 in Appendix A), were treated as binary (yes/no) variables. The remainder of the HRQOL items were treated as continuous variables, with a minimum score of 0 days and a maximum score of 30 days.
First, we examined relationships of arthritis diagnoses to each HRQOL item. We used Analysis of covariance (ANCOVA) models to compare continuous HRQOL items among subjects with no arthritis, OA diagnosis, and RA diagnosis, while controlling for covariates listed above. Similarly, we used logistic regression models (forward selection) to compare dichotomous HRQOL items across arthritis diagnosis groups, controlling for all covariates. Second, we examined relationships of demographic characteristics and comorbidity with HRQOL among subjects with OA and RA. For these analyses, we examined five representative HRQOL items, including the four Core CDC items and the pain item (because of its particular relevance to arthritis). We used logistic regression (forward selection) to examine relationships of subject characteristics with the dichotomous general health variable, and we used ANCOVA models to examine the four continuous HRQOL items. Statistical significance was set at p < 0.05 for all analyses, which were performed using Statistical Analysis System (SAS) version 8.0.
Demographic Characteristics of Sample
All Subjects (N = 41,467)
No Arthritis Diagnosis (N = 30,544)
Arthritis Diagnosis (N = 10,923)
Mean Age (SD)
Mean (SD) Annual Income
Mean (SD) Charlson Comorbidity Score
Mean HRQOL Responses According to Arthritis Diagnosis
"Not Good" Physical Health a
"Not Good" Mental Healthb
Feeling Very Healthya
Categorical HRQOL Responses According to Arthritis Diagnosis
Fair or Poor General Healtha
Any Health-Related Activity Limitationa
Need Help with Personal Careb
OR (95% CI)
OR (95% CI)
OR (95% CI)
Relationship of Subject Characteristics to HRQOL among Those with Arthritis
Fair or Poor General Health
Days of "Not Good" Physical Health
Days of "Not Good" Mental Healthb
Days of Activity Limitationa
Days of Paina
OR (95% CI)
In agreement with prior research [20, 22, 24, 31], results of this study show that arthritis has a significant impact on multiple dimensions of HRQOL. Specifically, older adults with OA and RA reported poorer general health, physical health, mental health, and sleep, as well as more activity limitation and pain, compared to those without arthritis. These results also confirm that arthritis differentially impacts specific aspects of HRQOL. Not surprisingly, pain showed the largest difference between subjects with arthritis and without arthritis. Although the sleep and mental health items showed statistically significant differences across groups, the magnitude of these differences was small (1–2 days) and of questionable clinical relevance. Mili et al. reported a similar difference in "not good" mental health days between subjects without arthritis and those reporting doctor-diagnosed arthritis in the BRFSS sample . Yet studies using other measures have shown that depression is a substantial problem among individuals with arthritis particularly RA .
Subjects with OA and RA in this sample had considerably poorer HRQOL than individuals in the BRFSS sample who were ≥ 65 years of age and reported having arthritis . For example, 40% of the BRFSS sample reported fair or poor general health, compared with 55% of subjects with OA and 66% of subjects with RA in our sample. In the BRFSS group, the mean number of days of activity limitation was 3.5, compared with 10 days in our OA group and 13 days in our RA group. These differences may be partially due to the definitions of arthritis used in these two studies. In the BRFSS study, the arthritis sample was defined as those reporting either the presence of chronic joint symptoms or a doctor's diagnosis of arthritis. The present study used ICD-9 codes from medical records, so all patients were under physician care for OA. Since all participants in the BRFSS sample did not report having a doctor's diagnosis, this may have been a sample with a lower average level of OA severity than our sample. However, demographic and health characteristics of the samples may also be related to the observed differences. Even among those without arthritis, HRQOL was poorer in the current study compared to the BRFSS sample. Our sample consisted of older adults with fairly low income levels, and they may been in generally poorer health than those in the BRFSS. It is significant that even in our sample of older adults with relatively low income and multiple comorbid illnesses, a diagnosis of arthritis was associated with poorer HRQOL. This suggests an important independent impact of arthritis on HRQOL among older adults.
Also in agreement with prior studies [21, 22, 25], this study revealed poorer HRQOL among individuals with RA compared to OA. Individuals with RA had poorer scores than those with OA on all HRQOL items, though this difference was not statistically significant for days of "not good" mental health. In general, RA is associated with greater disability than OA, though individuals with more severe OA and widespread pain may have comparable impairment . Although HRQOL may be lower for individuals with RA than OA, this study shows that OA also has a significant impact on HRQOL. Furthermore, the high prevalence of OA makes this a considerable public health concern.
Among subjects with OA and RA in this sample, we found that HRQOL differed according to demographic characteristics and comorbidity. These associations were largely in the expected direction and similar to other research [24, 33], with older age, non-white race, nursing home residence, lower income, and greater comorbidity being associated with poorer scores on at least one HRQOL item. In contrast to other research , men in this sample reported a greater number of days of "not good" physical and mental health compared with women. The reason for this association is not clear, but men in this sample may have had greater arthritis severity or overall poorer health (which was not captured adequately by the Charlson Comorbidity Score) compared to women.
This study also confirmed the utility of the CDC's HRQOL items for mail distribution and among older adults. This scale differentiated between individuals with arthritis and without arthritis, and it also detected differences between those with OA and RA. Because the CDC HRQOL Modules are brief and easy to administer by telephone or mail, they are particularly useful for large-scale epidemiological studies.
There are several limitations so this study. Compared to the general U.S. elderly population, PACE enrollees are older and have a lower annual income. PACE enrollees also include a greater proportion of females, a smaller percentage of minorities, and a smaller proportion of married individuals. This sample was also restricted to subjects with complete Medicare data during the observation period. These individuals were also less likely to be married than subjects who were excluded because of incomplete Medicare data. These sample characteristics may limit generalizability, and additional studies are needed among different samples of older adults. Because of the very small numbers (<20) in some racial/ethnic groups, it was not possible to examine differences across specific groups. We used a broad race categorization (white vs. non-white) that may have masked differences in some specific racial/ethnic groups, and further study is needed on more racially diverse samples.
Another limitation concerns the specificity of ICD-9 codes for OA. Studies have reported the sensitivity of ICD-9 codes for OA to be between 0.32 and 1.0, and the positive predictive value between 0.76 and 0.90 [34, 35]. Sensitivity and positive predictive value are both greater when codes are used to identify OA in general (as was done in this study), rather than site-specific OA. Because of these known issues regarding ICD-9 code accuracy, there may have been some misclassification in this study. However, there are also inaccuracies associated with self-reported diagnosis of arthritis, and radiographic evidence is not feasible for samples of this size.
A limitation of all survey studies is the potential for non-response bias. The response rate for this survey was similar to the average response rate in other published studies involving mail surveys . Non-respondents were similar to respondents on a variety of demographic characteristics. Though this survey was brief (16 questions), older adults with poorer health or greater functional limitation may have been less likely to complete the survey. Therefore this sample may under-represent older adults with poorer health and possibly greater arthritis severity.
In summary, this study revealed a substantial impact of OA and RA on HRQOL, as measured by the CDC items. Both pharmacological and non-pharmacological treatments can yield improvements in arthritis symptoms and HRQOL . However, both medical treatment and non-pharmacological interventions are underutilized [38–40], and some evidence suggests that medications are often prescribed at doses that may be too low to optimally affect symptoms . Efforts are needed to enhance access to medical care for OA, ensure optimal pharmacological management, and disseminate self-management interventions.
The authors would like to thank PACE and PHC4 for providing the data used in this study. This research was funded by a cooperative agreement (TS213) from the Centers for Disease Control and the Association of Teachers of Preventive Medicine. This research was also supported in part by the Department of Veterans Affairs, Veterans Health Administration, HSR&D Service, Program 824 Funds to the first author. The views expressed in this paper are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
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