Re-evaluation of the definition of remission on the 17-item Hamilton Depression Rating Scale based on recovery in health-related quality of life in an observational post-marketing study

Table 1 Results of ROC-AUC obtained by multivariate logistic regression

HAM-D17 Cut-off value	ROC-AUC	95% Confidence Interval	Selected Scores of HRQOL
1	0.868	0.813–0.942	BP, VT
2	0.854	0.799–0.909	BP,VT,SF,RE
3	0.828	0.779–0.877	VT,SF,RE
4	0.848	0.808–0.887	BP,SF,RE,MH
5	0.864	0.831–0.898	PF,BP,VT,SF,RE,MH
6	0.852	0.819–0.885	PF,VT,SF,RE,MH
7	0.837	0.803–0.870	PF,VT,SF,RE,MH
8	0.844	0.813–0.875	PF,BP,VT,SF,RE,MH
9	0.837	0.806–0.868	PF,BP,VT,SF, RE,MH
10	0.834	0.803–0.864	PF,BP,SF,RE,MH
11	0.836	0.806–0.866	PF,BP,VT,SF,RE,MH
12	0.830	0.800–0.860	PF,BP,SF,RE,MH
13	0.820	0.789–0.850	PF,BP,SF,RE,MH
14	0.825	0.795–0.855	PF,BP,SF,RE,MH
15	0.820	0.790–0.850	PF,BP,RE,MH
16	0.813	0.782–0.843	PF,BP,SF,RE,MH
17	0.794	0.762–0.826	PF,BP,SF,RE,MH
18	0.790	0.758–0.822	PF,BP,RE
19	0.793	0.761–0.825	PF,BP,SF,RE
20	0.789	0.756–0.823	PF,SF,RE
21	0.792	0.758–0.826	PF,SF,RE
22	0.779	0.732–0.817	PF,RE
23	0.773	0.733–0.813

Abbreviation: HRQOL health-related quality of life, PF physical functioning, RP role physical, BP bodily pain, GH general health perceptions, VT vitality, SF social functioning, RE role-emotional, MH mental health
The multivariate logistic regression with the HAM-D17 score as a dependent variable and with each of the eight domain scores of HRQOL (SF-36) as independent variables was conducted, and the maximal ROC-AUC of 0.864 was obtained. In addition, based on the cutoff value, by converting the HAM-D17 score into the binominal form of “0 or 1,” a multivariate analysis with HAM-D17 as a dependent variable and with each of the eight HRQOL domain scores (SF-36) as binominalized independent variables was performed. Then, the significantly (p < 0.05) associated scores of the eight HRQOL domains (SF-36) were identified. Specifically, after converting this cutoff score of HAM-D17 into the binominal form of “0 or 1” for HAM-D17 scores of ≥5 and ≤4, the domain scores of PF, BP, VT, SF, RE, and MH are significantly negatively correlated with HAM-D17

ISSN: 1477-7525