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Table 1 Specifications of studies entered into the meta-analysis

From: The effect of methadone on depression among addicts: a systematic review and meta-analysis

Author, year, Reference Place of study Sample size intervention group Mean ± SD of before Mean ± SD of after Method Study design Type of intervention Quality
Lotfi [15] Iran 10 28.7 ± 3.09 10.5 ± 5.58 BDI1 Clinical trial (with pretest –posttest and control group) 10 to 20 cc of methadone syrup per day for 12 weeks High
Pournaghash [16] Iran 50 6.91 ± 6.35 3.56 ± 3.7 GHQ-282 Clinical trial 12 to 24 cc of methadone syrup per day for 12 weeks High
Rezaei [17] Iran 50 1.7 ± 1.3 0.35 ± 0.67 BDI Randomized, controlled clinical trial 15 to 40 cc of methadone syrup per day for 6 weeks High
Yaghoubi [18] Iran 12 23.83 ± 2.24 17.33 ± 1.61 BDI Clinical trial Methadone syrup or tablets for 6 weeks High
Ardani [19] Iran 12 24.41 ± 10.5 11.16 ± 4.98 SCL-90-R3 Clinical trial 15 to 40 cc of methadone syrup per day for 9 weeks High
Ahmadvand [20] Iran 19 38.6 ± 10.59 28.22 ± 11.29 BDI Clinical trial Methadone therapy for 3 months Medium
Hosseini [21] Iran 107 26.03 ± 5.95 19.02 ± 7.23 BDI Clinical trial Methadone syrup for 6 weeks High
Jondaghi [22] Iran 10 17.26 ± 8.42 14.1 ± 3.95 SCL-90-R Clinical trial Methadone therapy for 12 weeks High
Khaledian [23] Iran 12 39.91 ± 4.33 32.08 ± 3.67 BDI Clinical trial (pretest –posttest and control group) Methadone syrup or tablets for 12 weeks Medium
Jenaabadi [24] Iran 19 32.38 ± 5.59 18.3 ± 3.03 BDI Clinical trial 0.5 mg / kg methadone syrup for 12 weeks Medium
Taimouri [25] Iran 12 21.43 ± 3.14 16.54 ± 3.22 BDI Clinical trial Methadone syrup or tablets for 9 weeks High
Saedy [26] Iran 14 26.1 ± 16.4 16.6 ± 11.6 BDI Clinical trial 0.5 mg / kg methadone syrup for 9 weeks High
Yin [27] China 1301 50.52 ± 10.99 48.22 ± 10.06 SDS4 Clinical trial Methadone syrup or tablets for 1 months High
Newville [28] USA 100 41.6 ± 7.1 38.6 ± 7.6 BDI Clinical trial Methadone syrup or tablets for 3 months High
Jovanović [29] USA 69 27.46 ± 4.16 17.69 ± 3.68 BDI Clinical trial Methadone syrup or tablets for 6 months Medium
Lin [30] Taiwan 50 18.51 ± 2.61 2.49 ± 2.89 BDI Clinical trial 0.5 mg / kg methadone syrup for 12 weeks High
Silverman [31] USA 24 28 ± 7 23 ± 3 BDI Clinical trial 15 to 40 cc of methadone syrup per day for 12 weeks High
Schreiber [32] Israel 63 17.4 ± 6.2 11.8 ± 8.4 BDI Clinical trial 10 to 20 cc of methadone syrup per day for 8 weeks High
El Hage [33] Canada 14 34.3 ± 1.5 17.3 ± 2.3 MADRS5 Clinical trial 15 to 40 cc of methadone syrup per day for 8 weeks High
  1. 1Beck depression inventory
  2. 2Goldberg health questionnaire
  3. 3Symptom check list-90-revised
  4. 4Self-rating depression scale
  5. 5Montgomery-asberg depression rating scale