Health-related quality of life and work productivity in UK patients with HER2-positive breast cancer: a cross-sectional study evaluating the relationships between disease and treatment stage

Table 4 Health-related quality of life as measured by the FACT-B scores by patient group

	Group 1	Group 2	Group 3	Between-group differences
	Group 1	Group 2	Group 3	Fisher p value
FACT-B subscales (mean, SD)
Physical wellbeing	20.57 (5.93) (n = 86)	22.63 (5.08) (n = 107)	18.81 (6.89) (n = 101)	< 0.001
Social wellbeing	23.62 (4.88) (n = 86)	22.26 (5.23) (n = 108)	20.65 (6.34) (n = 100)	0.001
Emotional wellbeing	18.13 (4.87) (n = 87)	17.68 (4.87) (n = 107)	15.19 (5.99) (n = 100)	< 0.001
Functional wellbeing	18.69 (6.32) (n = 88)	20.76 (5.52) (n = 108)	16.43 (7.30) (n = 101)	< 0.001
Breast cancer-specific	22.01 (7.00) (n = 86)	22.38 (7.68) (n = 108)	21.37 (6.96) (n = 101)	0.602
FACT-B summary scores (mean, SD)
FACT-G^a	80.89 (17.69) (n = 85)	83.19 (16.80) (n = 106)	71.07 (22.42) (n = 99)	< 0.001
FACT-B total	102.93 (23.41) (n = 85)	105.58 (23.00) (n = 106)	92.24 (27.38) (n = 99)	< 0.001
Trial outcome index^b	61.19 (16.95) (n = 86)	65.74 (16.05) (n = 107)	56.61 (18.14) (n = 101)	0.001

Higher scores reflect higher levels of HRQoL. n, numbers shown where data were not available for all patients
^aFACT-G: Functional Assessment of Cancer Therapy-General; constitutes the non-tumour specific core of the FACT-B subscale [18]
^bTrial outcome index calculated from the sum of the physical wellbeing, functional wellbeing, and additional concerns subscales of the FACT-B [18]

ISSN: 1477-7525