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Table 2 Comparison of SF-36 health domain scales (normal and norm-based) between DR-TB patients who reported an adverse event in the last four weeks and those who did not (n = 149)

From: The impact of adverse events on health-related quality of life among patients receiving treatment for drug-resistant tuberculosis in Johannesburg, South Africa

   Adverse event not reported (n = 91) Patient-reported adverse event (n = 58)  
SF-36 scalea (Normal scale) Items Mean SD Alpha* Mean SD Alpha* P value**
Physical functioning 10 89.0 16.9 0.910 73.0 24.8 0.869 0.0001
Role functioning/physical 4 68.7 43.2 0.906 29.7 43.3 0.849 0.0001
Role functioning/emotional 3 64.8 46.7 0.909 22.9 39.1 0.866 0.0001
Energy/fatigue 4 58.3 16.3 0.903 48.3 17.1 0.861 0.006
Emotional well-being 5 65.3 17.8 0.902 54.8 17.1 0.851 0.005
Social functioning 2 78.6 22.8 0.908 59.5 16.6 0.859 < 0.0001
Pain 2 78.5 20.9 0.906 63.4 12.0 0.86 0.0001
General health 5 66.6 15.1 0.914 59.3 13.8 0.869 0.003
SF-36 scalea (Norm-based scale)
 Physical functioning 10 52.4 7.1 0.911 45.7 14.9 0.869 0.0001
 Role functioning/physical 4 44.6 16.9 0.907 29.3 17.7 0.849 0.0001
 Role functioning/emotional 3 39.4 21.8 0.91 19.9 18.2 0.866 0.0001
 Energy/fatigue 4 50.0 8.1 0.904 44.9 8.5 0.861 0.0005
 Emotional well-being 5 44.5 10.0 0.903 38.6 8.6 0.851 0.007
 Social functioning 2 47.5 9.9 0.909 39.2 8.1 0.859 0.0001
 Pain 2 53.0 8.8 0.907 46.2 10.6 0.86 0.0001
 General health 5 48.0 7.2 0.914 44.5 6.6 0.869 0.003
 Mental health component summary (MCS)   42.2 13.0 n/a 32.1 9.9 n/a < 0.001
 Physical health component summary (PCS)   52.8 8.2 n/a 46.5 9.1 n/a < 0.0001
  1. a using the 36-Item Medical Outcomes Short Form Health Survey (SF-36)
  2. *For the Alpha, Cronbach’ alpha value of >0.80 was used to define good internal consistency of the SF-36 domains
  3. **For the P value, this was to indicate the difference between means for patients with AE vs those without. 0.05 was a cutoff for significance