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Table 2 Study characteristics (n = 41)

From: Predictors of health-related quality of life after cardiac surgery: a systematic review

Study (Author, year, country)

Study design (including (number of sites))

Patients (population (type of surgery) and sample size)

HRQoL tool used and time-point of predictive model (months unless otherwise stated)

Type of surgery

Sample size

Participation rate of eligible persons

Completed follow-up: total cohort

Myles 2001 [12]

Australia

Pre-op post-op (1)

CABG, valve, combined, other

120/125 (96%)

108/120 (90%)

SF-36 (3)

Baldassarre 2002 [15]

Canada

Prospective cohort (1)

Isolated CABG (primary)

34/64 (53%)

30/34 (88%)

SF-36 (3)

Falcoz 2003 [34]

France

Prospective cohort (1)

CABG, valve, combined, other (elective)

293/452 (65%)

264/293 (90%)

SF-36 (12)

Herlitz 2003 [57]

Sweden

Prospective cohort (2)

Isolated CABG (primary)

1225/2000 (61%)

976/2000 (49%)

NHP (10 years)

Schelling 2003 [58]

Germany

Prospective cohort (1)

CABG, valve, combined

223/387 (58%)

148/223 (66%)

SF-36 (6)

Baberg 2004 [17]

Germany

Prospective and retrospective cohort (1)

AVR ± MVR

201/414 (47%)

201/414 (49%)

SF-36 (3 years)a

Jarvinen 2004 [28]

Finland

Prospective cohort (1)

Isolated CABG

501/1128 (44%)

458/501 (91%)

SF-36 (12)

Rumsfeld 2004 [18]

America

Prospective cohort (14)

Isolated CABG (primary)

2480/3956 (63%)

1973/2480 (80%)

SF-36 (6)

Al-Ruzzeh 2005 [19]

UK

Cross-sectional (1)

Isolated CABG (primary)

437/463 (94%)

NA

SF-36 (12)a

Herlitz 2005 [59]

Sweden

Prospective cohort (1)

Isolated CABG (primary)

1225/2000 (61%)

637/1225 (52%)

NHP (10 years)b

Peric 2005 [60]

Serbia and Montenegro

Prospective cohort (1)

Elective CABG

243 (no mention of consent/refusal rate)

226/243 (93%)

NHP (6)

Le Grande 2006 [20]

Australia

Pre-op post-op (1)

Elective CABG

182/407 (45%)

117/182 (64%)

SF-36 (2, 6)

Myles 2006 [4]

Australia

Pre-op post-op (1)

CABG, valve, combined, other

108/120 (90%)

93/108 (86%)

SF-36 (3, 3 years)

Noyez 2006 [61]

Netherlands

Retrospective cohort (1)

Isolated CABG

428/428 (100%)

428/428 (100%)

EQ-5D (12)

Panagopoulou2006 [62]

Greece

Prospective cohort (1)

Elective CABG

157/256 (61%)

1mo:117/157 (75%)

6mo:104/157 (66%)

MNHD-Q (1, 6)

Dunning 2008 [63]

England

Prospective cohort (1)

Isolated CABG

911/1180 (77%)

621/911 (68%)

EQ-5D (10)a

El Baz 2008 [32]

Netherlands

Prospective observational (2)

CABG

198/256 (73%)

168/198 (85%)

SF-36 (6)

Jokinen 2008 [48]

Finland

Prospective observational cohort (1)

CABG, valve, combined, other

91/98 (93%)

46/91 (51%)

NHP (15, 8.2 years)b

Peric 2008 [64]

Serbia

Pre-op post-op (1)

Isolated CABG

Not reported

192/208 (92%)

NHP (6)

Deaton 2009 [31]

USA

Prospective cohort (2)

Isolated CABG

317/442 (72%)

270/317 (85%)

SF-36 (3)a

Herlitz 2009 [65]

Sweden

Prospective cohort (2)

Isolated CABG (primary)

Not reported

2000 screened

639/2000 (32%)

NHP (15 years)

Maisano 2009 [66]

Italy (implied by authorship, not stated)

Retrospective cohort with prospective assessment of HRQoL

(1) (implied)

Mitral valve surgery (± AVR, ± TV surgery, ± CABG)

225/225 (100%)

220/225 (98%)

MLHF (3 years)a

Rantanen 2009 [67]

Finland

Prospective cohort (1)

Elective CABG

1 mo:274/367 (75%)

6 mo:244/271 (90%)

12 mo:236/266 (89%)

1 mo:270/274 (99%)

6 mo:240/244 (98%)

12 mo:235/236 (100%)

15D (1, 6, 12)

Juergens 2010 [30]

Germany

Prospective cohort (1)

Elective CABG, valve, combined

56/85 (65%)

42/65 (75%)

SF-12 (3)

Peric 2010 [68]

Serbia

Prospective pre-op post-op (1)

Elective CABG

243/243 (100%)

226/243 (93%)

NHP (6)

Grady 2011 [21]

America

Prospective cohort (1)

CABG, valve, maze, combined

840/2524 (33%)

0 mo:173/840 (21%)

6 mo:177/840 (21%)

12 mo:174/840 (21%)

24 mo:129/840 (15%)

36 mo:69/840 (8%)

Total:816/840 (97%)

SF-36 (3, 6, 12, 2 years, 3 years)

Vainiola 2013 [47]

Finland

Prospective cohort (1)

CABG, valve, combined, aortic, other

785/980 (80%)

571/785 (73%)

15-D (6)

Kurfirst 2014 [14]

Czech republic

Prospective cohort (1)

CABG, valve, combined (elective)

310 eligible

260/310 (84%)

SF-36 (12)

Humphreys 2016 [33]

Australia

Prospective cohort (1)

Elective CABG

180 agreed to participate. No further details

173/180 (96%)

SF-36 (6)

Patron 2016 [22]

Italy

Pre-op post-op (1)

CABG, valve, combined (primary, elective)

92/92 (100%)

75/92 (82%)

SF-12 (12)

Bjornnes 2017 [69]

Norway

Secondary analysis of RCT (2)

CABG, valve, combined

416/525 (79%)

349/416 (84%)

15D (2 weeks, 3,6,12)

Norkiene 2018 [13]

Lithuania

Prospective cohort (1)

CABG, valve, combined

210/210 (100%)

No further details

105/210 (50%)

SF-36 (12)

Bishawi 2018 [70]

America

Secondary analysis of RCT (18)

Isolated CABG (urgent or elective)

2203/3670 (60%)

1770/2203 (80%)

SAQVR-36 (12)

Grand 2018 [23]

France

Prospective cohort (1)

CABG, valve, combined (elective)

495/548 (90%)

326/495 (66%)

SF-36 (6)

Coelho 2019 [24]

Portugal

Prospective cohort

(1) (implied)

CABG, valve, combined (elective)

Not stated

384/430 (89%)

SF-36 (12)

Blokzijl 2019 [25]

Netherlands

Retrospective cohort multicentre (3)

Elective CABG

2606/8643 (30%)

2606/8643 (30%)

SF-36 or SF12 (10–14)

Joskowiak 2019 [26]

Germany

Prospective cohort (1)

CABG, valve, combined, aortic, other, redo (elective)

164 consented but does not state number who were eligible and screened

164/164 (100%)

SF-36 (12)

Perrotti 2019 [27]

France

Prospective cohort (1)

Isolated CABG (elective)

272/272 (100%)

118/272 (43%)

SF-36 (10 years)

Kube 2020 [35]

Germany

Prospective cohort (2)

CABG, valve, combined (elective)

70/110 (64%)

53/70 (76%)

SF-12 (6)

Rijnhart-de Jong 2020 [29]

Prospective cohort (1)

Non-salvage cardiac surgery

1544/1773 (87%)

874/1544 (57%)

SF-36 (12)

Schaal 2020 [71]

Germany

Prospective cohort (1)

CABG, valve, combined, aortic,

8676/14043 (62%)

8676/14043 (62%)

NHP (6)

  1. aNo preoperative HRQoL assessment performed; b preoperative HRQoL assessment carried out in some, but not all patients
  2. AVR: aortic valve replacement; CABG: Coronary Artery Bypass Surgery; EQ-5D: EuroQol- 5 Dimension; HRQoL: Health-related Quality of Life; MLHF: Minnesota Living with Heart Failure questionnaire; MNHD-Q: MacNew Heart Disease Quality of Life Questionnaire; MVR: mitral valve replacement; NHP: Nottingham Health Profile; PF: physical function; SAQ: Seattle Angina Questionnaire; SF-12: 12 item short form health survey; SF-36: 36 item short form health survey; TV: tricuspid valve; VR-36: Veteran’s Rand (version of SF36)