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Table 2 Discontinuation due to any reasons in RCTs comparing PUFAs vs placebo: summary of findings

From: Equity, acceptability and feasibility of using polyunsaturated fatty acids in children and adolescents with autism spectrum disorder: a rapid systematic review

Should polyunsaturated fatty acids versus placebo be used for the treatment of children and adolescents with autism spectrum disorder?
Patient or population: children and adolescents with autism spectrum disorder
Setting: outpatients
Intervention: polyunsaturated fatty acids (PUFAs)
Comparison: placebo
OutcomesAnticipated absolute effects* (95% CI)Relative effect(95% CI)№ of participants (studies)Certainty of the evidence(GRADE)Comments
Risk with placeboRisk with PUFAs
Discontinuation due to any cause213 per 1.000226 per 1.000(119 to 432)RR 1.06(0.56 to 2.03)315
(7 RCTs) [20,21,22,23,24,25, 27]

LOW a
Polyunsaturated fatty acids could have no effect on the risk of discontinuation due to any cause.
  1. *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
  2. CI: Confidence interval; RR: Risk ratio; SMD: Standardised mean difference
  3. GRADE Working Group grades of evidence
  4. High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
  5. Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
  6. Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
  7. Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  8. aDowngraded of two levels because optimal information size (OIS) not met and there is a wide 95%CI, which includes no effect