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Table 5 Multivariate analyses of EORTC-QLQ-BR23

From: An assessment of quality of life for early phase after adjuvant radiotherapy in breast cancer survivors: a Korean multicenter survey (KROG 14–09)

  Symptomatic subscale
  Side effects of systemic therapy
OR (SE), p value
Arm symptoms
OR (SE), p value
Breast symptoms
OR (SE), p value
Hair loss
OR (SE), p value
Disease free period     
 (3rd year/1st year)   8.56 (1.69), <0.001 6.80 (1.32), <0.001  
 (2nd year/1st year)   5.82 (1.45), <0.001 4.66 (1.16), <0.001  
Disease stage     
 (III-IV/0)   -4.70 (2.29), 0.041 −4.21 (1.80), 0.019  
Axillary dissection     
 (axillary/none) −3.47 (0.98), <0.001 −4.83 (1.50), 0.001 −2.95 (1.17), 0.12 −8.72 (2.70), 0.001
Hormone therapy     
 (yes/no) −1.78 (0.56) 0.001    
Employment change     
 (employed/employed➔unemployed)   2.76 (1.34),   
 (unemployed/employed➔unemployed)   0.039 2.48 (1.24), 0.046  
Educational status     
 (high/low or middle)   3.54 (1.43), 0.013   
Household income     
 (low/high) −4.23 (0.97), <0.001 −3.33 (1.40), 0.018 −2.12 (1.02), 0.038  
Hobbies     
 (active/rare) 4.98 (1.14), <0.001 6.69 (1.58), <0.001 2.63 (1.24), 0.033 8.85 (3.34), 0.009
Medication of psychotropic drug -    
 (yes/no) 9.90 (1.85), <0.001 −7.09 (2.49), 0.004   
Medication of diabetes     
 (yes/no)   −5.61 (2.52), 0.026   
Current smoking     
 (yes/no) −7.06 (2.99), 0.018    
Supplementary drug     
 (yes/no) −3.17 (0.95), 0.001    
  Functional subscale
  Body Image
OR (SE), p value
Future perspective
OR (SE), p value
Sexual activity
OR (SE), p value
Sexual Enjoyment
OR (SE), p value
Disease free period     
 (3rd year/1st year) 3.92 (1.83), 0.032    
Breast surgery     
 (MRM/BCS) -9.16 (2.82), 0.001    
Axillary dissection     
 (axillary/none)     −5.55 (2.56), 0.031
Chemotherapy     
 (yes/no) −3.40 (0.78), <0.001   −1.15 (0.48), 0.018  
Hormone therapy     
 (yes/no)     2.80 (1.32), 0.034
Radiotherapy field     
 (breast/including regional nodes)     11.22 (2.98), <0.001
Menopausal status     
 (post−/pre-) 4.88 (1.55), 0.002 6.65 (2.00), 0.001   
Age group     
 (>60/<40)    −9.78 (1.49), <0.001 −38.16 (4.91), 0.001
 (51–60/<40)    −4.22 (1.00), <0.001 −22.82 (4.11), <0.001
 (41–50/<40)     −13.26 (4.01), 0.001
Employment change     
 (employed/employed➔unemployed) −8.74 (1.83), <0.001 −8.63 (2.31), <0.001   
Household income     
 (low/high) −3.61 (1.54), 0.019 −6.23 (1.98), 0.002   
Hobbies     
 (active/rare) 6.16 (1.81), 0.001 9.38 (2.31), <0.001 6.27 (1.41), <0.001 6.67 (2.53), 0.009
 (moderate/rare)    5.08 (1.16), <0.001  
Medication of psychotropic drug     
 (yes/no) −11.59 (2.85), <0.001    
Alcohol consumption     
 (yes/no) −3.82 (1.77), 0.031    
Supplementary drug     
 (yes/no) −4.34 (1.50), 0.004 −4.68 (1.95), 0.017   
  1. Negative sign is a negative effect and positive sign is a positive effect
  2. Abbreviations: EORTC-QLQ-BR23, the EORTC Quality of Life Questionnaire–breast cancer specific module, OR odds ratio, SE standard error, MRM modified radical mastectomy, BCS breast conserving surgery