Table 4 Linear mixed models of trouble swallowing, dry mouth, and numbness/tingling
Trouble swallowinga | Dry mouthb | Numbness/tinglingc | ||||
|---|---|---|---|---|---|---|
Effect | Estimate (SE) | P-value | Estimate (SE) | P-value | Estimate (SE) | P-value |
Intercept | 5.03 (2.519) | 0.047 | 2.81 (2.388) | 0.242 | 3.94 (1.791) | 0.029 |
Time (months) since diagnosis | −0.05 (0.014) | 0.001 | 0.04 (0.011) | 0.0003 | 0.02 (0.010) | 0.070 |
Treatment: cetuximab±RT (vs. cisplatin±RT) | −0.11 (0.546) | 0.835 | 0.17 (0.494) | 0.736 | −0.15 (0.367) | 0.677 |
Treatment* time since diagnosis | 0.01 (0.050) | 0.842 | −0.02 (0.038) | 0.605 | 0.01 (0.035) | 0.820 |
Age at diagnosis | −0.04 (0.022) | 0.070 | −0.01 (0.021) | 0.556 | −0.06 (0.016) | < 0.0001 |
Male (vs. female) | −0.81 (0.417) | 0.053 | −0.72 (0.399) | 0.071 | −0.49 (0.300) | 0.100 |
White (vs. minority/unknown) | 0.26 (0.378) | 0.500 | 0.44 (0.362) | 0.229 | −0.05 (0.272) | 0.861 |
Impaired composite performance status (vs. not impaired) | 0.97 (0.748) | 0.197 | −0.11 (0.716) | 0.879 | 0.49 (0.537) | 0.359 |
Weighted index of comorbid conditions | 0.22 (0.199) | 0.269 | 0.11 (0.190) | 0.557 | 0.16 (0.143) | 0.264 |
Smoking status: current or past (vs. never/unknown/undocumented) | − 0.32 (0.472) | 0.494 | 0.19 (0.451) | 0.677 | 0.41 (0.339) | 0.227 |
Alcohol status | – | 0.292 | – | 0.074 | – | 0.683 |
Current or past abuse (vs. never/unknown/undocumented) | 0.44 (0.494) | 0.377 | −0.32 (0.472) | 0.504 | 0.31 (0.355) | 0.387 |
Current or past use (vs. never/unknown/undocumented) | −0.25 (0.404) | 0.540 | −0.85 (0.387) | 0.028 | 0.17 (0.291) | 0.567 |
Stage at start: Stage III (vs. Stage IV) | 0.30 (0.358) | 0.399 | −0.15 (0.343) | 0.666 | 0.05 (0.258) | 0.862 |
Oral (vs. non-oral) | 0.96 (0.966) | 0.319 | 0.13 (0.917) | 0.889 | −0.63 (0.685) | 0.357 |
Pharynx (vs. non-pharynx) | 1.79 (0.942) | 0.058 | 0.70 (0.894) | 0.434 | −0.82 (0.667) | 0.221 |
Larynx (vs. non-larynx) | 1.06 (0.994) | 0.285 | −0.07 (0.944) | 0.941 | −0.79 (0.704) | 0.261 |
HPV test results (positive vs. non-positive) | 0.61 (1.005) | 0.541 | 1.52 (0.957) | 0.112 | 0.46 (0.719) | 0.526 |
P16 test results (positive vs. non-positive) | −0.24 (0.418) | 0.564 | 0.38 (0.401) | 0.344 | 0.60 (0.303) | 0.048 |
Feeding tube placement (vs. not placed) | 0.95 (0.360) | 0.008 | 0.77 (0.345) | 0.026 | −0.12 (0.259) | 0.651 |
BMI | −0.03 (0.029) | 0.380 | 0.05 (0.028) | 0.107 | 0.01 (0.021) | 0.618 |
Insurance | – | 0.180 | – | 0.083 | – | 0.026 |
Only public (vs. only private) | 0.64 (0.484) | 0.184 | 0.94 (0.462) | 0.043 | 0.89 (0.347) | 0.011 |
Both public and private (vs. only private) | 0.10 (0.454) | 0.836 | −0.004 (0.434) | 0.993 | 0.87 (0.326) | 0.008 |
Other/unknown/undocumented (vs. only private) | 2.04 (1.113) | 0.067 | 1.50 (1.054) | 0.171 | 0.36 (0.785) | 0.644 |
US Region South (vs. non-South) | 0.22 (1.693) | 0.897 | −0.44 (1.591) | 0.783 | 0.79 (1.190) | 0.508 |