Table 3 Study characteristics for Review Question B
From: Quality of life in primary sclerosing cholangitis: a systematic review
Study ID Country Qualityâ—Š | Study design | Sample size % Male | Age (mean) % IBD | PSC severity/stage | Recruitment setting | Factor(s) correlated with QoL? | Outcome measure(s) |
|---|---|---|---|---|---|---|---|
Benito de Valle 2012 Sweden, UK * | Cross-sectional | 182 70% | 50 79% | Cirrhosis = 8% Decompensated liver disease = 6% | Computerised discharge diagnosis register of all hospitals in one region (Sweden); all patients at the outpatient clinic of one hospital (UK) | (1) Age, (2) small/large duct PSC, (3) comorbid illness, (4) serum ALP | (1) Medical outcomes study 36-item short form survey†(2) Chronic liver disease questionnaire†(2) Fatigue impact scale (3) Hospital anxiety and depression scale |
Cheung 2016 Canada ** | Cross-sectional | 99 51% | 46 75% | Cirrhosis = 48% Decompensated liver disease = 16% Mean ALP: 243 U/L | Tertiary liver clinic in Canada (Toronto Centre for Liver Disease) | (1) Age, (2) gender, (3) marital status, (4) employment status, (5) symptoms, (6) history of decompensation | (1) Medical outcomes study 36-item short form survey†(2) Short inflammatory bowel disease questionnaire†(3) Liver disease quality of life questionnaire†(4) Patient health questionnaire-9 (depression) |
Gotthardt 2014 Germany * | Cross-sectional | 113 72% | 44 63% | Mayo Risk score: low = 42%, intermediate = 22%, high = 4%. Data not reported for 35 participants | Tertiary care centre (University Hospital of Heidelberg) | (1) Age, (2) gender, (3) IBD status, (4) dominant stenosis, (5) Mayo risk score, (6) itch | (1) Medical outcomes study 36-item short form survey†|
Haapamäki 2015 Finland ** | Cross-sectional | 341 54% | 43 70% | Asymptomatic = 45% ERC-score mean (SD): 5.9 (3.4) | Tertiary referral centre (The Endoscopy Unit of Helsinki University Central Hospital) | (1) Age, (2) gender, (3) symptoms | (1) 15D instrument†|
Kempinska-Podhorodecka 2017 Poland ** | Cross-sectional | 267 66% | 55‡ NR | Median ALP = 354 U/L | Two medical centres in Poland | (1) Vitamin D receptor polymorphisms | (1) Medical outcomes study 36-item short form survey†(2) PBC-40†(3) PBC-27†|
Raszeja-Wyszomirska 2015a Poland * | Cross-sectional | 33 67% | 35 61% | Cirrhosis = 7%, Mean ALP = 239 U/L | A single tertiary centre | (1) Fragility fractures | (1) Medical outcomes study 36-item short form survey†(2) PBC-40†(3) PBC-27†|
Raszeja-Wyszomirska 2015b Poland * | Cross-sectional | 102 72% | 36 72% | Cirrhosis = 33% | A medical institution in Warsaw, Poland | (1) Age, (2) gender, (c) cirrhosis, (d) IBD status | (1) Medical outcomes study 36-item short form survey†(2) PBC-40†(3) PBC-27†|
Tarter 1991 USA * | Cross-sectional | 52 42%¥ | 41¥ NR | Child–Pugh class: A = 49%, B = 38%, C = 14% | Presbyterian University Hospital of the University of Pittsburgh Health Sciences Center | (1) Child’s-Pugh class | (1) Sickness Impact Profile†|
Wunsch 2016 Poland ** | Cross-sectional | 115 65% | 35 NR | Mean ALP = 299 U/L Child–Pugh class: A = 53%, B = 40%, C = 7% | Liver Unit (Pomeranian Medical University) and the Liver and Internal Medicine Unit (Medical University of Warsaw) | (1) Serum autotaxin | (1) Medical outcomes study 36-item short form survey†(2) PBC-40†(3) PBC-27†|
Younossi 2000 USA * | Cross-sectional | 29 27%¥ | 55¥ NR | No cirrhosis = 36%¥ Child–Pugh class¥: A = 35%, B = 22%, C = 2% | NR | (1) Age, (2) bilirubin, (3) Child’s-Pugh class | (1) Medical outcomes study 36-item short form survey†(2) Chronic liver disease questionnaire†|