Table 3 Syphilis-related health states and utility weights used in cost-effectiveness studies where the primary outcome was QALYs

Castillo (2021) [40]

··

··

··

Susceptible

1

-

··

··

··

Stage 1 (primary)

0·737

4·93 years

··

··

··

Stage 2 (secondary)

0·737

3·38 years

··

··

··

Latent

0·737

0·33 years

··

··

··

Tertiary

0·737

-

··

··

··

Immune

1

0·2 years

Custer (2010) [42]

··

··

··

Primary syphilis

0·88 (0·85-0·91)

1 year

Tertiary syphilis

0·65 (0·6-0·70)

Not stated

Eaton (2018) [35]

··

··

··

Syphilis and HIV infection

0·82 (0·69-0·93)

1 year if positive screening test, 2 years if false negative screening test

Hersh (2018) [36]

Congenital syphilis

0·74 (0·6-0·8)

Lifetime

··

··

··

Intrauterine fetal demise

0

··

··

··

··

Neonatal death

0

··

··

··

··

··

··

··

Congenital syphilis (maternal perspective)

0·88 (0·7-0·9)

Lifetime

··

··

··

Stillbirth (maternal perspective)

0·92 (0·8-0·95)

Lifetime

··

··

··

Neonatal death (maternal perspective)

0·76 (0·7-0·8)

Lifetime

Huntington (2020) [37]

Congenital syphilis

0.74

Lifetime

··

··

··

Intrauterine fetal demise

0

··

··

··

··

Neonatal death

0

··

··

··

··

Suijkerbuijk (2018)^a [38]

··

··

··

Primary syphilis

1-0·015 = 0·985^b (age 1-44 years)

1-0·014 = 0·986^b (age 45+ years)

0·04 years

··

··

··

Secondary syphilis

1-0·048 = 0·952^b

1-0·044 = 0·956^b

0·07 years

··

··

··

Neurosyphilis

1-0·281 = 0·719^b

10 years

Tuite (2014) [39]

··

··

··

Primary syphilis

1-0·0072 = 0·9928^b

(0·0065-0·0079)

0·7 years

··

··

··

Secondary syphilis

1-0·041 = 0·959^b

(0·036-0·045)

3·6 years

··

··

··

Neurosyphilis and tertiary syphilis

1-0·094 = 0·906^b

(0·074-0·283)

7·7 years