Table 5 Determination of appropriate Confidence Intervals (CI) testing for significantly different MCIDs between time points
15-point GRC T0-T1 | 15-point GRC T0-T2 | 15-point GRC T0-T3 | 15-point GRC T0-T4 | 15-point GRC T0-T5 | Five-point GRC T0-T5 | |
|---|---|---|---|---|---|---|
CAT | ||||||
Mean change | −3.1 | −2.7 | − 2.7 | − 2.3 | −2.8 | −1.4 |
SD of the change | 5.3 | 6.4 | 6.7 | 6.1 | 6.7 | 5.9 |
N of patients | 196 | 107 | 96 | 80 | 88 | 81 |
ICC | 0.7 | 0.6 | 0.5 | 0.6 | 0.5 | 0.6 |
Z score required | 0.62 | 0.98 | 0.98 | 0.98 | 0.98 | 0.98 |
Standard Error | 0.4 | 0.6 | 0.7 | 0.7 | 0.7 | 0.7 |
CI | −3.4 to −2.9 | −3.4 to −2.1 | −3.4 to −2.1 | −3.0 to −1.6 | −3.5 to − 2.1 | −2.0 to − 0.8 |
Standardized mean change and CI | −7.8 (− 8.4 to − 7.2) | −6.9 (− 8.4 to −5.3) | −6.8 (−8.5 to −5.2) | −5.8 (− 7.4 to −4.1) | − 7.0 (− 8.8 to − 5.3) | − 3.5 (− 5.1 to − 1.90) |
CCQ Total | ||||||
Mean change | −0.6 | − 0.4 | − 0.4 | − 0.5 | −0.5 | − 0.3 |
SD of the change | 0.8 | 1.0 | 1.1 | 0.8 | 1.0 | 0.8 |
N of patients | 196 | 107 | 96 | 80 | 88 | 81 |
ICC | 0.7 | 0.6 | 0.5 | 0.7 | 0.5 | 0.6 |
Z score required | 0.62 | 0.98 | 0.98 | 0.62 | 0.98 | 0.98 |
Standard Error | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
CI | −0.7 to −0.5 | −0.5 to −0.3 | −0.5 to −0.3 | −0.6 to − 0.4 | −0.6 to − 0.4 | −0.4 to 0.2 |
Standardized mean change and CI | −9.3 (−10.0 to −8.7) | −7.3 (−9.0 to −5.7) | −7.0 (− 8.8 to −5.2) | −7.7 (− 8.7 to −6.7) | − 8.3 (− 10.0 to − 6.7) | − 5.5 (− 7.0 to −4.0) |
SGRQ Total | ||||||
Mean change | −8.4 | −7.6 | − 9.2 | − 10.3 | −8.8 | − 7.7 |
SD of the change | 11.8 | 13.8 | 14.0 | 12.9 | 14.1 | 12.9 |
N of patients | 196 | 107 | 96 | 80 | 88 | 81 |
ICC | 0.7 | 0.7 | 0.7 | 0.7 | 0.6 | 0.6 |
Z score required | 0.62 | 0.62 | 0.62 | 0.62 | 0.98 | 0.98 |
Standard Error | 0.8 | 1.3 | 1.4 | 1.4 | 1.5 | 1.4 |
CI | −8.9 to −7.9 | −8.4 to −6.8 | −10.1 to −8.3 | −11.2 to −9.4 | −10.3 to − 7.4 | −9.1 to − 6.3 |