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Table 1 Signs, symptoms, and impact of RSV identified in the literature

From: Assessing the patient experience of respiratory syncytial virus infection: development of a patient-reported outcome measure

RSV signs and symptoms and patient experiences

Literature source

RSV-iiiQ

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

Total a

Respiratory symptoms

 Coryza (catarrhal inflammation of the mucous membrane in the nose)

         

x

     

1

 

 Cough

x

x

 

x

x

x

x

x

x

x

x

x

x

x

x

14

x (and cough with phlegm)

 Crackles

 

x

             

1

 

 Croup-like cough

             

x

 

1

 

 Dyspnea (difficulty breathing, shortness of breath)

x

x

x

x

x

 

x

 

x

x

x

x

x

x

x

13

x

 Nasal congestion

x

 

x

x

x

x

 

x

x

x

   

x

x

10

x

 Orthopnea

           

x

   

1

 

 Rales

x

 

x

 

x

          

3

 

 Rhinitis

           

x

   

1

 

 Rhinorrhea

x

x

  

x

 

x

   

x

    

5

 

 Rhonchi

 

x

x

            

2

 

 Sputum production

  

x

 

x

   

x

  

x

  

x

5

 

 Wheezing

x

x

x

x

x

x

x

x

x

 

x

x

 

x

 

12

x

Infections

 Bacteremia

  

x

            

1

 

 Bronchiolitis

             

x

 

1

 

Pain

 Chest pain

x

            

x

 

2

 

 Chills

         

x

     

1

 

 Ear pain

 

x

   

x

 

x

       

3

 

 Headache

    

x

x

 

x

  

x

  

x

 

5

x

 Muscle aches

       

x

       

1

x (body aches and pains)

 Myalgias

      

x

  

x

 

x

 

x

 

4

x (body aches and pains)

 Sinus pain

 

x

   

x

         

2

 

 Nausea/abdominal pain

    

x

          

1

 

 Sore throat/pharyngitis

x

x

x

x

x

x

x

x

 

x

x

x

 

x

x

13

x

Systemic symptoms

 General systemic symptoms not described (group of symptoms that can affect many different systems of the body)

x

   

x

          

2

 

 Fatigue

       

x

       

1

x

 Lethargy/malaise

        

x

x

     

2

 

 Weakness

        

x

      

1

 

Fever-related symptoms

 Febrile seizures

             

x

 

1

 

 Fever or feverishness

x

x

x

 

x

x

x

x

x

x

x

x

x

x

x

14

x

 Rigors (a sudden feeling of cold with shivering accompanied by a rise in temperature, often with copious sweating, especially at onset or height of a fever)

           

x

   

1

 

 Sweating

         

x

     

1

 

Other, including symptoms and impacts

 Hoarseness

x

   

x

    

x

    

x

4

 

 Vomiting

             

x

 

1

 

 Work/training absence

   

x

 

x

         

2

 

 Diarrhea

             

x

 

1

 

 Interrupted sleep b

               

0

x

 Loss of appetite b

               

0

x

 Hospitalization due to RSV

xc

x

xc

    

x

x

  

xc

x

  

7

 

 ICU

        

x

   

x

  

2

 

 Ward confinement

   

x

           

1

 

 Inability to complete ADLs

              

x

1

x

 Inability to get out of bed

              

x

1

x

 Prepare meals/Get your own food b

               

0

x

 Perform your usual activities b

               

0

x

 Leave the home b

               

0

x

 Concentrate on tasks b

               

0

x

 Take care of yourself b

               

0

x

 Walk up a flight of stairs b

               

0

x

 Dress yourself b

               

0

x

 Irritable b

               

0

x

 Helpless b

               

0

x

 Frustrated b

               

0

x

 Worried b

               

0

x

  1. ADL Activity of daily living, ICU Intensive care unit, RSV Respiratory syncytial virus, RSV-iiiQ RSV Infection, Intensity and Impact Questionnaire
  2. aTotal number of identified resources mentioning the specific sign or symptom
  3. bAdditional ADLs and emotional impacts identified in the influenza literature[10, 25, 26]
  4. cStudy sample was defined as individuals who were hospitalized
  5. Sources: 1, Walsh et al. [27]; 2, Dowell et al. [28]; 3, Falsey et al. [2]; 4, O'Shea et al. [29]; 5, Falsey and Walsh [4]; 6, Hall et al. [7]; 7, Branche and Falsey [1]; 8, Sundaram et al. [17]; 9, Volling et al. [3]; 10, Wald et al. [30]; 11, Li et al. [14]; 12, Uckay et al. [18]; 13, Loubet et al. [15]; 14, Saxena et al. [16]; 15, Falsey et al. [2]
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Health and Quality of Life Outcomes

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