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Table 2 Comparison between different HQOL scores regarding demographic and laboratory data

From: Health-related quality of life in pediatric and adolescent patients with transfusion-dependent ß-thalassemia in upper Egypt (single center study)

Parameter Physical score Emotional score Social score School Achievement score Psychological score Total score
Mean ± SD p value Mean p value Mean p value Mean p value Mean p value Mean p value
Age 8-12 40.3 ± 22.6   53.1 ± 16.8   52.4 ± 21.7   40.8 ± 16.2   47.9 ± 15.2   46.8 ± 15.9  
13-18 31.6 ± 17.1 0.12 43.5 ± 16.2 0.03* 39.04 ± 18.1 0.013* 34.9 ± 13.9 0.14 41.1 ± 10.2 0.04* 37.7 ± 10.7 0.09
Sex Male 39.5 ± 22.3   49.1 ± 16.8   48.1 ± 20.5   40.2 ± 14.6   45.6 ± 14.1   44.3 ± 14.6  
female 31.6 ± 16.9 0.16 49.9 ± 17.7 0.85 45.2 ± 23.2 0.62 34.9 ± 19.02 0.2 44.5 ± 13.4 0.78 41.2 ± 15.1 0.29
Household income < 500 54.1 ± 16.1   56 ± 19.1   61.6 ± 13.1   47.5 ± 14.7   52.4 ± 10.1   54.3 ± 9.1  
500-1000 33.2 ± 21.8 0.45 46.6 ± 18.1 0.04* 44.1 ± 23.5 0.9 35.8 ± 15.3 0.78 43.8 ± 15.4 0.27 40.6 ± 16.1 0.39
> 1000 28.3 ± 13.5   48.7 ± 10.5   39.9 ± 16.8   35.6 ± 14.2   41.4 ± 11.3   38.3 ± 11.1  
Type of chelation Non 32.1 ± 19.6   41.8 ± 13.6   43.8 ± 19.7 0.54 38.1 ± 16   40 ± 9.4   38.9 ± 10.4  
Oral 49.6 ± 24.2 0.5 55.3 ± 18.8 0.82 58 ± 25.1   41.9 ± 16.6 0.27 54.9 ± 10.8 0.42 51.8 ± 16.4 0.44
Sc 39.7 ± 18.8   55.5 ± 17.6   51.5 ± 18.7   44.3 ± 12.6   48.9 ± 11.8   48 ± 11.4  
Splenectomy No 37.3 ± 23.9 0.54 52.1 ± 23.9 0.46 48.9 ± 24.1 0.63 40.7 ± 16.3 0.74 44.1 ± 9.8 0.08 45 ± 17.5 0.3
Yes 36.5 ± 17.3   46.3 ± 14.9   45.2 ± 17.9   36.1 ± 14.5   44.9 ± 17.5   41.4 ± 10.9  
Educational level Primary school 34.9 ± 19.8 0.81 51.2 ± 16.4 0.46 43.7 ± 15.3 0.72 35.7 ± 14.4 0.21 43.6 ± 13.1 0.29 41.3 ± 13.1 0.27
Secondary school 39.7 ± 21.9   52 ± 17.33   50.6 ± 23.6   40.04 ± 16.6   47.1 ± 15.7   45. ±16.4  
No school 31.8 ± 19.7   4.9 ± 14.6   42 ± 19.7   37.9 ± 14.2   42.3 ± 8.1   38.8 ± 10.6  
HCV infection Positive 28.4 ± 12.4 0.38 45.4 ± 11.9 0.87 39.3 ± 13.5 0.3 39.5 ± 14.3 0.45 41.01 ± 10.7 0.3 38.7 ± 10.6 0.31
negative 41.4 ± 23.1   51.4 ± 18.9   51.3 ± 23.5   38.1 ± 16.2   47.5 ± 14.7   45.6 ± 16.1
Pre-transfusion Hb% < 9 g% 49.9 ± 12.4 0.4 56.2 + 14.7 0.51 41.8 + 11.1 0.28 55.8 + 21.5 0.33 56.7 ± 18.5 0.23 51.2 ± 12.6 0.15
≥9 g% 50.7 ± 6.6   53.3 + 18.1   45.6 + 12.4   52.9 + 14.8   54.7 ± 5.6   50.9 ± 13.1
Serum ferritin (ng/ml) < 2500 41.7 ± 21.6 0.31 48.9 ± 19.1 0.09 52.3 ± 23.5 0.5 36.7 ± 15.1 0.06 46.1 ± 15.9 0.2 44.9 ± 15.1 0.07
≥2500 32.9 ± 19.7   49.6 ± 15.4   42.8 ± 18.5   40.03 ± 15.9   44.5 ± 12.9   41.9 ± 14.6
Age of start transfusion r 0.19 0.09 0.2 0.04 0.13 0.17
p-value 0.1 0.4 0.08 0.7 0.3 0.1
Age of start chelation r 0.17 0.23 0.09 0.13 0.17 0.19
p-value 0.1 0.06 0.4 0.2 0.1 0.1
  1. HCV Hepatitis C virus, Hb Hemoglobin, SC Subcutaneous. * = Significant (p < 0.05)