Table 1 Specifications of studies entered into the meta-analysis
From: The effect of methadone on depression among addicts: a systematic review and meta-analysis
Author, year, Reference | Place of study | Sample size intervention group | Mean ± SD of before | Mean ± SD of after | Method | Study design | Type of intervention | Quality |
|---|---|---|---|---|---|---|---|---|
Lotfi [15] | Iran | 10 | 28.7 ± 3.09 | 10.5 ± 5.58 | BDI1 | Clinical trial (with pretest –posttest and control group) | 10 to 20 cc of methadone syrup per day for 12 weeks | High |
Pournaghash [16] | Iran | 50 | 6.91 ± 6.35 | 3.56 ± 3.7 | GHQ-282 | Clinical trial | 12 to 24 cc of methadone syrup per day for 12 weeks | High |
Rezaei [17] | Iran | 50 | 1.7 ± 1.3 | 0.35 ± 0.67 | BDI | Randomized, controlled clinical trial | 15 to 40 cc of methadone syrup per day for 6 weeks | High |
Yaghoubi [18] | Iran | 12 | 23.83 ± 2.24 | 17.33 ± 1.61 | BDI | Clinical trial | Methadone syrup or tablets for 6 weeks | High |
Ardani [19] | Iran | 12 | 24.41 ± 10.5 | 11.16 ± 4.98 | SCL-90-R3 | Clinical trial | 15 to 40 cc of methadone syrup per day for 9 weeks | High |
Ahmadvand [20] | Iran | 19 | 38.6 ± 10.59 | 28.22 ± 11.29 | BDI | Clinical trial | Methadone therapy for 3 months | Medium |
Hosseini [21] | Iran | 107 | 26.03 ± 5.95 | 19.02 ± 7.23 | BDI | Clinical trial | Methadone syrup for 6 weeks | High |
Jondaghi [22] | Iran | 10 | 17.26 ± 8.42 | 14.1 ± 3.95 | SCL-90-R | Clinical trial | Methadone therapy for 12 weeks | High |
Khaledian [23] | Iran | 12 | 39.91 ± 4.33 | 32.08 ± 3.67 | BDI | Clinical trial (pretest –posttest and control group) | Methadone syrup or tablets for 12 weeks | Medium |
Jenaabadi [24] | Iran | 19 | 32.38 ± 5.59 | 18.3 ± 3.03 | BDI | Clinical trial | 0.5 mg / kg methadone syrup for 12 weeks | Medium |
Taimouri [25] | Iran | 12 | 21.43 ± 3.14 | 16.54 ± 3.22 | BDI | Clinical trial | Methadone syrup or tablets for 9 weeks | High |
Saedy [26] | Iran | 14 | 26.1 ± 16.4 | 16.6 ± 11.6 | BDI | Clinical trial | 0.5 mg / kg methadone syrup for 9 weeks | High |
Yin [27] | China | 1301 | 50.52 ± 10.99 | 48.22 ± 10.06 | SDS4 | Clinical trial | Methadone syrup or tablets for 1 months | High |
Newville [28] | USA | 100 | 41.6 ± 7.1 | 38.6 ± 7.6 | BDI | Clinical trial | Methadone syrup or tablets for 3 months | High |
Jovanović [29] | USA | 69 | 27.46 ± 4.16 | 17.69 ± 3.68 | BDI | Clinical trial | Methadone syrup or tablets for 6 months | Medium |
Lin [30] | Taiwan | 50 | 18.51 ± 2.61 | 2.49 ± 2.89 | BDI | Clinical trial | 0.5 mg / kg methadone syrup for 12 weeks | High |
Silverman [31] | USA | 24 | 28 ± 7 | 23 ± 3 | BDI | Clinical trial | 15 to 40 cc of methadone syrup per day for 12 weeks | High |
Schreiber [32] | Israel | 63 | 17.4 ± 6.2 | 11.8 ± 8.4 | BDI | Clinical trial | 10 to 20 cc of methadone syrup per day for 8 weeks | High |
El Hage [33] | Canada | 14 | 34.3 ± 1.5 | 17.3 ± 2.3 | MADRS5 | Clinical trial | 15 to 40 cc of methadone syrup per day for 8 weeks | High |