Table 5 Multivariate analyses of EORTC-QLQ-BR23

Side effects of systemic therapy

OR (SE), ^p value

Arm symptoms

OR (SE), ^p value

Breast symptoms

OR (SE), ^p value

Hair loss

OR (SE), ^p value

Disease free period

 (3rd year/1st year)

8.56 (1.69), <0.001

6.80 (1.32), <0.001

 (2nd year/1st year)

5.82 (1.45), <0.001

4.66 (1.16), <0.001

Disease stage

 (III-IV/0)

-4.70 (2.29), 0.041

−4.21 (1.80), 0.019

Axillary dissection

 (axillary/none)

−3.47 (0.98), <0.001

−4.83 (1.50), 0.001

−2.95 (1.17), 0.12

−8.72 (2.70), 0.001

Hormone therapy

 (yes/no)

−1.78 (0.56) 0.001

Employment change

 (employed/employed➔unemployed)

2.76 (1.34),

 (unemployed/employed➔unemployed)

0.039

2.48 (1.24), 0.046

Educational status

 (high/low or middle)

3.54 (1.43), 0.013

Household income

 (low/high)

−4.23 (0.97), <0.001

−3.33 (1.40), 0.018

−2.12 (1.02), 0.038

Hobbies

 (active/rare)

4.98 (1.14), <0.001

6.69 (1.58), <0.001

2.63 (1.24), 0.033

8.85 (3.34), 0.009

Medication of psychotropic drug

-

 (yes/no)

9.90 (1.85), <0.001

−7.09 (2.49), 0.004

Medication of diabetes

 (yes/no)

−5.61 (2.52), 0.026

Current smoking

 (yes/no)

−7.06 (2.99), 0.018

Supplementary drug

 (yes/no)

−3.17 (0.95), 0.001

Body Image

OR (SE), ^p value

Future perspective

OR (SE), ^p value

Sexual activity

OR (SE), ^p value

Sexual Enjoyment

OR (SE), ^p value

Disease free period

 (3rd year/1st year)

3.92 (1.83), 0.032

Breast surgery

 (MRM/BCS)

-9.16 (2.82), 0.001

Axillary dissection

 (axillary/none)

−5.55 (2.56), 0.031

Chemotherapy

 (yes/no)

−3.40 (0.78), <0.001

−1.15 (0.48), 0.018

Hormone therapy

 (yes/no)

2.80 (1.32), 0.034

Radiotherapy field

 (breast/including regional nodes)

11.22 (2.98), <0.001

Menopausal status

 (post−/pre-)

4.88 (1.55), 0.002

6.65 (2.00), 0.001

Age group

 (>60/<40)

−9.78 (1.49), <0.001

−38.16 (4.91), 0.001

 (51–60/<40)

−4.22 (1.00), <0.001

−22.82 (4.11), <0.001

 (41–50/<40)

−13.26 (4.01), 0.001

Employment change

 (employed/employed➔unemployed)

−8.74 (1.83), <0.001

−8.63 (2.31), <0.001

Household income

 (low/high)

−3.61 (1.54), 0.019

−6.23 (1.98), 0.002

Hobbies

 (active/rare)

6.16 (1.81), 0.001

9.38 (2.31), <0.001

6.27 (1.41), <0.001

6.67 (2.53), 0.009

 (moderate/rare)

5.08 (1.16), <0.001

Medication of psychotropic drug

 (yes/no)

−11.59 (2.85), <0.001

Alcohol consumption

 (yes/no)

−3.82 (1.77), 0.031

Supplementary drug

 (yes/no)

−4.34 (1.50), 0.004

−4.68 (1.95), 0.017