Assessment of quality of life of the children and parents affected by inborn errors of metabolism with restricted diet: preliminary results of a cross-sectional study
© Fabre et al.; licensee BioMed Central Ltd. 2013
Received: 4 June 2013
Accepted: 11 September 2013
Published: 19 September 2013
The development in therapeutic strategies has increased survival of children affected by inborn errors of metabolism with restricted diet (IEMRD). These diseases have mild- and long-term consequences on the health. Little is known about the impact on the quality of life (QoL) of children and their families. The aims of this study were: to compare the QoL of the children and parents affected by IEMRD with the QoL of the general population and one pathology associated with long-term consequences.
Patients and methods
This cross-sectional study was performed at the French Reference Center for inborn metabolic disorders (Marseille, France). Inclusion criteria were: a child with a diagnosis of organic aciduria, urea cycle defect, or maple syrups urine disease (MSUD). Socio-demographics, clinical data, and QoL were recorded.
Twenty-one of 32 eligible families were included during a planned routine visit. Ten (47%, 95% CI 27-69%) children were affected by organic aciduria, six (29%, 95% CI 10-48%) by urea cycle defects, and five (24%, 95% CI 6-42%) by MSUD. Among the younger children, the general well-being was significantly lower in the children with IEMRD than in the leukemia children (58 ± 16 versus 76 ± 15, p = 0.012), and among the older children, the leisure activities were significantly lower in the children with IEMRD than in the leukemia children (29 ± 18 versus 62 ± 22, p < 10-3), while the relationships with teachers were better (76 ± 23 versus 60 ± 23, p = 0.01). The physical QoL score was lower in the parents than in the French norms (66 ± 21 versus 75 ± 1, p = 0.05). Factors modulating QoL were: eating and neurologic disorders, enteral nutrition, and feeding modalities.
The children and the parents of children affected presented altered ‘physical’ and ‘social’ QoL scores compared with the norms and patients with leukemia and their families. Future studies based on larger cohort studies should determine the different weights of potential predictive factors of QoL.
Inborn errors of metabolism (IEM) are a heterogeneous group of genetic diseases that affect metabolic pathways . In this group, certain diseases require diets that include a restrictive lifelong regime when the patient has a stable clinical status and a specific emergency regime when the patient has an unstable clinical status. IEM caused by a deficiency in the activity of an enzyme that is responsible for the catabolism of amino acids or for the urea cycle constitute a group that requires a protein-restricted diet , known as IEM with restricted diet (IEMRD). The rapid development of diagnostic and therapeutic possibilities has increased survival and defined IEMRD as chronic illnesses .
However, the disease and its treatment have both physical and psychological effects on children and their families: poor growth due to the prolonged restricted diet [4–6], motor disorders [6–8], hepatic disorders [4, 9], renal disorders [4, 6, 10], and neurocognitive disorders [6, 8, 11, 12]. Mild- and long-term consequences of the diseases lead to an interest in assessing quality of life (QoL) and in clinical follow-up for surviving children [13–23].
Among the studies exploring the QoL of IEMRD patients, certain limitations should be mentioned, related to the evaluation of heterogeneous samples in terms of the nature of diseases, the assessment methods, and the treatment modalities. No studies connected children’s and parents’ QoL, and no data related to QoL determinants were available. In this work, we explored the QoL of children affected by three IEMRD conditions that needed the same treatment strategy, combining a long-term hypoproteic diet and an emergency diet in case of metabolic decompensation (due to stress, anesthesia, or infection): organic aciduria, a urea cycle defect, and MSUD. The objectives of our study were i) to compare the QoL levels of the children and parents affected by these three IEMRD conditions with the levels observed in the general population and in another pathology associated with long-term consequences (childhood leukemia survivors), ii) to assess the potential factors modulating the QoL of children and parents, and iii) to assess the relationship between the children’s and parents’ QoL scores.
Materials and methods
Study design and population
This study incorporated a cross-sectional design and was performed at the Reference Center for inborn metabolic disorders of a French public teaching hospital (La Timone, Marseille, France).
The inclusion criteria were as follows: a child with a diagnosis of one of three IEMRD conditions (organic aciduria, urea cycle defect, or MSUD), born between 1993 and 2010, with parents or legal guardians authorizing participation in the study. A medical database allowed the identification of eligible children according to the selection criteria. The study was proposed to consecutive parents and/or patients during a planned routine visit.
According to the French law (Article L1121-1, Law n°2011-2012 29 december 2011 - art. 5), ethical approval is not needed for researches in which all actions are performed and products used routinely. This study was conducted in accordance with the Declaration of Helsinki and French Good Clinical Practices. Consent was collected for each eligible family.
From the medical records, the following data were collected: 1. sociodemographic: age and gender of the child; 2. clinical: nature of IEMRD (organic aciduria, urea cycle defect, or MSUD), feeding modalities at inclusion (exclusively oral, home enteral nutrition), eating disorders at inclusion (presence or absence), current gastrostomy, and previous enteral nutrition; and 3. current clinical complications: neurologic (motor, sensory, or cognitive impairment), renal (based on creatine clearance level), cardiac (based on echocardiography), hepatic (biological markers), and protein-related (based on actual protein intake rate).
Evaluation of QoL
The QoL of the children and adolescents was assessed using the Vécu et Santé Perçue de l’Adolescent et de l’Enfant (VSP-A) questionnaire [24–27]. Two child versions were available: the VSP-Ae, designed to be answered by children aged from 8 to 10 years, and the VSP-A, designed to be answered by adolescents aged from 11 to 17 years. One parent version is available: the VSP-Ap, designed to be answered by the parents of children or adolescents of all ages. The 38-item child version (VSP-Ae), described eight dimensions and an index: relations with parents/family (RFa), body image (BI), vitality (VIT), relations with friends (RFr), general well-being (GWB), leisure activities (LEI), school performance (SCH), and relations with medical staff (RMS). The 39-item adolescent version (VSP-A), described 10 dimensions and an index: relations with parents/family (RFa), body image (BI), vitality (VIT), relations with friends (RFr), psychological well-being (PsWB), physical well-being (PhWB), leisure activities (LEI), school performance (SCH), relations with teachers (RT), and relations with medical staff (RMS). The 37-item parent version (VSP-Ap), described 10 dimensions and an index: relations with parents (Rpa), body image (BI), vitality (VIT), relations with friends (RFr), leisure activities (LEI), psychological well-being (PsWB), physical well-being (PhWB), school performance (SCH); relations with teachers (RT), and relations with medical staff (RMS). All scores range between 0 and 100, with higher scores indicating a better QoL. French norms are available . The scores of childhood leukemia survivors are also available (from the LEA cohort) . These data are the property of one of the author (PA) and their use needs no special permission.
The QoL of the parents was assessed using the French version of the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire, which is a generic questionnaire used worldwide [30, 31] that describes four domains: physical health, psychological health, social relationships, and environment. French norms are available only for three domains .
Continuous variables were expressed as the means and standard deviations and the medians and ranges. Qualitative variables were expressed as percentages. Nonparametric statistics were employed. The VSP-A scores were compared with the scores obtained from a sample of childhood leukemia survivors  and from French controls from a normative sample of 1060 subjects . The WHOQOL-BREF scores of the parents were compared with the scores obtained from French controls from a normative sample of 16000 subjects . Comparisons of mean QoL scores between different subgroups (gender of the child, nature of the IEMRD, feeding modality, eating disorders, other clinical disorders, previous or current enteral nutrition, and current gastrostomy) were performed using Mann–Whitney tests. Correlations between children’s QoL scores and parents’ QoL scores were tested using paired Student’s t-tests. The statistical analyses were performed using the SPSS software package, version 17.0 (SPSS Inc., Chicago, IL, USA). All tests were two-sided. Statistical significance was defined as p < 0.05.
N = 21
Mean ± SD
8.25 ± 5.60
Nature of IEMRD
Urea cycle defect
Feeding modality at inclusion
Oral and gastrostomy
Eating disorders at inclusion
Neurologic disorder at inclusion
Renal/cardiac/hepatic disorders at inclusion
Mean ± SD
1.07 ± 0.32
Natural protein (Gr/kg/j)
Mean ± SD
0.67 ± 0.29
N = 21
Mean ± SD
39.14 ± 6.64
QoL of IEMRD sample compared with general population and leukemia
QoL of children and adolescents
- QoL of children from self-report
- QoL of children from parents’ reports
QoL of parents
Factors modulating QoL of children with IEMRD and their parents
The results for the factors modulating the QoL of the children with IEMRD are provided in Additional file 1. The children affected by urea cycle defects had lower scores than children affected by the other two IEMRD conditions, especially for the relationships with family and body image dimensions. The vitality score was lower for the children presenting with eating and neurologic disorders. The score for psychological well-being was higher for the children who reported receiving enteral nutrition in the past. The index was not impacted by the various sociodemographic and clinical parameters.
The results for the factors modulating the QoL of the parents of children with IEMRD are shown in Additional file 2. The WHOQOL scores did not differ according to the sex of the child, nature of the IEMRD, feeding modality at inclusion, or eating disorders. The parents of children affected by neurologic disorders reported significantly altered social relationships. The parents of children with a current gastrostomy reported higher scores for two dimensions: physical health and social relationships.
Relationships between QoL assessments of parents and children
The results of the VSP-Ap (children’s QoL assessed by the parents) and VSP-A/VSP-Ae (children’s QoL assessed by the children themselves) only differed for the vitality score, which was lower in the parents’ assessment (Additional file 3).
An understanding of the impact of pediatric chronic illnesses on QoL is important for the health care workers who manage the relevant populations. We present one of the first studies to specifically assess children with IEMRD who are at risk of acute decompensation and their parents. Consistent with previous studies, our findings confirm that IEMRD impact the QoL of both parents and children affected by IEMRD [20, 33, 34]. One publication explored the QoL of children with maple syrup urine disease (MSUD), showing altered QoL scores compared with controls and similar QoL scores as children with cancer . Among the studies exploring the QoL of the parents, lower scores were found than for the parents of children affected by other chronic illnesses, such as sickle cell disease or Down syndrome, or for controls [20, 23, 34].
However, our results show that the ‘physical-like’ aspects of QoL are more impacted than the ‘psychological-like’ aspects, both for parents and for children. Indeed, the parents of these children reported lower scores on the physical dimension of the WHOQOL than the controls, and the children reported lower ‘physical’ scores than leukemia survivors. One explanation is the well-known phenomena of coping strategies and adjustment developed by patients and/or families . Relations with friends and leisure activities were also defined by the children as affected domains. We hypothesize that the dietary regime constraints are partly responsible for these affects, as shown in the comment that food preparation with minute weighting and logistics are problematic. Even if a parent stated always being prepared for potential decompensation, he or she also asserted that it can be hard to prepare for leisure and holidays. The limited diet was a complaint shared by the parents and the children. Alimentation plays a large cultural role; for example, parents complained that certain aliment cannot be shared, as these limitations are without exception. Moreover, in certain cases, it was noted that there are few pleasures in consuming food. These limits remain constant; indeed, in one study of approximately eight adults affected with MSUD and their parents, the dietary constraint was one of the major themes .
In contrast, the children reported better relationships with medical staff than did the leukemia survivors. In comparison with other chronic illnesses, such as cancer, IEMRD has specific features. The disease is lifelong, as opposed to cancer, for which the conventional treatment does not cure the disease. There is the lifelong strain of dietary management. Families and children face ongoing metabolic decompensation and a risk of death with decompensation and regularly visit hospitals and physicians throughout childhood. For all of the above reasons, we hypothesize that the parents and their children have faith in and rely on medical staff. Other authors did not report this phenomenon , which can be explained by the specifics of the health care system. The French free health care system most likely allows parents to not be worried by financial problems.
Interestingly, the presence of gastrostomy can have certain ‘protective effects’ on the self-reported QoL of parents, notably in the physical health and social relationship domains. A similar effect was previously shown , for children with inherited metabolic diseases  and cerebral palsy [37, 38]. Many explanations should be discussed. First, in case of enteral nutrition, gastrostomy removes the necessity of an enteral feeding tube, which is more apparent and less stable. Moreover, gastrostomy can be easily used in cases of difficulties in eating. Second, it has been previously reported that gastrostomy can decrease parents’ stress [34, 39]. Gastrostomy did not have an influence on children’s QoL, as found for children with cerebral palsy . In our cohort, the patients with urea cycle defects seemed to have a lower QoL, as reported by their parents. The influence of the nature of IEM was not explored in the previous studies . This finding could be related to the more severe natural course of the urea cycle defects, but we cannot exclude the effect of the size of the study population.
Moderate associations were possibly missed because of low statistical power due to the sample size, which was arguably too small. The sample size did not allow a multivariate approach that takes into account the potential confounding factors. A larger sample will allow the confirmation of these findings.
Cross-sectional studies examine individuals with heterogeneous disease durations. Longitudinal studies provide more valid information and are necessary to more accurately determine the weights of potential predictive factors of QoL. Future studies based on cohort studies should provide more robust findings, particularly regarding the childhood/adulthood transition, and should propose appropriate treatment strategies.
The children and the parents of children affected with organic aciduria, urea cycle defects, or MSUD presented altered ‘physical’ and ‘social’ QoL scores compared with the norms and patients with leukemia and their families. Future studies based on larger cohort studies should provide supplementary findings to validate these preliminary results and determine the different weights of potential predictive factors of QoL, allowing the adaptation of appropriate care strategies for children and their caregivers. Gastrostomy, when required, can provide a degree of help to the parents.
The authors are grateful to all the patients and parents for their participation in the study. The authors thank Marie-Claude Simeoni for her expertise related to QoL questionnaires of children, Jessica Fernandez for the contribution for the statistical analyses, the French Society of inborn error of metabolism (Société Française pour l’Etude des Erreurs Innées du Métabolisme, SFEIM), the French Group of Reference Centers for inborn metabolic disorders (Groupement des centres de référence et de compétence des Maladies héréditaires du Métabolisme, GMM).
This work was supported by institutional grants from the French 2009 Institut de Recherche en Santé Publique (Concepts, Usages et Déterminants en Qualité de Vie, CUD-QV).
- Saudubray JM, Sedel F: Classification et circonstance de découverte des maladies héréditaires du métabolisme. In Progrés en pédiatrie- Maladies métaboliques Héréditaires Edited by: Chabrol B, De Lonlay P. 2011, 1–10.Google Scholar
- de Baulny HO, Benoist JF, Rigal O, Touati G, Rabier D, Saudubray JM: Methylmalonic and propionic acidaemias: management and outcome. J Inherit Metab Dis 2005,28(3):415–423. 10.1007/s10545-005-7056-1PubMedView ArticleGoogle Scholar
- Cederbaum S, Lemons C, Batshaw ML: Alternative pathway or diversion therapy for urea cycle disorders now and in the future. Mol Genet Metab 2010,100(3):219–220. 10.1016/j.ymgme.2010.04.008PubMedView ArticleGoogle Scholar
- Rake JP, Visser G, Labrune P, Leonard JV, Ullrich K, Smit GP: Guidelines for management of glycogen storage disease type I - European Study on glycogen storage disease type I (ESGSD I). Eur J Pediatr 2002,161(Suppl 1):S112-S119.PubMedView ArticleGoogle Scholar
- Acosta PB, Yannicelli S, Ryan AS, Arnold G, Marriage BJ, Plewinska M, Bernstein L, Fox J, Lewis V, Miller M, et al.: Nutritional therapy improves growth and protein status of children with a urea cycle enzyme defect. Mol Genet Metab 2005,86(4):448–455. 10.1016/j.ymgme.2005.08.012PubMedView ArticleGoogle Scholar
- Horster F, Baumgartner MR, Viardot C, Suormala T, Burgard P, Fowler B, Hoffmann GF, Garbade SF, Kolker S, Baumgartner ER: Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB). Pediatr Res 2007,62(2):225–230. 10.1203/PDR.0b013e3180a0325fPubMedView ArticleGoogle Scholar
- Waggoner DD, Buist NR, Donnell GN: Long-term prognosis in galactosaemia: results of a survey of 350 cases. J Inherit Metab Dis 1990,13(6):802–818. 10.1007/BF01800204PubMedView ArticleGoogle Scholar
- le Roux C, Murphy E, Hallam P, Lilburn M, Orlowska D, Lee P: Neuropsychometric outcome predictors for adults with maple syrup urine disease. J Inherit Metab Dis 2006,29(1):201–202. 10.1007/s10545-006-0223-1PubMedView ArticleGoogle Scholar
- Masurel-Paulet A, Poggi-Bach J, Rolland MO, Bernard O, Guffon N, Dobbelaere D, Sarles J, de Baulny HO, Touati G: NTBC treatment in tyrosinaemia type I: long-term outcome in French patients. J Inherit Metab Dis 2008,31(1):81–87. 10.1007/s10545-008-0793-1PubMedView ArticleGoogle Scholar
- Cosson MA, Benoist JF, Touati G, Dechaux M, Royer N, Grandin L, Jais JP, Boddaert N, Barbier V, Desguerre I, et al.: Long-term outcome in methylmalonic aciduria: a series of 30 French patients. Mol Genet Metab 2009,97(3):172–178. 10.1016/j.ymgme.2009.03.006PubMedView ArticleGoogle Scholar
- Bachmann C: Long-term outcome of patients with urea cycle disorders and the question of neonatal screening. Eur J Pediatr 2003,162(Suppl 1):S29-S33.PubMedView ArticleGoogle Scholar
- Kyllerman M, Skjeldal O, Christensen E, Hagberg G, Holme E, Lonnquist T, Skov L, Rotwelt T, von Dobeln U: Long-term follow-up, neurological outcome and survival rate in 28 Nordic patients with glutaric aciduria type 1. Eur J Paediatr Neurol 2004,8(3):121–129. 10.1016/j.ejpn.2003.12.007PubMedView ArticleGoogle Scholar
- Bosch AM, Grootenhuis MA, Bakker HD, Heijmans HS, Wijburg FA, Last BF: Living with classical galactosemia: health-related quality of life consequences. Pediatrics 2004,113(5):e423-e428. 10.1542/peds.113.5.e423PubMedView ArticleGoogle Scholar
- Bosch AM, Tybout W, van Spronsen FJ, de Valk HW, Wijburg FA, Grootenhuis MA: The course of life and quality of life of early and continuously treated Dutch patients with phenylketonuria. J Inherit Metab Dis 2007,30(1):29–34. 10.1007/s10545-006-0433-6PubMedView ArticleGoogle Scholar
- Bosch M, van der Weijden T, Grol R, Schers H, Akkermans R, Niessen L, Wensing M: Structured chronic primary care and health-related quality of life in chronic heart failure. BMC Health Serv Res 2009, 9: 104. 10.1186/1472-6963-9-104PubMed CentralPubMedView ArticleGoogle Scholar
- Cederbaum JA, LeMons C, Rosen M, Ahrens M, Vonachen S, Cederbaum SD: Psychosocial issues and coping strategies in families affected by urea cycle disorders. J Pediatr 2001,138(1 Suppl):S72-S80.PubMedView ArticleGoogle Scholar
- Lambert C, Boneh A: The impact of galactosaemia on quality of life–a pilot study. J Inherit Metab Dis 2004,27(5):601–608.PubMedView ArticleGoogle Scholar
- Packman W, Mehta I, Rafie S, Mehta J, Naldi M, Mooney KH: Young adults with MSUD and their transition to adulthood: psychosocial issues. J Genet Couns 2012,21(5):692–703. 10.1007/s10897-012-9490-1PubMedView ArticleGoogle Scholar
- Gassio R, Campistol J, Vilaseca MA, Lambruschini N, Cambra FJ, Fuste E: Do adult patients with phenylketonuria improve their quality of life after introduction/resumption of a phenylalanine-restricted diet? Acta Paediatr 2003,92(12):1474–1478. 10.1111/j.1651-2227.2003.tb00834.xPubMedView ArticleGoogle Scholar
- Hatzmann J, Heymans HS, Ferrer-i-Carbonell A, van Praag BM, Grootenhuis MA: Hidden consequences of success in pediatrics: parental health-related quality of life–results from the care project. Pediatrics 2008,122(5):e1030-e1038. 10.1542/peds.2008-0582PubMedView ArticleGoogle Scholar
- Landolt MA, Nuoffer JM, Steinmann B, Superti-Furga A: Quality of life and psychologic adjustment in children and adolescents with early treated phenylketonuria can be normal. J Pediatr 2002,140(5):516–521. 10.1067/mpd.2002.123663PubMedView ArticleGoogle Scholar
- Simon E, Schwarz M, Roos J, Dragano N, Geraedts M, Siegrist J, Kamp G, Wendel U: Evaluation of quality of life and description of the sociodemographic state in adolescent and young adult patients with phenylketonuria (PKU). Health Qual Life Outcomes 2008, 6: 25. 10.1186/1477-7525-6-25PubMed CentralPubMedView ArticleGoogle Scholar
- Ten Hoedt AE, Maurice-Stam H, Boelen CC, Rubio-Gozalbo ME, Van Spronsen FJ, Wijburg FA, Bosch AM, Grootenhuis MA: Parenting a child with phenylketonuria or galactosemia: implications for health-related quality of life. J Inherit Metab Dis 2011,34(2):391–398. 10.1007/s10545-010-9267-3PubMed CentralPubMedView ArticleGoogle Scholar
- Simeoni MC, Auquier P, Antoniotti S, Sapin C, San Marco JL: Validation of a French health-related quality of life instrument for adolescents: the VSP-A. Qual Life Res 2000,9(4):393–403. 10.1023/A:1008957104322PubMedView ArticleGoogle Scholar
- Auquier P, Clément A, Sapin C, El Khammar M, San Marco JL, Siméoni MC: Development, validation of HRQL measurement in children: VSP-Ae. Qual Life Res 2001, 10: 268.Google Scholar
- Simeoni MC, Sapin C, Antoniotti S, Auquier P: Health-related quality of life reported by French adolescents: a predictive approach of health status? J Adolesc Health 2001,28(4):288–294. 10.1016/S1054-139X(00)00198-1PubMedView ArticleGoogle Scholar
- Sapin C, Simeoni MC, El Khammar M, Antoniotti S, Auquier P: Reliability and validity of the VSP-A, a health-related quality of life instrument for ill and healthy adolescents. J Adolesc Health 2005,36(4):327–336. 10.1016/j.jadohealth.2004.01.016PubMedView ArticleGoogle Scholar
- Ravens-Sieberer U, Auquier P, Erhart M, Gosch A, Rajmil L, Bruil J, Power M, Duer W, Cloetta B, Czemy L, et al.: The KIDSCREEN-27 quality of life measure for children and adolescents: psychometric results from a cross-cultural survey in 13 European countries. Qual Life Res 2007,16(8):1347–1356. 10.1007/s11136-007-9240-2PubMedView ArticleGoogle Scholar
- Michel G, Bordigoni P, Simeoni MC, Curtillet C, Hoxha S, Robitail S, Thuret I, Pall-Kondolff S, Chambost H, Orbicini D, et al.: Health status and quality of life in long-term survivors of childhood leukaemia: the impact of haematopoietic stem cell transplantation. Bone Marrow Transplant 2007,40(9):897–904. 10.1038/sj.bmt.1705821PubMedView ArticleGoogle Scholar
- Power M, Harper A, Bullinger M: The world health organization WHOQOL-100: tests of the universality of quality of life in 15 different cultural groups worldwide. Health Psychol 1999,18(5):495–505.PubMedView ArticleGoogle Scholar
- WHOQOL: Group: Development of the world health organization WHOQOL-BREF quality of life assessment. The WHOQOL group. Psychol Med 1998,28(3):551–558.View ArticleGoogle Scholar
- Baumann C, Erpelding ML, Regat S, Collin JF, Briancon S: The WHOQOL-BREF questionnaire: French adult population norms for the physical health, psychological health and social relationship dimensions. Rev Epidemiol Sante Publique 2010,58(1):33–39. 10.1016/j.respe.2009.10.009PubMedView ArticleGoogle Scholar
- Packman W, Henderson SL, Mehta I, Ronen R, Danner D, Chesterman B, Packman S: Psychosocial issues in families affected by maple syrup urine disease. J Genet Couns 2007,16(6):799–809. 10.1007/s10897-007-9114-3PubMedView ArticleGoogle Scholar
- Hatzmann J, Valstar MJ, Bosch AM, Wijburg FA, Heymans HS, Grootenhuis MA: Predicting health-related quality of life of parents of children with inherited metabolic diseases. Acta Paediatr 2009,98(7):1205–1210. 10.1111/j.1651-2227.2009.01269.xPubMedView ArticleGoogle Scholar
- Rapkin BD, Schwartz CE: Toward a theoretical model of quality-of-life appraisal: Implications of findings from studies of response shift. Health Qual Life Outcomes 2004,15(1):12.Google Scholar
- Avitsland TL, Kristensen C, Emblem R, Veenstra M, Mala T, Bjornland K: Percutaneous endoscopic gastrostomy in children: a safe technique with major symptom relief and high parental satisfaction. J Pediatr Gastroenterol Nutr 2006,43(5):624–628. 10.1097/01.mpg.0000229550.54455.63PubMedView ArticleGoogle Scholar
- Sullivan PB, Juszczak E, Bachlet AM, Thomas AG, Lambert B, Vernon-Roberts A, Grant HW, Eltumi M, Alder N, Jenkinson C: Impact of gastrostomy tube feeding on the quality of life of carers of children with cerebral palsy. Dev Med Child Neurol 2004,46(12):796–800.PubMedView ArticleGoogle Scholar
- Smith SW, Camfield C, Camfield P: Living with cerebral palsy and tube feeding: a population-based follow-up study. J Pediatr Gastroenterol Nutr 1999, 135: 307–310.Google Scholar
- Avitsland TL, Faugli A, Pripp AH, Malt UF, Bjornland K, Emblem R: Maternal psychological distress and parenting stress after gastrostomy placement in children. J Pediatr Gastroenterol Nutr 2012,55(5):562–566. 10.1097/MPG.0b013e31826078bdPubMedView ArticleGoogle Scholar
- Mahant S, Friedman JN, Connolly B, Goia C, Macarthur C: Tube feeding and quality of life in children with severe neurological impairment. Arch Dis Child 2009,94(9):668–673. 10.1136/adc.2008.149542PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.