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Table 3 Responsiveness of Depression Measures by Retrospective Global Rating of Change for Mood

From: Responsiveness of PROMIS and Patient Health Questionnaire (PHQ) Depression Scales in three clinical trials

Depression change Mean SRM CAMEO SPACE SSM
Score change* SRM (95% CI) P Score change* SRM (95% CI) P Score change* SRM (95% CI) P
PROMIS 4-item      .003     .002     .87
 Better .35 2.71 .37 (.16, .58) .217 3.27 .41 (.22, .60) .086 2.09 .27 (.10, .45) 1.00
 Same .17 0.37 .07 (− .23, .44) 1.04 .15 (− .03, .33) 2.08 .29 (.08, .52)
 Worse ‒.35 − 3.94 − .58 (− 1.2, − .08) .110 − 3.78 − .64 (− 1.1, − .28) .050 1.14 .18 (− .28, .69) .87
PROMIS 6-item      .0007     .018     .71
 Better .39 3.57 .47 (.26, .70) .102 3.68 .43 (.24, .61) .113 2.28 .27 (.11, .45) .94
 Same .19 0.70 .13 (− .18, .51) 1.41 .18 (.00, .37) 1.89 .25 (.03, .47)
 Worse ‒.24 − 3.81 − .52 (− 1.2, − .01) .089 − 2.03 − .30 (− .82, .22) .269 0.72 .11 (− .35, .61) .83
PROMIS 8-item      .0007     .016     .55
 Better .41 3.59 .49 (.27, .70) .135 3.71 .43 (.25, .62) .112 2.33 .30 (.13, .46) .99
 Same .21 0.90 .16 (− .15, .53) 1.45 .19 (.01, .38) 2.15 .29 (.08, .50)
 Worse ‒.25 − 3.91 − .51 (− 1.1, .02) .066 − 2.10 − .30 (− .80, .23) .239 0.30 .05 (− .41, .55) .60
PROMIS SF      .0005     .014     .63
 Better .42 3.82 .51 (.29, .74) .085 4.10 .48 (.30, .65) .096 2.40 .28 (.11, .45) .85
 Same .19 0.75 .13 (− .18, .48) 1.71 .22 (.04, .41) 1.78 .23 (.02, .45)
 Worse ‒.23 − 3.93 − .51 (− 1.2, .03) .085 − 1.82 − .27 (− .84, .27) .258 0.63 .10 (− .36, .60) .84
PROMIS average              
 Better .39   .46     .44     .28   
 Same .19   .12     .19     .27   
 Worse ‒.27   − .53     − .38     .11   
PHQ-9      .0001     .007     .009
 Better .55 3.35 .72 (.50, .97) .002 1.98 .53 (.32, .74) .127 2.16 .41 (.26, .57) .385
 Same .19 0.07 .02 (− .30, .34) 0.93 .26 (.07, .45) 1.22 .26 (.05, .48)
 Worse ‒.28 − 1.28 − .23 (− .65, .25) .601 − 1.20 − .30 (− 1.3, .26) .111 − 1.50 − .31 (− .74, .15) .082
PHQ-2      .077     .042     .088
 Better .38 0.76 .42 (.21, .65) .250 0.61 .48 (.29, .66) .203 0.44 .25 (.08, .42) .804
 Same .18 0.24 .16 (− .15, .50) 0.28 .22 (.03, .42) 0.28 .17 (− .06, .41)
 Worse ‒.20 − 0.11 − .10 (− .59, .39) .735 − 0.29 − .17 (− .81, .41) .310 − 0.50 − .34 (− .97, .12) .183
SF-36 Mental      .042         
 Better   7.92 .43 (.23, .63) .038         
 Same   − 1.10 − .09 (− .45, .22)         
 Worse   1.94 .06 (− .50, .48) .836         
  1. Total N (better, same, worse) with baseline and follow-up data in CAMEO = 138 (79, 41, 18); in SPACE = 224 (89, 120, 15); and in SSM = 238 (136, 82, 20)
  2. * Score change = baseline—follow-up (Positive score: improvement, negative score: worsening)
  3. SRM = (baseline − follow-up)/SD change score;
  4. Bolded p-values are from omnibus ANOVA tests comparing change scores among the three groups. Other p values were derived from pairwise comparisons of change scores between better vs. same, same vs. worse, and better vs. worse, and were adjusted for multiple comparisons using the Tukey–Kramer procedure. Since all better vs. worse pairwise comparisons were significant when the omnibus test was significant, only better vs. same and same vs. worse p-values are reported in this table