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Table 4 Symptoms based on interview by study nurse in patients by somatostatin analogue treatment for metastatic disease from small intestinal neuroendocrine tumour

From: Patient reported symptoms, coping and quality of life during somatostatin analogue treatment for metastatic small- intestinal neuroendocrine tumours

 Baseline1-year follow-up
Lanreotide (N = 34)Octreotide LAR (N = 54)Total N = 88Total N = 77
Acute complaints from the injections,n(%)
None17 (50.0%)24 (44.4%)41 (46.6%)44 (57.1%)
Sore lumps beneath the skin11 (32.4%)14 (25.9%)25 (28.4%)22 (28.6%)
Pain2 (5.9%)5 (9.3%)7 (8.0%)8 (10.4%)
Other5 (14.7%)16 (29.6%)21 (23.8%)9 (11.7%)
Persistent complaints from the injections,n(%)
None20 (58.8%)34 (63.0%)54 (61.4%)53 (68.8%)
Sore lumps beneath the skin6 (17.6%)7 (13.0%)13 (14.8%)15 (19.5%)
Pain1 (2.9%)3 (5.6%)4 (4.5%)2 (2.6%)
Flatulence4 (11.8%)6 (11.1%)10 (11.4%)3 (3.9%)
Diarrhoea5 (14.7%)5 (9.3%)10 (11.4%)2 (2.6%)
Other6 (17.6%)7 (13.0%)13 (14.8%)6 (7.8%)
Symptoms (based on interview)
Flatulence26 (76.5%)37 (68.5%)63 (71.6%)54 (71.1%)
   ≥ 5 / day (% of total)10 (29.4%)10 (18.9%)20 (23.0%)14 (18.4%)
2–4 / day (% of total)9 (26.5%)12 (22.6%)21 (24.1%)26 (34.2%)
1–2 / day (% of total)7 (20.6%)14 (26.4%)21 (24.1%)14 (18.4%)
Diarrhoea24 (70.6%)33 (61.1%)57 (64.8%)49 (64.5%)
   ≥ 5 / day (% of total)6 (17.6%)14 (25.9%)20 (22.7%)14 (18.7%)
2–4 / day (% of total)14 (41.2%)10 (18.5%)24 (27.3%)22 (29.3%)
1–2 / day (% of total)4 (11.8%)9 (16.7%)13 (14.8%)12 (16.0%)
Fatigue19 (55.9%)33 (61.1%)52 (59.1%)49 (63.6%)
Abdominal discomfort21 (61.8%)28 (51.9%)49 (55.7%)37 (48.1%)
Flushing12 (35.3%)20 (37.0%)32 (36.3%)32 (41.6%)
   ≥ 5 / day (% of total)1 (2.9%)3 (5.6%)4 (4.5%)2 (2.6%)
2–4 / day (% of total)05 (9.3%)5 (5.7%)6 (7.9%)
1–2 / day (% of total)11 (32.4%)12 (22.2%)23 (26.1%)23 (30.3%)
Depression/anxiety7 (20.6%)18 (33.3%)25 (28.4%)26 (33.8%)
Partial hair loss10 (29.4%)15 (27.8%)25 (28.4%)22 (28.6%)
Nausea7 (20.6%)12 (22.2%)19 (21.6%)12 (15.6%)
Effects of diet
Reaction to certain food items22 (64.7%)33 (61.1%)55 (62.5%)47 (61.0%)
Diarrhoea15 (44.1%)24 (44.4%)39 (44.3%)34 (44.2%)
Flatulence16 (47.1%)22 (40.7%)38 (43.2%)30 (39.0%)
Flushing2 (5.9%)2 (3.7%)4 (4.5%)4 (5.2%)
Other6 (17.6%)9 (16.7%)15 (17.0%)12 (15.6%)
Needs to avoid certain food13 (38.2%)22 (40.7%)35 (39.8%)29 (37.7%)
Reacts to alcohol11 (32.4%)19 (35.8%)30 (34.5%)24 (32.0%)