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Table 1 Results of ROC-AUC obtained by multivariate logistic regression

From: Re-evaluation of the definition of remission on the 17-item Hamilton Depression Rating Scale based on recovery in health-related quality of life in an observational post-marketing study

HAM-D17 Cut-off value ROC-AUC 95% Confidence Interval Selected Scores of HRQOL
1 0.868 0.813–0.942 BP, VT
2 0.854 0.799–0.909 BP,VT,SF,RE
3 0.828 0.779–0.877 VT,SF,RE
4 0.848 0.808–0.887 BP,SF,RE,MH
5 0.864 0.831–0.898 PF,BP,VT,SF,RE,MH
6 0.852 0.819–0.885 PF,VT,SF,RE,MH
7 0.837 0.803–0.870 PF,VT,SF,RE,MH
8 0.844 0.813–0.875 PF,BP,VT,SF,RE,MH
9 0.837 0.806–0.868 PF,BP,VT,SF, RE,MH
10 0.834 0.803–0.864 PF,BP,SF,RE,MH
11 0.836 0.806–0.866 PF,BP,VT,SF,RE,MH
12 0.830 0.800–0.860 PF,BP,SF,RE,MH
13 0.820 0.789–0.850 PF,BP,SF,RE,MH
14 0.825 0.795–0.855 PF,BP,SF,RE,MH
15 0.820 0.790–0.850 PF,BP,RE,MH
16 0.813 0.782–0.843 PF,BP,SF,RE,MH
17 0.794 0.762–0.826 PF,BP,SF,RE,MH
18 0.790 0.758–0.822 PF,BP,RE
19 0.793 0.761–0.825 PF,BP,SF,RE
20 0.789 0.756–0.823 PF,SF,RE
21 0.792 0.758–0.826 PF,SF,RE
22 0.779 0.732–0.817 PF,RE
23 0.773 0.733–0.813  
  1. Abbreviation: HRQOL health-related quality of life, PF physical functioning, RP role physical, BP bodily pain, GH general health perceptions, VT vitality, SF social functioning, RE role-emotional, MH mental health
  2. The multivariate logistic regression with the HAM-D17 score as a dependent variable and with each of the eight domain scores of HRQOL (SF-36) as independent variables was conducted, and the maximal ROC-AUC of 0.864 was obtained. In addition, based on the cutoff value, by converting the HAM-D17 score into the binominal form of “0 or 1,” a multivariate analysis with HAM-D17 as a dependent variable and with each of the eight HRQOL domain scores (SF-36) as binominalized independent variables was performed. Then, the significantly (p < 0.05) associated scores of the eight HRQOL domains (SF-36) were identified. Specifically, after converting this cutoff score of HAM-D17 into the binominal form of “0 or 1” for HAM-D17 scores of ≥5 and ≤4, the domain scores of PF, BP, VT, SF, RE, and MH are significantly negatively correlated with HAM-D17