Continued alcohol consumption and hepatic encephalopathy determine quality of life and psychosocial burden of caregivers in patients with liver cirrhosis

Table 2 Univariate and multivariate analyses to identify predictors for poorer quality of life (SF-36) of caregivers in the total cohort, in patients with alcoholic liver cirrhosis, and in patients with non-alcoholic liver cirrhosis

Variable	Univariate analysis		Multivariate analysis
Variable	r	p value	β	p value
Total cohort
Continued alcohol consumption	0.259	0.079	0.292	0.003
Psychosocial burden of caregivers (ZBI)	− 0.275	0.005	− 0.310	0.003
Health-related Quality of life of patients (CLDQ)	0.182	0.062	0.139	0.167
Alcoholic liver cirrhosis
Continued alcohol consumption	0.259	0.079	0.355	0.038
Psychosocial burden of caregivers (ZBI)	− 0.275	0.005	− 0.264	0.135
Health-related Quality of life of patient (CLDQ)	0.182	0.062	− 0.043	0.796
Non-alcoholic liver cirrhosis
History of ascites	− 0.272	0.042	− 0.094	0.516
History of SBP	− 0.359	0.007	− 0.216	0.091
History of gastrointestinal bleeding	− 0.360	0.006	− 0.210	0.097
Health-related Quality of life of patients (CLDQ)	0.344	0.009	0.071	0.610
Psychosocial burden of caregivers (ZBI)	− 0.409	0.002	− 0.358	0.010

Gender 1 for male, 2 for female; 1 for Alcohol consumption, 0 for no alcohol consumption; 1 for history of hepatic encephalopathy, 0 for no history of hepatic encephalopathy. Factors not predictive for SF-36 in the univariate analysis were gender, age, age of caregiver, sodium, creatine, bilirubin, albumin, INR, CRP, leucocytes, hemoglobin, platelets, MELD, Child–Pugh status, history of hepatorenal syndrome. With the remaining factors, a multivariate linear regression model with inclusion variable selection was built
ZBI, Zarit burden interview; CLDQ, chronic liver disease questionnaire; SBP, spontaneous bacterial peritonitis; SF-36, Short Form Health 36; INR, international standardized ratio; CRP, C-reactive protein; MELD, model of end-stage liver disease

ISSN: 1477-7525