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Table 3 Studies of older Patients Undergoing Conservative Management (CM): Symptom

From: Quality of life, symptoms, and sleep quality of elderly with end-stage renal disease receiving conservative management: a systematic review

Author Country Study type Type of intervention Participants, n Age(mean ± SD) Dropout Rate,% Exclusion Criteria Setting Outcome Measures Results Quality assessment
Wan Zukiman et al.
(2017) [24]
Malaysia Prospective cohort study Nondialysed, RRT 187 (100 nondialysed, 87 RRT) 60.97 (13.89) 0 Pregnancy; presence of any type of acute psychiatric disorder; lack of capacity to give informed consent; inability to communicate fluently in Malay or English language; or illiteracy. Nephrology department DSI No difference in the prevalence of symptom burden and severity between two groups. 7
Brown MA et al.(2015) [25] Australia Prospective cohort study Nondialysis,
467 74.5 15.4 NA Renal clinics MSAS-SF 57% had stable or improved symptoms over 12 months for nondialysis patients. 8
Yong et al.(2009) [22] Hong Kong Prospective cohort study Palliative-care,
191 61.9 (12.3) 6.3 Cognitive impairment or known
psychiatric illness
Hospital 23 symptoms related to ESRD was
assessed using NRS
No significant difference between the palliative care
group and the dialysis group (P = 0.243)
Murtagh et al. (2007) [28] United Kingdom Retrospective cohort study CM,
Advanced cancer
66 82 (6.6) 0 Lacked capacity to consent to research participation Renal units MSAS-SF Patients with ESRD have considerable symptom control needs, similar to advanced cancer populations. 6
Saini et al.(2006) [29] United Kingdom Prospective cohort study CM,
terminal malignancy
22 65 0 Aged< 18 years,unclear themselves diagnosis and its implications Renal clinic MSAS-SF Similar symptom burden for two groups. 7
  1. Abbreviations: DSI The 30-item Dialysis Symptom Index, NRS numerical rating scale, MSAS-SF Memorial Symptom Assessment Scale–Short Form, POSs the Patient Outcome Scale (symptom module)