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Table 1 Factors that should be considered while deciding which are the research questions to be included in a guideline

From: Introduction and methods of the evidence-based guidelines for the diagnosis and management of autism spectrum disorder by the Italian National Institute of Health

Factors that influence if a question is important in the context of a guideline
1. Common question in practice?
2. Uncertainty in practice?
3. New evidence to consider?
4. Variation in practice?
5. Consequences for resource use/cost?
6. Not previously or sufficiently addressed?