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Table 2 Disability weights for health economic evaluations where the primary outcome was measured in DALYs

From: Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection

Study

Neonatal

Adult

Health state

Disability weight

Duration

Health state

Disability weight

Duration

Bristow (2016) [21]

Congenital syphilis

0·315

3 years

··

··

··

Low birth weight or prematurity

0·106

1 year

··

··

··

Miscarriage

0

··

··

··

··

Stillbirth

0

··

··

··

··

Neonatal death

1

··

··

··

··

Hong (2010) [22]

Congenital syphilis

0·315

3 years

··

··

··

Fetal and neonatal death (including neonatal death due to low birth weight, neonatal death due to congenital syphilis, perinatal death, spontaneous abortion, medical/induced abortion)

1

··

··

··

··

Jayawardena (2019) [23]

··

··

··

Mild early syphilis (primary or secondary)

0·006 (0·002-0·012)

0·07 years

··

··

··

Tertiary syphilis

0·203 (0·134-0·29)

10 years

Congenital syphilis

0·315

3 years

··

··

··

Kahn (2014) [24]

Congenital syphilis

0·316

Lifetime

··

··

··

Low birth weight

0·106

Lifetime

··

··

··

Stillbirth

Calculated as a set number of DALYs per stillbirth – 4·95 DALYs

··

··

··

··

Neonatal death

Calculated as a set number of DALYs per neonatal death – 9·4 DALYs

    

Kuznik (2013) [25]

Congenital syphilis

0·315 (0·159-0·471)

Lifetime

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Kuznik (2015) [26]

Congenital syphilis

0·315 (0·159-0·471)

Not specified

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Larson (2014) [27]

Congenital syphilis

0·316

Lifetime

··

··

··

Low birth weight

0·106

Lifetime

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Owusu-Edusei (2011) [28]

··

··

··

Early syphilis (primary or secondary)

0·032 (0·015-0·048)

Not specified

··

··

··

Tertiary syphilis

0·283 (0·250-0·300)

Not specified

Congenital syphilis

0·315 (0·250-0·350)

3 years

··

··

··

Low birth weight

0·106 (0·090-0·130)

1 year

··

··

··

Miscarriage

1

··

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Owusu-Edusei (2014) [29]

··

··

··

Early (primary or secondary) syphilis

0·015 (0·0075-0·0225)

Not specified

··

··

··

Tertiary syphilis

0·283 (0·01415-0·4245)

Not specified

··

··

··

HIV-positive pregnant women with syphilis coinfection

0·38

Not specified

Congenital syphilis

0·315 (0·1575-0·47)

3 years

··

··

··

Low birth weight

0·106 (0·053-0·159)

1 year

··

··

··

Induced abortion

0

··

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Rodriguez (2021) [30]

Congenital syphilis

0·315

3 years

··

··

··

Low birth weight

0·106

1 year

··

··

··

Stillbirth

1

First 20 years of life

··

··

··

Neonatal death

1

First 20 years of life

··

··

··

Romero (2020) [31]a

Congenital syphilis

0·315

Lifetime

··

··

··

Low birth weight

0·106

Lifetime

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Russell (2021) [41]

··

··

··

Syphilis

0·12 (0·09-0·15)

90 days

Schackman (2007) [32]

Congenital syphilis

0·315 (0·1575-0·4725)

Lifetime

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

Terris-Prestholt (2003) [33]

Low birth weight

0·291

Lifetime

··

··

··

Stillbirth

1

··

··

··

··

Terris-Prestholt (2015) [34]

Congenital syphilis

0·315

Lifetime

··

··

··

Low birth weight

0·291

Lifetime

··

··

··

Stillbirth

1

··

··

··

··

Neonatal death

1

··

··

··

··

  1. Ranges or confidence intervals used for sensitivity analyses are placed in brackets
  2. DALY Disability-adjusted life year, HIV Human immunodeficiency virus
  3. aWeights not explicitly stated in the study but are taken from a paper referenced in the bibliography [25]