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Table 3 Pearson correlation coefficients between FACT-M and EQ-5D scores at baseline (n = 172)*

From: Update on the psychometric properties and minimal important difference (MID) thresholds of the FACT-M questionnaire for use in treatment-naïve and previously treated patients with metastatic Merkel cell carcinoma

Score at baselineEQ-5D mobilityEQ-5D self-careEQ-5D usual activityEQ-5D pain/ discomfortEQ-5D anxiety/ depressionEQ VASEQ-5D Index
FACT-G subscales
 Physical well-being− 0.43**− 0.39− 0.64− 0.68− 0.430.590.65
 Social/Family well-being−0.21− 0.14− 0.19− 0.12− 0.240.220.22
 Emotional well-being− 0.31− 0.27− 0.45−0.41− 0.590.520.48
 Functional well-being−0.46−0.33− 0.63−0.51− 0.520.560.61
Melanoma-specific subscales
 Melanoma subscale*−0.49−0.41− 0.70−0.65− 0.490.630.68
 Melanoma surgery scale−0.38−0.42− 0.53−0.45− 0.260.450.50
Summary scales
 FACT-M TOI−0.50−0.41− 0.72−0.66− 0.530.650.71
 FACT-G Total score−0.45−0.35− 0.60−0.54− 0.550.590.62
 FACT-M Total score−0.49−0.39− 0.67−0.60− 0.560.640.67
MCC-specific scores
 Physical function (PF)−0.56−0.40− 0.73−0.59− 0.470.570.68
 Psychological impact (PI)−0.30−0.26− 0.45−0.43− 0.580.500.48
 MCC summary score−0.49−0.38− 0.67−0.57− 0.570.600.66
  1. * Negative correlations are due to the different scoring of the two instruments, with high EQ-5D item scores reflecting greater health/function problems, whereas for scores from the FACT-M, higher scores indicate better well-being or health status
  2. ** Grey shadings indicate correlations between EQ-5D item / index / EQ VAS scores expected to correlate highest with FACT-M subscale / summary / MCC-specific scores
  3. TOI = Trial Outcome Index; MCC = Merkel cell carcinoma; *n = 171 for Melanoma subscale