Table 3 Mixed effect model analysis of metformin effect on general HRQoL outcome measured via WHOQOL-Bref
WHOQOL-Bref | Total Coefficient (SE) | Subgroups | |||
|---|---|---|---|---|---|
Normal weight Coefficient (SE) | Overweight Coefficient (SE) | Non- hyperandrogenism Coefficient (SE) | Hyperandrogenism Coefficient (SE) | ||
Total scores | |||||
 Treatment time |  |  |  |  |  |
  Visit 2 (reference = visit 1) | −0.93 (1.04) | 0.47 (0.77) | −1.72 (1.44) | 1.49 (1.26) | 0.79 (0.56) |
  Visit 3 (reference = visit 1) | 0.06 (0.94) | 0.07 (0.75) | −0.27 (1.45) | 0.52 (1.30) | 0.70 (0.56) |
Physical domain | |||||
 Treatment time | p = 0.010 |  | p = 0.036 |  | p = 0.015 |
  Visit 2 (reference = visit 1) | 0.58 (0.20)* | 0.50 (0.29) | 0.57 (0.28)* | 0.62 (0.50) | 0.55 (0.22)* |
  Visit 3 (reference = visit 1) | 0.54 (0.20)* | 0.50 (0.29) | 0.64 (0.27)* | 0.29 (0.51) | 0.60 (0.22)* |
Psychological domain | |||||
 Treatment time |  |  |  |  |  |
  Visit 2 (reference = visit 1) | −0.90 (0.06) | −0.17 (0.34) | −1.49 (0.57) | 0.63 (0.58) | −0.16 (0.23) |
  Visit 3 (reference = visit 1) | −0.06 (0.39) | −0.14 (0.33) | −0.76 (0.57) | 0.17 (0.60) | 0.002 (0.23) |
Social domain | |||||
 Treatment time |  |  |  |  |  |
  Visit 2 (reference = visit 1) | −0.61 (0.39) | 0.10 (0.31) | 0.18 (0.24) | −0.83 (0.69) | 0.05 (0.21) |
  Visit 3 (reference = visit 1) | −0.31 (0.35) | −0.31 (0.30) | 0.14 (0.25) | −0.02 (0.63) | −0.14 (0.21) |
Environment domain | |||||
 Treatment time |  |  |  |  |  |
  Visit 2 (reference = visit 1) | 0.13 (0.15) | −0.07 (0.23) | 0.29 (0.21) | −0.34 (0.27) | 0.23 (0.18) |
  Visit 3 (reference = visit 1) | 0.07 (0.16) | −0.06 (0.22) | 0.17 (0.22) | −0.16 (0.28) | 0.10 (0.18) |