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Table 4 Simulation Performance Measures for Complete Case Analysis (CCA), Maximum Likelihood (ML) and Multiple Imputation (MI)

From: Impact of missing data on bias and precision when estimating change in patient-reported outcomes from a clinical registry

Missing Mechanism

Model Parameter

Performance Measure

10% Missing

25% Missing

50% Missing

CCA

ML

MI

CCA

ML

MI

CCA

ML

MI

MCAR

β 0

Bias

5.57

6.90

7.53

2.03

1.09

3.97

−0.19

1.51

6.23

RMSE

1.89

1.83

1.84

2.14

1.96

1.97

2.68

2.19

2.23

CI Width

8.28

8.09

8.12

9.06

8.48

8.56

11.14

9.31

9.50

β T

Bias

−2.91

−3.29

−11.63

−3.47

−1.79

−20.61

− 1.90

−2.21

− 39.96

RMSE

0.47

0.47

0.45

0.54

0.52

0.49

0.68

0.60

0.53

CI Width

2.18

2.15

2.15

2.38

2.29

2.31

2.92

2.62

2.64

β TS

Bias

3.21

3.27

15.30

3.30

0.89

29.48

−4.47

−2.62

60.89

RMSE

0.59

0.59

0.55

0.68

0.66

0.56

0.86

0.76

0.58

CI Width

2.85

2.81

2.81

3.12

3.00

3.00

3.81

3.43

3.32

MAR

β 0

Bias

14.08

6.19

7.17

11.42

0.56

2.01

−13.98

−9.28

−6.69

RMSE

1.87

1.81

1.81

2.08

1.91

1.92

2.59

2.12

2.16

CI Width

8.21

8.05

8.08

8.89

8.39

8.47

10.67

9.12

9.24

β T

Bias

20.71

14.92

9.90

42.60

32.55

21.65

86.01

64.71

43.61

RMSE

0.47

0.46

0.44

0.56

0.52

0.47

0.81

0.66

0.52

CI Width

2.14

2.12

2.13

2.30

2.23

2.25

2.72

2.51

2.56

β TS

Bias

11.25

10.53

21.15

21.13

18.10

45.06

10.25

3.52

64.01

RMSE

0.60

0.59

0.56

0.69

0.66

0.59

0.85

0.75

0.59

CI Width

2.83

2.80

2.81

3.09

2.98

2.98

3.79

3.41

3.31

MNAR

β 0

Bias

−52.67

−41.61

−39.78

− 111.56

− 82.51

−80.01

− 171.53

− 105.67

− 102.79

RMSE

2.05

1.89

1.89

3.08

2.45

2.43

5.23

3.16

3.17

CI Width

8.13

7.95

7.97

8.79

8.27

8.34

10.70

9.16

9.35

β T

Bias

−1.46

7.61

−2.71

−25.40

−9.78

−36.13

−73.72

−47.93

− 110.44

RMSE

0.47

0.47

0.45

0.57

0.53

0.51

0.87

0.69

0.76

CI Width

2.19

2.15

2.17

2.42

2.32

2.34

3.04

2.70

2.73

β TS

Bias

−17.53

−18.53

−5.93

−32.42

−34.40

−3.92

−45.61

−45.24

17.64

RMSE

0.59

0.59

0.54

0.72

0.69

0.54

0.99

0.88

0.53

CI Width

2.85

2.81

2.82

3.13

3.01

3.02

3.90

3.50

3.41

  1. CI Width Average width of the 95% confidence interval, Bias Standardized bias, RMSE Root mean squared error