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Table 3 Mixed effect model analysis of metformin effect on general HRQoL outcome measured via WHOQOL-Bref

From: Correction to: Metformin improved health-related quality of life in ethnic Chinese women with polycystic ovary syndrome

WHOQOL-Bref Total
Coefficient (SE)
Subgroups
Normal weight
Coefficient (SE)
Overweight
Coefficient (SE)
Non- hyperandrogenism
Coefficient (SE)
Hyperandrogenism
Coefficient (SE)
Total scores
 Treatment time      
  Visit 2 (reference = visit 1) −0.93 (1.04) 0.47 (0.77) −1.72 (1.44) 1.49 (1.26) 0.79 (0.56)
  Visit 3 (reference = visit 1) 0.06 (0.94) 0.07 (0.75) −0.27 (1.45) 0.52 (1.30) 0.70 (0.56)
Physical domain
 Treatment time p = 0.010   p = 0.036   p = 0.015
  Visit 2 (reference = visit 1) 0.58 (0.20)* 0.50 (0.29) 0.57 (0.28)* 0.62 (0.50) 0.55 (0.22)*
  Visit 3 (reference = visit 1) 0.54 (0.20)* 0.50 (0.29) 0.64 (0.27)* 0.29 (0.51) 0.60 (0.22)*
Psychological domain
 Treatment time      
  Visit 2 (reference = visit 1) −0.90 (0.06) −0.17 (0.34) −1.49 (0.57) 0.63 (0.58) −0.16 (0.23)
  Visit 3 (reference = visit 1) −0.06 (0.39) −0.14 (0.33) −0.76 (0.57) 0.17 (0.60) 0.002 (0.23)
Social domain
 Treatment time      
  Visit 2 (reference = visit 1) −0.61 (0.39) 0.10 (0.31) 0.18 (0.24) −0.83 (0.69) 0.05 (0.21)
  Visit 3 (reference = visit 1) −0.31 (0.35) −0.31 (0.30) 0.14 (0.25) −0.02 (0.63) −0.14 (0.21)
Environment domain
 Treatment time      
  Visit 2 (reference = visit 1) 0.13 (0.15) −0.07 (0.23) 0.29 (0.21) −0.34 (0.27) 0.23 (0.18)
  Visit 3 (reference = visit 1) 0.07 (0.16) −0.06 (0.22) 0.17 (0.22) −0.16 (0.28) 0.10 (0.18)
  1. Note: Visit 1 is 1st office visit when patients were diagnosed with PCOS (baseline). Once PCOS was diagnosed, patients started metformin treatment. Visit 2 was 2nd office visit (1st-2nd month of treatment). Visit 3 was 3rd office visit (3rd- 4th month of treatment). The analysis was adjusted for the effect of medication adherence via the Morisky 8-item medication adherence scale
  2. Abbreviations: HRQoL health-related quality of life, SE standard error
  3. *p < 0.05