Table 4 Adjusted mean scores and mean difference in scores from baseline and after T0 (baseline CT) results for COS-LC Part 1

1. Anxiety (0–21)

0.42

0.61

CAT1

0

0, 0

0.04

-0.14, 0.21

CAT2

-0.10

-0.57, 0.37

0.29

-0.22, 0.80

CAT3

0.17

-0.56, 2.06

0.45

-0.28, 1.17

CAT4

0.73

-0.61, 2.06

0.50

-1.58, 2.58

CAT5

-0.85

-1.91, 0.22

0.36

-0.26, 0.97

2. Behavioural (0–21)

0.34

0.65

CAT1

0

0, 0

0.41

0.20, 0,62

CAT2

-0.43

-0.89, 0.04

0.53

0.03, 1.02

CAT3

0.15

-0.57, 0.87

0.67

-0.36, 1.71

CAT4

0.47

-1.52, 2.46

1.22

-0.44, 2.87

CAT5

-0.47

-1.90, 0.96

1.25

-0.15, 2.66

3. Sense of dejection (0–18)

0.79

0.65

CAT1

0

0,0

0.16

-0.02, 0.34

CAT2

-0.19

-0.65, 0.28

0.30

-0.19, 0.78

CAT3

0.02

-0.66, 0.69

0.44

-0.27, 1.15

CAT4

0.05

-1.10, 1.20

-0.39

-1.47, 0.70

CAT5

-0.67

-1.84, 0.49

0.47

-0.10, 1.04

4. Sleep (0–12)

0.53

0.10

CAT1

0

0, 0

-0.02

-0.19, 0.15

CAT2

-0.20

-0.64, 0.25

0.29

-0.08, 0.66

CAT3

0.48

-0.27, 1.23

0.07

-0.75, 0.89

CAT4

-0.23

-1.21, 0.76

0.89

-0.08, 1.85

CAT5

-1.28

-2.06, -0.51

1.52

0.28, 2.76

4.1 Sleep (0–9) modified scale

0.51

0.04

CAT1

0

0, 0

-0.05

-0.19, 0.08

CAT2

-0.26

-0.60, 0.09

0.33

0.04, 0.62

CAT3

0.48

-0.16, 1.11

0.08

-0.63, 0.79

CAT4

-0.31

-1.08, 0.46

0.50

-0.18, 1.19

CAT5

-0.94

-1.54, -0.34

1.48

0.22, 2.73

5. Focus on symptoms (0–24)

0.47

0.06

CAT1

0

0,0

0.16

-0.08, 0.39

CAT2

-0.28

-0.96, 0.39

0.40

-0.25, 1.06

CAT3

0.05

-0.91, 1.01

1.25

0.38, 2.13

CAT4

-1.47

-2.72, -0.22

1.88

0.28, 3.49

CAT5

-1.03

-2.79, 0.73

1.47

-0.96, 3.90

5.1 Focus on symptoms (0–21) modified scale

0.64

0.05

CAT1

0

0, 0

0.11

-0.11, 0.33

CAT2

-0.24

-0.89, 0.42

0.44

-0.20, 1.07

CAT3

0.01

-0.92, 0.94

1.13

0.31, 1.96

CAT4

-1.38

-2.64, -0.13

1.87

0.27, 3.48

CAT5

-0.92

-2.65, 0.81

1.46

-0.95, 3.87

6. Stigmatisation (0–12)

0.90

0.55

CAT1

0

0, 0

0.05

-0.08, 0.18

CAT2

-0.01

-0.43, 0.41

-0.03

-0.44, 0.38

CAT3

0.27

-0.34, 0.87

-0.03

-0.55, 0.50

CAT4

-0.16

-0.76, 0.44

0.06

-1.16, 1.28

CAT5

0.23

-0.46, 0.92

-0.40

-0.86, 0.06

7. Introvert (0–18)

0.91

0.28

CAT1

0

0, 0

-0.04

-0.22, 0.14

CAT2

-0.14

-0.71, 0.44

0.13

-0.40, 0.66

CAT3

-0.10

-0.81, 0.60

0.77

-0.06, 1.60

CAT4

-0.22

-1.46, 1.02

0.36

-0.60, 1.32

CAT5

-0.82

-1.76, 0.12

0.88

-0.66, 2.41

8. Harms of smoking (0–6)

0.82

0.50

CAT1

0

0, 0

-0.02

-0.13, 0.10

CAT2

-0.10

-0.43, 0.24

0.09

-0.22, 0.39

CAT3

0.10

-0.40, 0.59

0.34

-0.04, 0.72

CAT4

-0.11

-0.99, 0.78

0.16

-0.55, 0.87

CAT5

-0.12

-0.85, 0.62

0.39

-1.82, 2.60

9. Self-blame (0–15)

0.57

0.13

CAT1

0

0,0

0.16

-0.08, 0.40

CAT2

0.31

-0.47, 1.09

-0.00

-0.62, 0.61

CAT3

-0.12

-1.12, 0.88

1.04

0.22, 1.86

CAT4

-1.02

-1.99, -0.06

0.93

0.23, 1.62

CAT5

-0.34

-1.58, 0.90

0.47

-1.29, 2.24

9.1. Self-blame (0–12)

Modified scale

0.60

0.19

CAT1

0

0, 0

0.12

-0.07, 0.31

CAT2

0.26

-0.36, 0.88

0.02

-0.46, 0.50

CAT3

-0.11

-0.92, 0.70

0.76

0.12, 1.39

CAT4

-0.73

-1.57, 0.11

0.55

0.10, 0.99

CAT5

-0.10

-1.12, 0.93

0.45

-1.10. 1.99

Kept busy to take my mind off things (0–3)

0.65

0.65

CAT1

0

0, 0

0.06

-0.01, 0.12

CAT2

-0.05

-0.19, 0.08

0.11

-0.04, 0.25

CAT3

0.04

-0.15, 0.24

0.02

-0.27, 0.31

CAT4

0.08

-0.37, 0.53

0.46

-0.19, 1.11

CAT5

-0.07

-0.46, 0.31

-0.04

-0.23, 0.16

Less interest in sex (0–3)

0.22

0.39

CAT1

0

0, 0

0.02

-0.06, 0.10

CAT2

0.01

-0.22, 0.24

0.06

-0.15, 0.28

CAT3

0.22

-0.14, 0.58

0.41

0.04, 0.78

CAT4

-0.22

-0.54, 0.11

0.05

-0.33, 0.43

CAT5

-0.08

-0.62, 0.45

0.12

-0.42, 0.66