A time trade-off study to determine health-state utilities of transplant recipients with refractory cytomegalovirus infection with or without resistance

Ahmed, Waqas; Longworth, Louise; Oluboyede, Yemi; Cain, Peter; Amorosi, Stacey L.; Hill, Sarah; Hirji, Ishan

doi:10.1186/s12955-024-02239-w

Table 4 Results from a linear regression analyses^a

From: A time trade-off study to determine health-state utilities of transplant recipients with refractory cytomegalovirus infection with or without resistance

	Health state	Background characteristic	Coefficient	SE	R²	95% CI
Clinical health states	CS-symptomatic CMV	Education level	0.053**	0.016	0.050	0.022, 0.084
	CS-symptomatic CMV	Completion time	− 0.061***	0.011		− 0.083, − 0.039
	CS-asymptomatic CMV	Education level	0.046**	0.014	0.019	0.018, 0.073
	CS-asymptomatic CMV	Completion time	− 0.026*	0.010		− 0.046, − 0.006
	Non-CS CMV	Education level	0.045***	0.013	0.012	0.020, 0.071
Clinical health states with GvHD	CS-symptomatic CMV with GvHD	Gender	0.074*	0.036	0.063	0.004, 0.144
		Education level	0.049**	0.017		0.017, 0.082
		Completion time	− 0.076***	0.012		− 0.099, − 0.053
	CS-asymptomatic CMV with GvHD	Education level	0.044**	0.016	0.052	0.012, 0.075
	CS-asymptomatic CMV with GvHD	Completion time	− 0.060***	0.011		− 0.082, − 0.037
	Non-CS CMV with GvHD	Education level	0.055***	0.016	0.052	0.024, 0.085
	Non-CS CMV with GvHD	Completion time	− 0.057***	0.011		− 0.078, − 0.035
Clinical health states with kidney GL	CS-symptomatic CMV with kidney GL	Completion time	− 0.078***	0.018	0.064	− 0.113, − 0.043
	CS-asymptomatic CMV with kidney GL	Gender	0.111*	0.048	0.092	0.016, 0.206
		Education level	0.048*	0.022		0.004, 0.092
		Completion time	− 0.075***	0.017		− 0.107, − 0.042
	Non-CS CMV with kidney GL	Education level	0.060**	0.021	0.068	0.018, 0.101
	Non-CS CMV with kidney GL	Completion time	− 0.058***	0.016		− 0.089, − 0.027
Clinical health states with lung GL	CS-symptomatic CMV with lung GL	Gender	0.154**	0.053	0.133	0.050, 0.259
		Age	− 0.036*	0.017		− 0.069, − 0.003
		Completion time	− 0.109***	0.017		− 0.142, − 0.075
	CS-asymptomatic CMV with lung GL	Gender	0.123*	0.055	0.112	0.015, 0.231
		Age	− 0.050**	0.017		− 0.084, − 0.016
		Completion time	− 0.095***	0.018		− 0.130, − 0.061
	Non-CS CMV with lung GL	Gender	0.125*	0.055	0.075	0.016, 0.233
		Age	− 0.048**	0.017		− 0.082, − 0.014
		Completion time	− 0.059**	0.018		− 0.094, − 0.024

CMV cytomegalosvirus, CS-asymptomatic CMV clinically significant and asymptomatic CMV, CS-symptomatic CMV clinically significant and symptomatic CMV, GL graft loss, GvHD graft-versus-host disease, Non-CS CMV non-clinically significant CMV, SD standard deviation, SE standard error, CI confidence interval
^aCovariates included for each health state were gender, age, education level, current health, and completion time; only covariates that were statistically significant in each model are presented in table
^*p < 0.05
^**p < 0.01
^***p < 0.001

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