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Table 3 Mean (SD) of cognitive tests and mood scales in males and females at baseline and week 24 for the low and high dose group

From: Effect of low-normal and high-normal IGF-1 levels on memory and wellbeing during growth hormone replacement therapy: a randomized clinical trial in adult growth hormone deficiency

 

Males

Females

Low Dose

n = 9

High Dose

n = 10

Low Dose

n = 6

High Dose

n = 5

Baseline

Week 24

Baseline

Week 24

Baseline

Week 24

Baseline

Week 24

MEMORY

 PRM (%)

91.2 (8.7)

92.6 (5.8)

85.8 (15.2)

91.2 (8.2)

88.9 (8.2)

90.3 (10.1)

91.7 (8.3)

91.7 (11.4)

 SWM TE

15.3 (19.7)

16.8 (14.7)

28 (24.7)

21.7 (17.2)

42 (24.9)

26(23.3)**

27.4 (9.4)

34.4 (14.3)

 SWM STR

38.3 (11.1)

36.3 (8.8)

43.3 (9)

40.1(7.8)**

44.3 (6.4)

40.8 (9.4)

43.4 (2.1)

46 (3.5)

MOOD

 Depression

2.9 (3.2)

4.1 (6.7)

2.6 (3.3)

1.2 (2.5)

4.3 (4.9)

7 (7.3)

5.2 (3.1)

5 (6)

 Anger

5.4 (6.2)

4.9 (5.4)

4.8 (4.7)

4.2 (4.2)

9 (7.7)

7 (5.8)

5.2 (5.7)

5.6 (7.2)

 Fatigue

5.4 (6)

5.3 (6.6)

3.9 (3.4)

3 (1.8)

9.8 (7.5)

13.2 (3.7)

4.4 (4.7)

3.6 (3.8)

 Tension

3 (2.9)

3.7 (4)

4.5 (4.6)

3.7 (3.6)

4.5 (4.6)

7.8 (5.3)

6.2 (5.5)

5 (5.4)*

 Vigor

11.3 (4.1)

12.8 (4.8)

12.5 (3.4)

11.8 (3.9)

11.5 (5.2)

7.8 (4)*

12.8 (1.5)

12 (2.7)

  1. PRM (%) = Pattern Recognition Memory (percent correct)
  2. SWM TE Spatial Working Memory Total Errors, SWM STR Spatial Working Memory Strategy
  3. * p < 0.05, ** p ≤ 0.01; week 24 versus baseline