Table 6 Participants’ perceptions of sickle cell disease and hydroxyurea in relation to their health-related quality of life using PROMIS® measures
B-IPQ domains | Fatigue (N = 31) | Pain interference (N = 31) | PF-UE (N = 31) | PF-Mobility (N = 31) | Anxiety (N = 31) | Depression (N = 31) | Peer relationships (N = 23) | Social Isolation (N = 8) |
|---|---|---|---|---|---|---|---|---|
Consequences | 0.68 (<0.001) | 0.56 (<0.01) | −0.32 (0.08) | −0.59 (<0.001) | 0.55 (<0.01) | 0.64 (<0.001) | −0.1 (0.64) | 0.55 (0.15) |
Personal control | −0.28 (0.13) | −0.51 (<0.01) | 0.2 (0.28) | 0.2 (0.27) | −0.27 (0.14) | −0.3 (0.1) | 0.02 (0.94) | −0.61 (0.1) |
Treatment control | −0.6 (<0.001) | −0.39 (0.03) | 0.36 (0.04) | 0.59 (<0.001) | −0.47 (<0.01) | −0.62 (<0.001) | 0.17 (0.43) | −0.81 (0.01) |
Identity (symptoms) | 0.56 (<0.01) | 0.48 (<0.01) | −0.39 (0.03) | −0.52 (<0.01) | 0.31 (0.09) | 0.34 (0.06) | −0.07 (0.76) | 0.32 (0.44) |
Concerns | 0.44 (0.01) | 0.54 (<0.01) | −0.35 (0.06) | −0.35 (0.05) | 0.58 (<0.001) | 0.49 (<0.01) | −0.21 (0.33) | 0.82 (0.01) |
Understanding | −0.23 (0.21) | −0.3 (0.11) | 0.1 (0.59) | 0.1 (0.6) | 0.13 (0.5) | −0.004 (0.99) | 0.18 (0.42) | −0.08 (0.85) |
Emotional response | 0.74 (<0.001) | 0.63 (<0.001) | −0.37 (0.04) | −0.6 (<0.001) | 0.56 (<0.01) | 0.7 (<0.001) | −0.13 (0.55) | 0.74 (0.03) |