Cross-walk of the Chronic Liver Disease Questionnaire for Nonalcoholic Steatohepatitis (CLDQ-NASH) and the EuroQol EQ-5D-5L in patients with NASH

Table 3 Best fitting models for predicting EQ-5D-5L from CLDQ-NASH and the cross-validation results

Model	Description	Statistical model	Overall RMSE	Lower RMSE	Middle RMSE	Upper RMSE	Obese RMSE	Non-obese RMSE	T2D RMSE	Non-T2D RMSE
Mean	Benchmark	Constant model	0.1980	0.9164	0.5756	0.1372	0.2111	0.1602	0.2143	0.1756
GLM family (Gaussian)	Best model using overall CLDQ-NASH score as independent variables	GLM with gaussian family and power link (power -0.3), cubic splines with 3 knots	0.1455	0.7644	0.3517	0.1146	0.1505	0.1318	0.1583	0.1249
Fractional logistic	Best model using the CLDQ-NASH domains as independent variables	Fractional logistic, cubic splines with 3 knots	0.1452	0.7698	0.3477	0.1149	0.1533	0.1221	0.1585	0.1242

CLDQ-NASH Chronic Liver Disease Questionnaire – Nonalcoholic Steatohepatitis, GLM generalized linear model, RMSE root-mean squared error, T2D type 2 diabetes

ISSN: 1477-7525