Table 5 Factors associated with the changes of EQ-5D-Y and PedsQL scores/subscales among those who completed both initial and latest follow-up assessments across times (T2-T1) (n = 83)

Intercept

92.07

86.62

97.52

 < .0001

5.18

4.97

5.40

 < .0001

95.75

91.62

99.88

 < .0001

Time (every 6 months)

0.26

-0.08

0.60

0.1404

-0.03

-0.05

-0.01

0.0016

0.81

0.57

1.04

 < .0001

Aged 13–18 years (vs 7–12)

-4.98

-7.60

-2.35

0.0004

-0.05

-0.15

0.05

0.3064

0.63

-1.36

2.62

0.5296

Boys (vs Girls)

-1.04

-3.33

1.26

0.3686

0.07

-0.02

0.16

0.1084

-1.13

-2.88

0.61

0.1984

Baseline eGFR

0.02

-0.02

0.06

0.2643

0.00

0.00

0.00

0.2958

-0.02

-0.05

0.01

0.1392

Change in eGFR, per month

-1.15

-2.35

0.05

0.0596

0.04

-0.01

0.09

0.1584

-1.50

-2.41

-0.60

0.0015

Number of comorbidities at T1(vs none)

 1

0.31

-4.18

4.80

0.8892

-0.28

-0.45

-0.10

0.0023

-0.71

-4.12

2.69

0.6762

 2

-2.30

-9.81

5.22

0.5428

-0.47

-0.76

-0.17

0.0024

-2.99

-8.69

2.72

0.2985

  ≥ 3

-10.84

-23.00

1.32

0.0794

-0.57

-1.07

-0.07

0.0252

-7.28

-16.47

1.90

0.1177

Change in comorbidity (vs none at T1 &T2)

 Growth retardation

  baseline ( +) & latest (-)

5.65

-1.12

12.41

0.1000

-0.01

-0.27

0.25

0.9236

3.92

-1.24

9.07

0.1334

  baseline ( +) & latest ( +)

-0.45

-6.46

5.55

0.8805

0.30

0.06

0.54

0.0148

-1.62

-6.16

2.92

0.4782

  baseline (-) & latest ( +)

-0.66

-4.93

3.62

0.7590

0.18

0.02

0.34

0.0283

-2.28

-5.55

0.99

0.1674

 Overweight

  baseline ( +) & latest (-)

2.35

-3.91

8.62

0.4551

0.28

0.02

0.53

0.0340

3.33

-1.39

8.06

0.1632

  baseline ( +) & latest ( +)

6.32

2.05

10.59

0.0045

0.11

-0.06

0.28

0.1853

4.77

1.54

8.01

0.0046

  baseline (-) & latest ( +)

4.05

-0.01

8.11

0.0506

-0.05

-0.21

0.11

0.5184

1.14

-1.96

4.24

0.4637

 Hypertension

  baseline ( +) & latest (-)

2.74

-2.70

8.18

0.3176

0.22

0.00

0.43

0.0457

2.34

-1.80

6.48

0.2626

  baseline ( +) & latest ( +)

-2.09

-6.48

2.29

0.3426

0.18

0.00

0.35

0.0525

-0.68

-3.99

2.64

0.6847

  baseline (-) & latest ( +)

-4.00

-6.84

-1.15

0.0069

-0.03

-0.14

0.08

0.5755

-2.22

-4.38

-0.06

0.0444

 Hyperlipidemia

  baseline ( +) & latest (-)

7.91

-0.74

16.55

0.0723

-0.08

-0.45

0.29

0.6632

-0.49

-6.99

6.01

0.8809

  baseline ( +) & latest ( +)

0.75

-3.80

5.30

0.7425

0.37

0.20

0.54

 < .0001

0.05

-3.41

3.51

0.9766

  baseline (-) & latest ( +)

6.02

1.17

10.87

0.0160

0.06

-0.12

0.24

0.5361

2.45

-1.23

6.14

0.1879

 Mineral bone disorders/Anemia

  baseline ( +) & latest (-)

4.48

-1.49

10.46

0.1381

0.22

-0.01

0.45

0.0552

-1.13

-5.67

3.42

0.6214

  baseline ( +) & latest ( +)

-1.88

-8.45

4.69

0.5678

0.20

-0.06

0.46

0.1263

-6.45

-11.43

-1.47

0.0121

  baseline (-) & latest ( +)

0.42

-4.01

4.86

0.8491

-0.08

-0.25

0.10

0.3904

-3.40

-6.77

-0.03

0.0483

 Hyperuricemia

  baseline ( +) & latest (-)

2.65

-3.03

8.34

0.3538

0.29

0.07

0.52

0.0111

-0.28

-4.59

4.03

0.8962

  baseline ( +) & latest ( +)

2.38

-2.54

7.29

0.3366

0.24

0.04

0.44

0.0176

1.29

-2.43

5.00

0.4899

  baseline (-) & latest ( +)

1.40

-1.85

4.65

0.3913

-0.04

-0.17

0.09

0.5298

-3.41

-5.88

-0.94

0.0078

 Proteinuria

  baseline ( +) & latest (-)

-1.07

-6.27

4.13

0.6823

0.47

0.26

0.68

 < .0001

-2.31

-6.25

1.63

0.2449

  baseline ( +) & latest ( +)

1.94

-2.79

6.68

0.4141

0.18

0.00

0.37

0.0514

3.01

-0.58

6.60

0.0984

  baseline (-) & latest ( +)

4.45

-0.83

9.74

0.0971

0.00

-0.21

0.20

0.9763

1.49

-2.53

5.51

0.4600