Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa

Table 2 Two-part model of association between determinants and EQ-5D-3L health state values in South Africa and Uganda

Variable	Part 1: Logistic Regression EQ-5L-3L = 1			Part 2: Generalized Linear Model, EQ-5L-3L < 1
Variable	Odds ratio	95% CI	p-value	Co-efficient	95% CI	p-value
South Africa
Male (ref female)	1.85	1.19, 2.87	0.006	-	-	-
Comorbidities (ref no CM)	0.29	0.18, 0.46	< 0.001	-	-	-
HIV treatment side effects (ref no SE)	0.39	0.20, 0.75	0.005	-0.08	-0.14, -0.02	0.008
Opportunistic infection (ref no OI)	-	-	-	-0.10	-0.15, -0.05	< 0.001
Viral load > 50,000 (ref VL≤50,000)	-	-	-	-0.06	-0.11, -0.01	0.029
100% Adherence	-	-	-	0.07	0.02, 0.13	0.007
Uganda
Male (ref female)	1.87	1.24, 2.84	0.003	-	-	-
Comorbidities (ref no CM)	0.56	0.35, 0.90	0.016	-	-	-
Opportunistic infection (ref no OI)	0.41	0.23, 0.72	0.002	-	-	-
100% Adherence (ref < 100%)	1.64	1.00, 2.70	0.049	-	-	-
CD4
<200 (ref)
200–499	-	-	-	0.07	0.01, 0.13	0.027
≥ 500				0.11	0.04, 0.17	0.001

CM = comorbidities; OI = opportunistic infection; SE= side effects; ref = reference. Non−significant variables are removed from part 1 and part 2 of the model

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