Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors

Table 1 Demographic and clinical characteristics

	n	%		n	%
Total participants	200	100	Treatment method (non-recurrent)
Recurrence			Irradiation type
Yes	10	10.0	Local	3	1.7
No	180	90.0	WBI	138	76.6
Clinical data (non-recurrent)			CSI	39	21.7
Gender			Radiation dose, Gy
Female	56	31.1	Low (< 50)	114	63.3
Male	124	68.9	High (≥ 50)	66	36.7
Diagnosis			Surgery type
GCT	131	72.8	No surgery	134	74.4
NGGCT	49	27.2	Biopsy only	9	5.0
β-HCG range			Definitive surgery	37	20.6
Normal			Chemotherapy
High	105	58.3	Yes	177	98.3
AFP range	75	41.7	No	3	1.7
Normal			Depression/anxiety
High	156	86.7	Child depression
Tumor location	24	13.3	Healthy (CDI < 19)	86	92.5
Suprasellar region			Depression (CDI ≥ 19)	7	7.5
Pineal region	50	27.7	Child anxiety
Basal ganglia	43	23.9	Healthy (SCARED < 23)	80	74.8
Bifocal origins A^a	30	16.7	Anxiety (SCARED ≥ 23)	27	25.2
Bifocal origins B^a	30	16.7	Adult depression
Dissemination	5	2.8	Healthy (SCL-90 sub-score < 2)	35	68.6
	22	12.2	Depression (SCL-90 sub-score ≥ 2)	16	31.4
			Adult anxiety
			Healthy (SCL-90 sub-score < 2)	41	80.4
			Anxiety (SCL-90 sub-score ≥ 2)	10	19.6

GCT, germ cell tumour; NGGCT, non-germinoma germ cell tumour; WBI, whole brain irradiation; CSI, craniospinal irradiation; CDI, children’s depression inventory; SCARED, screen for child anxiety related emotional disorders; SCL-90, symptom checklist 90 revised
^aBifocal origins A: pineal and suprasellar regions. Bifocal origins B: suprasellar region and basal ganglia regions

ISSN: 1477-7525