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Table 2 Univariate and multivariate analyses to identify predictors for poorer quality of life (SF-36) of caregivers in the total cohort, in patients with alcoholic liver cirrhosis, and in patients with non-alcoholic liver cirrhosis

From: Continued alcohol consumption and hepatic encephalopathy determine quality of life and psychosocial burden of caregivers in patients with liver cirrhosis

Variable Univariate analysis Multivariate analysis
r p value β p value
Total cohort     
 Continued alcohol consumption 0.259 0.079 0.292 0.003
 Psychosocial burden of caregivers (ZBI) − 0.275 0.005 − 0.310 0.003
 Health-related Quality of life of patients (CLDQ) 0.182 0.062 0.139 0.167
Alcoholic liver cirrhosis     
 Continued alcohol consumption 0.259 0.079 0.355 0.038
 Psychosocial burden of caregivers (ZBI) − 0.275 0.005 − 0.264 0.135
 Health-related Quality of life of patient (CLDQ) 0.182 0.062 − 0.043 0.796
Non-alcoholic liver cirrhosis     
 History of ascites − 0.272 0.042 − 0.094 0.516
 History of SBP − 0.359 0.007 − 0.216 0.091
 History of gastrointestinal bleeding − 0.360 0.006 − 0.210 0.097
 Health-related Quality of life of patients (CLDQ) 0.344 0.009 0.071 0.610
 Psychosocial burden of caregivers (ZBI) − 0.409 0.002 − 0.358 0.010
  1. Gender 1 for male, 2 for female; 1 for Alcohol consumption, 0 for no alcohol consumption; 1 for history of hepatic encephalopathy, 0 for no history of hepatic encephalopathy. Factors not predictive for SF-36 in the univariate analysis were gender, age, age of caregiver, sodium, creatine, bilirubin, albumin, INR, CRP, leucocytes, hemoglobin, platelets, MELD, Child–Pugh status, history of hepatorenal syndrome. With the remaining factors, a multivariate linear regression model with inclusion variable selection was built
  2. ZBI, Zarit burden interview; CLDQ, chronic liver disease questionnaire; SBP, spontaneous bacterial peritonitis; SF-36, Short Form Health 36; INR, international standardized ratio; CRP, C-reactive protein; MELD, model of end-stage liver disease