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Table 3 Meta-regression of weighted mean differences in health utilities between self- and proxy-reports

From: A comparison of self-reported and proxy-reported health utilities in children: a systematic review and meta-analysis

  β 95% CI P Adjusted P
Constant 0.047 (0.004,0.090) 0.034  
Health condition*
 General population Reference    
 Infectious and parasitic diseases 0.000 (− 0.088, 0.088) 0.998 1.000
 Cancer 0.014 (− 0.049,0.077) 0.655 1.000
 Endocrine, nutritional and metabolic disorders 0.024 (− 0.024, 0.073) 0.330 0.997
 Mental and behavioral disorders 0.004 (− 0.044, 0.052) 0.876 1.000
 Nervous system disorders 0.054 (0.040, 0.148) 0.256 0.986
 Diseases of the ear 0.127 (0.046, 0.209) 0.002 0.024
 Circulatory system disorders − 0.050 (− 0.181, 0.082) 0.459 1.000
 Respiratory system disorders 0.021 (− 0.054, 0.096) 0.583 1.000
 Musculoskeletal disorders − 0.030 (− 0.086, 0.026) 0.288 0.994
 Genitourinary system disorders 0.098 (0.031, 0.166) 0.005 0.055
 Conditions originating in the perinatal period − 0.010 (− 0.066, 0.045) 0.711 1.000
 Congenital malformations − 0.020 (− 0.121, 0.082) 0.703 1.000
 Injury, poisoning and other consequences of external causes − 0.127 (− 0.255, 0.002) 0.053 0.490
 Chronic illness − 0.095 (− 0.170, − 0.020) 0.013 0.154
Valuation methods
 VAS Reference    
 SG 0.007 (− 0.040, 0.054) 0.767 1.000
 TTO − 0.059 (− 0.127, 0.008) 0.083 0.658
 EQ-5D − 0.110 (− 0.163, − 0.058)  < 0.001 0.001
 EQ-5D-Y − 0.045 (− 0.095, 0.006) 0.085 0.672
 HUI2 − 0.067 (− 0.111, − 0.024) 0.002 0.025
 HUI3 − 0.020 (− 0.052, 0.013) 0.228 0.967
 CHU-9D − 0.041 (− 0.094, 0.012) 0.132 0.837
 QWB − 0.041 (− 0.158, 0.076) 0.489 1.000
 PAHOM − 0.104 (− 0.175, − 0.034) 0.004 0.048
Proxy types
 Proxy assessment by parents Reference    
 Proxy assessment by clinicians 0.083 (0.016, 0.151) 0.016 0.185
 Proxy assessment by caregivers − 0.061 (− 0.114, − 0.008) 0.025 0.274
  1. VAS visual analogue scale, SG standard gamble, TTO time trade-off, HUI health utility index, EQ-5D-Y EuroQol 5-dimension youth version, CHU9D child health utility 9-dimension, QWB quality of well-being scale, PAHOM pediatric asthma health outcome measure
  2. *Health conditions were reported based on ICD-10 categories
  3. P values were adjusted by Monte Carlo permutation test with 1000 iterations