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Table 5 Participants’ perceptions of sickle cell disease and hydroxyurea in relation to adherence laboratory markers in homozygous sickle cell patients (N = 29)

From: Adherence to hydroxyurea, health-related quality of life domains, and patients’ perceptions of sickle cell disease and hydroxyurea: a cross-sectional study in adolescents and young adults

B-IPQ domains, median (IQR)

HbF%

MCV

Low <16% (n = 15)

High ≥16% (n = 14)

P-value

Low <102 (n = 15)

High ≥102 (n = 14)

P-value

Consequences

6 (1, 8)

5 (0, 7)

0.69

7 (2, 9)

3 (0, 5)

0.05

Personal control

5 (3, 10)

5 (4, 8)

0.82

5 (3, 7)

5 (7, 9)

0.32

Treatment control

7 (5, 9)

9 (7, 10)

0.15

6 (5, 8)

9 (7, 10)

0.01

Identity (symptoms)

6 (1, 8)

4 (0, 6)

0.2

6 (5, 8)

1 (0, 4)

0.01

Concerns

7 (4, 9)

5 (2, 9)

0.48

6 (4, 9)

5 (2, 8)

0.44

Understanding

10 (6, 10)

9 (8, 10)

0.83

10 (8, 10)

10 (7, 10)

0.65

Emotional response

7 (0, 10)

2 (0, 6)

0.1

7 (3, 10)

0 (0, 3)

<0.01

  1. Data are presented as medians and inter-quartile ranges
  2. P-value <0.05 was statistically significant (highlighted in bold)
  3. B-IPQ brief illness perception questionnaire; HbF fetal haemoglobin level; IQR inter-quartile range; MCV mean corpuscular volume
  4. Higher B-IPQ scores indicated worse perceptions of sickle cell disease related consequences, identity or disease-related symptoms, concerns, and emotional response, but better perceptions of personal control, treatment control, and understanding of sickle cell disease
  5. Higher HbF % or MCV values indicate higher hydroxyurea adherence rates