Impact of walk advice alone or in combination with supervised or home-based structured exercise on patient-reported physical function and generic and disease-specific health related quality of life in patients with intermittent claudication, a secondary analysis in a randomized clinical trial

Sandberg, Anna; Bäck, Maria; Cider, Åsa; Jivegård, Lennart; Sigvant, Birgitta; Nordanstig, Joakim

doi:10.1186/s12955-023-02198-8

Table 3 The SF-36 and the VascuQol, presented by group and over time

From: Impact of walk advice alone or in combination with supervised or home-based structured exercise on patient-reported physical function and generic and disease-specific health related quality of life in patients with intermittent claudication, a secondary analysis in a randomized clinical trial

	HSEP				SEP				WA				Between group P-value
		Change at:				Change at:				Change at:
SF-36
Domains	Base-line	3 months	6 months	12 months	Base-line	3 months	6 months	12 months	Base-line	3 months	6 months	12 months	0–3 months	0–6 months	0–1 year
PF	50.0 (35.0)	5.0 (12.1)	5.0 (20.0)	5.0 (17.6)	55.0 (30.0)	0.0 (20.0)	10.0 (16.8)	10.0 (20.0)	52.5 (27.5)	5.0 (20.0)	2.8 (20.0)	10.0 (15.0)	.724	.354	.391
RP	50.0 (100)	0.0 (25.0)	0.0 (25.0)	0.0 (25.0)	25.0 (100)	0.0 (12.5)	0.0 (47.9)	0.0 (25.0)	25.0 (81.3)	0.0 (25.0)	0.0 (50.0)	0.0 (66.7)	.569	.410	.941
BP	41.0 (11.0)	10.0 (20.0)	10.0 (29.0)	10.0 (23.8)	41.0 (25.5)	10.0 (24.0)	0.0 (21.5)	10.0 (26.0)	51.0 (26.0)	0.0 (21.0)	5.0 (12.5)	0.0 (31.3)	.107	.920	.149
GH	57.0 (26.5)	0.0 (19.3)	5.0 (23.0)	5.0 (20.0)	57.0 (27.0)	5.0 (18.8)	4.0 (20.0)	2.0 (20.0)	57.0 (25.0)	0.0 (15.7)	0.0 (20.0)	5.0 (17.1)	.223	.271	.855
VT	60.0 (30.0)	5.0 (15.0)	5.0 (20.0)	0.0 (15.0)	57.5 (26.3)	2.5 (18.8)	2.5 (25.0)	5.0 (15.8)	60.0 (32.5)	0.0 (10.0)	0.0 (15.0)	0.0 (20.0)	.735	.115	.525
SF	87.5 (37.5)	0.0 (12.5)	0.0 (12.5)	0.0 (21.9)	81.3 (37.5)	0.0 (25.0)	0.0 (0.0)	0.0 (25.0)	87.5 (43.8)	0.0 (12.5)	0.0 (25.0)	0.0 (15.6)	.282	.909	.329
RE	66.7 (100)	0.0 (33.3)	0.0 (8.3)	0.0 (33.3)	66.7 (100)	0.0 (33.3)	0.0 (33.3)	0.0 (33.3)	66.7 (75.0)	0.0 (33.3)	0.0 (66.7)	0.0 (33.3)	.963	.755	.627
MH	76.0 (28.0)	4.0 (14.0)	0.0 (20.0)	0.0 (16.0)	80.0 (32.0)	2.0 (15.0)	2.0 (16.0)	8.0 (17.0)	84.0 (24.0)	0.0 (16.5)	2.0 (12.0)	0.0 (13.0)	.096	.751	.133
PCS	37.0 (14.7)	0.9 (6.6)	2.1 (8.8)	3.3 (7.4)	35.2 (13.5)	2.2 (9.9)	3.5 (10.4)	3.4 (7.9)	35.4 (15.2)	0.6 (7.6)	0.1 (6.7)	2.4 (8.0)	.914	.212	.720
MCS	49.5 (17.7)	1.6 (9.2)	1.3 (8.5)	0.0 (12.0)	51.0 (21.2)	0.8 (13.0)	-0.1 (8.5)	2.2 (9.2)	51.0 (19.1)	0.9 (12.0)	-1.0 (10.5)	0.6 (10.2)	.694	.555	.294
VascuQol
n	55	44	47	50	52	45	43	47	54	50	46	47
Activity	4.31 (1.44)	0.50 (0.69)	0.25 (0.88)	0.50 (1.13)	4.38 (1.00)	0.50 (1.13)	0.56 (1.28)	0.50 (1.41)	4.50 (1.69)	0.25 (0.88)	0.25 (1.03)	0.13 (0.88)	.076	.390	.169
Symptom	4.25 (1.50)	0.50 (1.25)	0.25 (1.00)	0.38 (1.25)	3.75 (2.00)	0.00 (1.50)	0.50 (1.56)	0.25 (1.06)	4.00 (1.50)	0.25 (1.25)	0.00 (1.44)	0.25 (1.44)	.186	.511	.599
Pain	4.75 (1.50)	0.38 (0.94)	0.25 (1.00)	0.50 (1.38)	4.13 (2.00)	0.25 (1.13)	0.75 (1.00)	0.75 (1.50)	4.75 (1.19)	0.25 (1.00)	0.13 (0.75)	0.50 (1.00)	.072	.002	.057
Emotional	5.00 (1.64)	0.43 (1.00)	0.29 (1.07)	0.43 (1.43)	5.29 (1.57)	0.57 (1.50)	0.57 (1.36)	0.43 (1.14)	5.71 (1.86)	0.14 (0.75)	0.07 (0.79)	0.29 (0.86)	.010	.065	.245
Social	5.00 (2.50)	0.00 (1.00)	0.00 (1.00)	0.25 (1.50)	4.50 (2.38)	1.00 (1.50)	0.50 (1.00)	1.00 (1.50)	5.25 (2.50)	0.50 (1.50)	0.00 (1.00)	0.20 (0.80)	.080	.090	.040
Summary score	4.70 (1.25)	0.44 (0.78)	0.36 (0.68)	0.38 (0.89)	4.42 (1.28)	0.48 (0.94)	0.60 (1.08)	0.60 (0.96)	4.84 (1.24)	0.12 (0.68)	0.18 (0.56)	0.20 (0.80)	.008	.018	.060

Data are presented as the median and interquartile range (IQR)
HSEP Home-based structured supervised exercise program. SEP Hospital-based supervised exercise program. WA Walk advice. Between group differences are calculated with the Kruskal Wallis Test. PF Physical functioning, RP Role physical, BP Bodily pain, MH Mental health, RE Role emotional, SF Social functioning, VT Vitality and GH General health, PCS Physical component summary, MCS Mental component summary. Higher scores indicate better HRQoL

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