Psychometric properties of the itch numeric rating scale, skin pain numeric rating scale, and atopic dermatitis sleep scale in adult patients with moderate-to-severe atopic dermatitis

Table 3 Correlations between the Itch NRS, skin pain NRS, and ADSS with other instruments for BREEZE-AD1, BREEZE-AD2, and BREEZE-AD5 at baseline and week 16

Measure	Correlation	BREEZE-AD1^a correlation		BREEZE-AD2^a correlation		BREEZE-AD5^a correlation
Measure	Correlation	Baseline	Week 16	Baseline	Week 16	Baseline	Week 16
Itch NRS	ClinRO
	EASI	0.229	0.398	0.223	0.505	0.225	0.498
	PRO
	PGI-S-AD	0.762	0.767	0.759	0.788	0.752	0.834
	DLQI	0.495	0.590	0.506	0.586	0.544	0.666
	POEM	0.483	0.607	0.586	0.640	0.505	0.667
Skin pain NRS	ClinRO
	EASI	0.222	0.338	0.225	0.455	0.251	0.444
	PRO
	PGI-S-AD	0.707	0.691	0.727	0.710	0.689	0.768
	DLQI	0.529	0.549	0.591	0.582	0.586	0.658
	POEM	0.474	0.575	0.634	0.621	0.536	0.657
ADSS item 1	ClinRO
	EASI	0.281	0.363	0.140	0.403	0.233	0.376
	PRO
	PGI-S-AD	0.651	0.582	0.624	0.597	0.627	0.670
	DLQI	0.570	0.576	0.598	0.554	0.522	0.608
	POEM	0.507	0.508	0.531	0.518	0.499	0.582
ADSS item 2	ClinRO
	EASI	0.245	0.254	0.131	0.357	0.223	0.350
	PRO
	PGI-S-AD	0.451	0.424	0.435	0.446	0.449	0.495
	DLQI	0.445	0.486	0.447	0.486	0.411	0.516
	POEM	0.368	0.436	0.468	0.489	0.422	0.473
ADSS item 3	ClinRO
	EASI	0.298	0.237	0.152	0.394	0.187	0.300
	PRO
	PGI-S-AD	0.555	0.636	0.603	0.641	0.639	0.809
	DLQI	0.516	0.466	0.526	0.505	0.516	0.581
	POEM	0.439	0.472	0.460	0.474	0.403	0.563

ADSS, Atopic Dermatitis Sleep Scale; ClinRO, clinician-reported outcome; DLQI, Dermatology Quality of Life Index; EASI, Eczema Area and Severity Index; NRS, Numeric Rating Scale; PGI-S-AD, Patient Global Impression of Severity–Atopic Dermatitis; POEM, Patient Oriented Eczema Measure; PRO, patient-reported outcome
^aSpearman’s correlation coefficients were calculated as correlations between assessments and continuous reference measures. Concurrent validity was small if the resulting coefficient was < 0.4, moderate if the coefficient was > 0.4–0.7, and large if the coefficient was > 0.7

ISSN: 1477-7525