Table 1 Criteria for including studies in the review
i. Population | People with any stage CKD including patients on dialysis (haemodialysis or peritoneal dialysis) or with a renal transplant; any gender, any location, and any severity of CKD. Populations must be representative of the CKD population (i.e., general comorbidities, reasonable age range) and be greater than 25 people in size. Subgroups of interest include (not limited to): CKD patients with albuminuria (normo-, micro-, macro-albuminuria), T2DM, glomerulonephritis, IgA nephropathy. |
ii. Interventions/comparators | All interventions and comparative data were included. Where the intervention is not relevant for the study purposes in some cases only baseline or placebo arm data is included. |
iii. Outcomes | Health state utilities from standardised generic multi-attribute utility measures such as EQ-5D, SF-6D or Health Utilities Index (HUI). HSUs for all CKD stages, dialysis modalities (haemodialysis and peritoneal dialysis), or renal transplant. Disutility associated with cardiovascular events commonly included in health economic models in CKD (acute and chronic where available): myocardial infarction, stroke, heart failure. Disutility associated with adverse events commonly included in health economic models in CKD: potassium imbalances (hypo- and hyperkalaemia), volume depletion, acute kidney injury, major hypoglycaemic events, diabetic ketoacidosis, fractures, amputations (minor/major or toe, foot, limb, etc.). Impact of comorbidities or patient characteristics on HSUs: albuminuria (normo-, micro-, macro-albuminuria), T2DM, hypertension, heart failure or cardiovascular disease, age or sex on HSUs. Impact of complications related to renal replacement therapies on HSUs: dialysis related complications (e.g. vascular access thrombosis), renal transplant failure, renal transplant surgery. |
iv. Study Designs | Interventional or non-interventional research. |
v. Other requirements | Records from January 1, 1999 to present (August, 2019) only. Abstract and full-text must be available in English text. |