Minimal clinically important difference for the Mandarin version of the Tinnitus Questionnaire determined via anchor-based and distribution-based methods

Table 3 MCID for MTQ according to the ROC analyses

Subjective criteria	N	MCID	AUC (95% CI)	Sensitivity	Specificity	+ LR	− LR
Improvement
Self-report change impression	24	14.5	0.704 (0.577, 0.708)	0.708	0.365	1.940	0.459
ΔVAS	71	− 3.5	0.605 (0.407, 0.803)	0.905	0.667	1.357	0.286
Deterioration
Self-report change impression	9	13.5	0.775 (0.675, 0.876)	0.718	0.273	2.634	0.387
ΔVAS	22	6.5	0.602 (0.430, 0.775)	0.636	0.364	1.750	0.571

MCID, minimal clinically important difference; CI, confidence interval; + LR, positive likelihood ratio; − -LR, negative likelihood ratio; ΔVAS, VAS change from baseline was determined by subtracting the value at visit from baseline value

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