Table 1 Socio-demographic and clinical characteristics of patients
|  | Confirmed drug hypersensitivity (N = 93) | Excluded drug hypersensitivity (N = 107) | p value |
|---|---|---|---|
Gender, n (%) | |||
 Female | 74 (79.6) | 83 (77.6) | 0.863 |
 Male | 19 (20.4) | 24 (22.4) |  |
Age in years, Mean (SD) | 46.0 (15.0) | 43.0 (15.0) | 0.195 |
Academics studies, n (%) | |||
 ≤ 6 years | 4 (11.4) | 10 (24.4) | 0.325 |
 7–12 | 16 (45.7) | 18 (43.9) |  |
 > 12 | 15 (42.9) | 13 (31.7) |  |
Atopy, n (%) | |||
 Yes | 30 (33.3) | 28 (26.7) | 0.347 |
 No | 60 (66.7) | 77 (73.3) |  |
Co-morbidities, n (%) | |||
 Yes | 59 (63.4) | 58 (54.7) | 0.249 |
 No | 34 (36.6) | 48 (45.3) |  |
Daily medication, n (%) | |||
 Yes | 58 (62.4) | 55 (51.9) | 0.153 |
 No | 35 (37.6) | 51 (48.1) |  |
Family history of drug allergy, n (%) | |||
 Yes | 5 (5.5) | 7 (6.6) | 0.776 |
 No | 86 (94.5) | 99 (93.4) |  |
Δ reaction- study, n (%) | |||
 ≤ 2 years | 33 (44.0) | 23 (25.0) | 0.027 |
 > 2 and ≤ 5 years | 21 (28.0) | 29 (31.5) |  |
 > 5 years | 21 (28.0) | 40 (43.5) |  |
Type of reaction, n (%) | |||
 Immediate | 61 (66.3) | 41 (39.0) | < 0.001 |
 Non-Immediate | 24 (26.1) | 55 (52.4) |  |
 Unknown | 7 (7.6) | 9 (8.6) |  |
Clinical manifestations, n (%) | |||
 Anaphylaxis | 36 (40.0) | 4 (3.9) | < 0.001 |
 Urticaria/Angioedema | 24 (26.7) | 21 (20.6) |  |
 Maculopapular exanthema | 25 (27.8) | 54 (52.9) |  |
 Cardiovascular symptoms | 0 (0.0) | 8 (7.8) |  |
 Bronchospasm | 2 (2.2) | 2 (2.0) |  |
 Gastrointestinal symptoms | 0 (0.0) | 3 (2.9) |  |
 Fixed drug eruption | 1 (1.1) | 2 (2.0) |  |
 Unspecified general symptoms | 2 (2.2) | 8 (7.8) |  |
Severity of reaction n (%) | |||
 Mild | 5 (21.7) | 142 (72.1) | < 0.001 |
 Moderate | 5 (21.7) | 52 (26.4) |  |
 Severe | 13 (56.5) | 3 (1.5) |  |
Number of reactions,  Mean (SD) | 1.7 (1.0) | 1.3 (0.5) | < 0.001 |
Number of suspected drugs, Mean (SD) | 1.5 (0.8) | 1.3 (0.5) | 0.006 |
Suspected drug, n (%) | |||
Â ĂŸLantibiotics | 55 (59.1) | 78 (72.9) | 0.051 |
 Non-ĂŸLantibiotics | 14 (15.1) | 21 (19.6) | 0.458 |
 NSAID | 35 (37.6) | 9 (8.4) | < 0.001 |
 General anesthetics | 12 (12.9) | 3 (2.8) | 0.008 |
 RCM | 9 (9.7) | 6 (5.6) | 0.296 |
 Corticosteroids | 7 (7.5) | 3 (2.8) | 0.193 |
 Local anesthetics | 1 (1.1) | 7 (6.5) | 0.07 |
 PPI | 5 (5.4) | 2 (1.9) | 0.254 |
 Other | 9 (9.8) | 3 (2.8) | 0.069 |