The impact of adverse events on health-related quality of life among patients receiving treatment for drug-resistant tuberculosis in Johannesburg, South Africa

Table 2 Comparison of SF-36 health domain scales (normal and norm-based) between DR-TB patients who reported an adverse event in the last four weeks and those who did not (n = 149)

		Adverse event not reported (n = 91)			Patient-reported adverse event (n = 58)
SF-36 scale^a (Normal scale)	Items	Mean	SD	Alpha*	Mean	SD	Alpha*	P value**
Physical functioning	10	89.0	16.9	0.910	73.0	24.8	0.869	0.0001
Role functioning/physical	4	68.7	43.2	0.906	29.7	43.3	0.849	0.0001
Role functioning/emotional	3	64.8	46.7	0.909	22.9	39.1	0.866	0.0001
Energy/fatigue	4	58.3	16.3	0.903	48.3	17.1	0.861	0.006
Emotional well-being	5	65.3	17.8	0.902	54.8	17.1	0.851	0.005
Social functioning	2	78.6	22.8	0.908	59.5	16.6	0.859	< 0.0001
Pain	2	78.5	20.9	0.906	63.4	12.0	0.86	0.0001
General health	5	66.6	15.1	0.914	59.3	13.8	0.869	0.003
SF-36 scale^a (Norm-based scale)
Physical functioning	10	52.4	7.1	0.911	45.7	14.9	0.869	0.0001
Role functioning/physical	4	44.6	16.9	0.907	29.3	17.7	0.849	0.0001
Role functioning/emotional	3	39.4	21.8	0.91	19.9	18.2	0.866	0.0001
Energy/fatigue	4	50.0	8.1	0.904	44.9	8.5	0.861	0.0005
Emotional well-being	5	44.5	10.0	0.903	38.6	8.6	0.851	0.007
Social functioning	2	47.5	9.9	0.909	39.2	8.1	0.859	0.0001
Pain	2	53.0	8.8	0.907	46.2	10.6	0.86	0.0001
General health	5	48.0	7.2	0.914	44.5	6.6	0.869	0.003
Mental health component summary (MCS)		42.2	13.0	n/a	32.1	9.9	n/a	< 0.001
Physical health component summary (PCS)		52.8	8.2	n/a	46.5	9.1	n/a	< 0.0001

^a using the 36-Item Medical Outcomes Short Form Health Survey (SF-36)
*For the Alpha, Cronbach’ alpha value of >0.80 was used to define good internal consistency of the SF-36 domains
**For the P value, this was to indicate the difference between means for patients with AE vs those without. 0.05 was a cutoff for significance

ISSN: 1477-7525